LOCUS       NM_011221               8478 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus purine rich element binding protein B (Purb), mRNA.
ACCESSION   NM_011221 XM_989540
VERSION     NM_011221.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8478)
  AUTHORS   Foote,A.T. and Kelm,R.J. Jr.
  TITLE     Aromatic Residues Dictate the Transcriptional Repressor and
            Single-Stranded DNA Binding Activities of Purine-Rich Element
            Binding Protein B
  JOURNAL   Biochemistry 62 (17), 2597-2610 (2023)
   PUBMED   37556352
  REMARK    GeneRIF: Aromatic Residues Dictate the Transcriptional Repressor
            and Single-Stranded DNA Binding Activities of Purine-Rich Element
            Binding Protein B.
REFERENCE   2  (bases 1 to 8478)
  AUTHORS   Zhang,J., Li,Y., Chen,Y., Yu,X., Wang,S., Sun,H., Zheng,X.,
            Zhang,L., Wang,Y. and Zhu,D.
  TITLE     Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle
            autophagy by binding Purb
  JOURNAL   J Mol Cell Cardiol 176, 41-54 (2023)
   PUBMED   36716953
  REMARK    GeneRIF: Circ-calm4 regulates hypoxia-induced pulmonary artery
            smooth muscle autophagy by binding Purb.
REFERENCE   3  (bases 1 to 8478)
  AUTHORS   Ferris,L.A., Foote,A.T., Wang,S.X. and Kelm,R.J. Jr.
  TITLE     Purine-rich element binding protein B attenuates the coactivator
            function of myocardin by a novel molecular mechanism of smooth
            muscle gene repression
  JOURNAL   Mol Cell Biochem 476 (8), 2899-2916 (2021)
   PUBMED   33743134
REFERENCE   4  (bases 1 to 8478)
  AUTHORS   Jia,L., Jiang,Y., Li,X. and Chen,Z.
  TITLE     Purbeta promotes hepatic glucose production by increasing Adcy6
            transcription
  JOURNAL   Mol Metab 31, 85-97 (2020)
   PUBMED   31918924
  REMARK    GeneRIF: Purbeta promotes hepatic glucose production by increasing
            Adcy6 transcription.
REFERENCE   5  (bases 1 to 8478)
  AUTHORS   Rumora,A.E., Ferris,L.A., Wheeler,T.R. and Kelm,R.J. Jr.
  TITLE     Electrostatic and Hydrophobic Interactions Mediate Single-Stranded
            DNA Recognition and Acta2 Repression by Purine-Rich Element-Binding
            Protein B
  JOURNAL   Biochemistry 55 (19), 2794-2805 (2016)
   PUBMED   27064749
  REMARK    GeneRIF: site-directed mutagenesis revealed several basic amino
            acid residues in the intermolecular (R267) and intramolecular (K82
            and R159) subdomains that are essential for Purbeta transcriptional
            repressor function in Acta2 promoter-reporter assays. In keeping
            with their diminished Acta2 repressor activity in fibroblasts,
            purified Purbeta variants containing an R267A mutation exhibited
            reduced binding affinity for purine-ric...
REFERENCE   6  (bases 1 to 8478)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 8478)
  AUTHORS   Yano,H., Wang,B.E., Ahmad,I., Zhang,J., Abo,T., Nakayama,J.,
            Krempen,K. and Kohwi,Y.
  TITLE     Identification of (CAG)(n) and (CGG)(n) repeat-binding proteins,
            CAGERs expressed in mature neurons of the mouse brain
  JOURNAL   Exp Cell Res 251 (2), 388-400 (1999)
   PUBMED   10471324
REFERENCE   8  (bases 1 to 8478)
  AUTHORS   Kelm,R.J. Jr., Cogan,J.G., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Molecular interactions between single-stranded DNA-binding proteins
            associated with an essential MCAT element in the mouse smooth
            muscle alpha-actin promoter
  JOURNAL   J Biol Chem 274 (20), 14238-14245 (1999)
   PUBMED   10318844
REFERENCE   9  (bases 1 to 8478)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 8478)
  AUTHORS   Kelm,R.J. Jr., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Sequence of cDNAs encoding components of vascular actin
            single-stranded DNA-binding factor 2 establish identity to Puralpha
            and Purbeta
  JOURNAL   J Biol Chem 272 (42), 26727-26733 (1997)
   PUBMED   9334258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL646020.15.
