LOCUS       NM_027514               2902 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus poliovirus receptor (Pvr), mRNA.
ACCESSION   NM_027514
VERSION     NM_027514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Li,W., Zhang,Y., Liu,Y., Feng,C., Duan,C., Zhang,Z., Zhao,P.,
            Zhuang,R. and Ding,Y.
  TITLE     CD155 is essential for skeletal muscle regeneration by regulating
            satellite cell proliferation and differentiation
  JOURNAL   FASEB J 38 (2), e23440 (2024)
   PUBMED   38252072
  REMARK    GeneRIF: CD155 is essential for skeletal muscle regeneration by
            regulating satellite cell proliferation and differentiation.
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Yamada,T., Tatematsu,M., Takasuga,S., Fuchimukai,A., Yamagata,K.,
            Seki,S., Kuba,K., Yoshida,H., Taniuchi,I., Bernhardt,G.,
            Shibuya,K., Shibuya,A., Yamada,T. and Ebihara,T.
  TITLE     TIGIT mediates activation-induced cell death of ILC2s during
            chronic airway allergy
  JOURNAL   J Exp Med 220 (7) (2023)
   PUBMED   37036426
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Saha,S., Sparkes,A., Matus,E.I., Lee,P. and Gariepy,J.
  TITLE     The IgV domain of the poliovirus receptor alone is
            immunosuppressive and binds to its receptors with comparable
            affinity
  JOURNAL   Sci Rep 13 (1), 4609 (2023)
   PUBMED   36944702
  REMARK    GeneRIF: The IgV domain of the poliovirus receptor alone is
            immunosuppressive and binds to its receptors with comparable
            affinity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Briukhovetska,D., Suarez-Gosalvez,J., Voigt,C., Markota,A.,
            Giannou,A.D., Schubel,M., Jobst,J., Zhang,T., Dorr,J., Markl,F.,
            Majed,L., Muller,P.J., May,P., Gottschlich,A., Tokarew,N.,
            Lucke,J., Oner,A., Schwerdtfeger,M., Andreu-Sanz,D., Grunmeier,R.,
            Seifert,M., Michaelides,S., Hristov,M., Konig,L.M., Cadilha,B.L.,
            Mikhaylov,O., Anders,H.J., Rothenfusser,S., Flavell,R.A.,
            Cerezo-Wallis,D., Tejedo,C., Soengas,M.S., Bald,T., Huber,S.,
            Endres,S. and Kobold,S.
  TITLE     T cell-derived interleukin-22 drives the expression of CD155 by
            cancer cells to suppress NK cell function and promote metastasis
  JOURNAL   Immunity 56 (1), 143-161 (2023)
   PUBMED   36630913
  REMARK    GeneRIF: T cell-derived interleukin-22 drives the expression of
            CD155 by cancer cells to suppress NK cell function and promote
            metastasis.
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   Mueller,S., Cao,X., Welker,R. and Wimmer,E.
  TITLE     Interaction of the poliovirus receptor CD155 with the dynein light
            chain Tctex-1 and its implication for poliovirus pathogenesis
  JOURNAL   J Biol Chem 277 (10), 7897-7904 (2002)
   PUBMED   11751937
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Deng,A.Y.
  TITLE     Structure and organization of the rat endothelin-2 gene
  JOURNAL   Mamm Genome 8 (2), 157 (1997)
   PUBMED   9060420
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Chadeneau,C., LeCabellec,M., LeMoullac,B., Meflah,K. and Denis,M.G.
  TITLE     Over-expression of a novel member of the immunoglobulin superfamily
            in Min mouse intestinal adenomas
  JOURNAL   Int J Cancer 68 (6), 817-821 (1996)
   PUBMED   8980189
REFERENCE   10 (bases 1 to 2902)
  AUTHORS   Chadeneau,C., LeMoullac,B., LeCabellec,M., Mattei,M., Meflah,K. and
            Denis,M.G.
