LOCUS       NM_030722               5408 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pumilio RNA-binding family member 1 (Pum1), transcript
            variant 1, mRNA.
ACCESSION   NM_030722
VERSION     NM_030722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5408)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5408)
  AUTHORS   Botta,S., de Prisco,N., Chemiakine,A., Brandt,V., Cabaj,M.,
            Patel,P., Doron-Mandel,E., Treadway,C.J., Jovanovic,M., Brown,N.G.,
            Soni,R.K. and Gennarino,V.A.
  TITLE     Dosage sensitivity to Pumilio1 variants in the mouse brain reflects
            distinct molecular mechanisms
  JOURNAL   EMBO J 42 (11), e112721 (2023)
   PUBMED   37070548
  REMARK    GeneRIF: Dosage sensitivity to Pumilio1 variants in the mouse brain
            reflects distinct molecular mechanisms.
REFERENCE   3  (bases 1 to 5408)
  AUTHORS   Zhao,T., Xiao,T., Cao,D., Xia,W., Gao,L., Cheng,L., Zang,M., Li,X.
            and Xu,E.Y.
  TITLE     Sertoli cell PUMILIO proteins modulate mouse testis size through
            translational control of cell cycle regulators
  JOURNAL   Biol Reprod 107 (1), 135-147 (2022)
   PUBMED   35678316
  REMARK    GeneRIF: Sertoli cell PUMILIO proteins modulate mouse testis size
            through translational control of cell cycle regulators.
REFERENCE   4  (bases 1 to 5408)
  AUTHORS   Gong,Y., Liu,Z., Yuan,Y., Yang,Z., Zhang,J., Lu,Q., Wang,W.,
            Fang,C., Lin,H. and Liu,S.
  TITLE     PUMILIO proteins promote colorectal cancer growth via suppressing
            p21
  JOURNAL   Nat Commun 13 (1), 1627 (2022)
   PUBMED   35338151
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5408)
  AUTHORS   Kuc,C.A., Brott,J.T., Thorpe,H.H.A., Smart,A. and Vessey,J.P.
  TITLE     Staufen 1 is expressed by neural precursor cells in the developing
            murine cortex but is dispensable for NPC self-renewal and neuronal
            differentiation in vitro
  JOURNAL   Brain Res 1773, 147700 (2021)
   PUBMED   34678304
REFERENCE   6  (bases 1 to 5408)
  AUTHORS   Moore,F.L., Jaruzelska,J., Fox,M.S., Urano,J., Firpo,M.T.,
            Turek,P.J., Dorfman,D.M. and Pera,R.A.
  TITLE     Human Pumilio-2 is expressed in embryonic stem cells and germ cells
            and interacts with DAZ (Deleted in AZoospermia) and DAZ-like
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (2), 538-543 (2003)
   PUBMED   12511597
REFERENCE   7  (bases 1 to 5408)
  AUTHORS   Spassov,D.S. and Jurecic,R.
  TITLE     Cloning and comparative sequence analysis of PUM1 and PUM2 genes,
            human members of the Pumilio family of RNA-binding proteins
  JOURNAL   Gene 299 (1-2), 195-204 (2002)
   PUBMED   12459267
REFERENCE   8  (bases 1 to 5408)
  AUTHORS   Wang,X., McLachlan,J., Zamore,P.D. and Hall,T.M.
  TITLE     Modular recognition of RNA by a human pumilio-homology domain
  JOURNAL   Cell 110 (4), 501-512 (2002)
   PUBMED   12202039
REFERENCE   9  (bases 1 to 5408)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 5408)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY782432.1, CJ064695.1, CN538180.1, CN530471.1, BU708930.1,
            CN724656.1, CN530452.1, BE653001.1, CB724122.1, AK162742.1,
            CJ227969.1 and CF746520.1.
