LOCUS       NM_001081306            8039 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type Z,
            polypeptide 1 (Ptprz1), transcript variant 3, mRNA.
ACCESSION   NM_001081306 XM_888896
VERSION     NM_001081306.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8039)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 8039)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   3  (bases 1 to 8039)
  AUTHORS   Taki,S., Boron,W.F. and Moss,F.J.
  TITLE     Novel RPTPgamma and RPTPzeta splice variants from mixed
            neuron-astrocyte hippocampal cultures as well as from the
            hippocampi of newborn and adult mice
  JOURNAL   Front Physiol 15, 1406448 (2024)
   PUBMED   38952869
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8039)
  AUTHORS   Nagai,K., Muto,Y., Miura,S., Takahashi,K., Naruse,Y., Hiruta,R.,
            Hashimoto,Y., Uzuki,M., Haga,Y., Fujii,R., Ueda,K., Kawaguchi,Y.,
            Fujii,M. and Kitazume,S.
  TITLE     Brain-specific glycosylation enzyme GnT-IX maintains levels of
            protein tyrosine phosphatase receptor PTPRZ, thereby mediating
            glioma growth
  JOURNAL   J Biol Chem 299 (9), 105128 (2023)
   PUBMED   37543361
  REMARK    GeneRIF: Brain-specific glycosylation enzyme GnT-IX maintains
            levels of protein tyrosine phosphatase receptor PTPRZ, thereby
            mediating glioma growth.
REFERENCE   5  (bases 1 to 8039)
  AUTHORS   Sinha,A., Kawakami,J., Cole,K.S., Ladutska,A., Nguyen,M.Y.,
            Zalmai,M.S., Holder,B.L., Broerman,V.M., Matthews,R.T. and
            Bouyain,S.
  TITLE     Protein-protein interactions between tenascin-R and
            RPTPzeta/phosphacan are critical to maintain the architecture of
            perineuronal nets
  JOURNAL   J Biol Chem 299 (8), 104952 (2023)
   PUBMED   37356715
REFERENCE   6  (bases 1 to 8039)
  AUTHORS   Shintani,T., Watanabe,E., Maeda,N. and Noda,M.
  TITLE     Neurons as well as astrocytes express proteoglycan-type protein
            tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the
            PTPzeta/RPTPbeta gene was replaced with the LacZ gene
  JOURNAL   Neurosci Lett 247 (2-3), 135-138 (1998)
   PUBMED   9655611
REFERENCE   7  (bases 1 to 8039)
  AUTHORS   Ohyama,K., Kawano,H., Asou,H., Fukuda,T., Oohira,A., Uyemura,K. and
            Kawamura,K.
  TITLE     Coordinate expression of L1 and 6B4 proteoglycan/phosphacan is
            correlated with the migration of mesencephalic dopaminergic neurons
            in mice
  JOURNAL   Brain Res Dev Brain Res 107 (2), 219-226 (1998)
   PUBMED   9593903
REFERENCE   8  (bases 1 to 8039)
  AUTHORS   Blackshear,P.J., Silver,J., Nairn,A.C., Sulik,K.K., Squier,M.V.,
            Stumpo,D.J. and Tuttle,J.S.
  TITLE     Widespread neuronal ectopia associated with secondary defects in
            cerebrocortical chondroitin sulfate proteoglycans and basal lamina
            in MARCKS-deficient mice
  JOURNAL   Exp Neurol 145 (1), 46-61 (1997)
   PUBMED   9184108
REFERENCE   9  (bases 1 to 8039)
  AUTHORS   Levy,J.B., Canoll,P.D., Silvennoinen,O., Barnea,G., Morse,B.,
            Honegger,A.M., Huang,J.T., Cannizzaro,L.A., Park,S.H., Druck,T. et
            al.
