LOCUS       NM_181395               6632 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus peroxidasin (Pxdn), mRNA.
ACCESSION   NM_181395 XM_484128
VERSION     NM_181395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6632)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6632)
  AUTHORS   Peebles,K.E., LaFever,K.S., Page-McCaw,P.S., Colon,S., Wang,D.,
            Stricker,A.M., Ferrell,N., Bhave,G. and Page-McCaw,A.
  TITLE     Peroxidasin is required for full viability in development and for
            maintenance of tissue mechanics in adults
  JOURNAL   Matrix Biol 125, 1-11 (2024)
   PUBMED   38000777
  REMARK    GeneRIF: Peroxidasin is required for full viability in development
            and for maintenance of tissue mechanics in adults.
REFERENCE   3  (bases 1 to 6632)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   4  (bases 1 to 6632)
  AUTHORS   Patel,S.D., Anand,D., Motohashi,H., Katsuoka,F., Yamamoto,M. and
            Lachke,S.A.
  TITLE     Deficiency of the bZIP transcription factors Mafg and Mafk causes
            misexpression of genes in distinct pathways and results in lens
            embryonic developmental defects
  JOURNAL   Front Cell Dev Biol 10, 981893 (2022)
   PUBMED   36092713
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6632)
  AUTHORS   Sojoodi,M., Erstad,D.J., Barrett,S.C., Salloum,S., Zhu,S., Qian,T.,
            Colon,S., Gale,E.M., Jordan,V.C., Wang,Y., Li,S., Ataeinia,B.,
            Jalilifiroozinezhad,S., Lanuti,M., Zukerberg,L., Caravan,P.,
            Hoshida,Y., Chung,R.T., Bhave,G., Lauer,G.M., Fuchs,B.C. and
            Tanabe,K.K.
  TITLE     Peroxidasin Deficiency Re-programs Macrophages Toward
            Pro-fibrolysis Function and Promotes Collagen Resolution in Liver
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (5), 1483-1509 (2022)
   PUBMED   35093588
  REMARK    GeneRIF: Peroxidasin Deficiency Re-programs Macrophages Toward
            Pro-fibrolysis Function and Promotes Collagen Resolution in Liver.
REFERENCE   6  (bases 1 to 6632)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   7  (bases 1 to 6632)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 6632)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   9  (bases 1 to 6632)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 6632)
  AUTHORS   Hrabe de Angelis,M.H., Flaswinkel,H., Fuchs,H., Rathkolb,B.,
            Soewarto,D., Marschall,S., Heffner,S., Pargent,W., Wuensch,K.,
            Jung,M., Reis,A., Richter,T., Alessandrini,F., Jakob,T., Fuchs,E.,
            Kolb,H., Kremmer,E., Schaeble,K., Rollinski,B., Roscher,A.,
            Peters,C., Meitinger,T., Strom,T., Steckler,T., Holsboer,F.,
            Klopstock,T., Gekeler,F., Schindewolf,C., Jung,T., Avraham,K.,
            Behrendt,H., Ring,J., Zimmer,A., Schughart,K., Pfeffer,K., Wolf,E.
            and Balling,R.
  TITLE     Genome-wide, large-scale production of mutant mice by ENU
            mutagenesis
  JOURNAL   Nat Genet 25 (4), 444-447 (2000)
   PUBMED   10932192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142872.1, BC112913.1 and BP772471.1.
