LOCUS       NM_008987               1924 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus pentraxin related gene (Ptx3), mRNA.
ACCESSION   NM_008987
VERSION     NM_008987.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Doni,A., Sironi,M., Del Prete,A., Pasqualini,F., Valentino,S.,
            Cuccovillo,I., Parente,R., Calvi,M., Tosoni,A., Vago,G.,
            Nebuloni,M., Garlanda,C., Vecchi,A., Bottazzi,B. and Mantovani,A.
  TITLE     PTX3 is expressed in terminal lymphatics and shapes their
            organization and function
  JOURNAL   Front Immunol 15, 1426869 (2024)
   PUBMED   39640269
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Pathak,V., Bertelli,P.M., Pedrini,E., Harkin,K., Peixoto,E.,
            Allen,L.D., Mcloughlin,K., Chavda,N.D., Hamill,K.J.,
            Guduric-Fuchs,J., Inforzato,A., Bottazzi,B., Stitt,A.W. and
            Medina,R.J.
  TITLE     Modulation of diabetes-related retinal pathophysiology by PTX3
  JOURNAL   Proc Natl Acad Sci U S A 121 (41), e2320034121 (2024)
   PUBMED   39348530
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Wang,S., Yang,B., Mu,H., Dong,W., Yang,B., Wang,X., Yu,W., Dong,Z.
            and Wang,J.
  TITLE     PTX3 promotes cementum formation and cementoblast differentiation
            via HA/ITGB1/FAK/YAP1 signaling pathway
  JOURNAL   Bone 187, 117199 (2024)
   PUBMED   38992453
  REMARK    GeneRIF: PTX3 promotes cementum formation and cementoblast
            differentiation via HA/ITGB1/FAK/YAP1 signaling pathway.
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Liu,D., Kuang,Y., Chen,S., Li,R., Su,F., Zhang,S., Qiu,Q., Lin,S.,
            Shen,C., Liu,Y., Liang,L., Wang,J., Xu,H. and Xiao,Y.
  TITLE     NAT10 promotes synovial aggression by increasing the stability and
            translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 83 (9), 1118-1131 (2024)
   PUBMED   38724075
  REMARK    GeneRIF: NAT10 promotes synovial aggression by increasing the
            stability and translation of N4-acetylated PTX3 mRNA in rheumatoid
            arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Cui,N., Chen,Z., Yu,Z., Lv,X. and Hu,Z.
  TITLE     PTX3 mediates PI3K/AKT/mTOR signaling to downregulate apoptosis and
            autophagy to attenuate myocardial injury in sepsis
  JOURNAL   PeerJ 12, e17263 (2024)
   PUBMED   38784395
  REMARK    GeneRIF: PTX3 mediates PI3K/AKT/mTOR signaling to downregulate
            apoptosis and autophagy to attenuate myocardial injury in sepsis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Wallen,A., Zetterstrom,R.H., Solomin,L., Arvidsson,M., Olson,L. and
            Perlmann,T.
  TITLE     Fate of mesencephalic AHD2-expressing dopamine progenitor cells in
            NURR1 mutant mice
  JOURNAL   Exp Cell Res 253 (2), 737-746 (1999)
   PUBMED   10585298
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Bottazzi,B., Vouret-Craviari,V., Bastone,A., De Gioia,L.,
            Matteucci,C., Peri,G., Spreafico,F., Pausa,M., D'Ettorre,C.,
            Gianazza,E., Tagliabue,A., Salmona,M., Tedesco,F., Introna,M. and
            Mantovani,A.
  TITLE     Multimer formation and ligand recognition by the long pentraxin
            PTX3. Similarities and differences with the short pentraxins
            C-reactive protein and serum amyloid P component
  JOURNAL   J Biol Chem 272 (52), 32817-32823 (1997)
   PUBMED   9407058
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Introna,M., Alles,V.V., Castellano,M., Picardi,G., De Gioia,L.,
            Bottazzai,B., Peri,G., Breviario,F., Salmona,M., De Gregorio,L.,
            Dragani,T.A., Srinivasan,N., Blundell,T.L., Hamilton,T.A. and
            Mantovani,A.
  TITLE     Cloning of mouse ptx3, a new member of the pentraxin gene family
            expressed at extrahepatic sites
  JOURNAL   Blood 87 (5), 1862-1872 (1996)
   PUBMED   8634434
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Altmeyer,A., Klampfer,L., Goodman,A.R. and Vilcek,J.
  TITLE     Promoter structure and transcriptional activation of the murine
            TSG-14 gene encoding a tumor necrosis
            factor/interleukin-1-inducible pentraxin protein
  JOURNAL   J Biol Chem 270 (43), 25584-25590 (1995)
   PUBMED   7592730
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Lee,G.W., Lee,T.H. and Vilcek,J.
  TITLE     TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a
            novel member of the pentaxin family of acute phase proteins
  JOURNAL   J Immunol 150 (5), 1804-1812 (1993)
   PUBMED   7679696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA529293.1, BQ442682.1, AC121312.7 and BF471202.1.