  TITLE     The cloning of a receptor-type protein tyrosine phosphatase
            expressed in the central nervous system
  JOURNAL   J Biol Chem 268 (14), 10573-10581 (1993)
   PUBMED   8387522
REFERENCE   10 (bases 1 to 8039)
  AUTHORS   Krueger,N.X. and Saito,H.
  TITLE     A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is
            expressed in brain and has an N-terminal receptor domain homologous
            to carbonic anhydrases
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7417-7421 (1992)
   PUBMED   1323835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134445.3 and AC133599.3.
            
            On Mar 25, 2022 this sequence version replaced NM_001081306.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AC134445.3         76733-77086         c
            355-420             AC134445.3         26722-26787         c
            421-600             AC133599.3         38685-38864
            601-752             AC133599.3         40651-40802
            753-848             AC133599.3         44217-44312
            849-915             AC133599.3         44782-44848
            916-1073            AC133599.3         51767-51924
            1074-1224           AC133599.3         52067-52217
            1225-1409           AC133599.3         65186-65370
            1410-1536           AC133599.3         66386-66512
            1537-1583           AC133599.3         73573-73619
            1584-5130           AC133599.3         78255-81801
            5131-5275           AC133599.3         86329-86473
            5276-5367           AC133599.3         95194-95285
            5368-5453           AC133599.3         101254-101339
            5454-5474           AC133599.3         103769-103789
            5475-5571           AC133599.3         104000-104096
            5572-5654           AC133599.3         106888-106970
            5655-5789           AC133599.3         108275-108409
            5790-5924           AC133599.3         109645-109779
            5925-6088           AC133599.3         112398-112561
            6089-6224           AC133599.3         114100-114235
            6225-6371           AC133599.3         115940-116086
            6372-6465           AC133599.3         121379-121472
            6466-6539           AC133599.3         121803-121876
            6540-6668           AC133599.3         123302-123430
            6669-6815           AC133599.3         124660-124806
            6816-6958           AC133599.3         128586-128728
            6959-7094           AC133599.3         129452-129587
            7095-8039           AC133599.3         131027-131971
FEATURES             Location/Qualifiers
     source          1..8039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 9.92 cM"
     gene            1..8039
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /note="protein tyrosine phosphatase receptor type Z,
                     polypeptide 1"
                     /db_xref="GeneID:19283"
                     /db_xref="MGI:MGI:97816"
     exon            1..354
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..7235
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; 3F8 chondroitin sulfate proteoglycan; 3H1
