LOCUS       NM_001083119            5497 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type U (Ptpru),
            transcript variant 2, mRNA.
ACCESSION   NM_001083119
VERSION     NM_001083119.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5497)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5497)
  AUTHORS   Grad,M., Nir,A., Levy,G., Trangle,S.S., Shapira,G., Shomron,N.,
            Assaf,Y. and Barak,B.
  TITLE     Altered White Matter and microRNA Expression in a Murine Model
            Related to Williams Syndrome Suggests That miR-34b/c Affects Brain
            Development via Ptpru and Dcx Modulation
  JOURNAL   Cells 11 (1), 158 (2022)
   PUBMED   35011720
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5497)
  AUTHORS   Liu,Y., Xu,H., Dahir,N., Calder,A., Lin,F. and Gilbertson,T.A.
  TITLE     GPR84 Is Essential for the Taste of Medium Chain Saturated Fatty
            Acids
  JOURNAL   J Neurosci 41 (24), 5219-5228 (2021)
   PUBMED   33941648
REFERENCE   4  (bases 1 to 5497)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5497)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5497)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   7  (bases 1 to 5497)
  AUTHORS   Fuchs,M., Wang,H., Ciossek,T., Chen,Z. and Ullrich,A.
  TITLE     Differential expression of MAM-subfamily protein tyrosine
            phosphatases during mouse development
  JOURNAL   Mech Dev 70 (1-2), 91-109 (1998)
   PUBMED   9510027
REFERENCE   8  (bases 1 to 5497)
  AUTHORS   Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S.,
            White,R.A., Painter,C., Steinberger,A.A. and Avraham,H.
  TITLE     Characterization and chromosomal localization of PTPRO, a novel
            receptor protein tyrosine phosphatase, expressed in hematopoietic
            stem cells
  JOURNAL   Gene 204 (1-2), 5-16 (1997)
   PUBMED   9434160
REFERENCE   9  (bases 1 to 5497)
  AUTHORS   Yoneya,T., Yamada,Y., Kakeda,M., Osawa,M., Arai,E., Hayashi,K.,
            Nishi,N., Inoue,H. and Nishikawa,M.
  TITLE     Molecular cloning of a novel receptor-type protein tyrosine
            phosphatase from murine fetal liver
  JOURNAL   Gene 194 (2), 241-247 (1997)
   PUBMED   9272866
REFERENCE   10 (bases 1 to 5497)
  AUTHORS   Cheng,J., Wu,K., Armanini,M., O'Rourke,N., Dowbenko,D. and
            Lasky,L.A.
  TITLE     A novel protein-tyrosine phosphatase related to the homotypically
            adhering kappa and mu receptors
  JOURNAL   J Biol Chem 272 (11), 7264-7277 (1997)
   PUBMED   9054423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670959.8.
            
            On Dec 20, 2022 this sequence version replaced NM_001083119.2.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.107355.1,
                                           SRR9219380.6409.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AL670959.8         247104-247291       c
            189-320             AL670959.8         232852-232983       c
            321-592             AL670959.8         229728-229999       c
            593-674             AL670959.8         229202-229283       c
            675-790             AL670959.8         228982-229097       c
            791-965             AL670959.8         228549-228723       c
            966-1259            AL670959.8         227814-228107       c
            1260-1568           AL670959.8         217232-217540       c
            1569-1678           AL670959.8         212399-212508       c
            1679-1880           AL670959.8         211963-212164       c
            1881-1983           AL670959.8         211548-211650       c
            1984-2257           AL670959.8         208538-208811       c
            2258-2294           AL670959.8         207732-207768       c
            2295-2433           AL670959.8         206873-207011       c
            2434-2463           AL670959.8         203981-204010       c
            2464-2621           AL670959.8         202538-202695       c
            2622-2812           AL670959.8         197395-197585       c
            2813-2888           AL670959.8         196786-196861       c
            2889-2965           AL670959.8         196328-196404       c
            2966-3002           AL670959.8         189850-189886       c
            3003-3100           AL670959.8         189095-189192       c
            3101-3217           AL670959.8         188883-188999       c
            3218-3372           AL670959.8         188043-188197       c
            3373-3508           AL670959.8         185802-185937       c
            3509-3658           AL670959.8         185225-185374       c
            3659-3832           AL670959.8         183227-183400       c
            3833-3973           AL670959.8         181524-181664       c
            3974-4099           AL670959.8         180467-180592       c
            4100-4257           AL670959.8         180187-180344       c
            4258-4393           AL670959.8         178773-178908       c
            4394-5497           AL670959.8         177477-178580       c
FEATURES             Location/Qualifiers
     source          1..5497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.5 cM"
     gene            1..5497
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /note="protein tyrosine phosphatase receptor type U"
                     /db_xref="GeneID:19273"
                     /db_xref="MGI:MGI:1321151"
     exon            1..188
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..4456
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protein tyrosine phosphatase, receptor type, L;
                     Pancreatic carcinoma phosphatase 2; Protein-tyrosine
                     phosphatase-lamda; Receptor-type protein-tyrosine
                     phosphatase psi; Receptor-type tyrosine-protein
                     phosphatase U"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase U
