LOCUS       NM_145925               2375 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus pituitary tumor-transforming 1 interacting protein
            (Pttg1ip), mRNA.
ACCESSION   NM_145925
VERSION     NM_145925.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Read,M.L., Seed,R.I., Fong,J.C., Modasia,B., Ryan,G.A.,
            Watkins,R.J., Gagliano,T., Smith,V.E., Stratford,A.L., Kwan,P.K.,
            Sharma,N., Dixon,O.M., Watkinson,J.C., Boelaert,K., Franklyn,J.A.,
            Turnell,A.S. and McCabe,C.J.
  TITLE     The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in
            thyroid cells
  JOURNAL   Endocrinology 155 (4), 1222-1234 (2014)
   PUBMED   24506068
  REMARK    GeneRIF: protooncogene PBF is a negative regulator of p53 function
            in thyroid tumorigenesis, in which PBF is generally overexpressed
            and p53 mutations are rare compared with other tumor types
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ149002.1, AK035696.1 and AW049237.1.
            
            On Dec 30, 2017 this sequence version replaced NM_145925.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023961.1, AK088813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               CJ149002.1         2-105
            105-105             AK035696.1         8-8
            106-112             CJ149002.1         107-113
            113-2358            AK035696.1         16-2261
            2359-2375           AW049237.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2375
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /note="pituitary tumor-transforming 1 interacting protein"
                     /db_xref="GeneID:108705"
                     /db_xref="MGI:MGI:2652132"
     exon            1..273
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..692
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /note="pituitary tumor-transforming gene 1
                     protein-interacting protein; PTTG-binding factor;
                     pituitary tumor-transforming gene protein-binding factor"
                     /codon_start=1
                     /product="pituitary tumor-transforming gene 1
                     protein-interacting protein precursor"
                     /protein_id="NP_666037.1"
                     /db_xref="CCDS:CCDS23957.1"
                     /db_xref="GeneID:108705"
                     /db_xref="MGI:MGI:2652132"
                     /translation="MAPANLGLTPHWVMLLGAVLLLLLSGASAQEPPRVGCSEYTNRS
                     CEECLRNVSCLWCNENKACMDYPVRKILPPASLCKLSSARWGVCWVNFEALIITMSVL
                     GGSVLLGITVCCCYCCRRKKSRKPDKSDERAMREQEERRVRQEERRAEMKSRHDEIRK
                     KYGLFKEQNPYEKF"
     exon            274..326
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /inference="alignment:Splign:2.1.0"
     exon            327..435
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /inference="alignment:Splign:2.1.0"
     exon            436..607
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /inference="alignment:Splign:2.1.0"
     exon            608..654
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /inference="alignment:Splign:2.1.0"
     exon            655..2359
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /note="hexamer: AATAAA"
     polyA_site      2359
                     /gene="Pttg1ip"
                     /gene_synonym="1810010L20Rik; PBF"
                     /note="major polyA site"
ORIGIN      
        1 agctgcgccc gtaggcgggc ggaggtcagg gggcggagcc agcggctgcg cactcgcaag
       61 ctccgcccgt ctggctagct tacggaggcg gagcgcttac tgtggaaaca tcctagctcg
      121 gcgttggagt tgagtcgcct gaggtccccg ccgacgacgc actcaccatg gcgcctgcta
      181 accttgggct gacgccgcac tgggtgatgc tcctcggtgc cgtgctgctg ttgcttctgt
      241 ccggagcctc cgcgcaggaa cctccgagag tgggttgctc tgagtacaca aacagatcct
      301 gtgaagagtg cctcaggaat gtctcctgtc tgtggtgcaa tgagaacaag gcgtgtatgg
      361 actacccagt gaggaaaatc ttgccccctg cttctctctg taaattgagt tccgctcgct
      421 ggggcgtatg ctgggtgaac ttcgaggcct tgatcatcac catgtcggtc ctggggggct
      481 ctgtgctcct gggcatcact gtgtgctgct gctactgctg ccgccggaag aagagccgga
      541 agccagacaa gagcgatgag cgggccatga gagagcagga ggagaggaga gtgcggcagg
      601 aggaaaggag ggcggaaatg aagtcaagac atgatgaaat caggaaaaaa tacggtctgt
      661 ttaaagaaca aaacccgtat gagaagttct aaggtggctg gcacacactt gtggtggatc
      721 gtgcagttcc agagtttcct gggaatgcac tccccagcag agcctgcaga gacctcacca
      781 ccatggccac ccttgacctg ggtgatccct ccagcctcta ctggcaccag tgtggcctta
      841 agaggacaat cctactcttg ttccctctgt gtctgtatgt aatcacctga gaccttaatc
      901 tcgttgatgt cctttttggg gggaggaagt atacttggtc cccacactct gcaagccgat
      961 tacgaagctg gcagcctgag gtgctgacta gctgctgagt ggccttgctg gaagattcac
     1021 attgcaacaa gcaagagtca tgtttacttt gttaaggcaa gaactgacca ccacccttgc
     1081 ttcctgaagg ctgtgttttg tctgtaggcc cactgctgtg atgggccctt gttgttgtaa
     1141 ttttggtggc ctcttggaag gcactgtccc taagtctggt aaggattgcc ttcctaaccc
     1201 agctccatcc aatagcacaa aagcttataa agtcacctga agtctttaat aatccctcag
     1261 gaagcagtcc taccaaaacc tgccatgaga cgtccaggcc tcttggatga catttttcat
     1321 tttcagtctt tactagactg agaatttcct gctgtgggaa acctgagctc tgaatttagt
     1381 ttgatcctct tgtgagtgct gaatgtccag catgctggtg catggactcc agtgtcctta
     1441 gaagggcttt gtggagggtc ttggacatct ccctccacag atcaggcagc tgttgagttg
     1501 gtcctgtatg tatcatggag gatgaacagc atctccactg gccatcccat tgtgggagct
     1561 gagtgtgtag gaagatagga ggaccccaca ccattctgcc ttccaggaaa actgcctgag
     1621 ctggcataga cacccacctc acttccaccc tgcttccagc catgcctcct cacctatcgt
     1681 gcctgacaca tccgcacggg ccctgggaag gttgtcagga gacactcggg tccctgagat
     1741 tccgtccacg ctgtacattt ctttgaaatc cagatgtgtc ctagtaagca gatcacaacc
     1801 ctgatggcag ggtaaggagt aaagatattc cctctgggaa agcagccacc agcagatgag
     1861 gtggtcttac tgtaggctcc ctcatgccta agacctcacc tagcatctcg gtaacctttt
     1921 cacctgtcag tctgtccagg gattaatatt ttcctctctt cagatttcca caaagtaagg
     1981 gaataacctt taccacaatc tggagtctta ccatttttct gctttgctag gcatttgatg
     2041 gaacttaaag ccttgtcaaa catttcttaa gtattatagc aggcattgag agttatcttt
     2101 ctcctgtcta ttgaaaggga accctcctta caggccctga tgaacttcgt attaatatgt
     2161 cgcctgtata aattgtacct gttaggttgc tgagctgatg ttagagtatt taattctcca
     2221 gcctaaggag tgcagcaggt gctcgtggga gtggtctgtg cctacctttg agcagcatga
     2281 agccacagaa ccaagcctga caccatcaca ccccgtgcct tagtttttaa ccactgtcca
     2341 ataaaatggt tgaatatgaa aaaaaaaaaa aaaaa
//
