LOCUS       NM_013645                968 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus parvalbumin (Pvalb), transcript variant 2, mRNA.
ACCESSION   NM_013645
VERSION     NM_013645.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 968)
  AUTHORS   Yan,Y., Antolin,N., Zhou,L., Xu,L., Vargas,I.L., Gomez,C.D.,
            Kong,G., Palmisano,I., Yang,Y., Chadwick,J., Muller,F.,
            Bull,A.M.J., Lo Celso,C., Primiano,G., Servidei,S., Perrier,J.F.,
            Bellardita,C. and Di Giovanni,S.
  TITLE     Macrophages excite muscle spindles with glutamate to bolster
            locomotion
  JOURNAL   Nature 637 (8046), 698-707 (2025)
   PUBMED   39633045
REFERENCE   2  (bases 1 to 968)
  AUTHORS   Garbett,K., Tosun,B., Lopez,J.M., Smith,C.M., Honkanen,K. and
            Sando,R.C.
  TITLE     Synaptic Galpha12/13 signaling establishes hippocampal PV
            inhibitory circuits
  JOURNAL   Proc Natl Acad Sci U S A 121 (52), e2407828121 (2024)
   PUBMED   39693341
REFERENCE   3  (bases 1 to 968)
  AUTHORS   Parvathy,S., Basu,B., Surya,S., Jose,R., Meera,V., Riya,P.A.,
            Jyothi,N.P., Sanalkumar,R., Praz,V., Riggi,N., Nair,B.S.,
            Gulia,K.K., Kumar,M., Binukumar,B.K. and James,J.
  TITLE     TLX3 regulates CGN progenitor proliferation during cerebellum
            development and its dysfunction can lead to autism
  JOURNAL   iScience 27 (12), 111260 (2024)
   PUBMED   39628587
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 968)
  AUTHORS   Olinger,E., Schwaller,B., Loffing,J., Gailly,P. and Devuyst,O.
  TITLE     Parvalbumin: calcium and magnesium buffering in the distal nephron
  JOURNAL   Nephrol Dial Transplant 27 (11), 3988-3994 (2012)
   PUBMED   23144069
  REMARK    Review article
REFERENCE   5  (bases 1 to 968)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   6  (bases 1 to 968)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
REFERENCE   7  (bases 1 to 968)
  AUTHORS   Schleef,M., Zuhlke,C., Jockusch,H. and Schoffl,F.
  TITLE     The structure of the mouse parvalbumin gene
  JOURNAL   Mamm Genome 3 (4), 217-225 (1992)
   PUBMED   1611216
REFERENCE   8  (bases 1 to 968)
  AUTHORS   Zuhlke,C., Schoffl,F., Jockusch,H., Simon,D. and Guenet,J.L.
  TITLE     cDNA sequence and chromosomal localization of the mouse parvalbumin
            gene, Pva
  JOURNAL   Genet Res 54 (1), 37-43 (1989)
   PUBMED   2572511
REFERENCE   9  (bases 1 to 968)
  AUTHORS   Adolph,S., Berchtold,M.W. and Hameister,H.
  TITLE     Fine localization of genes on distal murine chromosome 15
  JOURNAL   Cytogenet Cell Genet 52 (3-4), 177-179 (1989)
   PUBMED   2630190
REFERENCE   10 (bases 1 to 968)
  AUTHORS   Iwasaki,Y., Ohkubo,A., Kamei,S. and Kosaka,K.
  TITLE     [Serial determination of serum GOT isozyme activities for the
            evaluation of acute hepatic damage (author's transl)]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 75 (1), 34-43 (1978)
   PUBMED   642215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589692.10, CK622340.1, AA467036.1, DV051867.1 and AI645659.1.
            
            On Sep 1, 2016 this sequence version replaced NM_013645.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027424.1, DV051867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL589692.10        109463-109477
            16-50               CK622340.1         1-35
            51-458              AA467036.1         28-435
            459-615             DV051867.1         477-633
            616-968             AI645659.1         12-364              c
FEATURES             Location/Qualifiers
     source          1..968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.93 cM"
     gene            1..968
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /note="parvalbumin"
                     /db_xref="GeneID:19293"
                     /db_xref="MGI:MGI:97821"
     exon            1..64
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /inference="alignment:Splign:2.1.0"
     exon            65..132
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /inference="alignment:Splign:2.1.0"
     exon            133..265
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /inference="alignment:Splign:2.1.0"
     exon            266..375
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /inference="alignment:Splign:2.1.0"
     exon            376..958
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /inference="alignment:Splign:2.1.0"
     regulatory      570..575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /note="hexamer: AATAAA"
     polyA_site      596
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /note="major polyA site"
     polyA_site      639
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
     regulatory      931..936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /note="hexamer: GATAAA"
     polyA_site      958
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
ORIGIN      
        1 ttcccaacag gatctcccac cagcccagct tttctgtata ggctccggcc tctgctcatc
       61 caagttgcag gatgtcgatg acagacgtgc tcagcgctga ggacatcaag aaggcgatag
      121 gagcctttgc tgctgcagac tccttcgacc acaaaaagtt cttccagatg gtgggcctga
      181 agaaaaagaa cccggatgag gtgaagaagg tgttccatat tctggacaaa gacaaaagtg
      241 gcttcattga ggaggatgag ctggggtcca ttctgaaggg cttctcctca gatgccagag
      301 acttgtctgc taaagaaaca aagacgcttc tggccgctgg agacaaggat ggggacggca
      361 agattggggt tgaagaattc tccactctgg tggctgaaag ctaagtggcg ctgactgctt
      421 gggtccccca cctctccatc cccaacgccc catctcagtc cttctcgcgg ccctcctgag
      481 tttctgttca gtttgtttgt gttatttttt actcccccat cctctatggc cctcggatga
      541 cgccattctt ctggaaatgc tggagaaaca ataaaggctg taccaatcgg acaccacctg
      601 tagggaggac ccaggcctgg cagggtgttg gtttggcaag ttttttttct ttctttttag
      661 ggcagtgggg gtatagtaga aaaagtgaga taagtcaaag gacaacgccc cgatatctcc
      721 tgcctgcttg gtactgagtg ctcatgtggg ccacctcgtt caatctctgc acctttccca
      781 caaggagatg ggggtgatgg atcgtccatc ttaaagatac agaaactgcc ttttaaagag
      841 cagaagggaa gggaaggggt tgagtccttc aggactagct agatcaaagg actccaatga
      901 cactctatca attgcttttg actttgctgt gataaaatac ctgaaaagag aaacttaaaa
      961 aaaaaaaa
//
