LOCUS       NM_001403084            3927 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus pumilio RNA-binding family member 3 (Pum3), transcript
            variant 3, mRNA.
ACCESSION   NM_001403084 XM_006527183
VERSION     NM_001403084.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   Zhao,T., Huang,W. and Lin,K.
  TITLE     Pum3 is dispensable for mouse oocyte maturation and embryo
            development in vitro
  JOURNAL   Zygote 31 (4), 359-365 (2023)
   PUBMED   37194574
  REMARK    GeneRIF: Pum3 is dispensable for mouse oocyte maturation and embryo
            development in vitro.
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Qiu,C., McCann,K.L., Wine,R.N., Baserga,S.J. and Hall,T.M.
  TITLE     A divergent Pumilio repeat protein family for pre-rRNA processing
            and mRNA localization
  JOURNAL   Proc Natl Acad Sci U S A 111 (52), 18554-18559 (2014)
   PUBMED   25512524
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Steiner,S.R., Milton,E. and Philbert,M.A.
  TITLE     A comparative study of protein carbonylation and mitochondrial
            dysfunction using the neurotoxicants 1,3-dinitrobenzene,
            3-nitropropionic acid, and 3-chloropropanediol
  JOURNAL   Neurotoxicology 37, 74-84 (2013)
   PUBMED   23623743
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Kuo,M.W., Wang,S.H., Chang,J.C., Chang,C.H., Huang,L.J., Lin,H.H.,
            Yu,A.L., Li,W.H. and Yu,J.
  TITLE     A novel puf-A gene predicted from evolutionary analysis is involved
            in the development of eyes and primordial germ-cells
  JOURNAL   PLoS One 4 (3), e4980 (2009)
   PUBMED   19319195
REFERENCE   5  (bases 1 to 3927)
  AUTHORS   Zhu,R., Ji,Y., Xiao,L. and Matin,A.
  TITLE     Testicular germ cell tumor susceptibility genes from the consomic
            129.MOLF-Chr19 mouse strain
  JOURNAL   Mamm Genome 18 (8), 584-595 (2007)
   PUBMED   17671812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124973.8.
            
            On Mar 25, 2022 this sequence version replaced XM_006527183.4.
            
            Summary: This gene encodes a member of the evolutionarily conserved
            Pumilio and Fem-3 mRNA-binding factor family of proteins, which are
            characterized by tandem 36 amino acid pumilio homolog domains and
            which function in diverse biological processes. This protein
            belongs to a group of atypical Pumilio and Fem-3 mRNA-binding
            factor proteins, whose members are distinguished from other Pumilio
            and Fem-3 mRNA-binding factor proteins by a novel protein fold with
            11 pumilio homolog domains and an ability to bind to DNA and
            single- and double-stranded RNA without sequence specificity. In
            mouse, lower levels of gene expression have been correlated with
            increased testicular germ cell tumors. A pseudogene of this gene is
            found on chromosome X. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1760922.1,
                                           SRR13422601.2131598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-497               AC124973.8         28324-28820
            498-589             AC124973.8         31060-31151
            590-808             AC124973.8         32174-32392
            809-944             AC124973.8         33844-33979
            945-1020            AC124973.8         34607-34682
            1021-1114           AC124973.8         35441-35534
            1115-1181           AC124973.8         35767-35833
            1182-1356           AC124973.8         36717-36891
            1357-1460           AC124973.8         38067-38170
            1461-1539           AC124973.8         39315-39393
            1540-1638           AC124973.8         41355-41453
            1639-1692           AC124973.8         42249-42302
            1693-1773           AC124973.8         45926-46006
            1774-1916           AC124973.8         58367-58509
            1917-2139           AC124973.8         59084-59306
            2140-2227           AC124973.8         61806-61893
            2228-2318           AC124973.8         63860-63950