                     keratan sulfate proteoglycan; phosphacan; receptor-type
                     tyrosine-protein phosphatase zeta"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase zeta
                     isoform 3 precursor"
                     /protein_id="NP_001074775.1"
                     /db_xref="CCDS:CCDS39437.1"
                     /db_xref="GeneID:19283"
                     /db_xref="MGI:MGI:97816"
                     /translation="MRILQSFLACVQLLCLCRLDWAYGYYRQQRKLVEEIGWSYTGAL
                     NQKNWGKKYPICNSPKQSPINIDEDLTQVNVNLKKLKFQGWEKASLENTFIHNTGKTV
                     EINLTNDYYLSGGLSEKVFKASKITFHWGKCNVSSEGSEHSLEGQKFPLEMQVYCFDA
                     DRFSSFEEAVKGKGRLRALSILFEVGVEENLDYKAIIDGTESVSRFGKQAALDPFVLQ
                     NLLPNSTDKYYIYNGSLTSPPCTDTVEWIVFKDTVSISESQLAVFCEVLTMQQSGYVM
                     LMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEVVCSSEPENVQADPENYTSLLVTWER
                     PRVVYDAMIEKFAVLYQPLAGNDQAKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAVC
                     SNGLYGKYSDQLIVDMPTEDAELDLFPELIGTEEIIKEEEYGKDNEEDTGLNPGRDSV
                     TNQIRKKEPQVSTTTHYNHMGTKYNEAKTNRSPTRGSEFSGKSDVPNTSPNSTSQHVA
                     EFETERGISLPSQTGTNLPPHNVEGTSASLNSGSKTLFIFPQMNLSGTAESLNTVPIT
                     EYKEVSADVSEEENFLTDFKLDTGADDSSGSSPSTSTVPFSSDNLSHGYITSSDMPEA
                     ITYDVLKPGSTRNAPEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQSETGSGRESFL
                     QVNSTDIQIDESRETTESFSPDATVSQDPSVTDMGMPHYSTFAYLPTEVTPQAFTPSS
                     RPLDLAPTINILHSQTTQPVYNGETPLQPSYSSEVFPLATPLLLDNQTLNTTPAASSS
                     DSALHATPVSPSVGVSFESILSSYDDAPLLPFSSASFSSEMFRHLHTVSQTLPQVTSA
                     AERDELSLHASLLVARGDLLLEPSLVQYSDVASHQATTRAASDTLGFGSESAVFYKTS
                     MVSQIESPRSDVVMHAYSSGPEPSYTVEGSHHVPTVSYSSAMPLHGSVDVSDQGSLLI
                     NPSHISMPESSFITPTASLLQPPPALSGDGEWSGASSDSELLLPDADGLRTLNISSPV
                     SVAEFTYTTSVFADGIKPLSKSEMMYGNETELKMSSFSDMAYPSKSTVVPKMSDVVHK
                     WSESLKETSVSISSMKSVFPESLVYPTTKGFEQGVSHVPEIIFPVQPTHTASQASGDT
                     WLKPGLSANSEAAFSDTASREVVHPSTQPLLYEAATPFNTEALLQPSFQASDVDTLLK
                     TALPSVPSDPILAGTPQVEQSSSSVSHPMASESGSSESMLHFTSVPILDISPSKVHST
                     PLQGLTVPHSSKKFSEQGLLKSKSPQQVLPSLFSNDEFFQSAHLDVSQAYPPKGRHAF
                     VTPVLSIDEPQNTLINKLVYSEDIFSSTEISITDKVLTGLPTLASDVLSSTDHSVPLG
                     SGPISLTMVSPNRDDSVTTAKLLLPSTATSKLTQSARSDADLVGGGEDGDDYDDDDYD
                     DIDRGRFPVNKCMSCLPYRESREKVMNDSDTQESSLVDQSDPISPLLFENTEEENGGT
                     GVTRVDKSPPPSMLPQNHNDGKEDSDIQMGSAVLPHTPGSKAWAVLTSDEESGSGQGT
                     SDSLNDNETSTDFSFPDVNEKDTDGVLETDDTGIAPGSPRSSTPSVTSGHSGVSNSSE
                     AEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHF
                     YLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLHASNGFTEEFETLKEFYQ
                     EVQSCTADLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANY
                     VDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDG
                     SEEYGSFLVNQKSVQVLAYYTVRNFTLRNTKLKKGSQKGRSSGRLVTQYHYTQWPDMG
                     VPEYSLPVLAFVRKAAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNI
