LOCUS       NM_008989               5949 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus purine rich element binding protein A (Pura), mRNA.
ACCESSION   NM_008989 XM_910702 XM_921719 XM_921736
VERSION     NM_008989.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5949)
  AUTHORS   Chuang,H.C., Hsueh,C.H., Hsu,P.M., Tsai,C.Y., Shih,Y.C., Chiu,H.Y.,
            Chen,Y.M., Yu,W.K., Chen,M.H. and Tan,T.H.
  TITLE     DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha
  JOURNAL   J Clin Invest 133 (21), e166269 (2023)
   PUBMED   37909329
  REMARK    GeneRIF: DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5949)
  AUTHORS   Shi,X., Ren,S., Zhang,B., Guo,S., He,W., Yuan,C., Yang,X.,
            Ig-Lzevbekhai,K., Sun,T., Wang,Q. and Cui,J.
  TITLE     Analysis of the role of Puralpha in the pathogenesis of Alzheimer's
            disease based on RNA-seq and ChIP-seq
  JOURNAL   Sci Rep 11 (1), 12178 (2021)
   PUBMED   34108502
  REMARK    GeneRIF: Analysis of the role of Puralpha in the pathogenesis of
            Alzheimer's disease based on RNA-seq and ChIP-seq.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5949)
  AUTHORS   Kuo,C.J., Lee,K.H., Huang,C.C., Wang,I.F., Hsieh,C.C., Lin,H.C. and
            Lee,Y.C.
  TITLE     Puralpha regulates the induction of Znf179 transcription during
            neuronal differentiation
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1477-1483 (2020)
   PUBMED   33333713
  REMARK    GeneRIF: Puralpha regulates the induction of Znf179 transcription
            during neuronal differentiation.
REFERENCE   4  (bases 1 to 5949)
  AUTHORS   Mitsumori,K., Takei,Y. and Hirokawa,N.
  TITLE     Components of RNA granules affect their localization and dynamics
            in neuronal dendrites
  JOURNAL   Mol Biol Cell 28 (11), 1412-1417 (2017)
   PUBMED   28404748
REFERENCE   5  (bases 1 to 5949)
  AUTHORS   Barbe,M.F., Krueger,J.J., Loomis,R., Otte,J. and Gordon,J.
  TITLE     Memory deficits, gait ataxia and neuronal loss in the hippocampus
            and cerebellum in mice that are heterozygous for Pur-alpha
  JOURNAL   Neuroscience 337, 177-190 (2016)
   PUBMED   27651147
  REMARK    GeneRIF: Quantitative immunohistochemical assays of the vermal
            region of the cerebellum and CA1-3 regions of the hippocampus
            revealed reduced numbers of neurons in general, as well as reduced
            numbers of Pur-alpha+-immunopositive neurons and dendrites in
            heterozygous Pur-alpha mice, compared to wild-type littermates
REFERENCE   6  (bases 1 to 5949)
  AUTHORS   Kelm,R.J. Jr., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Sequence of cDNAs encoding components of vascular actin
            single-stranded DNA-binding factor 2 establish identity to Puralpha
            and Purbeta
  JOURNAL   J Biol Chem 272 (42), 26727-26733 (1997)
   PUBMED   9334258
REFERENCE   7  (bases 1 to 5949)
  AUTHORS   Osugi,T., Ding,Y., Tanaka,H., Kuo,C.H., Do,E., Irie,Y. and Miki,N.
  TITLE     Involvement of a single-stranded DNA binding protein, ssCRE-BP/Pur
            alpha, in morphine dependence
  JOURNAL   FEBS Lett 391 (1-2), 11-16 (1996)
   PUBMED   8706895
REFERENCE   8  (bases 1 to 5949)
  AUTHORS   Ma,Z.W., Bergemann,A.D. and Johnson,E.M.
  TITLE     Conservation in human and mouse Pur alpha of a motif common to
            several proteins involved in initiation of DNA replication
  JOURNAL   Gene 149 (2), 311-314 (1994)
   PUBMED   7959008
REFERENCE   9  (bases 1 to 5949)
  AUTHORS   Bergemann,A.D., Ma,Z.W. and Johnson,E.M.
  TITLE     Sequence of cDNA comprising the human pur gene and
            sequence-specific single-stranded-DNA-binding properties of the
            encoded protein
  JOURNAL   Mol Cell Biol 12 (12), 5673-5682 (1992)
   PUBMED   1448097
REFERENCE   10 (bases 1 to 5949)
  AUTHORS   Bergemann,A.D. and Johnson,E.M.