            2319-3927           AC124973.8         67875-69483
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 21.96 cM"
     gene            1..3927
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /note="pumilio RNA-binding family member 3"
                     /db_xref="GeneID:52874"
                     /db_xref="MGI:MGI:106253"
     exon            1..497
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            498..589
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..2451
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /codon_start=1
                     /product="pumilio homolog 3"
                     /protein_id="NP_001390013.1"
                     /db_xref="GeneID:52874"
                     /db_xref="MGI:MGI:106253"
                     /translation="MMEVKGKKKFTGKSPQTSQGKNKFHKNSESSSSKTFPRKAVKEG
                     GPKVTSKNFEKGATKPGKKGVKQFKNKPQGGKGPKDKFQKANKFSKKRKFQPDGESDE
                     SGAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKHIWESLRRKDCDKEKRVKLMS
                     DLQKLIQGKIKTIAFAHDSTRVIQCFIQYGNEEQRKQAFQELQGDLVELSKAKYSRNI
                     VKKFLMYGSKPQVAEIIRSFKGHVRKMLRHSEASAIVEYAYNDKAILEQRNMLTEELY
                     GNTFQLYKSADHPTLDKVLELQPAKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLD
                     FFTYAPPKPRSELIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVE
                     KVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIISSLPSIVNDKYGRKVLLYLMSPRD
                     PAHTVPELIELLQKGDGNAHSKKDTAIRRRELLESISPALLSYLQGHTQEVVLDKSAC
                     VLVSDMLGSATGDVQPAMDAIASLAAAELHPGGKDGELHVAEHPAGHLVLKWLLEQDK
                     KMKESGKEGCFAKTLVERVGMKNLKSWASINRGAIILSSLLQSCDQEVVNKVKGGLKP
                     LIPTLEKNKSSSRGIQTLLEKLTA"
     exon            590..808
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            809..944
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1020
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1114
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1181
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1356
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1460
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1539
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1638
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1692
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1773
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1916
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2139
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2227
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2318
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..3927
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2557..2562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /note="hexamer: TATAAA"
     polyA_site      2579
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /note="major polyA site"
     regulatory      3756..3761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /note="hexamer: AATAAA"
     polyA_site      3787
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
     regulatory      3894..3899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
                     /note="hexamer: ATTAAA"
     polyA_site      3927
                     /gene="Pum3"
                     /gene_synonym="1110069H02Rik; D19Bwg1357e"
ORIGIN      
        1 agaacgcgga agcggaagcg gaagcggcgg ggggtggtgg cggaactctg cgagtttctg
       61 ccccacgtgt gcggtgagtg ttgtggagag tttggtgcgg gaagtgtggg gcgagtgtcc
      121 gccggccgct cgggagcggg gagctctgcg gggtggtggg cgagcggcgt cttcagctcc
      181 atctccggga cggtctacct ggccgcttct ctggcccgga gttggaggaa ccctggcgag
      241 ggcaggggtt aagccctctc tgttaacttg attattgtag agctaaagga acaagtttcg
      301 ctgtcaaact ccggcctgtg cgagtcacag tcagcccact cgtcccgtgt cagacgttgt
      361 gcataggagc agtgcaggga aaactgaagc gatccataag ccaagcatga tgggaggcaa
      421 gagtatttta aacagaggca gtgggatgtc ccggaggtgg aagtcaggag taaggcgcgg
      481 actggacaaa gaggaagaag tactatgatg gaagtcaaag ggaagaaaaa gtttacagga
      541 aagagtccac agacatcaca aggaaagaat aaatttcata agaacagtga gtctagttct
