LOCUS       NM_133993               2579 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PWP1 homolog, endonuclein (Pwp1), mRNA.
ACCESSION   NM_133993
VERSION     NM_133993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   4  (bases 1 to 2579)
  AUTHORS   Shen,J., Jia,W., Yu,Y., Chen,J., Cao,X., Du,Y., Zhang,X., Zhu,S.,
            Chen,W., Xi,J., Wei,T., Wang,G., Yuan,D., Duan,T., Jiang,C. and
            Kang,J.
  TITLE     Pwp1 is required for the differentiation potential of mouse
            embryonic stem cells through regulating Stat3 signaling
  JOURNAL   Stem Cells 33 (3), 661-673 (2015)
   PUBMED   25335925
  REMARK    GeneRIF: Authors found that the level of Pwp1 in mESCs is much
            higher than that in mouse embryonic fibroblasts (MEFs) and Pwp1 KD
            critically affects the conversion of mESCs from pluripotency to
            differentiation.
REFERENCE   5  (bases 1 to 2579)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 2579)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 2579)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2579)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY771053.1, AK082158.1 and BB032128.1.
            
            On Jan 16, 2010 this sequence version replaced NM_133993.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009972.1, AK082158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY771053.1         1-59
            60-2577             AK082158.1         2-2519
            2578-2579           BB032128.1         270-271
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.73 cM"
     gene            1..2579
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /note="PWP1 homolog, endonuclein"
                     /db_xref="GeneID:103136"
                     /db_xref="MGI:MGI:1914735"
     exon            1..184
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            185..243
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            244..428
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..514
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..611
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..722
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..853
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..915
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1012
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1074
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1186
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1277
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1399
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1505
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..2579
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1812..1817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1832
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /note="major polyA site"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
     regulatory      2549..2554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2579
                     /gene="Pwp1"
                     /gene_synonym="2310058A11Rik; 2610205J09Rik"
ORIGIN      
        1 gagtgacgtc agcgagcgcc cgcgcctgcg cgttgttccc ctccgcggag ctcaagagta
       61 gtgtctccca gctcccaggg ctccaacctg cgccgggttc aaaccgaaga tcatgaaccg
      121 cagccgccaa gtgacctgcg tggcctgggt ccgccgcggc gtggccaaag agactccaga
      181 caaggtagag ctaagtaaag aggaagtgaa ccgtctcatc gctgaagcaa aaggaaagtt
      241 gcaagaagaa ggtgggagtg aagaagagga ggcaggcaac ccttcagaag atggcatgca
      301 gagtggcccg acccaggcac cgcctaggga gtccctggag gatggggatc cacaagatga
      361 ccgcacactg gacgatgacg agctggcggg gtacgactta gataattatg acgaagagga
      421 taacccagat gctgagacca ttggcgagtc tctgttgggt cttacggtct atggcagtaa
      481 tgaccaggat ccatatgtca ccttgaaaga cacggaacaa tatgagcatg aagatttctt
      541 gattaagccg actgacaacc tcatcgtttg tggccgtgct gaacaagagc agtgcaatct
      601 agaggtgcac gtttacaatc aagaagagga gtctttctac gtccaccatg acatactcct
      661 gtctgcatac cctctgagtg tggaatggct gaattttgat cctagcccag atgcatctac
      721 tgggaattac attgctgtgg gaaacatgac tcctgtcatc gaggtatggg acctggatat
      781 agtggactct ctagaaccag tcttcacact gggaagcaag ctttccaaaa agaagaagaa
      841 gaaagggaag aagagttcct cagcagaagg acatactgat gctgtccttg acctatcctg
      901 gaataagaca gtcagaaatg tgcttgcaag tgcatcggca gacagcactg tagttctctg
      961 ggatctgtct gtggggaagt cagtagccag gcttactgca catacagaca aggttcagac
     1021 tctgcagttt catccatttg aagcacagac tctgatttct gggtcctatg acaaatcggt
     1081 ggctctgtat gactgcagag atcccagcca gaaccaccgc cagtggcggt tcagtgggca
     1141 gatcgagaga gtgacctgga accacttctc accgtgtcat ttcttggcca gtacagatga
     1201 tggctttgtc tataacctgg atgcacgttc agacaagcca atctttacac ttaatgcaca
     1261 caacgatgaa atctctggtc ttgatcttag cagtcagatc aaaggctgcc ttgtgactgc
     1321 ttccgctgac aaatttgtga agatctggga catcttagga gataggccaa gtctcattca
     1381 ctctagagac atgaaaatgg gagttctctt ttgttcctcc tgctgtcctg acttgccatt
     1441 tgtttatgcc tttggaggac agaaagaagg gcttcgggtt tgggacataa gcactgtgtc
     1501 ttcagtaaat gaagcatttg gaagacggga gcgactcgtt ataggcggca cgaaaggttt
     1561 atctgttagc ggcccctgtg ggagcaggag tccacagcag acaccaatgg agtcctgaca
     1621 aagatcagtt tcctgctgtg cttaccttaa ctccgtttca aaagactggc ctaaaaatgt
     1681 ccacgtatat ctacaaccat agatggaaat tcaggtcctg ttgccatcct ttctgcagcc
     1741 ttggtggcag tccacagcct ttgggctgcc ttctactggg tactgtacag agttcttgcc
     1801 tttcttgaaa atataaagtt ttttaaaaat gattccttaa caggccatct gacctttgga
     1861 actctaggca taaaatacat ggtaactgga gagtttttga tacgggtctt gctgtgttag
     1921 caaagcactg gtgtggtggc tcgtgcttgt cccagtcctg gggaggagag agagacaggc
     1981 agattcctag gaccaggctg cccagcgaat ctcacctatc tccatcttcc caggctagga
     2041 ttacctatat gcatggtagg ttctagaatt gaattcaggc cctcgtgttg gcaaatcaaa
     2101 catttcacta actgagcagt gtccctaacc cattgataaa tgtgatccct aaaggtattt
     2161 tcaccttttg aatgttaatc atattttgac aacttttggt tttaaacttc catgttttca
     2221 gggatatttt gtttaaaatg tcaattattt tttaaatggg gattttgttc atacaatttt
     2281 ctatgatcaa aatattttac taaatagaca acaaactgtc aaagtaatac ataaccttgt
     2341 aagttttggt cccagtacat tctcccatct atttccttca aataaacttg aacttgtcaa
     2401 gcccataaag ccttctggac ttaagaggtc ctaaattagc aatctcacac cacctcacag
     2461 aaaggctgtc cactccctcc tcccagactc caccattact aagctgattt cccaagtttc
     2521 aggatgttgg tactttttga agtaatagaa taaactgttc tatttgtcat tgaaattca
//
