LOCUS       NM_001403066            5298 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus paxillin (Pxn), transcript variant 3, mRNA.
ACCESSION   NM_001403066 XM_006530202
VERSION     NM_001403066.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5298)
  AUTHORS   Weidner,A.E., Roy,A., Vann,K., Walczyk,A.C. and Astapova,O.
  TITLE     Paxillin regulates androgen receptor expression associated with
            granulosa cell focal adhesions
  JOURNAL   Mol Hum Reprod 30 (5) (2024)
   PUBMED   38718206
  REMARK    GeneRIF: Paxillin regulates androgen receptor expression associated
            with granulosa cell focal adhesions.
REFERENCE   2  (bases 1 to 5298)
  AUTHORS   Saikia,B.B., Bhowmick,S., Malat,A., Preetha Rani,M.R., Thaha,A. and
            Abdul-Muneer,P.M.
  TITLE     ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic
            Brain Injury-Induced Inflammatory Leukocyte Adhesion and
            Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent
            Rho GTPase Pathway
  JOURNAL   J Neurosci 44 (11), e1742232024 (2024)
   PUBMED   38326036
  REMARK    GeneRIF: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from
            Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and
            Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent
            Rho GTPase Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5298)
  AUTHORS   Zhang,Y., Li,N. and Kobayashi,S.
  TITLE     Paxillin participates in the sphingosylphosphorylcholine-induced
            abnormal contraction of vascular smooth muscle by regulating
            Rho-kinase activation
  JOURNAL   Cell Commun Signal 22 (1), 58 (2024)
   PUBMED   38254202
  REMARK    GeneRIF: Paxillin participates in the
            sphingosylphosphorylcholine-induced abnormal contraction of
            vascular smooth muscle by regulating Rho-kinase activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5298)
  AUTHORS   Vann,K., Weidner,A.E., Walczyk,A.C. and Astapova,O.
  TITLE     Paxillin knockout in mouse granulosa cells increases
            fecunditydagger
  JOURNAL   Biol Reprod 109 (5), 669-683 (2023)
   PUBMED   37552051
  REMARK    GeneRIF: Paxillin knockout in mouse granulosa cells increases
            fecunditydagger.
REFERENCE   5  (bases 1 to 5298)
  AUTHORS   Hijazi,N., Shi,Z. and Rockey,D.C.
  TITLE     Paxillin regulates liver fibrosis via actin polymerization and ERK
            activation in hepatic stellate cells
  JOURNAL   J Cell Sci 136 (18) (2023)
   PUBMED   37667902
REFERENCE   6  (bases 1 to 5298)
  AUTHORS   Kessels,M.M., Engqvist-Goldstein,A.E. and Drubin,D.G.
  TITLE     Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src
            kinase target, with dynamic regions of the cortical actin
            cytoskeleton in response to Rac1 activation
  JOURNAL   Mol Biol Cell 11 (1), 393-412 (2000)
   PUBMED   10637315
REFERENCE   7  (bases 1 to 5298)
  AUTHORS   Engqvist-Goldstein,A.E., Kessels,M.M., Chopra,V.S., Hayden,M.R. and
            Drubin,D.G.
  TITLE     An actin-binding protein of the Sla2/Huntingtin interacting protein
            1 family is a novel component of clathrin-coated pits and vesicles
  JOURNAL   J Cell Biol 147 (7), 1503-1518 (1999)
   PUBMED   10613908
REFERENCE   8  (bases 1 to 5298)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 5298)
  AUTHORS   Mazaki,Y., Uchida,H., Hino,O., Hashimoto,S. and Sabe,H.
  TITLE     Paxillin isoforms in mouse. Lack of the gamma isoform and
            developmentally specific beta isoform expression
  JOURNAL   J Biol Chem 273 (35), 22435-22441 (1998)
   PUBMED   9712867
REFERENCE   10 (bases 1 to 5298)
  AUTHORS   Liu,F., Sells,M.A. and Chernoff,J.
  TITLE     Transformation suppression by protein tyrosine phosphatase 1B
            requires a functional SH3 ligand
  JOURNAL   Mol Cell Biol 18 (1), 250-259 (1998)
   PUBMED   9418872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159539.6.
