LOCUS       NM_029546               3871 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus PWP2 periodic tryptophan protein homolog (yeast)
            (Pwp2), mRNA.
ACCESSION   NM_029546 XM_003689492 XM_003689493 XM_003946427 XM_006544784
            XM_011238284
VERSION     NM_029546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   2  (bases 1 to 3871)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   3  (bases 1 to 3871)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   4  (bases 1 to 3871)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   5  (bases 1 to 3871)
  AUTHORS   Mittaz,L., Rossier,C., Heino,M., Peterson,P., Krohn,K.J., Gos,A.,
            Morris,M.A., Kudoh,J., Shimizu,N., Antonarakis,S.E. and Scott,H.S.
  TITLE     Isolation and characterization of the mouse Aire gene
  JOURNAL   Biochem Biophys Res Commun 255 (2), 483-490 (1999)
   PUBMED   10049735
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK088254.1.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011238284.1, XM_006544784.1, XM_003946427.1, XM_003689492.1,
            XM_003689493.1, NM_029546.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088254.1, AK088983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3871              AK088254.1         2-3872
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3871
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /note="PWP2 periodic tryptophan protein homolog (yeast)"
                     /db_xref="GeneID:110816"
                     /db_xref="MGI:MGI:1341200"
     exon            1..79
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2821
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /note="WD-repeat protein p103"
                     /codon_start=1
                     /product="periodic tryptophan protein 2 homolog"
                     /protein_id="NP_083822.1"
                     /db_xref="CCDS:CCDS35958.1"
                     /db_xref="GeneID:110816"
                     /db_xref="MGI:MGI:1341200"
                     /translation="MKFAYRFSNLLGTVYRCGNLNFTHDGNSVISPVGNRVTVFDLKN
                     NRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSV
                     SFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSKCFV
                     VGSKDMSTWVFGAERWDNLIYYALSGHKDAIVACFFESNSLDLYSLSQDGALCVWQCD
                     TPPEGLRLKAPRGWKADILQREKEEEEEDEEEGDRETTIRGKTTPAEQERVGKVKYSR
                     LAKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVA
                     SVAINSSGDWIAFGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGG
                     DDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNF
                     RTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPVSGLC
                     FNPMKSILASASWDKTVRLWDMFDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQ
                     ITFWDPENAVQVGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGG
                     MSKFVCLYHVREQILVKRFELSCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGEENGV
                     AVPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFE
                     LDTSVTPGRIREALRQREFTRAILMAFRLNEKKLAQEALEAVPQNEIEVVSTSLPELY
                     VVKVLEFLAASFEESRHLEFYLIWTQKLLMSHGQRLKSRAGQLLPVVQFLQKGLQRHL
                     DDVSKLCDWNRFNIQYVLAVSKQRGMKRTLEPVDTEEDSDASDEDSLHLLRAAGEEEE
                     EEMLI"
     exon            80..192
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            193..287
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            288..387
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            388..531
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            532..667
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            668..897
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1041
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1112
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1249
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1398
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1546
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1697
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1878
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2026
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2135
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2201
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2420
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2571
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2646
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..3871
                     /gene="Pwp2"
                     /gene_synonym="6530411D08Rik; Pwp2h; wdp103"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggagatt gtttgtattc cggaagtggt tgcagtacgg taccccacgt gtggttccag
