LOCUS       NM_178403               3907 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pseudouridylate synthase 7 (Pus7), transcript variant
            3, mRNA.
ACCESSION   NM_178403 XM_621654 XM_901301 XM_901304 XM_906076
VERSION     NM_178403.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3907)
  AUTHORS   Quesnel-Vallieres,M., Dargaei,Z., Irimia,M.,
            Gonatopoulos-Pournatzis,T., Ip,J.Y., Wu,M., Sterne-Weiler,T.,
            Nakagawa,S., Woodin,M.A., Blencowe,B.J. and Cordes,S.P.
  TITLE     Misregulation of an Activity-Dependent Splicing Network as a Common
            Mechanism Underlying Autism Spectrum Disorders
  JOURNAL   Mol Cell 64 (6), 1023-1034 (2016)
   PUBMED   27984743
REFERENCE   3  (bases 1 to 3907)
  AUTHORS   Quesnel-Vallieres,M., Irimia,M., Cordes,S.P. and Blencowe,B.J.
  TITLE     Essential roles for the splicing regulator nSR100/SRRM4 during
            nervous system development
  JOURNAL   Genes Dev 29 (7), 746-759 (2015)
   PUBMED   25838543
REFERENCE   4  (bases 1 to 3907)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 3907)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY067917.1, BY065820.1, AK160849.1, AK145380.1, AC117614.14 and
            CD741583.1.
            
            On Jan 31, 2014 this sequence version replaced NM_178403.4.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. Variants 2 and
            3 encode the same isoform (2), which lacks an internal segment and
            is shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160849.1, AK142271.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY067917.1         2-29
            29-50               BY065820.1         25-46
            51-3359             AK160849.1         3-3311
            3360-3399           AK145380.1         3710-3749
            3400-3467           AC117614.14        164617-164684       c
            3468-3907           CD741583.1         1-440               c
FEATURES             Location/Qualifiers
     source          1..3907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.42 cM"
     gene            1..3907
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /note="pseudouridylate synthase 7"
                     /db_xref="GeneID:78697"
                     /db_xref="MGI:MGI:1925947"
     exon            1..200
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            201..627
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2215
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /EC_number="4.2.1.70"
                     /note="isoform 2 is encoded by transcript variant 3;
                     pseudouridylate synthase 7 homolog"
                     /codon_start=1
                     /product="pseudouridylate synthase 7 homolog isoform 2"
                     /protein_id="NP_848490.2"
                     /db_xref="CCDS:CCDS51431.1"
                     /db_xref="GeneID:78697"
                     /db_xref="MGI:MGI:1925947"
                     /translation="MEMTSTSLKRGCLVVEDNDSVTPHDETKKQKVSEGCLTSSQDGV
                     ENDGLHRSENEPGPPEAESTVKDDENSSAQVQEEEEEEEEEDGLSEAGEEEEAESFAD
                     MMKHGLTELDVGICKFVSSHHGFSGILKERYSDFVVHEIGKDGRISHLDDLSVPVDEE
                     DPPEDALTVLTAEDRQQLEELQLFKNKETSVAIEVIEDTKEKRTVIHQAIKSLFPGLE
                     TKTEDREGRKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLS
                     KYLRVKPNIFSYMGTKDKRAITVQEIAVLKISAQRLAHLNKCLMNLKLGNFSYQKTPL
                     KLGALQGNHFTVVLRNITGTDEQVQQAMQSLRETGFINYYGMQRFGTTAVPTYQVGRA
                     ILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPASALKKLPVKRCVEGQLLRG
                     LSRYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNTMVSRRIEEYGLRPVPGDLVLKGA
                     TPTYIEEDDVDNYSIHDVVMPLPGFDVIYPKHKISEAYREMLAADNLDIDNMRHTIRD
                     YSLSGAYRRIIIRPQSVSWEVVAYDDPKIPLFNTDVDNLEGKPPPVFASEGKYRALKM
                     DFSLPPSTYATMAIREVLKMDTSIKNQTQLNTSWLR"
     exon            628..712
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..814
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..959
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1071
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1149
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1278
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1404
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1466
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1627
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1754
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1856
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1986
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2078
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..3890
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3388..3393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3407
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /note="major polyA site"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
     regulatory      3871..3876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3890
                     /gene="Pus7"
                     /gene_synonym="C330017I15Rik"
ORIGIN      
        1 ggggcgtggt cggcgcggcg cagcgccgca cgtgtgcgag cccggcggct ggtgggataa
       61 cccgtccctg tgcgtctcca cgcggtgcag cctgtgctgg tcggcgctgg ccgccgcctc
      121 ctgcgagtca ccgccgccgc cctcccgcgt cccgagccga gcgtcctctt ctccgctcgg
      181 cccgcgccct caggctcccg gttctcttaa atgttttctt ggagccttaa agatggaaat
      241 gacaagcacg tccctgaaac gtgggtgcct tgttgtggaa gataatgaca gtgtgacccc
      301 acacgacgaa acaaagaaac agaaggtgtc cgagggctgt ctgaccagca gtcaggatgg
      361 ggtagagaat gacggtctac accgcagtga gaacgagcct gggcctccag aagctgaaag
      421 caccgtgaaa gatgacgaga attccagcgc tcaggtgcaa gaggaagagg aggaggagga
      481 ggaagaagac ggcctttcag aagcagggga agaggaagaa gcagagagtt ttgcagacat
      541 gatgaaacat gggctcacag aacttgatgt gggcatctgc aagttcgtga gttcccatca
      601 cggcttctcg gggatcttaa aagaaagata ctctgacttt gtcgttcacg aaatcgggaa
      661 agatggacgg atcagccatt tggatgactt atctgttccg gtggatgaag aggaccctcc
      721 agaagacgct ctcactgtct tgacagctga ggacaggcag cagttggagg agctccagct
      781 tttcaaaaat aaagaaacca gtgttgccat cgaggtcatt gaggacacca aagagaagcg
      841 aacagtcatc catcaagcca ttaaatctct cttcccagga ctagagacaa agacagagga
      901 tagagagggg cggaaataca tcgtagccta ccatgcagct ggcaaaaagg ctttggcaaa
      961 tccaagaaaa cattcttggc caaaatcccg gggaagttac tgccattttg ttctctacaa
     1021 agaaaacaaa gacaccatgg atgccatcaa tgttctatcc aagtacctgc gggtaaagcc
     1081 aaacatattc tcctatatgg gaaccaaaga caaaagggca atcacagtcc aggagattgc
     1141 tgttctcaaa ataagtgcac aaagacttgc ccacctcaat aagtgcctga tgaacttgaa
     1201 gctcgggaat ttcagctatc agaaaacccc tctgaagtta ggagcgctcc aaggaaacca