            
            On Aug 27, 2011 this sequence version replaced NM_011221.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF017630.1, CJ113010.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8478              AL646020.15        44406-52883         c
FEATURES             Location/Qualifiers
     source          1..8478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.16 cM"
     gene            1..8478
                     /gene="Purb"
                     /gene_synonym="2310015K15Rik; Cager-2; D11Bwg0414e"
                     /note="purine rich element binding protein B"
                     /db_xref="GeneID:19291"
                     /db_xref="MGI:MGI:1338779"
     exon            1..8478
                     /gene="Purb"
                     /gene_synonym="2310015K15Rik; Cager-2; D11Bwg0414e"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1165
                     /gene="Purb"
                     /gene_synonym="2310015K15Rik; Cager-2; D11Bwg0414e"
                     /note="transcriptional activator protein Pur-beta;
                     vascular actin single-stranded DNA-binding factor 2 p44
                     component; PurB beta; purine-rich single-stranded
                     DNA-binding protein beta"
                     /codon_start=1
                     /product="transcriptional regulator protein Pur-beta"
                     /protein_id="NP_035351.1"
                     /db_xref="CCDS:CCDS24420.1"
                     /db_xref="GeneID:19291"
                     /db_xref="MGI:MGI:1338779"
                     /translation="MADGDSGSERGGGGGGGGGPGGFQPAPRGGGGGGGGPGGEQETQ
                     ELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDF
                     IEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQ
                     TVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGDEDELAGGPGG
                     GAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKA
                     WGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED"
     regulatory      8451..8456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Purb"
                     /gene_synonym="2310015K15Rik; Cager-2; D11Bwg0414e"
                     /note="hexamer: AATAAA"
     polyA_site      8473
                     /gene="Purb"
                     /gene_synonym="2310015K15Rik; Cager-2; D11Bwg0414e"
                     /note="major polyA site"
ORIGIN      
        1 gggccgtgcc gcacggaagc cgcgggggcg gggcgcggag gcgatggggg gcggcggcga
       61 ccggcgatga gcggcgggcg cgcgtgagga gccggcgggc gaggctgggg ggccccggag
      121 cgcgagccgc agggcggagg gcgggggcgc gagcgcagcg ggcggcggcg gcgaggcggc
      181 ggccgagaag atggcggacg gcgacagcgg cagcgagcgc ggcggtggcg gcggcggcgg
      241 cggcgggccc ggcggcttcc agcccgcgcc ccgcggcggc ggcggcggcg gtggcgggcc
      301 gggcggcgag caggagacgc aggagctggc ctcgaagcgg ctggacatcc agaacaagcg
      361 cttctacctg gacgtgaagc agaacgccaa gggccgcttc ctcaagatcg ccgaggtggg
      421 cgcgggcggc tccaagagcc gcctcacgct gtcgatggcg gtggccgccg agttccgcga
      481 ctcgctgggc gacttcatcg agcactacgc gcagctgggt cccagcagcc ccgagcagct
      541 ggcggcgggc gccgaggagg gcggcgggcc gcgccgcgcg ctcaagagcg agttcctggt
      601 gcgcgagaac cgcaagtact acctggacct caaggagaac cagcgcggcc gcttcctgcg