       61 gatgaaattc gcttaccggt tctcgaattt gttgggtacg gtttatcggt gtggaaactt
      121 aaatttcaca catgatggaa attctgttat cagccccgtg ggaaatagag tcactgtgtt
      181 tgaccttaag aacaacagat ccaacacatt gcctctggcc accaaataca acatcaagtg
      241 cgtggggctg tccccagatg gtcgcctcgc aatcatcgtt gatgaagggg gtgctgctct
      301 gctggtcagc ttggtgtgca ggtcggtgct ccaccacttc cacttcaagg gctccgtgca
      361 cagcgtctcc ttctctcccg atggcagaaa attcgttgtc acaaagggca acattgcgca
      421 aatgtaccac gcccccggaa agaagcgaga gttcaatgcg tttgttctgg acaaaaccta
      481 tttcgggccc tatgatgaga ccacatgcat cgactggaca gatgactcca agtgctttgt
      541 ggttggaagc aaagacatgt ccacctgggt gtttggagct gagcgctggg acaacctcat
      601 ctactatgca ctgagtggac acaaggatgc cattgtggcc tgcttcttcg agtccaacag
      661 cctagatcta tactcgctca gtcaagatgg agccctgtgt gtgtggcagt gtgacacacc
      721 ccctgagggc ctgcggctta aggcacccag gggctggaag gcagacatac ttcagaggga
      781 gaaggaagaa gaggaggagg atgaggagga gggggatcga gaaaccacca tccgagggaa
      841 gaccacacca gcggagcagg agagggtcgg gaaagtgaaa tactcccgac tggccaagta
      901 cttcttgaac aaagaaggag actttaacaa cctgacatcc gcggcgtatc ataagaagac
      961 ccatctcttg gtcacgggtt ttgcttctgg aatcttccat ctgcacgagc tcccagagtt
     1021 caacctgatc cactccctga gcatctccga tcagagggtt gcttcggttg ccatcaacag
     1081 ctctggggac tggattgcct ttggctgctc aggcatgggc cagctgcttg tgtgggaatg
     1141 gcagagtgaa tcctatgtgc tcaagcagca gggccatttc aacagcatgg tggccctggc
     1201 ctactcccct gacgggcagt acattgtcac cggtggggac gatggcaagg ttaaggtgtg
     1261 gaacaccctc agtggcttct gctttgtcac tctcacggag cactccagtg gggtcactgg
     1321 agtgacattc accaccacgg gccatgtcat cgtcacctcc tccttggatg gcactgtgag
     1381 agccttcgat cttcacaggt accggaattt ccgcaccttc acgtctccac gccccacaca
     1441 gttctcctgt gtggctgtcg actcgagtgg ggaaatcgtc tctgcagggg cgcaggactc
     1501 ctttgagatc tttgtgtggt ccatgcagac aggcaggctt cttgatgttc tgtctggcca
     1561 tgagggaccc gtcagtggtc tttgctttaa cccaatgaag tctatcctgg ctagtgcctc
     1621 ttgggacaag acagtgcgtc tgtgggacat gttcgacagt tggagaacca aagagacctt
     1681 gactctgacc tctgacgccc tagctgtgac tttccggcct gatggtgcag agctggctgt
     1741 ggccacgctg aattcacaga tcacgttttg ggaccctgag aatgctgtac aggtgggctc
     1801 catcgagggc aggcatgacc tgaagaccgg caggaaggag ctggacaaga tcacagccaa
     1861 acattcagcc aagggcaagg ccttcactac cctgtgttac tctgcggacg ggcagagcat
     1921 cctggcggga ggcatgtcca agttcgtgtg cctttaccac gtccgggagc aaatcctggt
     1981 gaagaggttt gagctctcct gcaacctgtc tctggatgcc atggaggaat tcctgaaccg
     2041 gagaaagatg acagagtttg gcaacctggc actcattgat caagatgctg gggaggagaa
     2101 tggggtggca gttccactgc caggagtaag gaaaggtgat atgagctcca gacacttcaa
     2161 acctgaaatc agggtgactt ctctgcgctt ctctcccacg gggcgctgct gggcggccac
     2221 cagcacagag ggcctcctca tcttctccct ggatgcccag atgctcttcg acccatttga
     2281 gctggacacc agtgtgaccc ctggacggat ccgggaggcg ctccgacaga gggagtttac
     2341 ccgggccatc ctcatggcct tccgcctcaa tgagaaaaaa ctggcccagg aggccctgga
     2401 ggctgtgcca cagaatgaaa ttgaggtagt cagcacgtcc ctgcctgagc tgtacgtagt
     2461 gaaagtactg gagttcttag ctgcctcctt tgaagaatct aggcacctgg aattctacct
     2521 tatatggact cagaagttac ttatgtcaca tggacagcgg ctgaagtcca gggcgggaca
     2581 gttgctgcct gtggtccagt tccttcagaa gggcctccag cggcatctgg atgatgtttc
     2641 caaactctgt gactggaacc gcttcaacat ccagtacgtg ctggcagttt ccaagcagcg
     2701 gggcatgaaa cgcaccctgg aacctgtgga cacagaagag gactcagatg catctgatga
     2761 ggacagtctg cacctactca gagctgcagg tgaagaagag gaagaggaga tgctgatata
     2821 gaaccatata tttcacggcc tgattggctg gagatgaaac cactgtgctc ctgggcccag
     2881 gaagtgggag gtgccagaga ccccgagacc ctccagcccg gactcttcct gtgagactgc
     2941 tcatgctgcc atgagacagc aagccaacct ttcagggccg ggaccaggat acagcgggca
     3001 cacttatgct ttgggcccag aatgcttgcg ttgtggatgg ccctgcacag acttcctagg
     3061 gaaggtttag aagtgtggac ttgcaaactt tctgtcagag ttatttatat ttttaatacg
     3121 atgctctaag gatgaatttc gggttgggaa gagctttttt gtaaatgtga ggactttgct
     3181 tctcaacttt gagtttccgg tgtttctaat gtgtcctggg tgagacattg tcttcaagta
     3241 agcagggaga tcggtgactg ctcgggcctg tggccctgat atctgtaagt agtgaagaaa
     3301 tggtgtgtgc tgggctgacc ccagcgggtg gctgtgacag cccaaggctg gccagggaag
     3361 cttggactga tctttgccag tatgtacagg ttatgtggga gaagggacat gcctgagtgg
     3421 tgctttaccg atacttcctg ttcatggggt tgaccaggcc cagcatgtca ctcgccagtg
     3481 aagagaccca caggtgccaa ctcatgctga taactattca ctggcctctg tccaggccac
     3541 aggaatggat ctgtgtggca cctggtgcac tgagagccat tagctgtcgc acccttgtca
     3601 tactcaggat acactgatac tatactgtct tggtcacctg gaacccgctc aggcttgaac
     3661 accgttatgg ggagaagcca gagcttagcc tggtgtcgcc aggtttcctg ttctgcagag
     3721 catttctctg tgtagcttgg ggtagaaaag gaaactgctt cttatgtgcc cagggacagc
     3781 caggcccctg gccgcccaga caaggacccg cttgttttgg tgccatcttg ggatccccat
     3841 ctgcagtaca aatacagttt tatgaagctt t
//
