LOCUS       NM_001382845            1933 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus PX domain containing 1 (Pxdc1), transcript variant 1,
            mRNA.
ACCESSION   NM_001382845 XM_006516728
VERSION     NM_001382845.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124687.4.
            
            On May 26, 2020 this sequence version replaced XM_006516728.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2400347.1,
                                           SRR12282455.22726028.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               AC124687.4         75916-76417
            503-594             AC124687.4         89499-89590
            595-712             AC124687.4         90315-90432
            713-772             AC124687.4         91290-91349
            773-884             AC124687.4         98135-98246
            885-1933            AC124687.4         99709-100757
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.16 cM"
     gene            1..1933
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="PX domain containing 1"
                     /db_xref="GeneID:66895"
                     /db_xref="MGI:MGI:1914145"
     exon            1..502
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1002
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="isoform 1 is encoded by transcript variant 1; PX
                     domain-containing protein C6orf145 homolog; PX
                     domain-containing protein 1"
                     /codon_start=1
                     /product="PX domain-containing protein 1 isoform 1"
                     /protein_id="NP_001369774.1"
                     /db_xref="GeneID:66895"
                     /db_xref="MGI:MGI:1914145"
                     /translation="MASAVFEGTSLVNMFVRGCWVNGIRRLIVSRRGDEEEFFEIRTE
                     WSDRSVLYLHRSFADLGRLCKRLRDAFPEDRSELARTPLRQGLLAIKGAHDIETRLNE
                     VEKLLETVISMPCKYSRSEVVLTFFERSPLDQVLKNDNVHKIQPSFQSPVKISEAKEG
                     TGALRTGVVDGCEPPEIMRSNGFCLANTETIVIDHSIPNGKDQLLDADSTEHLFENGG
                     EFTSELEDGDDPEAYVTNLSYYHLVPFETDILD"
     exon            503..594
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..712
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..772
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            773..884
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1933
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="Pxdc1"
                     /gene_synonym="1300014I06Rik"
                     /note="major polyA site"
ORIGIN      
        1 agactcctgg cggcgccgcc ctgagcgcgc gggccacacg tagccgcccc agagtgagcg
       61 cagagctgcg gcgtattcgc ggggcaccaa cttctccccc acggggactc ttaaccgccg
      121 ttgcgggaat cgagcgcgtc ccacggagaa cccctgatcg cccctgccag gactcactct
      181 gcccaggcgg accccaggcg ggggccgagg gcgcccccgg cggcaggggc atgcgccgcc
      241 cgcggcatgg cctcggcggt gtttgagggc acgtcgctcg tgaacatgtt cgtgcgcggt
      301 tgctgggtga acgggatccg caggctcatc gtcagcaggc gcggcgatga ggaggagttc
      361 ttcgaaatcc gcaccgagtg gtcggaccgc agcgtgctct acctgcaccg cagcttcgcc
      421 gacctgggcc gcctgtgcaa gcgcctccgc gatgccttcc ccgaggaccg gtctgagctg
      481 gcgcgcacgc cgctgcggca aggactgctc gccatcaagg gtgcacatga catagagacc
      541 aggctcaatg aggtcgagaa gctgctggag acggtcatca gcatgccgtg taagtattcc
      601 aggtctgagg ttgttctcac cttctttgaa agatcgcctt tggatcaggt gttaaaaaat
      661 gataatgtcc ataagatcca acccagcttt caaagtcctg ttaaaatatc agaggctaaa
      721 gaaggcactg gagctctcag aactggagtg gtagacggtt gtgagccacc agaaatcatg
      781 aggtccaatg gattttgttt ggcaaacaca gagaccatag tcattgacca cagcataccc
      841 aacgggaagg accagctcct ggatgcggat tccacagagc atttgtttga gaatggtggt
      901 gagttcacct cagagctgga agatggtgac gacccagagg cttatgtcac caacttgtcc
      961 tattaccatt tggttccgtt tgagacggac attttggact gagcctctcc atcgggcctt
     1021 ctctgcctcc aacctcgact gcatgtcctc atgctgtcta ctgtgctcct ccaagggcca
     1081 aagctactgc tcagcctgga cctcctaggg tcctgaggtt cagcaggcct gggtatttag
     1141 aaagcagagg cacacgggat cccgatgacc ataggcagca ccgaggggcc ttcttcctgc
     1201 tctcagcccc tccagcccgc ctcttctggg atgccaggcc atgcttcttc ttgtctcact
     1261 gccgacttag ggaacattcc tcttggtcac atggccctga ctccccactt ttctcttgtg
     1321 tgtcaaaggc acacacaaag tatttcaaga ggatttttgc taagttacca agttctggac
     1381 ctcgtggacg ggggatatta agtgattcag gacctcccta agaaggatgt gtggctcttt
     1441 tttttttctt tacatctgct ccctggaatc tgggtttggg atgagccgga aggagcgttt
     1501 acacaacatc aagcctggag aagattgcta gcttcggcga ggggaaagca ttcatggtcc
     1561 tgtgcatatg aacctgatat aaagttttct tccagggaag agagcgtcct cctcactgcc
     1621 agcacctgtc agctcttctg ccaggcggtg atgcggtcac cactgcctag ggtgctcgaa
     1681 gtccttcccc tgctgacctc aatggcacaa gtgccaggat ggatcagaaa ggaagggatg
     1741 ggaaggaagg aagggatgct tacagcttag accacagaag gtctgggtcc tgcaagctca
     1801 tgtcctcact gtgtctacta acgaccagca cttgctaatg taaataatag taaattattg
     1861 agaattctaa ttcttttaca cagtctgttt ttaatctatt ttaattaaat aaaaatctat
     1921 tgttctactt tga
//