            
            On Nov 17, 2009 this sequence version replaced NM_181395.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142872.1, BC150789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1743              AK142872.1         1-1743
            1744-3989           BC112913.1         541-2786
            3990-4815           AK142872.1         3990-4815
            4816-6609           BC112913.1         3613-5406
            6610-6632           BP772471.1         20-42               c
FEATURES             Location/Qualifiers
     source          1..6632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     gene            1..6632
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /note="peroxidasin"
                     /db_xref="GeneID:69675"
                     /db_xref="MGI:MGI:1916925"
     exon            1..289
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..4526
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /EC_number="1.11.1.7"
                     /note="peroxidasin homolog"
                     /codon_start=1
                     /product="peroxidasin homolog precursor"
                     /protein_id="NP_852060.2"
                     /db_xref="CCDS:CCDS25856.1"
                     /db_xref="GeneID:69675"
                     /db_xref="MGI:MGI:1916925"
                     /translation="MAVRPTRRCLLALLLCFAWWAMAVVASKQGAGCPSRCLCFRTTV
                     RCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRSLNTLLLNNNQIKKIPNGA
                     FEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPESFQHLPKLERL
                     FLHNNRITHLVPGTFSQLESMKRLRLDSNALHCDCEILWLADLLKTYAQSGNAQAAAT
                     CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIW
                     LRNNNELSMKTDSRLNLLDDGTLMIQNTQEADEGVYQCMAKNVAGEAKTQEVTLRYLG
                     SPARPTFVIQPQNTEVLVGESVTLECSATGHPLPQITWTRGDRTPLPIDPRVNITPSG
                     GLYIQNVAQSDSGEYTCFASNSVDSIHATAFIIVQALPQFTVTPQSRVVIEGQTVDFQ
                     CAAKGHPQPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQ
                     KVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQLPCSSQGEPEPAITWNKDGVQVTESG
                     KFHISPEGFLTINDVGTADAGRYECVARNTIGYASVSMVLSVNVPDVSRNGDPYVATS
                     IVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVGQARAGEIFERTLQL
                     IQEHVQHGLMVDLNGTSYHYNDLVSPQYLSLIANLSGCTAHRRVNNCSDMCFHQKYRT
                     HDGTCNNLQHPMWGASLTAFERLLKAVYENGFNTPRGINSQRQYNGHVLPMPRLVSTT
                     LIGTEVITPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSSVCSNDPPCFS
                     VMIPPNDPRVRSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYG
                     STDHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGD
                     HRANEQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTVYHETRKIVGAEIQHITYRH
                     WLPKILGEVGMKMLGEYRGYDPSVNAGIFNAFATAAFRFGHTLINPLLYRLDENFEPI
                     PQGHVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNTELTERLFSMAHT
                     VALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIKSPVIREKLQRLYGS
                     TLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYENPGVFSPAQLTQL
                     KQTSLARILCDNSDNITRVQQDVFRVAEFPHGYSSCEDIPRVDLRVWQDCCEDCRTRG
                     QFNAFSYHFRGRRSLEFSYEDDKPTKRARWRKALSVKHGKHLSNATSATHEHLEGPAT