      601 tcaaagacat tcccaaggaa agctgttaag gaaggcggac ctaaagtcac atctaagaac
      661 tttgagaaag gtgccacaaa acctggcaag aaaggtgtga agcagttcaa gaacaagcca
      721 caagggggca aaggaccgaa ggacaaattt cagaaggcaa ataaattcag caagaagcgg
      781 aaattccagc cagatggtga aagtgatgaa tcaggagcca agaaacccaa gtgggatgac
      841 ttcaaaaaga agaagaaaga gctgaagcag agcaggcagc tcagtgacaa gaccaactat
      901 gacatcgtgg ttcgagcaaa gcacatttgg gagagcttga gaagaaaaga ttgtgacaag
      961 gaaaaacggg tgaagctcat gagtgatttg cagaagttga ttcaagggaa aattaaaact
     1021 atcgcctttg cacatgactc gacgcgcgtg atccagtgct tcattcagta tgggaacgag
     1081 gagcagagga agcaggcttt ccaagagttg caaggcgact tggttgaatt aagtaaagcc
     1141 aaatattcca ggaatatcgt taagaaattt ctcatgtatg gaagtaagcc acaagttgcg
     1201 gagataatca gaagttttaa aggtcatgtg aggaagatgc tgcggcattc ggaggcatcg
     1261 gccattgtgg agtacgcata caacgacaaa gccattttgg aacagaggaa catgctgaca
     1321 gaggagctct atgggaacac gtttcagctt tacaagtcag cagatcaccc aacgctggac
     1381 aaggtgctgg agctgcagcc agcaaagcta gagcttatca tggacgagat gaagcagatt
     1441 ctgacaccga tggcccaaaa ggaagctgtg attaagcact cactcgttca taaagtattc
     1501 ttggactttt ttacctacgc acccccaaaa cctcgatcag aactaattga agccatccgg
     1561 gaagcagtgg tgtacctggc ccacacacac gatggcgcca gagtggccat gcactgcctg
     1621 tggcacggca cacccaagga caggaaagtg atcgtgaaaa cgatgaagac gtatgtggag
     1681 aaggttgcca atggccagta ctctcacttg gttctcctgg cagcgtttga ctgtattgat
     1741 gatactaagc ttgtgaagca gataatcata tcagaaatca tcagttcctt gcccagcata
     1801 gttaatgaca aatacggaag gaaagtcctc ttgtacttga tgagccccag agaccccgcc
     1861 cacacggtgc ccgagctcat cgagcttctg cagaagggtg atggcaacgc gcacagcaag
     1921 aaggacactg caatccgccg gcgtgagctc ttggagtcca tctctccagc tttgctgagc
     1981 tacctgcaag gacacactca agaggtggtg ctggataagt ctgcatgtgt gctggtgtct
     2041 gacatgctgg gatctgctac tggagatgtt cagcctgcta tggatgccat cgccagtttg
     2101 gcagcagcag aactgcatcc tggtggcaag gacggagagc ttcatgttgc tgagcatcct
     2161 gcaggacatc tggttctcaa atggttacta gagcaagata aaaagatgaa agaaagcgga
     2221 aaggaaggtt gttttgcaaa aacccttgta gagcgtgttg gtatgaagaa cctcaagtcc
     2281 tgggccagca tcaaccgagg tgccattatt ctttccagcc ttcttcagag ttgtgaccaa
     2341 gaagttgtaa acaaagtcaa aggtggactg aaacccctga ttcctacctt ggaaaaaaac
     2401 aaaagcagca gcagaggcat ccagaccctg cttgagaagc tgactgcgta ggcagcagga
     2461 tgagcaagcg ggaacccgct tcccagagga gaaggtggaa tctctcatac tcacaactgg
     2521 acgctctgtg catgcatttg ttaaaggacc tatttatata aaattgtttc taaaagagac
     2581 ctttggttta atgtcaactg tctgatctgt gagactgagt actacacagt atggcagtga
     2641 tctgtgggcc caggtgtgtg ctctgtggtt gaatggctta atttaggaaa ggagacagct
     2701 atgatctgag aaggtttcct ggtgtaggtg aactttagag ggatgttata acaaaagaat
     2761 taaggacatg aagttcaaac agagtgtgta tagtggagca ggaaagtggt ctgaactccg
     2821 ggaagcctgt ggccagggca gcctgcactg gggacagctg cttcctcagc tgccgtgcag
     2881 actgagttcc atcaggtttg tttggaagct gctctggtca gtccagcaca tggagggaag
     2941 tgtgctagag gaatcaggag atgatgggtc ctcgcttgaa gtcagcgttg ctgggaaagt
     3001 ctgatctttg tatttgggcc ttcagggtaa ataccttcca aggagaatga ggacattgtc
     3061 ccatgaacaa tccctaaaat agtcagagcc catagtgtga ctaaaagggg gaactgtaga
     3121 ggattgagtg taggtagtat gtttggactt taaaaataca gctggctttc agcggcaaaa
     3181 ctggagatct gtagaccatg agaacttgtg tagcaggcgt ttttagtaca gaggcctgtc
     3241 cttgctgctc tgcatgtctg atatatacta aggcggccat ctgaccctct gaggaattgt
     3301 ctgtgcctta cctgtcccaa cttaaggttc caggactact aatgcagctt ctaggactct
     3361 cctgccctct cgtgctgggg tgtagtaagc cctttcccag gcatgacacc tgccactgtt
     3421 ggctggatcc tctaggcatg gagtgaggag gagagtgggg aaagacagtt tgatttgctt
     3481 ctgtgtggct aacataccat gactcgagtt ttcgttctcc gtataaagga ccgtttagag
     3541 agatgagagt cgggtgctaa catgtttaat ctttaaaagt gaaaaacacg tacataactt
     3601 gaaaggtgct tttgtgcagc ttgtagaaaa agcagctgtt tcctctgtag ttctaattca
     3661 cgctctccat aatgacttga gttcttagct ctggtgaatt tctaaacatg tagtatgaag
     3721 tcccgagtac ctaaaacgta tatattcaaa tacacaataa agagcatgtt tattttttgt
     3781 tttttaaggc aggatcttgc tatgtagctc tgactgtttt gaaatttatt gtgtagacca
     3841 aactggcctc aaactcacag agatctgcct gcctctgtct ccctggtgct gcgattaaag
     3901 atgtgggcca ccacatccag ctgagga
//