      661 catccgccag acggtgaacc gcggcggcgg cggcttcggc ggggggcccg ggcccggcgg
      721 cctgcagagc ggccagacca tcgcgctgcc cgcgcagggc ctcatcgagt tccgcgacgc
      781 gctcgccaag ctcatcgacg actacggggg cgacgaggac gagctggccg gcggcccggg
      841 aggcggcgcc ggcggccccg ggggcggcct gtacggagag ctcccggagg gcacctccat
      901 caccgtggac tcgaagcgct tcttcttcga cgtcggctgc aacaagtacg gggtgttcct
      961 gcgagtgagc gaggtgaagc cgtcctaccg caatgccatc accgtgccct tcaaggcctg
     1021 gggcaagttt ggaggcgcct tctgtcggta tgcagatgaa atgaaagaga tccaggagcg
     1081 acagagggat aagctttacg agcgacgcgg cgggggcagc ggtggcggcg acgagtcgga
     1141 gggtgaggaa gtggatgagg attgaagcag gcagcttccc gtaccggcct cccccaaccc
     1201 caccaccatc cccttggcta gagagcgccc tttccttctc gtccccagtg agctagtgga
     1261 gagggatcag gggaggccgc agacgaagaa aacaaaaaaa aaaataaaat aatatagtta
     1321 agagaaataa ccataagaaa acagtcacag acaattagag aaaagcagtt aagttccaag
     1381 gaactgccag caacctgcaa agaggagcag catctcctca cctgcgcaag agtctcagct
     1441 tctgttgttt aaaaccgagg ttcggaaatt catcaggaaa acactggaag ggatagatag
     1501 atcttcgagc gtctgggacc aaaaccacac ctgggttacc cagactcatg cattgggaat
     1561 agctgaattt gtgttcttcc tgggtaatct ggtcttagga tccctccagg cctcactact
     1621 atcagcatct atcccttcac ctccatcgaa atcagcattt tggatctagg tcttagtgga
     1681 atctttgaga agaaagaggc cttttgcagt tacccagttc tgagggtaca ggtttatgaa
     1741 aaggaatgca actttacaca atcatggaca gggcaagaga agaattcaag aagccattgg
     1801 agaattcgaa aattagatcc atttaaaaaa aatggttttg catggaacct ggaccaaggc
     1861 ccctgtcttt tctttgcaga attgttttcc gggatgcaaa tgaattcaga gatcaaagct
     1921 tgaactagaa tccattacta aaatagttta aaagttggca attttttttt tcaaaaacaa
     1981 aagcattttt acaatgggga ttgctgaggt gggcacaaga agtcaggcat aaagcacaaa
     2041 gtggactgtt tgagtggatt ggttgctgct cattaaagtt cttcccttga tctcttaagt
     2101 atggaggtct ttaccaagaa atggcttagc atgagtggga gctgaatccc agtggctcca
     2161 ccgtatgaac cagagaatta tggctaattc ggctgttaca gccactggct ggctgcattt
     2221 taaaccttaa aacttgacta tctgcaaaaa aggaacagtg tggctacaag cctgagcttt
     2281 aatgaaatag acatcctcac agagaagttg gaaataacag aactgaagtc ttaatttacc
     2341 ttcagtttaa tctgtggatt tattgaaata ctgacgatcc tcaggtccag aattccagca
     2401 tcatttattc ttttaaaata aatttttaag aacttgatcc atcttattca gtacctcaca
     2461 atcaaagttg gcaaatgatg gatgaatgat tcaagcgttg cacccggtag aagctgaatc
     2521 catttgtgaa tggactgaag tgaacgcgaa tgctgactct atcctggaag catttttata
     2581 ccatcttgaa atttcaacaa actggcactt gccggtttat ccagctgtct ttcaagaata
     2641 aaagttgggg ttttcaagga tcgcctcttc tatattttaa atggattttc agtataaatg
     2701 atttttctaa tcaagttaat cccaccccat caaaaggtat tcctagaaat gtcatagacc
     2761 taggcaactt tgaattgaat gggagctaat gttctttcca aagtttttca ggtatctgtg
     2821 tgacaccttc tcaagaacca ggaggcaagt aaccccacct ccactatctt agtatttttt
     2881 ttaactgcat gcctgccctt tatttgagct gcctttttaa tttattgcat atccttttta
     2941 ttatcttatt ttggtattat tcaatctata caatcttttt gtatttattc ggaaataagt
     3001 aatatacaaa aaggtcattt tttgtgtctg tggctgagag ggagggaaat atttgtgtat
     3061 ataaaattag gctttgaaaa aaaaaataga ctgattcaga atattgttga tcttagactt
     3121 aaaaatggaa gagccacaaa cattggtgcc cttacagact atttctctac tctcatcatc
     3181 cacagtagaa tttttaaaca gattttttta atgcttttct tttaaatttt tctccgttgc
     3241 aaagaatgtt tcctaaattg tatgggagca atagtatttt tgatgttcta atgacatccg