                     NDLKEFVLEMQKIITDLRKQINSLESRLSTTECVDDSGESHGGNTKWKKDPCTVCECK
                     NGQITCFVEACQPAACPQPVKVEGACCPVCLKNTAEEKP"
     exon            290..361
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..433
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..505
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..577
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..649
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..819
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..937
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1107
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1380
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1497
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1656
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1769
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1926
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2035
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2193
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..3697
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3832
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..4041
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4162
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4292
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4406
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..6614
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6588..6593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /note="hexamer: AATAAA"
     polyA_site      6614
                     /gene="Pxdn"
                     /gene_synonym="2310075M15Rik; E330004E07; mKIAA0230; VPO1"
                     /note="major polyA site"
ORIGIN      
        1 ggaccggagg gctcagttgg gagccggcgg tggacgcgcc cgccgaggcc tcctccgctg
       61 ctgttcacgc gtgccagctc ctgtccgcgc catctgccat ggccgtgcgc cccacgcgcc
      121 gctgcctgct ggcgctcctg ctgtgctttg cctggtgggc catggcggtg gtcgcctcga
      181 agcaaggggc aggctgtcca agccgctgcc tgtgtttccg taccaccgtg cgctgcatgc
      241 atctgttgct ggaggccgtg cccgccgtgg cgccgcagac ctccatccta gatcttcggt
      301 tcaacagaat cagagagatc caacccgggg cattcaggag gctgaggagc ctgaacacac
      361 tgcttcttaa caacaaccag atcaagaaga tccccaatgg tgcatttgag gacctggaga
      421 acttaaaata cctctatttg tacaagaatg agatccaatc aattgacagg caagcattta
      481 agggacttgc ctctctagag caactgtacc tgcactttaa tcagatagaa acgctggacc
      541 ctgaatcctt ccagcacctg ccaaagctgg agagactgtt tttgcacaac aaccgtatca
      601 cgcacttagt tcctgggacg ttcagtcagt tagagtccat gaaacggctg cgattggact
      661 cgaatgcact ccactgtgac tgtgaaatcc tatggctagc ggatctactg aagacctacg
      721 cccaatctgg aaacgcacaa gcagcagcta catgcgagta tcccagacgc atccaaggac
      781 gctctgtggc taccatcacc ccagaagagc tgaactgtga aaggccccgg attacctcag
      841 agccacagga tgcagatgtc acctcaggga acacagtgta cttcacctgc agagctgagg
      901 gcaaccccaa acctgagatc atctggcttc gaaacaataa cgagttgagc atgaagacgg
      961 actctcgctt aaacttgctg gacgatggca cgctgatgat tcagaacaca caggaggcgg
     1021 atgagggtgt ctaccagtgc atggcgaaaa atgtggctgg agaggcgaaa acgcaggagg
     1081 tgaccctcag gtacttgggg tctccagccc gacccacttt tgtaatccag ccgcagaaca
     1141 cagaggtact ggtgggtgag agtgtcactc tggagtgcag tgccacaggc caccctctgc
     1201 ctcagatcac ctggacaaga ggtgaccgca cacccttgcc aattgaccct cgagtgaata
     1261 tcactccctc tggaggactg tatatacaga acgtcgccca gagtgacagc ggcgagtaca