            
            On Mar 25, 2022 this sequence version replaced XM_006530202.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.6181.1,
                                           SRR10223970.7903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC159539.6         70389-70580
            193-419             AC159539.6         108055-108281
            420-535             AC159539.6         108593-108708
            536-672             AC159539.6         109084-109220
            673-874             AC159539.6         109316-109517
            875-1010            AC159539.6         110525-110660
            1011-1841           AC159539.6         111994-112824
            1842-2108           AC159539.6         113833-114099
            2109-2501           AC159539.6         114295-114687
            2502-2603           AC159539.6         115200-115301
            2604-2774           AC159539.6         115563-115733
            2775-2948           AC159539.6         115816-115989
            2949-3030           AC159539.6         116476-116557
            3031-3179           AC159539.6         116690-116838
            3180-5298           AC159539.6         117581-119699
FEATURES             Location/Qualifiers
     source          1..5298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.1 cM"
     gene            1..5298
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /note="paxillin"
                     /db_xref="GeneID:19303"
                     /db_xref="MGI:MGI:108295"
     exon            1..192
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3446
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="paxillin isoform 3"
                     /protein_id="NP_001389995.1"
                     /db_xref="GeneID:19303"
                     /db_xref="MGI:MGI:108295"
                     /translation="MDDLDALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIA
                     VPPPVPPPPSSEALNGTVLDPLDQWQPSGSRYAHQQPPSPLPVYSSSAKNSSASNTQD
                     GVGSLCSRAGEEEHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHSPP
                     GFPADEAESSPPLPGALSPLYGIPENNTPLGGKAGPLVKEKPKRNGGRGLEDVRPSVE
                     SLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDF
                     KTSTSAVLLSSQGLLPGSSPPPPLTLLHPPLPPTNSSPGDHTPEALYTEGSSQVLLPS
                     VAPRWLGLGSPEETSDTQNSRYPSVAASQQSRGAKSQAQVRCGLMGAVGPPSRTPPCH
                     TPYPARSIGSPGPLANHVFSEETVAPIWGQPQALTASRPESPHGVTYSFQEGLEPPAV
                     ALDRQDILPDTWALTKECALQERVQSEPEGLGSTCPAAGDKEPLRGKTPQKGSLGGPT
                     EALGSPGNPEGTTEATLEARKEQPEPSYAMAVGTPSVSERISTSGQIRSVIRRSRETG
                     HVHPMSRELSPRRRLDPASLSRNPSQEQLIAELQGRLGIQLAAEEVAGTPEQDWLTEG
                     VVITVQPRGRQAGGQLVEKVVYPPDSPVPLRRTISVVAPSPPAPLLQDHPDPSTGSSP
                     LPPSLPTPSWPGPLAAASASSSGVQTEGGKSPEEGGRGPPGLTSVPHTVRSVGCQTNE
                     DPLFCPMQAGLQAPCPARALSRPEPPPNSEDAAEMQGLEQRVDGERPWAASWPPSSRQ
                     SSPEGQDEGGFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCG
                     ACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRC
                     YYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPK
                     CGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS
                     LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFVKLFC
                     "
     exon            193..419
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            420..535
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            536..672
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            673..874
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1010
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1841
