LOCUS       NM_001378438            1001 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus poliovirus receptor related immunoglobulin domain
            containing (Pvrig), mRNA.
ACCESSION   NM_001378438 XM_011240967
VERSION     NM_001378438.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1001)
  AUTHORS   Yang,J., Wang,L., Byrnes,J.R., Kirkemo,L.L., Driks,H., Belair,C.D.,
            Aguilar,O.A., Lanier,L.L., Wells,J.A., Fong,L. and Blelloch,R.
  TITLE     PVRL2 Suppresses Antitumor Immunity through PVRIG- and
            TIGIT-independent Pathways
  JOURNAL   Cancer Immunol Res 12 (5), 575-591 (2024)
   PUBMED   38588410
REFERENCE   2  (bases 1 to 1001)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1001)
  AUTHORS   Murter,B., Pan,X., Ophir,E., Alteber,Z., Azulay,M., Sen,R.,
            Levy,O., Dassa,L., Vaknin,I., Fridman-Kfir,T., Salomon,R.,
            Ravet,A., Tam,A., Levin,D., Vaknin,Y., Tatirovsky,E.,
            Machlenkin,A., Pardoll,D. and Ganguly,S.
  TITLE     Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and
            Dampens Antitumor Immunity
  JOURNAL   Cancer Immunol Res 7 (2), 244-256 (2019)
   PUBMED   30659055
  REMARK    GeneRIF: our results suggest PVRIG is an inducible checkpoint
            receptor and that targeting PVRIG-PVRL2 interactions results in
            increased CD8(+) T-cell function and reduced tumor growth.
REFERENCE   4  (bases 1 to 1001)
  AUTHORS   Zhu,Y., Paniccia,A., Schulick,A.C., Chen,W., Koenig,M.R.,
            Byers,J.T., Yao,S., Bevers,S. and Edil,B.H.
  TITLE     Identification of CD112R as a novel checkpoint for human T cells
  JOURNAL   J Exp Med 213 (2), 167-176 (2016)
   PUBMED   26755705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157588.8.
            
            On Feb 13, 2020 this sequence version replaced XM_011240967.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3060384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC157588.8         53489-53626         c
            139-492             AC157588.8         53048-53401         c
            493-616             AC157588.8         52848-52971         c
            617-674             AC157588.8         52710-52767         c
            675-1001            AC157588.8         46866-47192         c
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..1001
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /note="poliovirus receptor related immunoglobulin domain
                     containing"
                     /db_xref="GeneID:102640920"
                     /db_xref="MGI:MGI:5596028"
     exon            1..138
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..728
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /codon_start=1
                     /product="transmembrane protein PVRIG"
                     /protein_id="NP_001365367.1"
                     /db_xref="GeneID:102640920"
                     /db_xref="MGI:MGI:5596028"
                     /translation="MRTGNTQAAHATNMGQMQTLVLFSTLLTLCVSEASPEVWVQVQM
                     EATNLSSFSVHCGVLGYSLISLVTVSCEGFVDAGRTKLAVLHPEFGTQQWAPARQAHW
                     ETPNSVSVTLTMGQSKARSSLANTTFCCEFVTFPHGSRVACRDLHRSDPGLSAPTPAL
                     NLQADLVRILGTSGVFLFGFIFILCLRWQQRHWCLSKSQPSLTSTQAQVETQDYPSST
                     QCLDVGLCISF"
     exon            139..492
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /inference="alignment:Splign:2.1.0"
     exon            493..616
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /inference="alignment:Splign:2.1.0"
     exon            617..674
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1001
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /inference="alignment:Splign:2.1.0"
     regulatory      969..974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /note="hexamer: AATAAA"
     polyA_site      1001
                     /gene="Pvrig"
                     /gene_synonym="Gm36869"
                     /note="major polyA site"
ORIGIN      
        1 agtgcctcta actgctgaca atgtgaaaac ctccagccat gagaacaggc aacacacagg
       61 ctgcccatgc aacaaatatg ggccagatgc agaccctggt tctattctca acattgctga
      121 ccctctgtgt ctctgaagca agccctgagg tgtgggtgca agtccagatg gaggccacca
      181 acctctcgtc tttctcagtt cactgtgggg tcttaggata tagcctcatc tccctggtaa
      241 cagtgagctg tgaaggattt gttgacgctg gaaggaccaa actagctgtg ttacatccag
      301 aatttggtac ccagcagtgg gctcctgcca ggcaggccca ctgggaaacc ccaaacagcg
      361 tctctgtcac tctgaccatg ggacaatcca aagcaagaag ctctctagcc aacaccacat
      421 tctgctgcga gtttgttacc tttcctcatg gttccagggt tgcctgtaga gacctgcata
      481 gatcagatcc aggactctct gccccaactc cagccctcaa tcttcaagca gacctggtga
      541 ggatcttggg aacctcagga gttttcctgt ttggtttcat ctttatacta tgtctccggt
      601 ggcagcagag gcattggtgt ttgagtaaat ctcagccatc tctcactagc acccaggcac
      661 aggtggagac tcaggattac ccaagttcca ctcaatgttt ggatgtgggt ctctgcatca
      721 gcttctaaga gttgctggat gaagcccctc tgataagatt tatgcaaggc tccttgtcat
      781 gtttgccttt ctgctgggtt atatcactaa ggatgatctt ttctagttcc acccacttgc
      841 ctgaaaattt catgatgtca ttgtttgtaa tgactaagta atactccatt atgtaaatgt
      901 accacatttt aaaaatccat tcttcctttg agggacatct agtttgtttc cagtctctgg
      961 ctattatgaa taaagctgct atgaacataa ttgagcaagc a
//