     1261 cttcactgtt gttctcagga atataacagg aactgatgag caggtgcagc aagccatgca
     1321 gtctctgagg gagaccggct tcattaacta ctatggcatg caaaggttcg ggaccacagc
     1381 tgttccaacg taccaggttg gaagagcaat tctacagaat tcctggacag aagtcatgga
     1441 tttaatactg aaaccccgtt ctggagctga gaagggttac ttggtgaaat gcagagaaga
     1501 atgggccaag accaaagacc cagcctctgc tctcaaaaag ctgcccgtca aaaggtgtgt
     1561 ggaagggcag ctgctccgag gactttccag atatggaatg aagaatatag tctctgcatt
     1621 tggcataatt ccaagaaaca atcgcttaat gtacatccac agttatcaga gctacgtgtg
     1681 gaacaccatg gtgagcagaa gaattgagga gtacgggctg aggcctgtgc ccggggacct
     1741 tgttctcaaa ggagccacgc ccacctacat tgaggaagat gacgttgaca actactccat
     1801 ccacgatgtg gtgatgcctt tgcctgggtt tgatgttatc taccccaagc ataaaatcag
     1861 cgaggcctac agggaaatgc ttgctgcaga caaccttgat attgacaaca tgagacacac
     1921 gattcgagat tactccttat cgggggccta ccgaaggatc atcatcaggc ctcagagcgt
     1981 cagctgggaa gttgttgcat atgatgatcc taaaattcca cttttcaaca cggatgtgga
     2041 caacctcgag gggaaaccac caccagtgtt tgcttctgaa ggcaaataca gggctctgaa
     2101 gatggacttt tctcttcctc cttctactta cgccaccatg gccattcgag aagtgctcaa
     2161 aatggacacc agcatcaaga accagaccca gctaaatacg agctggctgc gatgaacagt
     2221 gcatcgctca gagaggggat gcagacctgc ttctgacctc ctattctggt ctttttttaa
     2281 gtgctgactc atgtttggag tttaaaactt ttgtagtaaa ggatgatttg tattttgtaa
     2341 agtttttaat cagcttaaat actttgcaat atttgtacac atatacaagt cctgaggatc
     2401 ctaatttcag ctcagagatc gaattgggtc agcatatcct gtaggtgctt agattctagt
     2461 acagcatcag cttcctgcct ttaacacagg gaagggggac ttggtttaaa gttgcggttt
     2521 taggttttgc tgcacacctg aagtacaaac cagaatctta gatgtttgtg atgagattac
     2581 acatggtccg tgtcagagca aatgcagcag actggaaact agagactgca cacttaacac
     2641 gcagttcccg tgttggtttc aataataaca aaacatccac gggtttataa acacggcgtg
     2701 gcttttgttg agtgactgtg ttagcttcag gtgagcattt atacacatct tagcttgcag
     2761 tggcttttct ggttagtcta tcagcatctt tcagggcact cttttccttg ataggagcct
     2821 gtagcttttc ttgggtacag tctgatttta ctctgggtgc ctcttactct cagaaccttt
     2881 tcactggact cagaagtaaa tagtgtgagt tccaggacag ccagggctac acagagaaac
     2941 cctgtctcga acgcaaaaaa acaaacaaac aaaaggtaaa tagtgaccat gaaggaaatc
     3001 tgggaaactt agaatggctc ctgcagccgg gcgtggtggc cacgccttta attccagccc
     3061 ccgggaggca gaggcaggcg gatttctgag ttcaaggcca tcctggtcta cagagtgagt
     3121 ttcaggacag agaaaccctg tctcaaaaaa ccaaaaaaaa aaaaagaaga agggctccta
     3181 cttccatctg cagcgctgac cctcagccag cagctgctta ggggtttcca tcatggcagt
     3241 gcagaaaacc ctcctctaaa aagatggata tgcctttcag acagtgtgag acatgactct
     3301 agccagtttt attttctgtt atttcttaaa gcaaatgtaa taaatatttt taagaacaca
     3361 ttttttacta attatgtaaa taaatcaaat aaatattcta aaactgagtg catgtaaaaa
     3421 tcttgtccct ggctaacggg caacaaggcg ctcgatgagt ggacagttga cagtcgtcag
     3481 cagatgtggc atagtggcgt ctctatcaag atgggctgtg agactcatac agtatccact
     3541 ggggtgactg actcatggcc tggactcaag gtaattcctc ccacggtgtc gctccctggc
     3601 ctcccagtgt gctttctgga gtgaagaaga tgcctggaga gagacaacag ccattaaagt
     3661 ataattgagg gggctgatga gatggctcag tggttaagag cgccaactgc tcttccgaag
     3721 gtcctgagtt caaatcccag caatcacatg ttggctcata accatccgta acgaaatctg
     3781 atgctctctc ttttggagtg tctgaagaca gctacagtgt acttacatat aataaataaa
     3841 taaataaata aataaataaa taaataaata aataaataag ggggaaagta aaaaaaaaaa
     3901 aaaaaaa
//