  TITLE     The HeLa Pur factor binds single-stranded DNA at a specific element
            conserved in gene flanking regions and origins of DNA replication
  JOURNAL   Mol Cell Biol 12 (3), 1257-1265 (1992)
   PUBMED   1545807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131191.4.
            
            On Jul 18, 2018 this sequence version replaced NM_008989.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02098.1, AK075821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC131191.4         22007-22451         c
            446-5949            AC131191.4         11021-16524         c
FEATURES             Location/Qualifiers
     source          1..5949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18"
     gene            1..5949
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="purine rich element binding protein A"
                     /db_xref="GeneID:19290"
                     /db_xref="MGI:MGI:103079"
     exon            1..445
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..5949
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..1541
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="purine-rich single-stranded DNA-binding protein
                     alpha"
                     /codon_start=1
                     /product="transcriptional activator protein Pur-alpha"
                     /protein_id="NP_033015.1"
                     /db_xref="CCDS:CCDS29151.1"
                     /db_xref="GeneID:19290"
                     /db_xref="MGI:MGI:103079"
                     /translation="MADRDSGSEQGGAALGSGGSLGHPGSGSGSGGGGGGGGGGGGSG
                     GGGGAPGGLQHETQELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGNKSRLTLS
                     MSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQAQDEPRRALKSEFLVRENRKYYMDLKE
                     NQRGRFLRIRQTVNRGPGLGSTQGQTIALPAQGLIEFRDALAKLIDDYGVEEEPAELP
                     EGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEE
                     MKKIQEKQREKRAACEQLHQQQQQQQEETTAATLLLQGEEEGEED"
     regulatory      2347..2352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="hexamer: ATTAAA"
     polyA_site      2370
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="major polyA site"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="hexamer: ATTAAA"
     polyA_site      3683
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="hexamer: AGTAAA"
     polyA_site      4720
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
     polyA_site      5141
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
     regulatory      5919..5924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
                     /note="hexamer: AATAAA"
     polyA_site      5949
                     /gene="Pura"
                     /gene_synonym="6330411E07Rik; CAGER-1; Pur-alpha;
                     ssCRE-BP"
ORIGIN      
        1 gggttacgcg ccgacgtctg gctgccacga ctcgccgtgg cggcggcgag cggatcccgc
       61 tagggaagga ggagagagag ggagagagag agagctgacg ggggctgtga gtgagcggga
      121 ggagcggggt gtcagcccgg ccggcccgcg ggagtgaaag gcagagcgaa cgaggccccg
      181 agcccgccgc gcggccgccg cctccgcctc ctcccctccc ctcgcgcgcg gcccgccccc
      241 gcccgcagcc cgccctcctc gcggctcagc ccgcagagcc cgagcgaggc gccgttcggc
      301 tcgcgcgccg tccagaacag gtgtgcgcgc gcctcccccc tccctccctc ctcctcctcg
      361 cgcccgcctg cgcgcgccgg cctccctcca gcctgcgccc tccctcacct gcggcaggac
      421 agcgcccgcc agcccgcccg tcccgatctc gcgagagtgg ctgactggct gtgggggttg