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2108
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2501
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2603
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2774
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2948
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3030
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3179
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..5298
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5271..5276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /note="hexamer: AATAAA"
     polyA_site      5298
                     /gene="Pxn"
                     /gene_synonym="Pax"
                     /note="major polyA site"
ORIGIN      
        1 atcctgtcgc gggcgcgcgc gccggcggcg gcggcggtgg tggaggagga ggcagcgcgg
       61 cagcgggttc cgttccgggc cgaggctgga cgcggaaaag ttgcggggcg gcgaggagca
      121 gcccggagac gggcagcgag ggcgacatcg agccggggac tggcgtctga ggaccagcca
      181 tggacgacct cgatgccctg ctggcagact tggaatctac cacctcccac atctccaaac
      241 ggccagtgtt cttgtcagag gagcccccct actcctaccc aactggaaac cacacatacc
      301 aggagattgc ggtgccacct ccggtcccac caccaccgtc cagcgaggcc ctcaatggca
      361 cggtcctgga ccctttagat cagtggcagc ctagtggttc cagatacgct caccagcagc
      421 ctccgtcccc actgcccgtg tacagctcca gtgctaaaaa ttccagtgcc tccaacaccc
      481 aggacggcgt gggctccctt tgttcccgag caggcgagga agagcacgtc tacagcttcc
      541 ccaacaagca gaagtcggca gagccctcac ctaccgtcat gagctcctcc ctgggcagca
      601 acctctctga acttgaccgg ctgttactgg agctgaacgc agtgcagcac agcccgcctg
      661 gcttccctgc agatgaagcc gaatcgagcc cccccttgcc tggagccctg agcccccttt
      721 atggcatccc agaaaataac actcccttgg ggggcaaagc ggggcccctg gtgaaagaga
      781 agccaaagcg aaatggaggc cgggggctgg aggatgtgcg gcccagcgtg gagagcctct
      841 tggatgaact ggagagttcc gtgcccagcc ctgtcccggc catcactgtg aaccagggag
      901 agatgagcag tccgcagcga gtcacctcca gccagcagca gacccggatc tcggcctcct
      961 ctgccaccag ggagctggac gagctcatgg cgtcactgtc agatttcaag actagcactt
     1021 ctgctgtgct gctgagctcc caggggctgc tgcccggctc ttctccaccc ccgcccctca
     1081 ccctccttca tcctcctctt cctcccacta actcctcccc tggagaccac accccagagg
     1141 ccctctacac agaaggaagt agtcaggtcc ttttaccttc tgtggctccc agatggcttg
     1201 gtttgggtag tcctgaggag acgtctgaca ctcaaaattc aaggtatcct tctgtggcgg
     1261 cttctcaaca gtcacgtggt gcgaagagcc aggctcaagt taggtgtggc ctgatgggtg
     1321 ctgtgggtcc cccctctagg actcccccat gccacactcc ataccctgca aggagcatag
     1381 ggtccccggg gccactggcc aaccatgtgt tttcagagga gactgtggct cccatttggg
     1441 gacagccaca ggctctgaca gcatccaggc ctgagagtcc ccatggagtg acttacagct
     1501 ttcaggaagg gcttgagcca cccgccgtgg cattagatcg gcaagatatc cttcctgaca
     1561 cctgggctct caccaaggag tgtgccctgc aggagagggt acagtcagaa ccagagggcc
     1621 tgggaagcac ttgtcctgcc gcaggggaca aggagccgct ccgtgggaag actccccaga
     1681 agggaagcct tgggggaccc actgaggcac tcgggagccc agggaaccca gaaggtacca
     1741 ctgaagccac tctggaggcc aggaaggagc agccggagcc ttcttatgcc atggccgtgg
     1801 ggacacccag cgtctcggag aggatttcca cctccggcca gatccgctct gtgatcagga
     1861 ggagccggga gacgggccac gtgcacccca tgtcccggga gctttcccct cgccgcaggc
     1921 tggaccctgc cagcctgagc aggaacccat cccaggagca gctcattgct gagctgcagg
     1981 gccggctggg catccagctg gcggccgagg aggtggcagg gacccccgag caggactggc
     2041 tgacggaagg cgttgttatc accgtgcagc cacgtgggag gcaggccggg gggcagttgg
     2101 tagagaaggt tgtctaccct cctgactctc ccgttcccct gagaagaacc atctctgttg
     2161 tggctccttc tccccctgcc cctttgctcc aggatcaccc tgacccttcg actggcagct
     2221 ctcctctccc acccagcctg cccactccct cctggccagg gcccttggct gctgcttctg
     2281 cttcatcttc tggggtccag actgaagggg ggaagtcccc agaggagggt gggcgtggcc
