LOCUS       NM_001362799             774 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus pituitary tumor-transforming gene 1 (Pttg1),
            transcript variant 3, mRNA.
ACCESSION   NM_001362799 XM_006533515
VERSION     NM_001362799.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 774)
  AUTHORS   Xu J, Zhou X, Zhang T, Zhang B and Xu PX.
  TITLE     Smarca4 deficiency induces Pttg1 oncogene upregulation and
            hyperproliferation of tubular and interstitial cells during kidney
            development
  JOURNAL   Front Cell Dev Biol 11, 1233317 (2023)
   PUBMED   37727504
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 774)
  AUTHORS   Zhou Q, Li L, Sha F, Lei Y, Tian X, Chen L, Chen Y, Liu H and Guo
            Y.
  TITLE     PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular
            Carcinoma Progression
  JOURNAL   Cancer Res 83 (14), 2372-2386 (2023)
   PUBMED   37159932
  REMARK    GeneRIF: PTTG1 Reprograms Asparagine Metabolism to Promote
            Hepatocellular Carcinoma Progression.
REFERENCE   3  (bases 1 to 774)
  AUTHORS   Tien S, Zhou H, Zhou Q, Liu H, Wu B and Guo Y.
  TITLE     PTTG1 alleviates acute alcoholic liver injury by inhibiting
            endoplasmic reticulum stress-induced hepatocyte pyroptosis
  JOURNAL   Liver Int 43 (4), 840-854 (2023)
   PUBMED   36737842
  REMARK    GeneRIF: PTTG1 alleviates acute alcoholic liver injury by
            inhibiting endoplasmic reticulum stress-induced hepatocyte
            pyroptosis.
REFERENCE   4  (bases 1 to 774)
  AUTHORS   Perramon M, Carvajal S, Reichenbach V, Fernandez-Varo G, Boix L,
            Macias-Munoz L, Melgar-Lesmes P, Bruix J, Melmed S, Lamas S and
            Jimenez W.
  TITLE     The pituitary tumour-transforming gene 1/delta-like homologue 1
            pathway plays a key role in liver fibrogenesis
  JOURNAL   Liver Int 42 (3), 651-662 (2022)
   PUBMED   35050550
  REMARK    GeneRIF: The pituitary tumour-transforming gene 1/delta-like
            homologue 1 pathway plays a key role in liver fibrogenesis.
REFERENCE   5  (bases 1 to 774)
  AUTHORS   Di Domenico M, Jokwitz M, Witke W and Pilo Boyl P.
  TITLE     Specificity and Redundancy of Profilin 1 and 2 Function in Brain
            Development and Neuronal Structure
  JOURNAL   Cells 10 (9), 2310 (2021)
   PUBMED   34571959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 774)
  AUTHORS   Wang Z, Yu R and Melmed S.
  TITLE     Mice lacking pituitary tumor transforming gene show testicular and
            splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant
            cell cycle progression, and premature centromere division
  JOURNAL   Mol Endocrinol 15 (11), 1870-1879 (2001)
   PUBMED   11682618
REFERENCE   7  (bases 1 to 774)
  AUTHORS   Mei J, Huang X and Zhang P.
  TITLE     Securin is not required for cellular viability, but is required for
            normal growth of mouse embryonic fibroblasts
  JOURNAL   Curr Biol 11 (15), 1197-1201 (2001)
   PUBMED   11516952
REFERENCE   8  (bases 1 to 774)
  AUTHORS   Tarabykin V, Britanova O, Fradkov A, Voss A, Katz LS, Lukyanov S
            and Gruss P.
  TITLE     Expression of PTTG and prc1 genes during telencephalic neurogenesis
  JOURNAL   Mech Dev 92 (2), 301-304 (2000)
   PUBMED   10727870
REFERENCE   9  (bases 1 to 774)
  AUTHORS   Wang Z and Melmed S.
  TITLE     Pituitary tumor transforming gene (PTTG) transforming and
            transactivation activity
  JOURNAL   J Biol Chem 275 (11), 7459-7461 (2000)
   PUBMED   10713046
REFERENCE   10 (bases 1 to 774)
  AUTHORS   Wang Z and Melmed S.
  TITLE     Characterization of the murine pituitary tumor transforming gene
            (PTTG) and its promoter
  JOURNAL   Endocrinology 141 (2), 763-771 (2000)
   PUBMED   10650958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670472.7 and CK624973.1.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_001362799.2.
            
            On Apr 28, 2018 this sequence version replaced XM_006533515.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK624973.1, CD768651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL670472.7         209767-209827
            62-622              CK624973.1         1-561
            623-774             AL670472.7         215623-215774
FEATURES             Location/Qualifiers
     source          1..774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.68 cM"
     gene            1..774
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /note="pituitary tumor-transforming gene 1"
                     /db_xref="GeneID:30939"
                     /db_xref="MGI:MGI:1353578"
     exon            1..78
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /inference="alignment:Splign:2.1.0"
     exon            79..177
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..689
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /note="isoform 1 is encoded by transcript variant 3;
                     securin; pituitary tumor-transforming gene 1 protein;
                     pituitary tumor-transforming 1"
                     /codon_start=1
                     /product="securin isoform 1"
                     /protein_id="NP_001349728.1"
                     /db_xref="CCDS:CCDS48771.1"
                     /db_xref="GeneID:30939"
                     /db_xref="MGI:MGI:1353578"
                     /translation="MATLIFVDKDNEEPGRRLASKDGLKLGTGVKALDGKLQVSTPRV
                     GKVFNAPAVPKASRKALGTVNRVAEKPMKTGKPLQPKQPTLTGKKITEKSTKTQSSVP
                     APDDAYPEIEKFFPFNPLDFESFDLPEEHQISLLPLNGVPLMTLNEERGLEKLLHLGP
                     PSPLKTPFLSWESDPLYSPPSALSTLDVELPPVCYDADI"
     exon            178..356
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /inference="alignment:Splign:2.1.0"
     exon            357..450
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..609
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..774
                     /gene="Pttg1"
                     /gene_synonym="Pttg; Pttg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttacagt ttaaactgcg gtgtgccggg tcgttggtgg cgcagtcttc ggtgagttta
       61 gctgtgagct cgtcgtggag taatccagaa tggctactct tatctttgtt gataaggata
      121 atgaagaacc cggccgccgt ttggcatcta aggatgggtt gaagctgggc actggtgtca
      181 aggccttaga tgggaaattg caggtttcaa cgcctcgagt cggcaaagtg ttcaatgctc
      241 cagccgtgcc taaagccagc agaaaggctt tggggacagt caacagagtt gccgaaaagc
      301 ctatgaagac tggcaaaccc ctccaaccaa aacagccgac cttgactggg aaaaagatca
      361 ccgagaagtc tactaagaca caaagttctg ttcctgctcc tgatgatgcc tacccagaaa
      421 tagaaaagtt cttccctttc aatcctctag actttgagag ttttgacctg cctgaggagc
      481 accagatctc acttctcccc ttgaatggcg tgcctctcat gaccctgaat gaagagagag
      541 ggctggagaa gctgctgcat ctgggccccc ctagccctct gaagacaccc tttctatcat
      601 gggaatctga tccgctgtac tctcctccca gtgccctctc cactctggat gttgaattgc
      661 cgcctgtttg ttacgatgca gatatttaaa cttcttactt ctttgtagtt tctgtatgta
      721 tgttgtatta ataaagcatt tgtgcatatg ttcagattgt gaatacttaa ccaa
//