                     FGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTLLIPGPTG
                     KTKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDY
                     INASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYW
                     PNKDEPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPN
                     PDSPISKTFELISIIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENAMDV
                     YQVAKMINLMRPGVFTDIEQYQFLYKVVLSLVSTRQEENPSTSLDSNGAALPDGNIAE
                     SLESLV"
     exon            355..420
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            421..600
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            601..752
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            753..848
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            849..915
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1073
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1224
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1409
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1536
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1583
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..5130
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5131..5275
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5367
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5368..5453
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5454..5474
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5475..5571
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5572..5654
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5655..5789
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5790..5924
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            5925..6088
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6089..6224
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6225..6371
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6372..6465
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6466..6539
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6540..6668
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6669..6815
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6816..6958
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            6959..7094
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     exon            7095..8039
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8022..8027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /note="hexamer: TATAAA"
     polyA_site      8039
                     /gene="Ptprz1"
                     /gene_synonym="DSD-1-PG; PTPbeta; Ptprz; Ptpz; PTPzeta;
                     R-PTP-zeta; Rptpbeta; RPTPz"
                     /note="major polyA site"
ORIGIN      
        1 agatcctggc cgctgcagcc cgctcaggca ggggacagcg tcccgcctga agccaggcgc
       61 ttggtccagg ctcggtcccc gcacccacgc gccgcctagc cttgtattct cttcttctct
      121 cttctcttcc tctctctctc tctctctctc tctctctctc tctctctctc tctctctcta
      181 tcactcgttc acctagaccc tggccagtca ccggcgtccc ctgcctcggt gtccccaccc
      241 tctgtaccct aagctgtacc cctgcggctg gcgaggggcc gcggaccggg ctggagatgc
      301 gaatcctgca gagcttcctc gcgtgcgttc agctcctgtg cctgtgtcgc ctggactggg