     1321 cgtgctttgc atccaatagt gtggacagta tccatgccac agccttcatc attgtacaag
     1381 cccttcctca gttcactgtg accccacaga gccgagtggt cattgaaggg cagactgtgg
     1441 atttccagtg tgcggctaag ggacaccctc agcctgtcat agcctggacc aagggaggga
     1501 gccagctctc agtggacagg cggcacctgg tgctgtcctc aggaacactc aggatttctg
     1561 gggtggccct gcatgaccag ggccagtatg agtgccaggc cgtcaatatc attggctccc
     1621 agaaggtcgt ggcccacctg acagtacagc ctagagtcac cccggtattt gccagcattc
     1681 ccagtgacat gactgtagag gtgggcacca acgtgcagct gccttgtagc tcccagggag
     1741 aaccagagcc agccatcacc tggaacaagg atggtgttca ggtaacagaa agtggaaaat
     1801 ttcacatcag ccccgaagga ttcttgacca tcaatgatgt tggcactgcc gatgcaggtc
     1861 gctatgagtg tgtagctcgg aacacaattg gatatgcctc tgtgagcatg gtactcagtg
     1921 tgaatgttcc tgatgtaagt cggaatgggg atccctatgt tgctacctct attgttgaag
     1981 ccattgcaac tgttgacaga gccatcaact ctacaaggac acacttgttt gacagccgtc
     2041 ctcgttctcc aaatgacctg ctcgctctgt tccggtaccc acgggatcca tacacagtgg
     2101 gacaagccag ggcaggagag atattcgagc ggaccctgca gctgatccag gagcatgttc
     2161 agcatggctt gatggtggac ttgaatggaa caagttacca ctacaatgat ctggtgtccc
     2221 cgcagtacct gagcctcatc gccaacctgt caggctgcac tgcacaccgc cgcgtgaaca
     2281 actgctcaga catgtgcttc caccagaagt ataggacgca cgatggcacg tgcaacaatc
     2341 tacagcaccc gatgtggggt gcctcactga ccgcctttga gcgcctgttg aaggctgtgt
     2401 atgagaatgg gttcaacaca ccccggggca ttaattccca gcgtcagtac aatgggcatg
     2461 tactacccat gccccgcctg gtgtccacca cactgattgg gacagaggtg atcacccccg
     2521 atgagcagtt tacacacatg ctgatgcaat ggggccagtt ccttgaccat gacctagact
     2581 ctacagtggt agccctgagc caggcccgct tctctgacgg ccagcattgc agctctgtgt
     2641 gcagcaatga ccctccctgt ttctcggtca tgatcccccc caatgatccc cgggtgcgga
     2701 gtggcgcccg atgcatgttc ttcgtgcgat cgagccccgt gtgtggcagc ggcatgacgt
     2761 ccctgctcat gaactctgtg taccctcgag agcagatcaa ccagctcacc tcctacatcg
     2821 atgcctccaa tgtgtacggc agcacagacc acgaagcccg cagcatccgg gacctggcca
     2881 gccaccgtgg cctgctgcgt cagggcattg tgcagaggtc tggcaagccc ctgcttccct
     2941 ttgccaccgg gccacccact gagtgcatgc gcgatgagaa cgagagcccg ataccatgct
     3001 ttctggccgg cgaccaccgt gccaacgagc agcttggcct gaccagcatg catacgctgt
     3061 ggttccggga gcacaaccgc attgcagcag agctgttgaa gctaaacccg cactgggatg
     3121 gggacactgt ctaccatgag acccgcaaga tagtcggggc agagatacag cacatcacct
     3181 accggcactg gctgcccaag atcctggggg aggtgggcat gaagatgctc ggtgagtacc
     3241 ggggctacga ccccagtgtc aatgctggca tctttaatgc ctttgccact gcagccttca
     3301 ggttcggtca cactctgatc aaccctctgc tctaccggct ggatgagaac tttgagccca
     3361 tccctcaggg ccatgtgccc ctccacaaag ccttcttctc gcccttccgg attgtcaacg
     3421 aggggggcat cgacccactt ctccgagggc tgtttggagt ggcagggaag atgcgcattc
     3481 cctctcaatt gctgaacaca gagctcacgg agaggctgtt ctccatggcc cacacagtgg
     3541 ccctggacct ggctgccatc aatatccagc gaggccggga ccatggcatc ccaccctacc
     3601 atgactacag agtctactgc aacttgtcgg ctgcttacac ctttgaggac ctgaaaaatg
     3661 agatcaagag ccctgtgatc cgggagaaac tgcagaggct gtatggctcg actctcaaca
     3721 ttgatctgtt cccagccctc atggtagaag acctagtacc tggcagccgc ttggggccca
     3781 cactcatgtg cctgctcagc acacagttcc gacgcctgcg ggatggagac aggttgtggt
     3841 atgagaaccc aggcgtgttc tcccccgccc agctgactca gctcaagcag acgtccctgg
     3901 cgaggatcct ttgtgacaac tcagacaaca tcacccgtgt gcagcaggat gtgttcaggg