     3301 tatacttgta ctgtattttg tactacaagg cagctgtttt caataatgtc ctgctgtatt
     3361 tacctatgtg ttttgagtgt ttgtttcttt gctgcggaga acaaattcct acttttagta
     3421 aaggagctga gaagctagca ttaggtttgc agaaactgtt tacagtttca aactctgagg
     3481 cagcaatgaa aattaaggtt gcagctcttc attgattgct gtaacgtttt cattttgaaa
     3541 tcatgtacta ttcctgtgta gaccaacttg ttttcttgct tcagtggttc tgttgctcag
     3601 ctgcagtgag ccagttcaat tttgcaaagg tgcagtacct ctccttttca aggggttggt
     3661 ttttgttttt tgtttttctc ttttcttttt atttggctga attgcagtaa ctagccttgc
     3721 ctttctattc tgtagaaatg acagggtctt cacaatcctt caccagtggc tactaagcta
     3781 taattagctg aatagaaaga atgtggaagt ggtctgaggc atatagagta tatgccaaga
     3841 acactaccat atatggcatc agctttggtt accagagaaa ttttcttagt cattagacca
     3901 tataacagta atatatcata tgtaaatctt tagatttcaa tttgagaatc ctccaaaaaa
     3961 aggagcaaag aatgcataag ctatgtgttg gcaaaagtaa tttatattaa aattttgacc
     4021 tgcctttgta agattaagtg gtaaatgtca tagtggtggg tttttatgtc ttaaccaatc
     4081 tctgaggttt atttctcctg caggggatgg ttcatggcct ctcttcccac tgtaggaaga
     4141 tagcagaagg atgggggtta attgtagcat ttcactgacc ctcatccagg gactagggac
     4201 aatagaaatc tgcaaacatg gagagtcagt cataaatact agctttttga aggcattgtt
     4261 ggtctttgtt gatttctgtc agaaaatggc attgtacaaa ttatgggaag caaccaactt
     4321 ttctgttctg tttttgaagt gctactatga acgattcaga gtggtatttt ttttttcttt
     4381 taaatttggc agatagccca gctaatgaaa aatagtcaca ttcctgagaa gttggagcta
     4441 aaactccaaa ttattgttga aatacttgtt tctactgtat gtagaaatgt atttttaaga
     4501 aaatcaaaga ggaaaaaaaa atctatgcag agaccctact actttgtggt ttctattgtc
     4561 cctacacatc atttcagcat gtctataatg gcagttcttg tcagcaagtc cttcagtgca
     4621 tatgctgcac aaaacaaaac ataaatctgc acggcaccaa aaaccaaaca aaagcaaacc
     4681 aaaaacccag acaccctatg tatctgttgg aggcatgtag gtggtacaaa tgactgtagc
     4741 catgagcaca catggcttct tgtcatgtca ctttccataa ttatttactg caaaatgatt
     4801 gagaggcttt tggtgcaggc agccattagc ctcctgcttc ctttgttacc cctggatcac
     4861 tttgcagtaa attgcaggtc ttttaaaaga ttcaagcttc ggttttctca aaacaaaaca
     4921 attatcctgt cttacctgaa aatgcagggt tgtgggcaaa agaggctggt tataataatg
     4981 ccctcatatt gagtggtctg taaatggctg cacacttcag gcactagagt tgctgaggat
     5041 gctttgttaa tgtgaccttg actggcttta caggcgtgta gaacagtcta cacgggcgac
     5101 tatttgcatc catcttgttg ttgaggtgga tgaaaataag gaaagactgg agtgtgtaag
     5161 tcatgcacat aagtattcac tgtaaatttt attttcattt ttaacccaat tatggtactt
     5221 tgtccaatgc acaactgatc tctcagtaga tattcatttg aaaatagtgt ggccttgctc
     5281 agtgagaagg ggaagaagtg acttagactt gtgttaagat gacctgttgg ctgagagtgg
     5341 tcgttctgca gcactcttaa tggcaagttt tgattaggga gagttaatgt ttttgaccct
     5401 gaattgagtt ttcttctatt tttaggaagt atcagaattg ctctgatgag taacgaagtt
     5461 gactgctttg atgtccaatc tcaggtttta aaagatagtg gtataaaagc ccactgttac
     5521 taattcttaa gacagttttg atttagtatc ccctaaaagt cacatgcata ataaggcctg
     5581 ttcaaagagc agagcctcca tctttttgct ccttttccat gttgtacttc acttgaagag
     5641 gtgtcaagtg actttgcatt gtatatttcc attttaaccc tgacatagtt ctcaaagata
     5701 aagcactttt tgaacatgaa atacatggat aatgtgtgat gtggatcatg gtttctcagg
     5761 cccctagata atccacttct gagtattgtt ctatgtaagg agagtggaga tctttgctaa
     5821 tgttagaaag tttgtattct tggttagaat gcacttgcta gtttccaatg gatgggagag