      361 cttatggata ctacagacaa cagaggaaac ttgttgaaga gattggctgg tcctacacag
      421 gagcactaaa tcaaaaaaat tggggaaaga aatatccaat atgtaatagc ccaaagcagt
      481 ctcctattaa tattgatgaa gatcttacac aagtcaatgt gaatcttaag aaactgaaat
      541 ttcagggttg ggaaaaagcg tccttggaaa acacgttcat tcacaacact gggaaaacag
      601 tggaaataaa tctcactaat gactactatc tcagtggagg actttcagaa aaggtcttca
      661 aggcaagcaa gataactttc cactggggaa aatgcaatgt gtcatctgaa ggatcggaac
      721 atagcttaga aggacagaag ttcccactgg agatgcaagt ctactgcttt gatgcggaca
      781 gattttccag ttttgaggaa gcagttaaag gaaaaggaag attaagggct ttatccattt
      841 tatttgaggt tggagttgaa gaaaatttgg attacaaagc cattattgat ggaactgaga
      901 gtgttagtcg ttttggaaag caggctgctt tagatccatt cgtcttgcag aacctcctgc
      961 caaactccac tgacaagtat tacatttaca atggatcatt gacatcccct ccctgcacag
     1021 acaccgtgga atggattgtt tttaaggata cagttagcat ctctgaaagc cagctggctg
     1081 tattttgtga agttctcaca atgcaacagt ctgggtatgt catgttgatg gattacttac
     1141 aaaacaattt ccgagaacaa cagtacaagt tttccaggca ggtgttttcc tcatatactg
     1201 gaaaggaaga gatccacgaa gtagtgtgta gttcagaacc agaaaatgtg caagctgacc
     1261 ctgagaatta caccagcctt ctggtcacat gggaaagacc tcgggtcgtt tatgacgcca
     1321 tgattgagaa gtttgcagtt ctgtaccagc cactggcggg aaatgaccaa gccaagcatg
     1381 agttcttaac agatggctat caggacttgg gtgccattct caataattta ctacctaaca
     1441 tgagttacgt tcttcaaata gtggccgtat gctctaatgg tttatatgga aagtacagtg
     1501 accaactgat agtggacatg cccactgaag atgccgaact tgaccttttt cctgaattaa
     1561 ttgggactga agaaataatc aaggaggaag aatatggaaa agacaatgaa gaagacactg
     1621 gcttgaatcc tggtagagac agtgtcacaa accaaataag gaaaaaggaa ccccaggttt
     1681 ctaccacgac tcactataat cacatgggga ctaaatacaa tgaagccaag actaaccgat
     1741 ctccaacaag aggatctgaa ttctctggaa agagtgatgt tcccaacact tccccgaatt
     1801 ctacttccca acatgttgct gaattcgaaa cagaaagagg aatttccttg ccttctcaga
     1861 ctggaactaa cctgccacca cacaatgtgg aaggcacttc agcctcctta aacagtggct
     1921 ctaaaactct ctttatcttc ccacagatga acttgtctgg gactgcagaa tccttaaata
     1981 cggttcccat aacagagtac aaagaggttt ctgctgacgt cagtgaggaa gaaaacttcc
     2041 tgactgattt caagctcgat acgggagccg atgactcttc aggctccagc ccctcaacct
     2101 ccactgtccc cttttcctca gataatctat cccatggata cataacttct tcagacatgc
     2161 ccgaggctat cacgtatgat gtccttaagc caggatctac aagaaatgcc ccagaggatt
     2221 cagctccatc aggttcagag gaatcactaa aggatccatc tcttgaaggg agtgtatggt
     2281 ttcctggctc cacagaccta acaacgcagt ctgagactgg atccggccga gagagctttc
     2341 tccaggttaa ctccacagac atacaaattg atgaatcgag ggagacaacc gagtcgtttt
     2401 ctccagatgc taccgtgtca caggatcctt cagtcacaga catgggaatg ccacattatt
     2461 ctacctttgc ctacctccca accgaagtga caccacaggc tttcactcca tcctccagac
     2521 cacttgattt ggctcctact atcaacatcc tccattcgca gacgactcaa ccagtataca
     2581 atggtgagac acctcttcaa ccttcctaca gtagtgaagt ctttcctcta gccacccctt
     2641 tgttgcttga caatcagacc ctcaacacta cccctgctgc ttcaagtagt gattcggcct
     2701 tgcatgctac gcctgtatcc cccagtgttg gtgtgtcatt tgaatccatc ctgtcttcct
     2761 atgatgatgc acctctgctc ccattttcct ctgcttcctt cagtagtgaa atgtttcgcc
     2821 atctgcatac ggtttctcaa acccttccgc aagtcacttc agctgctgag agggatgagc
     2881 tgtctttgca tgcttctctg ctggtggcta ggggtgattt gctgttagaa cccagccttg