      481 cggcggcagc aggcggagcc ggggagggaa agcagcggcg gctgaggcga ctgaggcggc
      541 gggcggagcg gcaggcggcg gcggagcgca gcatcatggc ggaccgagac agcggcagcg
      601 agcagggtgg tgcggcgctg ggctcgggcg gctccctagg gcacccgggc tcgggctcag
      661 gctccggcgg gggcggtggt ggcggcgggg gcggcggcgg cagtggcggc ggcggcgggg
      721 ccccgggggg gctgcagcac gagacgcagg agctggcctc caagcgggtg gacatccaga
      781 acaagcgttt ctacctggac gtgaagcaga acgctaaggg ccgtttcctg aagatcgcag
      841 aggtgggcgc tggcggcaac aagagccgcc tcaccctctc catgtctgtg gccgtggagt
      901 tccgcgacta cctgggcgac ttcatcgagc actacgcgca gctgggcccc agccagccac
      961 ccgacctggc ccaggcacag gacgagccac gccgggcgct caagagcgag ttcctggtgc
     1021 gcgaaaaccg caagtactac atggatctca aggagaacca gcgcggccgc ttcctgcgca
     1081 tccgccagac agtcaaccgg gggcccggcc tgggctccac gcagggccag accattgcgc
     1141 tgcccgcaca gggtctcatc gagttccgtg acgctctggc caagctcatc gacgactatg
     1201 gagtggagga ggagccggcc gagctgcccg agggcacctc cttgactgtg gacaacaagc
     1261 gcttcttctt cgatgtgggt tccaacaagt acggcgtgtt tatgcgagtg agtgaggtga
     1321 agcccaccta ccgcaactcc atcaccgtgc cctacaaggt gtgggccaag ttcggacaca
     1381 ccttctgcaa gtactccgag gagatgaaga agattcaaga gaaacagagg gagaagcggg
     1441 ccgcttgtga gcagctccac cagcagcaac agcagcagca agaggagacc accgctgcca
     1501 ccctgctact gcagggcgag gaagaagggg aagaagattg atcaaactga atgaaacaca
     1561 cacacacaca cacacacgca tacacatacg tgtacacaca cacacacaca gccacacaca
     1621 gagaaaatat actgtaaaga gagaaaataa aaagttaaaa aaaaaaaaaa aactccaagg
     1681 gagcaccacc cacagaacct ccaccaactg acagtttctc ttcttgactt gccacccatc
     1741 gctggatgtt gtccacttta tccaccatat aaaacagtaa gcagctgcta aaacaaaaaa
     1801 caaaaaaata tacaaaaagt aataacatta tatgaactgt gtttcctact tgattaaaaa
     1861 atataaagaa ctgagtgttt atttccctaa ttaaccaaga acttttgtac acgtttaagc
     1921 tattattatt aaaagtgttt gcaaaatggt caagattata atattgctga attatataaa
     1981 aagtcctttt catgttgagc taacatttga ctttagcaca aaaaaaagag atattttaga
     2041 acacgtaaaa taatattttt agtttttctc attttgttac caaatttcaa accttacatg
     2101 gaggttatta tagtatattt gacatcctat atacctgtga ttagagatgt gtatatatat
     2161 gagggctagg catgctgtgt gtctgagctt tgtctaaatg ttatgcagaa gtttgtagag
     2221 ttcaaggtac gtaggtttaa ttcatgcaag gtaaacaata agtgctctct tttatacaat
     2281 atgcattgca tctggacctt aaacatataa aatggtcagt gaaacttctg tgaacatgaa
     2341 gaaattatta aaaaaggcat ttaaatgaaa tttgctaagt tgtgattttt atggttggaa
     2401 ccaaagttat tcaaatagta aaagaaaaaa agagaaagaa aaaggaaatt tcccataata
     2461 tttttctgca tctgtttgct ttgactgagt agatgttttg ttattattgt gtatatgaga
     2521 tgtacttgta ttgttcataa tatatatttt ttattatgtg tagaaagatt ttaaaaacct
     2581 aactaacgtg cagcaatttc cagtgaacct gtatttggat atcaggtagt gagtctattt
     2641 gtggtcacta gcactgtctc ctaaacttgt gagaggtctg aagctatcct ttgatttttg
     2701 ccagtgctat taacttatgt agacctgttt aaaagcaaag caacaccatt atagttatcc
     2761 tactgagcca tggattctga gtttcatttc aaaagtgaaa gccaagttgg tgtatgtaaa
     2821 ggatttccat gtagctgtgg tgctagttat tactggctac attatatgct aagtgtattt
     2881 gtgttcccaa gtgtacacgc cttctgtcaa aagtatgttc tattatcact catattcaaa
     2941 gtgtagggta tgaaaacgca agcttaggag agcactttac caagctggtg tcctccactg
     3001 aaattgtttg taacgatagt cttttacagg ttttcattta aagatgttta tgtgctttta
     3061 attgacaact aacttcttgc tgctgtatag taaaatatta atatattttt tatcattaaa
     3121 ctgctgcatg actatcatct ttgagtgaag agaaaatgtt ataaaaaaga tgccttaaat
     3181 acagtacatt ttggtttgga attctgtaga aagtattttg gtaaaaaaag aaaaaagaaa
