LOCUS       NM_178595                923 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus peptidyl-tRNA hydrolase 1 homolog (Ptrh1), mRNA.
ACCESSION   NM_178595
VERSION     NM_178595.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Gao,C., Chen,J., Bai,J., Zhang,H., Tao,Y., Wu,S., Li,H., Wu,H.,
            Shen,Q. and Yin,T.
  TITLE     High glucose-upregulated PD-L1 expression through RAS
            signaling-driven downregulation of PTRH1 leads to suppression of T
            cell cytotoxic function in tumor environment
  JOURNAL   J Transl Med 21 (1), 461 (2023)
   PUBMED   37434177
  REMARK    GeneRIF: High glucose-upregulated PD-L1 expression through RAS
            signaling-driven downregulation of PTRH1 leads to suppression of T
            cell cytotoxic function in tumor environment.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772271.11.
            
            On Jan 5, 2022 this sequence version replaced NM_178595.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098218.1, AK075833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL772271.11        190677-190757
            82-301              AL772271.11        191166-191385
            302-401             AL772271.11        191569-191668
            402-447             AL772271.11        191845-191890
            448-923             AL772271.11        191984-192459
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..923
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /note="peptidyl-tRNA hydrolase 1 homolog"
                     /db_xref="GeneID:329384"
                     /db_xref="MGI:MGI:1913779"
     exon            1..81
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..630
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /EC_number="3.1.1.29"
                     /codon_start=1
                     /product="probable peptidyl-tRNA hydrolase"
                     /protein_id="NP_848710.1"
                     /db_xref="CCDS:CCDS15931.1"
                     /db_xref="GeneID:329384"
                     /db_xref="MGI:MGI:1913779"
                     /translation="MRRSWALSRQVSEARFPGKRWLVAGLGNHGMPGTRHSVGMAVLG
                     QIARRLGVAENWTRDSRCAADLALAPLGDAQLVLLRPRRLMNVNGRSVARAAELFGLT
                     AEEIYLVHDELDKPLGKLALKLGGSARGHNGVRSCISCLNSNAMPRLLVGIGRPTHPN
                     MVENHVLGCFSPEEQELLSPLMDQATDLLLDHIRARSQGPLSGL"
     exon            82..301
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /inference="alignment:Splign:2.1.0"
     exon            302..401
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /inference="alignment:Splign:2.1.0"
     exon            402..447
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /inference="alignment:Splign:2.1.0"
     exon            448..923
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /note="hexamer: ATTAAA"
     polyA_site      923
                     /gene="Ptrh1"
                     /gene_synonym="2210013M04Rik; PTH"
                     /note="major polyA site"
ORIGIN      
        1 ctttttagtc cagggatgcg gcggagttgg gccttgagcc ggcaggtttc cgaggctcgg
       61 ttccccggga agcggtggct ggtggctggc ctggggaacc acggaatgcc cggcacccgg
      121 cacagtgtgg gcatggcggt gctggggcaa atagcaaggc gactgggagt ggcggagaat
      181 tggactcgtg actcgcgctg tgctgctgac ctcgccctgg ccccgctcgg ggatgctcag
      241 ctggtactgc tccggccgcg gcgcctcatg aacgtcaacg ggcgcagcgt agcccgagct
      301 gcggagctgt ttgggctgac tgcggaggag atctatctgg tccatgatga actggacaag
      361 ccgttgggaa agctggctct gaagctgggg ggcagcgcaa ggggccataa tggagtccgt
      421 tcctgcatta gctgtctgaa ctccaatgca atgccaaggc tgctggtggg catcgggcgc
      481 cccacacacc ctaatatggt ggagaaccat gtcctgggct gtttctcccc ggaggagcag
      541 gagctactgt ccccattgat ggatcaggcc actgacctgc tcctggacca catccgtgct
      601 cgaagccagg gaccattgtc aggcctctaa taccagtgga tatatctacc tgtttgactg
      661 cctgccggtg ccatgaagcc aagacagggc cacagaactg caatgacaca gtggtaccca
      721 atgtttatat aacttccctg ggtttcccca ggctacttgc agattcaagg agggactgtg
      781 gccacatcag tctgtttctg cagcagcttg gtctccccgt tcgctatttg cggtgtagga
      841 aaggtctagg aagggtaaac tttctgaacc ttttgagagc tccagatggg tagatctgca
      901 agattaaaga tacgaacttg aaa
//
