LOCUS       NM_172437               2848 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pseudouridylate synthase 7-like (Pus7l), mRNA.
ACCESSION   NM_172437 XM_910210
VERSION     NM_172437.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2848)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2848)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2848)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 2848)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY780892.1, AK029027.1 and AV296268.1.
            
            On Oct 22, 2009 this sequence version replaced NM_172437.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029027.1, AK019372.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY780892.1         43-59
            18-2640             AK029027.1         2-2624
            2641-2641           AV296268.1         164-164
            2642-2848           AK029027.1         2625-2831
FEATURES             Location/Qualifiers
     source          1..2848
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.52 cM"
     gene            1..2848
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /note="pseudouridylate synthase 7-like"
                     /db_xref="GeneID:78895"
                     /db_xref="MGI:MGI:1926145"
     exon            1..48
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            49..970
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2169
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /EC_number="5.4.99.-"
                     /note="pseudouridylate synthase 7 homolog-like protein"
                     /codon_start=1
                     /product="pseudouridylate synthase PUS7L"
                     /protein_id="NP_766025.1"
                     /db_xref="CCDS:CCDS27771.1"
                     /db_xref="GeneID:78895"
                     /db_xref="MGI:MGI:1926145"
                     /translation="MAEDTDGGIRFNSLCFINDHVGFQGSIKTSPSDFIVIEIDEQGQ
                     LVSKATDGSLYEISKIQSEPSNSVKKPKLNIQNVSLEHKNSEGAADLPGCSDGDRSHQ
                     SDSEKENSVNSVTSKCEEESVDLLRSLLDEKTHTSLGQFACDIKRMWNSQTELTEPSP
                     ELSLGKILDKNRRAVLHSAVRQAFPFLITVGNQGEVVVKPNRECKELCRLVSEEEALG
                     FFKYLDAKKENSKFTFKPDPNKDHRKAVHHFLNKKFGNLVETKSFPGQHHSAGNPDSA
                     ITVRFREKARGKRSHPEGCERGKAVYTAFTLQKENLETFEAIGLLAVKLGVIPSDFSY
                     AGLKDKRAITYQSMVVKKVTPERLKSIKEEIEKKRMNVFNIRSVGDCLRLGQLKGNHF
                     EIIIRHLRNQLNDSANLTERILEAIENVKNKGFVNYYGPQRFGKGQKIQTDQIGLALL
                     KNEMVKAIKLFLTPEDVDDPVNKAKQYFLRTEDAKGTLSLMPEFRVRERALLESLHRF
                     GVTEEGCVRAWFSFPHSMRIFYIHAYSSRIWNEAASYRLAAYGPKVVEGDLICSDEDA
                     DKHFPSSKVHLVTKEEESAHTYALHQVVLPVLGYNVQYPENQVGRWYQEALSRDGLQA
                     CRFRVPALKLNVPGCYRHIVKHPRNVSHRLVHPDPATEEARVEGPHSDDTASSLSLSF
                     DLDASCYATVCLREMMKGDI"
     exon            971..1130
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1323
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1422
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1504
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1782
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1836
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2848
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2793
                     /gene="Pus7l"
                     /gene_synonym="3000003F02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcatgcgca ctgtgtcact cggcggacca ctttctcacg gaagcgaggc accgtgaagg