            
            On Oct 10, 2017 this sequence version replaced NM_030722.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122205.1, AK141921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               BY782432.1         1-351
            352-636             CJ064695.1         311-595
            637-1067            CN538180.1         165-595
            1068-1627           CN530471.1         140-699
            1628-2118           BU708930.1         194-684
            2119-2507           CN724656.1         211-599
            2508-2927           CN530452.1         325-744
            2928-3356           BE653001.1         65-493
            3357-3708           CB724122.1         243-594
            3709-4829           AK162742.1         3358-4478
            4830-5387           CJ227969.1         138-695
            5388-5408           CF746520.1         560-580
FEATURES             Location/Qualifiers
     source          1..5408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..5408
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:80912"
                     /db_xref="MGI:MGI:1931749"
     exon            1..147
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            148..521
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            522..590
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            591..699
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            700..878
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1045
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1316
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1410
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1515
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1667
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1806
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1950
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2247
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2484
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2752
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2882
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3017
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3155
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3281
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3403
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3596
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..5389
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5367..5372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /note="hexamer: AATACA"
     polyA_site      5389
                     /gene="Pum1"
                     /gene_synonym="mKIAA0099; Pumm"
                     /note="major polyA site"
ORIGIN      
        1 ggcgccggcg ccgctcccat gatgcaccgc gtcagcccag tccccagtgg gccgccatgt
       61 tgtcggagtg aaaggtaagg gggagcgaga gcgccggcga gcgaagatcg gggggccgga
      121 atccatcttc atcctaccgc tccgcccgtg ttggtggaat gagcgttgca tgtgtcttga
      181 agagaaaagc agtgctttgg caggactctt tcagccccca cctgaaacat caccctcaag
      241 aaccagctaa tcccaacatg cctgttgttt tgacatctgg aacagggtcg caagcgcagc
      301 cacagccagc tgcaaatcag gctcttgcag ctggaacaca ctccagccct gtcccaggat
      361 ccataggagt tgcaggccgt tcccaggacg acgctatggt ggactacttc tttcagaggc
      421 agcatggtga gcagcttggg ggaggaggaa gtggtggagg cggctataat actagcaaac
      481 atcgatggcc tacaggggat aacattcatg cagaacacca ggtacgctct atggatgaat
      541 tgaatcatga ttttcaagca cttgctctgg aagggagagc tatgggcgag cagctcttgc
      601 caggtaaaaa gttttgggaa acagatgaat ccagcaaaga tggaccaaaa ggaatattcc
      661 tgggtgatca atggcgagac agtgcctggg gaacatcaga tcattcagtt tcccagccaa
      721 tcatggtgca gagaagacct ggtcagagtt tccatgtgaa cagtgaggtc aattctgtac
      781 tgtccccacg gtcggagagt gggggactag gcgttagcat ggtggagtat gtgttgagct
      841 catccccggg cgactcctgt ctaagaaaag gaggatttgg cccaagggat gcagacagtg
      901 atgaaaacga caaaggtgaa aagaagaaca agggtacgtt tgatggagat aagctaggag
      961 atttgaagga ggagggagat gtgatggaca agaccaatgg tttgccagtg cagaatggga
     1021 ttgatgcaga cgtcaaagat tttagccgta cccctggtaa ttgccagaac tctgctaatg
     1081 aagtggatct tctgggtcca aaccagaatg gttctgaggg cttagcccag ctgaccagca
     1141 ccaatggtgc caagcctgtg gaggatttct ccaacatgga gtcccagagt gtccccttgg
     1201 accccatgga acatgtgggc atggagcctc tgcagtttga ttattcaggc acgcaggtac
     1261 ctgtggactc tgcagcagca actgtgggac tttttgacta caattctcaa caacagctat
     1321 tccaaagacc caatgcactt gctgttcagc agttgacagc tgcccagcag cagcagtatg
     1381 cacttgcagc agcccaccag cctcacatcg caggtttagc tcccgctgcg tttgtcccca
     1441 acccatacat catcagcgct gctcccccag ggacggaccc ctacacagct ggattggctg
     1501 cagcagcgac actcggccca gctgtggtcc ctcaccaata ttatggagtc acgccatggg
     1561 gtgtctaccc tgccagtctc ttccagcagc aggcagctgc agctgcagca gctacaaact