     3241 aaaagaggat cttgtatctt gtctgacaga gagagttctg gacatgcaat tgtttcttgg
     3301 caaagccagc catctagctc tacctgctgt atgtagaaga aaccacctgt aggactggga
     3361 aggtgtcagc acctctccca ttggacagta tcggcctagg aaggcagaac agttatcttt
     3421 tttgaaggat tttttttttt tcctgctggc tctttaggtt ttgatttgat agttttaagc
     3481 tttctggttg agtgtgttgt ctttgttttt gagatctact gtatgtgttg aatagcaagc
     3541 tattttcatt gtactgtgca ttttcccatt gtttgctttt catattcata caatgttaaa
     3601 tatgaggtga ccgtaaaata gttaggagtt tctttactta caaaatcact ggaaattatt
     3661 aaattgcttt cccctccccc caaggtgcat tttttattat tttcatatag taaagttgag
     3721 cttttacagt gcataatgtg acatttggaa tgcttatcaa ctgcatgtaa acattaataa
     3781 cctgcacttt ttgtcttaag gtttgttgag ctgttttgtt cactgtactt taactgtgat
     3841 atggaaaaga ttgcattctc tgtgctgttt ctaattagga aagagaattg ctttgatttt
     3901 gtctcttgtt tactatagct tcttaaagtt aagccttgtg ctacgagttg ttggagtact
     3961 cctagatcag tgttttgtag tagccagcag tcagtagtgc aagtcaacaa aaacacagca
     4021 aacttaggca aagtgtcctt tctttgagat gcaagttctt tcgtaaggtt ttctttaggg
     4081 tcagttacct aaagtaaaac ctttcttacc tgtagacttc agattctgct tggaatccta
     4141 ccggatcaag aagcacatgt attgtgcagt tgtctttaca ctattaacag ttaacacaat
     4201 cttactagga ctttgaatcc attgtctgat ttatggtcag tgggtttaaa aagaaatcca
     4261 catgcagatc ttttaagact taaaaagtgg tcatagagaa gactgagtga ctgtaaagat
     4321 gctctttttg tttaaagcat ctcacttttc tctcccattg acctcctaac ctccccttgc
     4381 ccttctcctg tttcatcctt ccccctacat ttcccctccc aggtgctcgg tactttacca
     4441 aggttctata tttcagtgta ttatgttaag agtctcttct tgtttttatt ttactagtgg
     4501 gtagccccag tttgtgctga aaaaaagggg ggggtatatt tgaccatatg tgttactcat
     4561 tgacaacagt atgatcaaat gtgccaaaaa caagcaaaca gaacttaatt catgacaagt
     4621 atgccttatt tttattgatc tgctttgtct tacaattaag gtccaagagc ttggttaaac
     4681 tatgttatat gcctaagtaa aaaagaaaac ttgaaatgca ttgaaatatt gatgtttttt
     4741 aaaatgagag acactgtcaa gtaatttgat tcaaagatca gccaccagat ttggagagtg
     4801 agtgagtgag tgagtgagtg agtgagtgag tgagtgagag agtgtgtgtg tatgtgtgtg
     4861 tattggttgt agtggtggta gtgatgatgg tatttgtggc ttttcccccc ttttaaatta
     4921 ccaaatctta ttttaaagct accttttatt tgtgcctcgt atttatcatg ctgatgttag
     4981 aagcagcagt catccagcca cagagggagc taaagttaac taaccagaac tgtagaaatc
     5041 attcatgcct ttgacaacaa aggaagttca taggaaagcc atgttggctt ttcctctact
     5101 agacacatgt tggaggtaga tgaatatttg ccaaatgagg ggaaaaaaag acaaagtagt
     5161 caggaaagac aaacggtttt ccagcttctc aaaagccatg gaaagtagaa accaaaacca
     5221 atggaaaatt taaaagacct tgaaagtctc actttctagt cccatgcagg ggttaaaatt
     5281 tgactcaaaa tgaaaagtct atcaattttt ggttttagac ccttacatct agagatggtt
     5341 aactattcca gttttttgtt ttgttttgtt ttattttagg taatggagaa agctgctagt
     5401 gattttaacc cctgctgaaa ggagacagat aatttcattt gggagcaaat acttattgcc
     5461 ttgagaaata gcactgtaat agtttatgtt aattagtcat agaataacct ttatcccttt
     5521 caagctatgc aaattattaa ataggtataa attagaattg aattaaagag agttgattat
     5581 attgcaatca gatggcattc acaaacttaa ctggagcata tacaaataaa atctattagt
     5641 ttaagaggtt ttttttagtg ctgacataaa aaatataatt tagctacctg ttctaaaatg
     5701 ctgaatacta ttaacattgt atgataggtc tgggaagact gcctcctttt ttgaagagag
     5761 agattaagaa tttttataat tgcttttcat caaattttaa tatttttgtc aagtttttag
     5821 gtatttaatt tgtaaaacag tttgctttgt actggcatac agatattagg gtatattgat
     5881 ttaaaaattt ttgaagccaa gtgatcaagt acatttgtaa taaaagtcaa tggatctcta
     5941 tcagttgta
//
