LOCUS       NM_008993               1021 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus peroxisomal membrane protein 2 (Pxmp2), transcript
            variant 1, mRNA.
ACCESSION   NM_008993
VERSION     NM_008993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Vapola,M.H., Rokka,A., Sormunen,R.T., Alhonen,L., Schmitz,W.,
            Conzelmann,E., Warri,A., Grunau,S., Antonenkov,V.D. and
            Hiltunen,J.K.
  TITLE     Peroxisomal membrane channel Pxmp2 in the mammary fat pad is
            essential for stromal lipid homeostasis and for development of
            mammary gland epithelium in mice
  JOURNAL   Dev Biol 391 (1), 66-80 (2014)
   PUBMED   24726525
  REMARK    GeneRIF: Pxmp2 in the mammary fat pad is plays a critical role in
            stromal lipid homeostasis and in development of mammary gland
            epithelium in mice
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Rokka,A., Antonenkov,V.D., Soininen,R., Immonen,H.L., Pirila,P.L.,
            Bergmann,U., Sormunen,R.T., Weckstrom,M., Benz,R. and Hiltunen,J.K.
  TITLE     Pxmp2 is a channel-forming protein in Mammalian peroxisomal
            membrane
  JOURNAL   PLoS One 4 (4), e5090 (2009)
   PUBMED   19352492
  REMARK    GeneRIF: Pxmp2 channel, with an estimated diameter of 1.4 nm, shows
            weak cation selectivity and no voltage dependence. The long-lasting
            open states of the channel indicate its functional role as a
            protein forming a general diffusion pore in the membrane
REFERENCE   3  (bases 1 to 1021)
  AUTHORS   Luers,G.H., Otte,D.M., Subramani,S. and Franz,T.
  TITLE     Genomic organization, chromosomal localization and tissue specific
            expression of the murine Pxmp2 gene encoding the 22 kDa peroxisomal
            membrane protein (Pmp22)
  JOURNAL   Gene 272 (1-2), 45-50 (2001)
   PUBMED   11470509
REFERENCE   4  (bases 1 to 1021)
  AUTHORS   Bryant,D.D. and Wilson,G.N.
  TITLE     Differential evolution and expression of murine peroxisomal
            membrane protein genes
  JOURNAL   Biochem Mol Med 55 (1), 22-30 (1995)
   PUBMED   7551822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118260.7.
            
            On Apr 21, 2022 this sequence version replaced NM_008993.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI789805.1, BC057975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC118260.7         157041-157327       c
            288-395             AC118260.7         154803-154910       c
            396-558             AC118260.7         152354-152516       c
            559-678             AC118260.7         148812-148931       c
            679-1021            AC118260.7         145443-145785       c
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.44 cM"
     gene            1..1021
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /note="peroxisomal membrane protein 2"
                     /db_xref="GeneID:19301"
                     /db_xref="MGI:MGI:107487"
     exon            1..287
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..747
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /note="isoform 1 is encoded by transcript variant 1; 22
                     kDa peroxisomal membrane protein; peroxisomal membrane
                     protein 2, 22 kDa"
                     /codon_start=1
                     /product="peroxisomal membrane protein 2 isoform 1"
                     /protein_id="NP_033019.2"
                     /db_xref="CCDS:CCDS19524.1"
                     /db_xref="GeneID:19301"
                     /db_xref="MGI:MGI:107487"
                     /translation="MAPAASRLRVESELGSLPKRALAQYLLLLKLYPVLTKAVSSGIL
                     SALGNLLAQTIEKRKKDSQNLEVSGLLRYLVYGLFVTGPLSHYLYLFMEYSVPPEVPW
                     ASVKRLLLDRLFFAPTFLLLFFFVMNLLEGKNVSVFVAKMRSGFWPALQMNWRMWTPL
                     QFININYVPLQFRVLFANMAALFWYAYLASLGK"
     exon            288..395
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /inference="alignment:Splign:2.1.0"
     exon            396..558
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /inference="alignment:Splign:2.1.0"
     exon            559..678
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1021
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      993..998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /note="hexamer: AATAAA"
     polyA_site      1021
                     /gene="Pxmp2"
                     /gene_synonym="PMP22"
                     /note="major polyA site"
ORIGIN      
        1 gcactagctg gccgcgcgcg tggcgggacg gccgggctcg ctgagggcgg aggaagggca
       61 gaaaatgtca ggccgtcccc gccctgtgcc ctgtgtcccg ggccgggtgc ccgactgcct
      121 agctgttggg tgggcgcccg gggcgactta gacatccgga ccgcgatggc acctgcggcg
      181 tccaggctgc gggtggaatc cgagctcggg tcgcttccca agcgagcgct cgcccaatac
      241 ttgctgctcc taaagctcta cccggtgctc accaaagcag tcagcagcgg cattttgtca
      301 gcccttggaa accttctggc ccagacgatt gagaagcgga aaaaagactc tcaaaatcta
      361 gaagtcagtg ggcttctcag atatttagtt tatgggttgt ttgtcacagg tccactgagt
      421 cactacctct acctcttcat ggaatactcg gtccctcctg aggttccctg ggccagcgtc
      481 aagaggctcc tgctggatcg cctgttcttt gccccaactt ttctgctgct gttcttcttc
      541 gtcatgaact tgctggaggg gaaaaacgtc agtgtctttg ttgccaagat gaggagtggc
      601 ttctggcccg cactgcaaat gaactggagg atgtggacac ctttgcagtt cattaacatc
      661 aactatgtgc ccctgcagtt ccgggtgctc tttgccaaca tggcagctct gttctggtat
      721 gcctacctgg cgtctctggg gaagtgatgt cagatacacc gcggatgggg tctggggaga
      781 tccatccacc agcaggagag aacagaatcc atcattaagg acaccatctg gctaatatga
      841 tgtgattcac gatgccttaa aattacagag ggaggaaatg tgtgggtgtc agaatcatgt
      901 gcttcagaga gtcttggtgg agttagtcta agttgtcact gtgagcaaag agattatctt
      961 agttgtcact gtgaacaagg agataaaagg tcaataaatg gtgatgcagc tgtgtctgta
     1021 a
//