  TITLE     Isolation and chromosomal location of mE4, a novel murine gene of
            the immunoglobulin superfamily
  JOURNAL   Mamm Genome 7 (8), 636-637 (1996)
   PUBMED   8678999
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY276828.1 and BC032283.1.
            
            On Aug 13, 2009 this sequence version replaced NM_027514.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032283.1, AB195430.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY276828.1         2-53
            53-2902             BC032283.1         13-2862
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.95 cM"
     gene            1..2902
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /note="poliovirus receptor"
                     /db_xref="GeneID:52118"
                     /db_xref="MGI:MGI:107741"
     exon            1..191
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1339
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /note="tumor-associated antigen 1"
                     /codon_start=1
                     /product="poliovirus receptor precursor"
                     /protein_id="NP_081790.1"
                     /db_xref="CCDS:CCDS20916.1"
                     /db_xref="GeneID:52118"
                     /db_xref="MGI:MGI:107741"
                     /translation="MAQLARATRSPLSWLLLLFCYALRKAGGDIRVLVPYNSTGVLGG
                     STTLHCSLTSNENVTITQITWMKKDSGGSHALVAVFHPKKGPNIKEPERVKFLAAQQD
                     LRNASLAISNLSVEDEGIYECQIATFPRGSRSTNAWLKVQARPKNTAEALEPSPTLIL
                     QDVAKCISANGHPPGRISWPSNVNGSHREMKEPGSQPGTTTVTSYLSMVPSRQADGKN
                     ITCTVEHESLQELDQLLVTLSQPYPPENVSISGYDGNWYVGLTNLTLTCEAHSKPAPD
                     MAGYNWSTNTGDFPNSVKRQGNMLLISTVEDGLNNTVIVCEVTNALGSGQGQVHIIVK
                     EKPENMQQNTRLHLGYIFLIVFVLAVVIIIAALYTIRRCRHGRALQSNPSERENVQYS
                     SVNGDCRLNMEPNSTR"
     exon            192..539
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            540..836
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            837..963
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1115
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1238
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1273
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..2888
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /note="hexamer: AATAAA"
     polyA_site      2888
                     /gene="Pvr"
                     /gene_synonym="3830421F03Rik; CD155; D7Ertd458e; HVED;
                     mE4; necl-5; PVS; Taa1; Tage4"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcacc cgcttagctg agattccagc acttgacttc agggtttcgg agagataagg
       61 cgcttggccg ttactaactg gactacaaag agctggatcg gaccggaacc acatggctca
      121 actcgcccga gccacccgct ccccgctgtc atggctgctg ctgctgttct gctatgcact
      181 ccggaaagcg ggtggggata tacgtgtgct ggtgccctac aattcgacag gcgtcttggg
      241 agggtcgacc accttgcact gtagtctgac ttctaatgag aatgtgacta tcactcaaat
      301 aacctggatg aagaaggatt caggtggatc ccacgctctt gtggctgtct tccaccccaa
      361 gaaggggccc aacatcaaag agccagagag ggtgaaattc ttggctgccc aacaggatct