            
            On Sep 2, 2006 this sequence version replaced NM_008987.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X83601.1, BF134305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               CA529293.1         1-393
            394-815             BQ442682.1         281-702
            816-1715            AC121312.7         100519-101418
            1716-1924           BF471202.1         1-209               c
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.25 cM"
     gene            1..1924
                     /gene="Ptx3"
                     /gene_synonym="TSG-14"
                     /note="pentraxin related gene"
                     /db_xref="GeneID:19288"
                     /db_xref="MGI:MGI:104641"
     exon            1..305
                     /gene="Ptx3"
                     /gene_synonym="TSG-14"
                     /inference="alignment:Splign:2.1.0"
     exon            306..707
                     /gene="Ptx3"
                     /gene_synonym="TSG-14"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1922
                     /gene="Ptx3"
                     /gene_synonym="TSG-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptx3"
                     /gene_synonym="TSG-14"
                     /note="hexamer: AATAAA"
     polyA_site      1922
                     /gene="Ptx3"
                     /gene_synonym="TSG-14"
                     /note="major polyA site"
ORIGIN      
        1 gggaactccc tcgcgctgtg ccaccgacat tagtcattca tcccgctcat gctttggagc
       61 gtttattaag ggcttcactc ctgcctcaca ctatctctcc cgggctcaaa ctcggatcac
      121 tgtagagtct cgcttcttcc cctgcggctg cgaagcaaat ttcgcctctc cagcaatgca
      181 cctccctgcg atcctgcttt gtgctctctg gtctgcagta gtggctgaga cctcggatga
      241 ctacgagctc atgtatgtga atttggacaa cgaaatagac aatggacttc atcccaccga
      301 ggaccccacg ccatgcgact gccgccagga gcactcggag tgggacaagc tgttcatcat
      361 gctggagaac tcgcagatgc gggagggcat gctgttgcag gccaccgacg acgtcctccg
      421 tggagagctg cagcggctgc gggcagagct ggggcggctg gcgggcggca tggcgaggcc
      481 gtgcgcagcc ggtggccccg cagacgccag gctggtgcgg gcgctggagc cgctgctgca
      541 ggagagccgt gacgcgagcc tcaggctggc gcgcctggag gacgcggagg cgcggcgacc
      601 cgaggcgaca gtgcctggcc taggcgctgt gctggaggaa ctgcggcgga cgcgcgccga
      661 cctgagcgcc gtgcagagct gggtcgcccg ccactggctg cccgcaggtt gtgaaacagc
      721 aattttcttc ccaatgcgtt cgaagaagat ttttggaagc gtgcatcctg tgagaccaat
      781 gaagcttgaa tcttttagta cttgcatttg ggtcaaagcc acagatgtat taaacaaaac
      841 catcctgttt tcttatggca caaagtggaa cccctatgag attcagctgt acctcagttc
      901 ccagtcccta gtgttggtgg tgggtggaaa ggagaacaag ctggctgcag acactgtggt
      961 gtccctgggg aggtggtccc acctgtgtgg cacctggagt tcagagcagg ggagcatgtc
     1021 cctgtgggca aacggggagc tggtggctac cactgtagag atggccaaaa gtcactctgt
     1081 tcctgagggt ggactcctac agattggcca agaaaagaat ggttgctgtg taggtggggg
     1141 ctttgacgaa tcattagcat tttctggaag aatcacaggc ttcaatatct gggatcgggt
     1201 tctcagcgag gaggagatac gggccagtgg aggagtcgaa tcctgtcaca tccggggaaa
     1261 tgtcgtcggg tggggagtca cagagattca ggcgcacgga ggagcccagt atgtttctta
     1321 agtgttgtga aaatctactt gaagccaaag gagactcaca ttttaaatat gccagttgga
     1381 aaagtctgaa aacttcggtg cgtaatagac gaatgaagga gagacttgag attgtctttg
     1441 tttatcttgg caaaatactg aatacacagt tgaagggaag gcttgagaga gggctccggg
     1501 atgttgttac taagccttat actgtggtgc tttcagatta atgtctgcct ctgtcagata
     1561 aaccctcaga taactaaaca ggactggact ctgaacagag ggacgattgt gtgacttttt
     1621 ttttttttta ttttggttaa ttttattttg gccagagaca tttttatatt ggaagaataa
     1681 caaaacaagc tctgttgccc attgttcatt ctttctggtg tgtattttgt gacaaaagag
     1741 atgatgagaa aaccatattt ataccacaaa gtgacttatt aacgaacata aatgtagctt
     1801 acgtgttata atccaatgtt ccatttggga gaaggtagtt gtgtaattta tattgtgaaa
     1861 tgtatttgta ttaattttat ttttgtaaaa gtctactgta aataaaatgt tttataaagc
     1921 taaa
//