     2941 ttcagtattc tgatgtggcg tcacatcagg ccactactcg tgctgcttcg gacacattgg
     3001 gatttggtag tgagtctgct gtcttttata aaacgtccat ggtttctcag attgaatcac
     3061 ccagaagtga tgttgttatg catgcatact cttcggggcc tgaaccttct tataccgttg
     3121 agggctccca ccacgtaccc actgtttctt acagttctgc aatgcctctg catggttctg
     3181 tcgatgtatc tgatcagggg tccttactta tcaatcctag ccatatatca atgcctgagt
     3241 cctcctttat tactccaact gcatcattac tgcagcctcc tccagccctc tctggtgatg
     3301 gggaatggtc tggagcctcc tctgatagtg aattgctttt acctgacgca gatgggctga
     3361 gaactcttaa catttcttca cctgtttccg tagctgaatt tacatatacg acatctgtgt
     3421 ttgctgatgg tattaagccg ctctctaaaa gtgaaatgat gtatggaaat gagactgaac
     3481 tgaaaatgtc ttctttcagt gacatggcat acccttctaa aagcacagtt gtgccaaaga
     3541 tgtcagatgt tgtacataag tggagtgaat ctttaaaaga aacctctgtt tctatttcta
     3601 gcatgaagag tgtgtttcca gagtctcttg tttatcccac aactaagggt tttgaacagg
     3661 gggttagtca cgttccagaa attatcttcc cagttcaacc tacacacact gcatctcaag
     3721 catctgggga cacttggctt aaacccgggc ttagcgcaaa ctcagaggca gcgttctcag
     3781 acactgcttc tagggaagta gtacaccctt caacacagcc cttgctctat gaggccgcaa
     3841 ctccttttaa tactgaagcg ttgctgcaac cttcctttca ggcttctgat gttgacacct
     3901 tgcttaaaac tgctctccca tctgtgccta gtgatccaat actggctgga accccccagg
     3961 ttgaacaaag tagctcttcc gtgtctcatc ccatggcatc agagtctggt tcaagcgaaa
     4021 gcatgctgca ctttacgtct gtacctattc tcgatatatc accttctaag gtgcactcca
     4081 ctccacttca aggcttaaca gttcctcact cgagtaagaa attttctgaa caaggtttgc
     4141 ttaagagcaa aagtccccag caagtgctgc catctttgtt cagcaatgac gagtttttcc
     4201 aaagcgcaca tctggacgtt agccaggcct atcctccaaa agggaggcat gcatttgtta
     4261 ctcctgtttt atcaattgat gaaccacaaa atacgcttat aaacaagctt gtgtattctg
     4321 aggacatttt ctcgagcact gagatttcta ttactgataa ggtacttact ggtctcccaa
     4381 cgcttgcttc tgatgtactt tcatctactg accattctgt tccattagga agtgggccca
     4441 tttccttgac aatggtttct cccaacagag atgattctgt gaccacagcc aagttgcttc
     4501 ttccttctac agctacttct aagctgactc agagcgccag atctgatgcc gatttagtgg
     4561 gaggtggtga agatggtgat gactatgatg atgatgacta tgatgacata gataggggtc
     4621 gctttcctgt gaataagtgt atgtcatgct tgccctatag agaatcccgg gaaaaggtaa
     4681 tgaatgactc ggacacccag gagagcagtc ttgtggatca gagtgaccca atttcacctt
     4741 tactctttga gaatacagaa gaagaaaatg gaggcacagg tgtaactagg gtggataagt
     4801 caccaccacc aagtatgcta ccccagaatc acaatgatgg aaaagaggac agtgacatcc
     4861 aaatgggtag tgctgtcctt cctcataccc caggatctaa agcgtgggca gttttgacaa
     4921 gtgatgaaga gagtgggtca gggcaaggca cctcagatag ccttaatgat aatgagacgt
     4981 ccacagattt cagttttcca gatgttaatg aaaaggatac tgatggtgtc ctggaaacag
     5041 atgacacagg catagctccg ggatctccac ggtcctccac accatctgtt actagtgggc
     5101 actcaggagt atccaacagt tcagaggcag aggccagtaa tagtagccat gagtctcgta
     5161 ttggtctagc tgaggggttg gagtctgaga agaaagcggt tatacccctt gtgatcgtgt
     5221 ctgccctgac ttttatctgt ctagtggttc ttgttggtat tctcatctat tggagaaaat
     5281 gcttccagac tgctcacttt tatttagaag acaatacatc ccctcgagta atatctacac
     5341 caccaacacc catctttcca atttcagatg atattggagc aattccaata aagcattttc
     5401 caaagcacgt tgcagattta catgcaagta atgggttcac tgaagaattt gagacactga