      421 gaggaacgca tctctggcca tctcgaactt aagtgtagaa gacgaaggca tctatgaatg
      481 tcagattgcc acattcccca gaggcagtag aagcaccaat gcctggctga aggtgcaagc
      541 ccgacctaag aacactgcag aggccctgga gccctctccc accttgatac tgcaggatgt
      601 ggctaaatgc atctctgcca atggtcaccc tcctggacga atctcttggc cctcgaatgt
      661 gaatggaagt caccgtgaaa tgaaggaacc agggtcccag ccgggcacca ccacagttac
      721 cagctacctc tccatggtac cttctcgcca ggcagacggc aagaacatca cctgcacggt
      781 ggagcatgaa agcttacagg agctggacca gctgctggtg accctttccc aaccctatcc
      841 acctgaaaac gtgtccatct ctggctatga cggcaactgg tatgttggcc tcactaactt
      901 gaccctgacc tgtgaagctc acagcaaacc agcgcctgac atggctggat ataactggag
      961 cacgaacacg ggtgactttc ccaactctgt taagcgccag ggcaatatgc ttctaatctc
     1021 caccgtagag gatggtctca ataacacggt cattgtgtgc gaagtcacca atgccctagg
     1081 gtctgggcag ggccaagtgc acatcattgt taaagagaaa cctgagaata tgcagcaaaa
     1141 tacaagatta cacctaggct acatctttct tatcgtcttt gtcctcgctg tagtcatcat
     1201 catcgcagca ctatacacta tacgaagatg caggcatggt cgtgctctgc agtccaatcc
     1261 ctcagagagg gagaacgtcc agtattcatc tgtgaacggc gactgtagac tgaacatgga
     1321 gccaaacagc acaaggtgac ggtgctgggt agacagaact aaggaacttg aaggcatagc
     1381 aactggaacc ctactctcat aaatgaagaa gcctccagag agactggctg ctcagtgtga
     1441 tgagcatagc aagtttgggg ggtctcccag gatgctgccg aattccacgt tgtcaaaagg
     1501 acccatggag gccagtgtgt tggctcactc ttgacatctc agcaagctgg gggggggggg
     1561 gggagcataa agcaaggttg agtctagctt gggctataga gcaaagccct gtccatacac
     1621 aaacaagcta aggggctttg agacggtcag aaactgaagt cttgctttgg gtaaggtaaa
     1681 tcctctaccg catgtatgtg ctagacttga aagacttcca cacagacctc tttataagtt
     1741 gactccattg gggctatccc ctcctctctg gacaaggtct ctgtatgtag ccaaggctag
     1801 gctcaaactc acagagatat gtctgcttct acctccccag tgctagagtt gaaagtattt
     1861 gtgccactgc acttttctag gtcttctttt aatgaagtaa agtatatatt tataaaaagc
     1921 tatttagtta tatatatata tatttttgag actatttcat agagcccaag ctaacctcaa
     1981 acttactatg tagccaagag tgatggtaaa ctaatttatt ttaatttatt tgtcttcaat
     2041 tttaaccatc acccaacccc tgctcccttc catatcttct ttcaatccat ttcattgtct
     2101 ttttcttccc agacactatt ctgacttacg tctccattac aaacatttta ttgaactaca
     2161 taaaaatgtg tgaaccacaa aaaaaaaatg tatttgtcaa aattgtagtt gtctttctga
     2221 ggctgacctg agttctctga taccattctc tccagttgta tccagtttcc tgtaaacaat
     2281 gtgactttgt ttttctcagt agctaaaaca tcccaattat gtgagtgtac actttcttta
     2341 ctcattcctc tgtgggccac cagctgggtt ggttccatat ctgagctatt gtgcatggaa
     2401 ttgtctctgt ggtgggttta gtaaactccc aggaatgcct gtacatgttt gtagaggcca
     2461 gaagaaggca caaaatcttg agccaggctt acatgcactt gtgagtagcc ccacataggt
     2521 gctaagaacc cagttcaggt cctctgctgt gggatggtgg gctgtgcaca gaaagcctgg
     2581 tcccggtcta gcaaaggtct ggaactccgg agccggtggg ctgtgattta caccagcatg
     2641 ggatggaagg agttggacct cgcctcctgg gcacctggct cctgtcacat agctacagcc
     2701 tcccacagcc cccctatagg gaggtatgca gcatcaatca catagtagct gcactaagcc
     2761 ctcccacatg caaataaggt ttccccaaac tctcagtcca agccaatgaa aagtacctgc
     2821 tgtcaaaccc taaatcatcc ccaaaactct gtaagtccta tcagggaata aaatgtgtgt
     2881 gaaaactaaa aaaaaaaaaa aa
//
