LOCUS       NM_023292               2350 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus pseudouridine synthase 3 (Pus3), mRNA.
ACCESSION   NM_023292 XM_011242586
VERSION     NM_023292.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Zhao,X., Patton,J.R., Ghosh,S.K., Fischel-Ghodsian,N., Shen,L. and
            Spanjaard,R.A.
  TITLE     Pus3p- and Pus1p-dependent pseudouridylation of steroid receptor
            RNA activator controls a functional switch that regulates nuclear
            receptor signaling
  JOURNAL   Mol Endocrinol 21 (3), 686-699 (2007)
   PUBMED   17170069
  REMARK    GeneRIF: Pus1p- and Pus3p-dependent pseudouridylation of SRA
            controls a coactivator-corepressor switch in SRA with major
            consequences for NR signaling.
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Chen,J. and Patton,J.R.
  TITLE     Pseudouridine synthase 3 from mouse modifies the anticodon loop of
            tRNA
  JOURNAL   Biochemistry 39 (41), 12723-12730 (2000)
   PUBMED   11027153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118232.10.
            
            On or before Nov 10, 2017 this sequence version replaced
            XM_011242586.2, NM_023292.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.135476.1,
                                           SRR7345562.1288126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC118232.10        93094-93267         c
            175-389             AC118232.10        92310-92524         c
            390-803             AC118232.10        86630-87043         c
            804-1369            AC118232.10        85972-86537         c
            1370-2350           AC118232.10        84426-85406         c
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.32 cM"
     gene            1..2350
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /note="pseudouridine synthase 3"
                     /db_xref="GeneID:67049"
                     /db_xref="MGI:MGI:1914299"
     exon            1..174
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            175..389
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..803
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1369
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2350
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2092
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /note="major polyA site"
     polyA_site      2137
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
     regulatory      2328..2333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2350
                     /gene="Pus3"
                     /gene_synonym="2610020J05Rik; 5730412F04Rik"
ORIGIN      
        1 gggcggaggg agagaggtgc ggggcgcagc tgtgcgggac acccgcgagc tttccgtttg
       61 accagccggc catccgcaca gcagagagaa agtgggcacg gaggcggtac acacaccgcg
      121 ctgcaggctc tcgtgcgggt atctctcccg acagccccgc ttgggcatca ccagaccaga
      181 ctatatttct cgtattggct tgcggtaaag aggaagctgc atcagaaacc tgcgcatgcg
      241 gtgggcttcg gctaaaagcc cacaccgtgc cttccgaact acatttccca gaaccgtcgg
      301 cgcacgcttg gtgaagccgc gcatgcttac tgaagacgga aagccatagc ttccggctag
      361 ccgcatggcc gcctactgag gaccggaagg gtggacctgc atgatttctt cctggggatg
      421 tcatggctga aaacacagac agaaaccaga ttgagaaact cctaaacaga gtgaaggaac
      481 tggaacagga ggtggaaaga cttaagaaaa agaaagaaca ggccaacaat ataaaagact
      541 caagcatcag agaaaattcg ttaggctctg gaaaagctaa gcgtgctttt gatttcagtg
      601 ctcatggccg tagacatgta gctctaaaaa tagcctatct aggctgggga taccagggct
      661 ttgccagtca ggaaaacaca agcaatacaa ttgaagagaa actgtttgag gctttaacta
      721 agacccgact agtagaaagc agacagacat ccaactatca taggtgtggt cgaacagaca
      781 aaggtgttag tgcctttgga caggtgattt ctttagacct acgttctcag tttccaacga
      841 gcagggattc agaagattct aatttaaagc atgaagctga tgatcttgct aaagagatcc
      901 gttatactca cattctcaat cgggtgcttc ctgcagacat ccgagtattg gcctgggccc
      961 ctgtagaacc tagcttcagt gctaggttta gctgtcttga gcggacttat cgctattttt
     1021 tccctcgtgc ggatttagat attgcaacca tgaattatgc agctcagaaa tatgttggca
     1081 ctcatgattt cagaaacttg tgtaaaatgg atgtagccaa tggagtgatt aattttcaga
     1141 ggactattct gtgtgcacaa gtacaactag tggcccagag cccaggcgag gagagaaggc
     1201 aagaaccatt ccagttatgt caatttgaag taattggcca ggcattcttg taccatcaag
     1261 ttcggtgtat gatggctatc ctcttcctga ttggccaagg aatggagaag ccagagatta
     1321 ttgatgaatt gctgaacata cagaaaaatc cccagaaacc tcaatatagc atggctgttg
     1381 aatttcctct agtcttatat gactgtaaat ttgaaaatac caagtggatt tatgatcatg
     1441 aggttcagga attcaatgtt acccacctac aacagctgtg ggctaatcat gctgttaaaa
     1501 ctcacatgct atatagtatg ctgcaaggtc tagactctgt tatggtaaca tgtgcagcag
     1561 gaacaaagat ggatgaagca acagaatgga gaaacattca accccctgtc ataaagcaca
     1621 cgagtgcctt tgtagaagga gtgaaaatgc gcacatataa gcccctcatg gatcgtccca
     1681 agtgccaagg actggaatcc cggatccggc attttgtgag tagaggcaga attgagcacc
     1741 cacatttact ccataaggaa gaaataaaag ccagaaggga ctgtgctgac aaagaagaaa
     1801 atactgttgt agagaatcca agtaagaggg tttgtataat agatgcagaa attaacagca
     1861 ttgcataatc ctaggaagcc tagcatctct aacaggatcc agggagcaat aaccagttaa
     1921 aattctaatg atggcaaaag ggcctaacaa gttgttaaac agaaaaggat gtattctcta
     1981 atccctgtcc aaaagagtga tgaaatgaaa gacgcaaaaa gcacttgtca gttatatgca
     2041 cctggaaatc cgtgccttgt gttcaaatcc attaaagtct ggtctacaag tatatttgtt
     2101 ctttttcaag gcaaatgtga taactaataa tctcaaagat ctttgccaaa gtgtcttact
     2161 tcctaagaat tcatcaacta aagatagata gatgcattct gtgccaggca tgaagctacc
     2221 cagcatccac ctaactcaag gctgtacaac atgttttaac gaggcagcta agtacagagg
     2281 cagagaaact ttttagtaag ggtaggagta aaaactttta ggttctgaat aaaatgatat
     2341 attgaactca
//