     5881 tacacgatgc tgcactcaca gtttaatgag ttgctttccc tcagccttaa gggaactttt
     5941 cttttctgtc cacaacagca ctgaagtttt agtaagtgaa tgagattatc tgttttcagg
     6001 gttggtttta gagtactgta aattaattag ctgtcttcct aaagagtcgt aactcccttc
     6061 aatagactga atggtgggtg tgggaggggg gatagggaag ggagagaggt agtttgtaga
     6121 aaagaaaaaa gaaaaaaaga gctacattta ccttaaaata cagagaaaaa aaggaaaaaa
     6181 aaggtcctgt cctgtcctgt tggaaattta agatgtaagg tggaaatggt gaagtatttt
     6241 atttcccctg cttttaattc agaagaccta agttatttta aaatattagc ccccccccca
     6301 attttaagag atagctagac tcataaaagg tgaattttat agatatatga ctttgccatt
     6361 taaagttacc tttttcagtc ttcaattttt aaacctagtt tcattactga agtatttaat
     6421 aaatttgtat gtgaacaaat gggagccagt catcaatttt gaaacttaaa tttggaaaat
     6481 ggaaaaaaaa ataaaattgc accataaaga tttatttccg cagtgattcc catttgctgt
     6541 gtgtactcct gacccaaatt aaggccttta tgaatgtatt ttatatttcc taatgaaata
     6601 ggaaatagcc accaatgtaa tcacataact actttttcat ttgaaaagca aatgcctctt
     6661 aaattagaca ttccaattgg aataggtaga gccattttaa aacaatagta aatgccatat
     6721 ttgtagtttc agtaggactt ctaataaaga gaacagatct ttgttagaag ttaaagcctt
     6781 tttgtgattt taacactttg aagaaggatt ttaactataa acataaggtt ctgtgaacag
     6841 attttatgcc cactacatta ctgtcccctg gcatggataa gagggatcat ttttgtcctc
     6901 tagtaaatgg gtctcaagtt ctagagagaa aacagtagta ggccttgctc agtgtccacc
     6961 atgaagtgca gaaggcacag gtgtgacctt tccccacctt caggaactct tcactggcta
     7021 acgttttcaa cacaattttt atttcttaaa ggcaaaatat tttgtgtcct gtgttgcaag
     7081 atcacaatgg ttagtaaaat cttagtattt ggaaatagaa taagcttgtt tcttcccttt
     7141 taaaatgtct gtctcagaaa tataagtcca ggaaagtcca agaaaatgag caggggcata
     7201 ctctgagcat ggtgtatgtg ggaatttgga ggttttgtaa aacccttttc tccaagccca
     7261 tgtcactatc cattgaacca aagtcctcag gagtctggaa agtcgggagg ttgggccaaa
     7321 agtctagaaa cttggctgta ggtcagcgtg acacactttt ttacagagtc tgtggttttg
     7381 catatttttt tggcaggcaa gtatatttta gttatttttc tgtgaccttg atatttgaaa
     7441 ttaagattgt cagtgtattt ggactttttt tttcccctga agttagaaca gttgtattag
     7501 gcatttactc ttgtgaatct ttatgcagat gtcttaccag tcttgtgaat aaagtgcaga
     7561 tgacatactt tgtattgtag gaatctcact gcccatcctg tctgccagtg gctctgttag
     7621 gctaggttct tcactccaaa gctgggactt aatgtccttc tagttgggaa tcttcagaag
     7681 taatttgaat gagttcaaac caaatcttga tagcaggaga cagcttcctg gtctagatgt
     7741 acaattagct taggttggaa ttaaagaggg tttgggaatg tctttagtct ctgtgtaaat
     7801 accaacgtgc ttattatgca tcgtaaacca gtgtgtatgc ctgtgtatgg gtctgtagag
     7861 ctggtttctg cttcaagtga agctgcacct ttgattttat aaggtcccct ccacccggaa
     7921 ccctataaac gtttgtaaat agaacactaa aatttgtagc gataggatca atttgggaaa
     7981 tatctgctga gagaccaaaa agttcatttt tttaagtacc ttggttaaag agtaaagatt
     8041 attcctctta ttttttaaaa gaagtatgca ctttaacaaa cacagctgca tgggcaattc
     8101 aaacaaatcc atgaagtgca gtacccatcc agaaaccaca cttcctgaaa accgttcaaa
     8161 gcagagtcca gacgggctgg tgatctcact gcctgtaggt tgaagctcag attctgataa
     8221 attgtgagac aagcagggct gcttcaaaga gcaatgtgaa tacagccaga agcttcagac
     8281 aggtctgtaa aatggcgggt cccgtattta ccactaacta gcaaaactga cagaaaaact
     8341 catagaaata aagttaagaa tccttcctgc tggtgtgcac tccttccaat agcagacttt
     8401 tgcaaatgga gttttacagt ctatatttaa aaaattgtat gtttgtaaca aataaagtat
     8461 gcggaaaagt gaatgaca
//