     2341 ctcctggtct cacctctgtg ccccacaccg tgaggtctgt gggctgccag accaatgagg
     2401 acccactctt ctgcccgatg caggccggcc tccaggcacc ttgccctgcc cgtgccctgt
     2461 ctcgtcccga gccacctccc aactctgagg atgctgcaga gatgcagggc ctggaacaga
     2521 gagtggatgg agagcggccg tgggcagcca gctggccccc cagcagcagg cagagcagcc
     2581 ccgaagggca ggacgaggga gggttcatgg cccaggggaa aactgggagc agctcacccc
     2641 ctgggggact ctccaagccc gggagccagc tggacagcat gttggggagt ctgcagtccg
     2701 acctgaacaa gctaggggtc gccaccgttg ccaaaggggt ctgtggagcc tgcaagaagc
     2761 ccatcgccgg gcaggtcgtg accgccatgg ggaagacatg gcaccccgag cactttgtgt
     2821 gcacccactg ccaggaggag attggatccc gaaacttttt tgagcgggac ggacagccct
     2881 actgtgagaa ggactaccac agcctcttct ccccacgctg ctactactgc aacggaccca
     2941 tcctggataa agtggtgaca gcgctggacc gcacatggca cccggaacac ttcttctgtg
     3001 cccagtgtgg agccttcttt ggtccagaag gcttccacga gaaggacggc aaagcgtact
     3061 gtcgtaaaga ttacttcgac atgtttgctc ccaagtgcgg cggctgcgcc cgtgccatcc
     3121 tggagaacta catttcagcc ctcaacaccc tctggcaccc cgaatgcttt gtgtgcaggg
     3181 agtgcttcac acccttcgtc aacggcagct tctttgagca cgacgggcag ccgtactgtg
     3241 aggtccacta ccacgagcgg cgcggctcgc tgtgctccgg ctgccagaag cccatcacgg
     3301 gccgctgcat caccgccatg gccaagaagt tccaccccga gcatttcgtg tgcgcctttt
     3361 gcctgaagca gctcaacaag ggcaccttca aggagcagaa cgacaaaccc tactgccaga
     3421 gctgcttcgt gaagctcttc tgctaggccg gtgcctgccc tccccgcctt ccccagccag
     3481 ccagtgccgc cacgcactgc tcgcttgggg ccaatccacc aatggaaact ggaacctcac
     3541 cccctcagca ggcacaggcg caggacagga ctccgggtcg gtcctgcctg tctctcgtcc
     3601 ctaccacctg ctaaaggggc ctcctccccc ttccgtggct ctcctgggct ctgtgcactt
     3661 catcttcccc agaggtggaa gctgctgccc agttgtcccg tggatgtccc taagagccag
     3721 cacctcacac tggagccttt gacagtcacc tttccacagt gtggtcattg ggagggcaga
     3781 gagggtcagc taggggctct ttttatcctt ctccaaaccc ctactgtatt ggggacaccg
     3841 ggccccacta gacaatgcca gcataaagtc acccatgggc catcaaaggc actttgggtg
     3901 ccaccaccca gtctcccaga gtctgggtga ctgccccgtt tgtaccggcc ccggggtctc
     3961 tgagaaagcc tcctccagca ataacctttt atatagacac gtgcttcatc tctggggacg
     4021 gcgtgaggtg ggagtgtcac ccgcccacgc ctcaacactg taccaaattt gatagatttc
     4081 tacactgagg ttcaacttcg tatggctcaa gttgctttta tgtatctcca caagatgatt
     4141 ttgaagagat ttaaagaact cccccttttg tactctggtc tgtccttgcc gctgggtcag
     4201 cccgtggcat tggttttggt atggactttg ctttgtatga gggggaaata ctttgtatct
     4261 ttatgttatt tcttagcaca atgagctggg agcggccctt gacgacttct gaaacctcgc
     4321 agctcccggg actgttttta aactgctgta ttttcaaacc cttccctcac tgcccaggcc
     4381 aacgggctct tcattaagaa ctactctaag aatgtccagc cctttggacc tggagttttg
     4441 aacctcacgt gtcctgttcc caaggcaggc aaaggggaaa gacatatttg ggggtctgct
     4501 tcctgcctaa gtaagccatc tggaaccagc ctctgctccc tgtgaaattt tttttggcga
     4561 caaggagaaa cccctgaatt ttctcagcct cctcattgct tctctggggc tcgctcttct
     4621 tccttctcag gaaagccggt gtctgatttt gaccaggaag atggtaaagg atctctggtc
     4681 tccactccac tgggcgcatc tctccctccc tcaaacttcc tgtcagctga ccggggctaa
     4741 ggctgttccc tttcacaggt ggggtttgtg ttggggggct ggggaagggg gtctgagaat
     4801 gccccaagct ggaacagggg agcctggtag gagttggggc agagggacaa gatccctatt
     4861 agagtaacga aaagtcccag agctcccagt ccaaaggatg agatgggagc agccagcttg
     4921 gaaatggctg gggaaaaagg cgtctggaaa agggattcca gacaattcca taggctgggg
     4981 acctacacct tacatcagct tcccagtaga ggaccagcgt gatggggtcc cagacaagga
     5041 tccccagtca aggtcagctc tggcagtggc tgcagacacc ggcacttcca cccacaggcc
     5101 ttactgctct gtttacagtg acctgctcca gcccccctcc ccctccaaga cgaggtcggg
     5161 gtatctggag ggccattctc tgggtcaatg gatctgtgat catttgattc ccctccccct
     5221 tataaacttt taacctggct tttctcattt caactcctgt gatatatgcc aataaagttt
     5281 gccatgattt tcacccga
//