     5461 aagagtttta ccaggaagtg cagagctgta ctgctgactt aggcatcaca gcagacagct
     5521 ccaatcaccc agacaacaag cacaagaaca gatacgtcaa tatcgtagcc tatgatcata
     5581 gcagggttaa gctcacacaa cttgctgaaa aagatggaaa actgactgat tacatcaatg
     5641 ccaattatgt tgatggttac aacagaccaa aggcttacat tgctgcccag ggtccactga
     5701 agtccacagc tgaagacttc tggagaatga tctgggagca taatgtggaa gtcatcgtca
     5761 tgatcacaaa cctcgtggag aaaggaagaa gaaaatgtga ccagtactgg cctactgatg
     5821 gtagtgaaga atatgggagc ttcctagtca accaaaagag tgttcaggtg cttgcttatt
     5881 atactgtgag gaatttcacc ctaagaaaca caaagttaaa gaagggctct cagaaaggaa
     5941 gatccagtgg gcgcctagtc acacagtatc attacaccca gtggcctgac atgggtgttc
     6001 ccgagtactc cctgcccgtg ctggcctttg tgagaaaggc tgcccaggcc aagcgccatg
     6061 cagtcgggcc agttgttgtc cactgcagtg ctggcgtggg gagaacgggg acatacattg
     6121 tgctagacag tatgctgcag cagattcaac atgaaggaac cgtcaacata tttggcttct
     6181 taaagcacat tcgttctcaa aggaattatt tggtgcaaac agaggagcag tatgtcttca
     6241 ttcacgatac actggtcgag gccatactca gcaaggaaac ggaggtacct gacagccaca
     6301 ttcactccta tgttaataca ctcctcatac ccggaccaac aggcaagaca aaactagaga
     6361 aacaattcca gcttctgagt cagtcaaata tcctccagag tgactactcc acagccctga
     6421 agcagtgtaa cagggagaag aacagaacat cgtccatcat ccctgtggaa agatcaaggg
     6481 tgggcatttc atccctgagt ggggaaggca cagactacat caatgcatcc tatattatgg
     6541 gctattacca gagcaatgaa ttcatcatca cccagcatcc cctgctgcac accatcaagg
     6601 acttctggag aatgatatgg gatcataatg cccagctggt ggttatgatt ccagatggtc
     6661 aaaacatggc agaggatgag tttgtctact ggccaaataa agatgagccc ataaattgtg
     6721 aaagcttcaa agtcacgctt atgtctgaag aacacaaatg cctttcgaac gaggaaaaac
     6781 tgatcgttca agacttcatc ttggaagcaa cacaggatga ctatgtgctg gaagtaaggc
     6841 atttccagtg ccccaaatgg ccaaatccgg atagtcccat tagtaaaaca tttgaactta
     6901 taagtattat caaagaagaa gctgctaaca gggatgggcc catgattgtt cacgatgagc
     6961 acgggggagt aacagcagga actttttgtg ctcttacaac ccttatgcac caactagaaa
     7021 aagaaaacgc catggatgtt taccaagtag ccaagatgat caatttgatg aggccgggag
     7081 tcttcactga cattgagcag tatcagtttc tgtacaaagt agtcctcagc ctcgtcagca
     7141 caaggcagga agagaaccca tccacctctc tggacagtaa tggtgcagct ttgcctgatg
     7201 gaaatatagc tgaaagcctg gaatctttag tctaacgaag aaagggtgta ggacatccct
     7261 catccatgca ttgtctcttt ctaaaattag aaaaaaaaaa atgaatccag ttctgttatt
     7321 tgtttacttc ttgtgacctg acagtaactc attctgctgc caaattgaca ccattaacaa
     7381 cgtgtgcctt tttgaatgac ttcttgtaat tcacttatta tgtctgaact aaaatgattg
     7441 aattttacag tgtttctaag aattgaattg tggtattttt ttccatattg actttaacag
     7501 aaaaaaatca atttgtagat aataggaaac accaaccttg gaagatattt gttcttaagt
     7561 gtcaaatttt tagctgtatt tgtagcaatc atcagatttg ctagaaatat aacttttaat
     7621 atagtagatt gtaagtaaac cacttcatcc ccgataatat tcaacatttt acaactgcag
     7681 tattcacctg aagtagagtg atagtaactt atgtaaatac tgctctggtg tctccatgga
     7741 ccaaatttat atttataatt gtagattttt atattttact actgtgtgag ttttctagtg
     7801 gtgtacttga gtttaataat gtagcttact ctctggtctt acttactcta aatgtcttct
     7861 aaaactgtaa tgtgttatcc aagaaactaa ccctgtttct gcatgtcatt ttgacttttg
     7921 tgaaaataga aaaccacttg tttgaaaaga tgtttttatg agaataacac ctcaccaaac
     7981 attccttaca tggtttttat ctgagaagtt gcaaaaataa atataaatat tgctattaa
//