     3961 tggcagagtt cccccacggt tatagcagct gtgaggacat ccccagggtg gacctgcgag
     4021 tgtggcagga ctgttgtgaa gattgtagga ccaggggaca attcaatgct ttctcctacc
     4081 atttccgggg aagacggtct ctagaattta gctatgagga cgataagccc acaaagagag
     4141 ccaggtggcg gaaagcacta agtgtaaagc atggcaaaca tcttagcaat gccacatcag
     4201 ccacccacga gcacttggaa gggccagcaa ctaatgatct caaggaattt gttctggaaa
     4261 tgcaaaagat catcacagac ctcagaaaac agataaacag cttggagtct cggctcagca
     4321 ccacagaatg tgtggatgac agcggtgaat ctcacggcgg caacacaaag tggaaaaaag
     4381 acccatgcac agtttgtgag tgcaaaaatg gccagatcac ctgctttgtg gaagcttgcc
     4441 agcctgcagc ctgcccccag cctgtgaaag tggaaggcgc ttgctgtccc gtctgcttaa
     4501 agaacactgc agaggaaaag ccttagtgtt cccgagctta gctcctcgaa gctggtccac
     4561 agaatacttg tgagcctaga tgacaacatg gggagcttca gaccacagga caagttggga
     4621 tctcagacat ttcaggacct ctgctgtgcc atcgcagaag cagccggggc tgcttcacac
     4681 cctgtgtttg tagaaggaaa ttgagcaggc gggagtgggt gcaggctctg gccctcactt
     4741 catgttagac ttctcaggtt tatatttaag tgtttttaaa tggaaaattg gtgctactat
     4801 taaatcacac agttgagaca tgggtttcga aattgcttcg gcctgatgat gccacttctg
     4861 tttaagcgag gcagaaggtc tttgacaggc ttcatttaaa cagaagcatt tggcaaatgg
     4921 aacaggatct tataaaataa tatcctgggc caaaatccct acagggatac tagggctttc
     4981 tcccactgct ccctcatgtc tgccatcttc cccttcaggg cccttcagcg tctaataaca
     5041 ataccaacac aaacctgcac cttgcgacca tgtccaccct tctacacagg actgtcacat
     5101 tatcaagcca cagttagaaa taatcttgtt tccacttaga aaatgtgtaa atactgcctt
     5161 gctgtaaatt gaatgtgaaa tcctttggtc ctatgccatg ttgagtgacc cgaatagccc
     5221 cttgcatcgg caggatggtc tgcagccacc acctgccttg gttcctggcc atggtgtagg
     5281 gagggtgatg gtctgcagcc accacctgcc ttggttcctg gccatggtgt agggagggtg
     5341 attcactctc caggtccttt gaataggtga cagacaggca gagcctgaat gtcaggaaat
     5401 tccattgtat gaatgcttta aaggaaaacg ttccctatac ctcattattt tttattgcat
     5461 gatgttttat aaaaatttgc ccattttaga tgttagaaaa attatttcca ctatgcaaat
     5521 ttctttttaa ttcagtgaaa agcaactgtt atacctcata gtctcttgtt tttaattgac
     5581 caaaatattc cattctattc tcacaaggtt ctgaggtctc tgcctgaaaa agcaagtctc
     5641 accctataga cactgatgtg cccagcacta cgtgccagcc attgtgggaa cacaagaggg
     5701 tcacctgccc aagggctagg gaggaagacc tcaagaacac agaggaggtg gaaaaggaca
     5761 aaataggtgc cattttaggg agaccatggt cagatagggg gatgctcagt tccttgcagc
     5821 ctcgggcggg cttatgttgg cactaaggcc attgtggagt gtacttatat gatccctatg
     5881 ctgataggat taccttccta gacatagcta gacgcaaagc cacatgtgta aggctgctga
     5941 gcaaagacag catcccagca tgggtgtgtt cacggtggat tcaccacgtt gcatatgtaa
     6001 agtggtcccc ttggcttacc cttcactttg ctcatgagat tcagaagctg gtggtccagc
     6061 aggggtgagc atttgtgaaa tagtaagctg aacttagtgg tgagatttca gaacagactt
     6121 ctgtgaagta agagatgtaa ccatgcatct aaaatcagat ggccgtgtaa ctgctcgggc
     6181 atagaaatgg tgggagaacc tgtcctgggt acctggcatt tcacatgagc ccagggatat
     6241 gtcttgtgcc aaggcacaca agtgtccatg gacttggaca ggtgccaagg gtttttgtct
     6301 ctgttcctat gtgggaggct ggctgtgatt tacattaatt tctgtatttc aaacgaagat
     6361 gtctgcagat ctccattttg atgttacagc ctcattgccc aggcagtggg cagtgcccag
     6421 acaccctttc tgactagcca ctgcattggg cttctgtgat tcaaagtagt gtatatattt
     6481 atttacttct ctgactgtgg ccaacagcca aatgccattt tatgttcctt gtattcagtc
     6541 cattaccaaa gaggtgtttg cactttgtaa tgataccttt cagttcaaat aaaaggacca
     6601 catcgttaag tggaaaaaaa aaaaaaaaaa aa
//
