LOCUS       NM_153390               1015 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus peroxisomal, testis specific 1 (Pxt1), mRNA.
ACCESSION   NM_153390
VERSION     NM_153390.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1015)
  AUTHORS   Tomczyk,I., Rokicki,M., Sienko,W., Rozek,K., Nalepa,A., Wiench,J.
            and Grzmil,P.
  TITLE     Mouse Pxt1 expression is regulated by Mir6996 miRNA
  JOURNAL   Theriogenology 210, 9-16 (2023)
   PUBMED   37467697
  REMARK    GeneRIF: Mouse Pxt1 expression is regulated by Mir6996 miRNA.
REFERENCE   2  (bases 1 to 1015)
  AUTHORS   Pawlicka,B., Duliban,M., Zieba,M., Bochenek,M., Zieba,K., Adham,I.,
            Studencka-Turski,M., Meinhardt,A. and Grzmil,P.
  TITLE     Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice
  JOURNAL   Reprod Fertil Dev 35 (11), 589-600 (2023)
   PUBMED   37393946
  REMARK    GeneRIF: Increased DNA strand breaks in spermatozoa of Pxt1
            knockout mice.
REFERENCE   3  (bases 1 to 1015)
  AUTHORS   Kaczmarek,K., Studencka,M., Meinhardt,A., Wieczerzak,K., Thoms,S.,
            Engel,W. and Grzmil,P.
  TITLE     Overexpression of peroxisomal testis-specific 1 protein induces
            germ cell apoptosis and leads to infertility in male mice
  JOURNAL   Mol Biol Cell 22 (10), 1766-1779 (2011)
   PUBMED   21460186
  REMARK    GeneRIF: PXT1 induces apoptosis via the BH3-like domain and that
            this process is inhibited by BAT3
REFERENCE   4  (bases 1 to 1015)
  AUTHORS   Kaczmarek,K., Niedzialkowska,E., Studencka,M., Schulz,Y. and
            Grzmil,P.
  TITLE     Ccdc33, a predominantly testis-expressed gene, encodes a putative
            peroxisomal protein
  JOURNAL   Cytogenet Genome Res 126 (3), 243-252 (2009)
   PUBMED   20068295
REFERENCE   5  (bases 1 to 1015)
  AUTHORS   Grzmil,P., Burfeind,C., Preuss,T., Dixkens,C., Wolf,S., Engel,W.
            and Burfeind,P.
  TITLE     The putative peroxisomal gene Pxt1 is exclusively expressed in the
            testis
  JOURNAL   Cytogenet Genome Res 119 (1-2), 74-82 (2007)
   PUBMED   18160785
  REMARK    GeneRIF: Pxt1 gene is so far the first gene coding for a putative
            peroxisomal protein which is expressed in later steps of
            spermatogenesis, namely in pachytene spermatocytes
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF486826.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF486826.1, BC100437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.03 cM"
     gene            1..1015
                     /gene="Pxt1"
                     /gene_synonym="1700001G18Rik; Stepp"
                     /note="peroxisomal, testis specific 1"
                     /db_xref="GeneID:69307"
                     /db_xref="MGI:MGI:1916557"
     exon            1..66
                     /gene="Pxt1"
                     /gene_synonym="1700001G18Rik; Stepp"
                     /inference="alignment:Splign:2.1.0"
     exon            67..194
                     /gene="Pxt1"
                     /gene_synonym="1700001G18Rik; Stepp"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..299
                     /gene="Pxt1"
                     /gene_synonym="1700001G18Rik; Stepp"
                     /note="small testis-specific peroxisomal protein"
                     /codon_start=1
                     /product="peroxisomal testis-specific protein 1"
                     /protein_id="NP_700439.1"
                     /db_xref="CCDS:CCDS37534.1"
                     /db_xref="GeneID:69307"
                     /db_xref="MGI:MGI:1916557"
                     /translation="MQLRHIGDSVNHRVIQEHLAQEVGDVLAPFVALVFVRGQVLLRF
                     FWNNHLL"
     exon            195..1015
                     /gene="Pxt1"
                     /gene_synonym="1700001G18Rik; Stepp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtttggagc ttgggcttct gagcagttag gctggagcct tgggctgcag caaaggcaag
       61 gcggaggtca ccatctgctt tgtcagccta aagagaacac tggccagaac catcatcagc
      121 gggaagacat ccagacgctc accatgcagc ttagacacat tggggacagt gtcaatcaca
      181 gggtgattca ggagcatctt gcacaggaag tcggagatgt gctggctcct tttgtggcgc
      241 tggtgttcgt gagaggccag gtgctgctga gatttttctg gaacaaccat ttgctgtaaa
      301 ggaaggacag acagacaagt cccacactct ggagtcaagc tgctgtgacc caaaccctct
      361 ccaactcttc ctcctcctcc cactgaggaa ggtctaccct gggtcatgcc ctttgatcct
      421 gcatttatca cctgtatcta gatcttcatt aagaaccaac ttcattaaga gacttgtcta
      481 cctgggcccc agatcctctg ctctgtgcgg agctgaaagg agccgggtct ccagtacgca
      541 gccctgagcc ctggcccagc caccttccct tccattagac accaccacct gttcctggtc
      601 tatttcctgc tctgactgtg ccacgtgggt ttccgctctt tctcaggcct aaggaagccc
      661 tcctgccctg aggttccctc aggcctcgcc tgatcccatc cctcaccctg cagccccatc
      721 ccctccaggg tgcctcctgc ttgcccagca agctcagctt ctagggagct ggaaactgcg
      781 acaattacat tacacccgag gcccaccaag acgactctgc cttttgagtt tgttttactc
      841 tttctcattg ttttcccagg ctttatctgt ctcatggccc ctcccacccc tgtaaaagaa
      901 tttctaatcc taagaaagtt cgttagtaat tatgagtcct atgtatacat atcctgaggt
      961 tttagtatgt agtgttactt tttttaaaaa gtgaaataaa tattttattg agcac
//
