LOCUS       NM_025831               1872 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus PX domain containing 1 (Pxdc1), transcript variant 2,
            mRNA.
ACCESSION   NM_025831
VERSION     NM_025831.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005003.1 and AC124687.4.
            
            On Sep 22, 2006 this sequence version replaced NM_025831.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018520.1, BQ928411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-589               AK005003.1         3-591
            590-594             AC124687.4         89586-89590
            595-1872            AK005003.1         592-1869
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.16 cM"
     gene            1..1872
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="PX domain containing 1"
                     /db_xref="GeneID:66895"
                     /db_xref="MGI:MGI:1914145"
     exon            1..502
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..942
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="isoform 2 is encoded by transcript variant 2; PX
                     domain-containing protein C6orf145 homolog; PX
                     domain-containing protein 1"
                     /codon_start=1
                     /product="PX domain-containing protein 1 isoform 2"
                     /protein_id="NP_080107.3"
                     /db_xref="CCDS:CCDS36632.1"
                     /db_xref="GeneID:66895"
                     /db_xref="MGI:MGI:1914145"
                     /translation="MASAVFEGTSLVNMFVRGCWVNGIRRLIVSRRGDEEEFFEIRTE
                     WSDRSVLYLHRSFADLGRLCKRLRDAFPEDRSELARTPLRQGLLAIKGAHDIETRLNE
                     VEKLLETVISMPCKYSRSEVVLTFFERSPLDQVLKNDNVHKIQPSFQSPVKISEIMRS
                     NGFCLANTETIVIDHSIPNGKDQLLDADSTEHLFENGGEFTSELEDGDDPEAYVTNLS
                     YYHLVPFETDILD"
     exon            503..594
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..712
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..824
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1872
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="putative"
     polyA_site      1872
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="putative"
ORIGIN      
        1 agactcctgg cggcgccgcc ctgagcgcgc gggccacacg tagccgcccc agagtgagcg
       61 cagagctgcg gcgtattcgc ggggcaccaa cttctccccc acggggactc ttaaccgccg
      121 ttgcgggaat cgagcgcgtc ccacggagaa cccctgatcg cccctgccag gactcactct
      181 gcccaggcgg accccaggcg ggggccgagg gcgcccccgg cggcaggggc atgcgccgcc
      241 cgcggcatgg cctcggcggt gtttgagggc acgtcgctcg tgaacatgtt cgtgcgcggt
      301 tgctgggtga acgggatccg caggctcatc gtcagcaggc gcggcgatga ggaggagttc
      361 ttcgaaatcc gcaccgagtg gtcggaccgc agcgtgctct acctgcaccg cagcttcgcc
      421 gacctgggcc gcctgtgcaa gcgcctccgc gatgccttcc ccgaggaccg gtctgagctg
      481 gcgcgcacgc cgctgcggca aggactgctc gccatcaagg gtgcacatga catagagacc
      541 aggctcaatg aggtcgagaa gctgctggag acggtcatca gcatgccgtg taagtattcc
      601 aggtctgagg ttgttctcac cttctttgaa agatcgcctt tggatcaggt gttaaaaaat
      661 gataatgtcc ataagatcca acccagcttt caaagtcctg ttaaaatatc agaaatcatg
      721 aggtccaatg gattttgttt ggcaaacaca gagaccatag tcattgacca cagcataccc
      781 aacgggaagg accagctcct ggatgcggat tccacagagc atttgtttga gaatggtggt
      841 gagttcacct cagagctgga agatggtgac gacccagagg cttatgtcac caacttgtcc
      901 tattaccatt tggttccgtt tgagacggac attttggact gagcctctcc atcgggcctt
      961 ctctgcctcc aacctcgact gcatgtcctc atgctgtcta ctgtgctcct ccaagggcca
     1021 aagctactgc tcagcctgga cctcctaggg tcctgaggtt cagcaggcct gggtatttag
     1081 aaagcagagg cacacgggat cccgatgacc ataggcagca ccgaggggcc ttcttcctgc
     1141 tctcagcccc tccagcccgc ctcttctggg atgccaggcc atgcttcttc ttgtctcact
     1201 gccgacttag ggaacattcc tcttggtcac atggccctga ctccccactt ttctcttgtg
     1261 tgtcaaaggc acacacaaag tatttcaaga ggatttttgc taagttacca agttctggac
     1321 ctcgtggacg ggggatatta agtgattcag gacctcccta agaaggatgt gtggctcttt
     1381 tttttttctt tacatctgct ccctggaatc tgggtttggg atgagccgga aggagcgttt
     1441 acacaacatc aagcctggag aagattgcta gcttcggcga ggggaaagca ttcatggtcc
     1501 tgtgcatatg aacctgatat aaagttttct tccagggaag agagcgtcct cctcactgcc
     1561 agcacctgtc agctcttctg ccaggcggtg atgcggtcac cactgcctag ggtgctcgaa
     1621 gtccttcccc tgctgacctc aatggcacaa gtgccaggat ggatcagaaa ggaagggatg
     1681 ggaaggaagg aagggatgct tacagcttag accacagaag gtctgggtcc tgcaagctca
     1741 tgtcctcact gtgtctacta acgaccagca cttgctaatg taaataatag taaattattg
     1801 agaattctaa ttcttttaca cagtctgttt ttaatctatt ttaattaaat aaaaatctat
     1861 tgttctactt tg
//