       61 atggcagagg acacagatgg tggcatcagg tttaactcct tgtgtttcat caacgatcac
      121 gtgggctttc agggcagcat aaaaacctca cccagtgact tcattgttat cgagatcgat
      181 gaacagggac agttagtcag taaggccacc gatggatctc tctatgaaat tagtaaaata
      241 caatctgaac cgagcaattc tgtcaagaag ccaaagttaa atattcagaa tgtatcctta
      301 gaacataaaa atagtgaagg agctgctgac ttgcccgggt gctcggatgg tgaccggagc
      361 catcagtctg actccgagaa agaaaacagt gtcaacagtg tgacttctaa atgtgaagaa
      421 gaaagtgttg atttattacg ttcactttta gatgagaaaa ctcacacatc gctgggtcag
      481 tttgcctgtg acatcaaaag gatgtggaat tcacaaactg aattaactga gccatctcct
      541 gaattgtccc taggcaagat ccttgacaaa aaccgcagag ctgttctgca cagtgctgtg
      601 aggcaggcct ttcctttttt gatcaccgta ggaaaccagg gtgaagttgt tgtaaaacca
      661 aaccgtgagt gtaaagaact ctgccgtctg gtgtcggaag aggaggctct tggctttttc
      721 aaatatttgg acgcaaagaa agaaaattcc aagtttacct ttaagccgga tccgaacaag
      781 gatcacagga aggctgtgca ccattttctc aacaagaagt tcggaaacct ggtggaaacc
      841 aaatcttttc ccgggcagca ccacagtgct gggaacccag actcagccat aactgtaaga
      901 ttccgggaaa aagcacgcgg gaagagatct cacccggaag gctgcgagag aggaaaagct
      961 gtgtacacag cttttaccct gcaaaaggaa aatctggaga cgttcgaagc aattggctta
     1021 ttagccgtca aacttggtgt tattccttcg gatttcagtt acgcgggcct taaagacaag
     1081 agagcaatca cctatcaatc gatggttgtt aaaaaagtga ctccggagag gttgaaaagt
     1141 atcaaagaag aaattgagaa gaagagaatg aatgtgttca atattcggtc tgtaggcgat
     1201 tgtctcagac ttggtcagct caagggaaat cactttgaaa ttatcatcag gcacctgaga
     1261 aatcagctca atgattctgc aaacctgaca gagagaattt tggaggcaat agaaaatgtt
     1321 aagaataaag gttttgtgaa ttactatgga ccacagagat ttgggaaagg acagaaaatc
     1381 caaacggacc aaattgggtt ggctctactg aagaatgaga tggtgaaggc cataaaatta
     1441 tttcttacac cagaagacgt ggatgatcct gtcaataaag caaagcaata ctttctccga
     1501 actgaggatg ccaaaggcac tctttcactg atgcccgagt tccgggttcg agagcgtgcg
     1561 ctgctggagt cattgcatcg ctttggagtg acggaggaag gctgtgtccg ggcctggttc
     1621 tccttccccc attccatgcg tatattctac atccacgcat acagtagcag gatttggaac
     1681 gaggcagcat cttacagact ggcagcctat ggacccaagg tggtggaggg ggacctgatc
     1741 tgctcggatg aagatgcgga caagcatttc ccaagcagta aagttcatct ggtgaccaaa
     1801 gaagaggagt cagcgcacac atatgcactg caccaggtag ttctgcccgt gcttggatac
     1861 aacgttcagt acccggagaa ccaagtaggg cggtggtacc aagaagccct cagcagggac
     1921 ggactgcagg cctgtaggtt cagggtgccc gccctgaagc tgaacgtacc cggatgctac
     1981 aggcacatcg tgaaacaccc ccgcaacgtg tcacaccgac tagtccatcc tgaccccgcc
     2041 accgaggagg cccgagtgga aggtccccac tccgatgata cagcctcatc gctgtccttg
     2101 tccttcgacc ttgacgcttc gtgttacgct actgtttgtc tgagggaaat gatgaagggc
     2161 gacatttaag ctcacacacc ctgatgtcac cgcgtgcggg gcattcggaa gcaagggtag
     2221 ccgcggttcc aagggctctg ccttgagctt cgcggttctc gctcctcact tttcacagtg
     2281 tcctgagagg tcggggtgtg atgtattaac gtaagcaccg gtgtcttaag tttaaagcta
     2341 tatgactgtg ctctctaagg tcatgcttca gggatttttc tccggtcgtg aaagttctag
     2401 gtctttggag caccactctg agcacgggct gctccacgcc actcttgaga ggtggagaga
     2461 gaacagcgtc cgcgctgctt ggagaggtga tggcgaaacc tcggtgcttt tctcccgcac
     2521 tgcctccttt ccaccgcgaa gtggctggtg tgacaccgtg caagggcagt atctgttctc
     2581 ataatgtatt tatgagatac tgaagatttt atttaaaatt tttatactag tttttttttt
     2641 tacctgtttt cctaaccgtt tgttgttttc taccacctaa aactcagatt ttatactcct
     2701 gtcggtaccc acgttctatt tctaacacat accaacgaca ttggaaatgg tagtgattct
     2761 ctttgaaaaa taaagacatt ctcgatttct tgagttacta tcgaattgtc tctatgtttt
     2821 atgctgcaaa aaagaaaaca tattgtcc
//