     1621 ctgctactca gcagagcgct ccgcaggccc agcagggaca gcagcaggtt cttcgtggag
     1681 gagctagcca acgtcctttg accccaaatc agaaccagca gggacaacaa acagatcccc
     1741 ttgtagcagc tgcagcagtg aattctgctc ttgcctttgg acaaggattg gctgcaggta
     1801 tgccaggtta tccagtcttg gcacctgctg cttactatga ccaaactggt gcccttgtgg
     1861 tgaatgcagg ggcaagaaat ggcctcggag ctccagtccg gcttgttgct ccagccccag
     1921 tcatcattag ctcctcagct gcacaagcag ctgttgcagc ggctgcagcg tcagcaaacg
     1981 gagcagctgg tggtcttgcc ggaactacaa atggaccatt tcgaccttta ggcacccagc
     2041 agccccagcc ccagcctcag cagcagccca gtaacaatct ggcttccagc tctttctatg
     2101 gcaacaactc tctgagcagt aactcccaga gcagctccct cttctctcag ggctctgcac
     2161 agcctgccaa cacgtccttg ggattcggaa gcagcagttc ccttggtgcc accctgggat
     2221 cggcccttgg agggtttgga acagcagttg caaactccaa cactggcagt ggctcccgcc
     2281 gtgactccct gactggcagc agtgaccttt ataagaggac atcgagcagc ttggccccca
     2341 ttggacacag tttttatagc agccttagct attcctcctc tcctggaccc gtgggcatgc
     2401 ctctccctag tcagggacca ggacattcac agacaccacc tccttccctc tcttcacatg
     2461 gatcctcttc aagcttaaac ctgggaggac tcacaaacgg cagtggaaga tacatctctg
     2521 ctgctcccgg tgccgaagcc aagtaccgca gtgcaagcag tgcctccagc cttttcagcc
     2581 ccagcagcac ccttttttct tcctctcgtt tgcgatatgg aatgtctgat gttatgccct
     2641 ctggcaggag cagacttctg gaagattttc gaaacaaccg gtaccctaat ttacaactgc
     2701 gggagattgc tgggcatata atggaatttt ctcaagacca gcatggctct agattcattc
     2761 agctgaaact agagcgtgcc acagcagctg agcgccagct tgtcttcaat gaaatcctcc
     2821 aggctgcgta ccaacttatg gtggatgtgt ttggaaatta cgtcattcag aagttttttg
     2881 aatttggcag tcatgaacag aagctggctc tggctgaacg gattcgaggc catgtcctat
     2941 cattggcact gcagatgtac ggctgccgag tcatccagaa agctttggag tttattccct
     3001 cagaccagca ggtaattaac gagatggtgc gggagctaga tggccatgtc ctgaagtgtg
     3061 tgaaagacca gaacggcaac catgtggttc agaagtgcat tgagtgtgta cagccccagt
     3121 ctttgcagtt tatcatcgat gcattcaagg ggcaggtgtt tgctttgtct acgcacccgt
     3181 acggctgtag ggtgatccag aggatcctag agcactgtct ccctgaccag accctcccca
     3241 tcctggagga gcttcaccag cacacagagc agcttgtgca ggatcagtat ggaaattatg
     3301 taatccaaca tgtactggag catggtcgtc ctgaggataa aagcaaaatt gtagcagaga
     3361 tccgaggcaa tgtacttgta ttgagtcagc acaagtttgc aagcaatgtt gtggagaagt
     3421 gtgttactca cgcctcacgt acagagcgtg ctgtgctcat tgatgaggtg tgcaccatga
     3481 acgacggtcc ccacagtgcc ttatacacca tgatgaagga tcagtatgct aactatgtgg
     3541 tccagaagat gatcgatgtg gctgagccgg gtcagcggaa gattgtcatg cacaagatcc
     3601 ggccacacat tgcgacgctt cgaaagtaca cctatggcaa gcacatcctg gccaagctcg
     3661 agaagtacta catgaagaat ggcgtggact tggggcccat ttgtggtccc cctaatggta
     3721 tcatctgaac agtgcaccca cgtccctgtc ccgctgacct cactgaccct ggcagatcca
     3781 accagcaacc agaggtgccc agctcagcgt cggaagtggg caacggttgc tccgggattg
     3841 ctccctcctc caaaaaacag aatcagatcc acttgtggaa aggcctttgt aaatttcatt
     3901 ttattacaca taacatgtac taattatttt ttttaattga ctaattgccc tgctgtttac
     3961 tggtgtatag gaacttgtac ataggtaatc agtgtacatg ggaggccaca tgctttgttc
     4021 aatgttgtat ctatattcca catgtggaca ctttcagggt ggttggttta acaaaaaaag
     4081 ttaaaaaaaa agacaaaaaa aggtttttaa ctcatttgcc ttgtggcaag ttttgcaaat
     4141 agctcttccc cacctcctca ttttattatt aaaaaaaaaa aacctgagaa atttgaattt
     4201 tagttaaatg atctcaaact ggcatttaac actgtttata aaatatatat atatatacat
     4261 atatacatat atgaaatggg aacgtttcag agttgctaga gcatcagcct gtgatatgga
     4321 gtttatgacg ctcttttttt ggagatgacc tcgtgctgag ggaggtggta gctgcagatc
     4381 caggaggagc ggggacccca gaggcccaag gccagtgggc atggccactt gctgcctgtg
     4441 gttgcctgtg tgaacactgg gaagcaggat ctgactgttt agcatgagag aatacccagc
     4501 tcggccctgg tctggcttct atagatacat agtgtatact tgtgtagact ttgcatatat
     4561 acggatttgt agtattttcc tgttttgatg tctaatctgt atctataatg taccctagta
     4621 gtcggacata cttttgattg tacaattgta catttgtata cctgtaatgt aaatgtggag
     4681 gagtttgatc aacacgaaca cgtttttggt aagaagagaa tcagccagcc cgtgcactct
     4741 gtatatccca ccttttatgg tcgtagcaga tagtgttgta tattgtaaat tgtaatttca
     4801 accagaagta aatttttttc ttttgaagga ataaatgttc tttatacagc ctagttaatg
     4861 tttaaaaagg aaaaaaaaat agcttggttt atttgtcagc tagtcaagac ggtagtgaga
     4921 gcctttctaa atgttacttc agatgcttca gttcacacta gtgtcccccc cccccctttt
     4981 tttttaatcc taaaaaaggt aatgtttcgc ttattttgtg acagtcaaaa aggatgtgca
     5041 gaagtttcgc ctgccccctc cctgctcagc gccacccctt gtaaagtgac tcgccctccg
     5101 ttttgtacag atgagctgta ttttgcattt tgtctacttg taagtgaatg taacatactg
     5161 tcaaccctcg tttgaatata gactgtaaca ctacacggtg tacatttcca gagccttgtg
     5221 tatatttcca atgaactttt tgcaagcaca cttgtaacca tatgtgtata attaacaaac
     5281 ctgtgtatgc ttatgcctgg gcaactattt tttgtaactc ttgtgtagat tgtctctaaa
     5341 caatgtgtga tctttatttt gaaaaaaata cagaactttg gaatctgaaa aaaaaaaaaa
     5401 aaaaaaaa
//