                     isoform 2 precursor"
                     /protein_id="NP_001076588.1"
                     /db_xref="CCDS:CCDS38896.1"
                     /db_xref="GeneID:19273"
                     /db_xref="MGI:MGI:1321151"
                     /translation="MARAQALVLALTFQFCAPETETPAAGCTFEEASDPVVPCEFSQA
                     QYDDFQWEQVRIHPGTRTPEDLPHGAYLMVNASQHAPGQRAHIIFQTLSENDTHCVQF
                     SYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQV
                     LFEALISPDHKGYIGLDDILLFSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAE
                     AEHFFLQRQSGVLVPAAGVRHISHRRFLATFPLASVGRSEQDLYRCVSQAPRGAGVSN
                     FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEV
                     HAVNLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPTRAPKGLAF
                     AEIQARQLTLQWEPLGYNVTRCHTYAVSLCYRYTLGGSHNQTIRECVKMERGASRYTI
                     KNLLPFRNIHVRLILTNPEGRKEGKEVTFQTDEDVPGGIAAESLTFTPLEDMIFLKWE
                     EPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFS
                     VRARTSKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISV
                     YQVVVEEERPRRLRREPGAQDCFSVPLTFETALARGLVHYFGAELAASSLLEAMPFTV
                     GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQ
                     RSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDRYAYSYYPKPVNMTKATVNYRQE
                     KTHMMSAVDRSFTDQSTLQEDERLGLSFMDAPGYSPRGDQRSGGVTEASSLLGGSPRR
                     PCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKL
                     KGGRQEPVSAYDRHHVKLHPMLADPDADYISANYIDGYHRSNHFIATQGPKPEMIYDF
                     WRMVWQEQCASIVMITKLVEVGRVKCSRYWPEDSDMYGDIKITLVKTETLAEYVVRTF
                     ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAG
                     TGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL
                     CGETTIPVNEFKATYREMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR
                     DKNRSMDVLPPDRCLPFLISSDGDPNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFW
                     RLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFVSGTANEDLVSRV
                     FRVQNSSRLQEGHLLVRHFQFLRWSAYRDTPDSRKAFLHLLAEVDKWQAESGDGRTVV
                     HCLNGGGRSGTFCACATVLEMIRCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA
                     LEYLEALELR"
     exon            189..320
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            321..592
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            593..674
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            675..790
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            791..965
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1259
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1568
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1678
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1880
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1983
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2257
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2294
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2433
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2463
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2621
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2812
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2888
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..2965
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3002
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3100
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3217
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3372
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3508
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3658
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3832
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3973
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4099
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4257
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4393
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..5497
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5474..5479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /note="hexamer: AATAAA"
     polyA_site      5497
                     /gene="Ptpru"
                     /gene_synonym="Ftp-1; PCP-2; Pcp2; PTP; PTP-lambda; Ptpf;
                     PTPlambda; Ptprl; R-PTP-psi; R-PTP-U; RPTPlambda"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgctc cgcgcggcac tgctccacta cggctcccgc tcgccttggg ctcccggtcg
       61 ggctccggag gcgtcgcctc cccagctgcg ggtctccagg acctaggcgg cggccatggc
      121 ccgggctcag gctctggtcc tggcgctcac cttccagttc tgcgcgcctg agaccgagac
      181 tcccgcagct ggctgcacct tcgaggaggc gagtgacccg gtcgtgccct gcgagttcag
      241 ccaggctcag tatgacgact tccaatggga gcaagtgcgg atccaccccg gcacccggac
      301 ccctgaagac ctgccccatg gtgcctactt gatggtcaat gcttctcagc atgccccagg
      361 tcagagggcc cacatcatct tccagaccct gagcgagaac gacacccatt gtgtgcagtt
      421 cagctacttc ctgtacagca gggatgggca cagcccaggc accctggggg tctacgtgcg
      481 cgtgaatggg ggccctctgg gcagtgccgt gtggaatatg accggatccc acggccgtca
      541 gtggcaccag gctgagctgg ctgtcagcac cttctggccc aatgagtatc aggtgctgtt
      601 tgaggccctc atctccccag accacaaggg ctacataggc ttagacgaca tcttgctctt
      661 cagctatccc tgcgcaaagg cccctcactt ctcccgcctt ggggacgtgg aggtcaatgc
      721 aggccagaac gcatccttcc aatgcatggc agcaggcaga gccgcagagg cagaacactt
      781 cttcctgcag cgtcagagtg gagtgctggt gcctgcggcc ggggtgcggc acatcagcca
      841 ccgtcgcttc ctggccactt ttccgctggc ctcggtaggc cgctcagagc aggatctgta
      901 ccgttgcgtg tcccaggccc cgcgtggtgc tggcgtctcc aactttgcag agctcatcgt
      961 caaagagcct cccaccccca tcgcgccccc acagctgctg cgtgcaggcc ccacctacct
     1021 cattatccag ctcaacacca actccatcat tggcgacggg ccgatcgtgc gcaaggagat
     1081 cgagtaccgc atggcacggg gcccgtgggc cgaggtgcac gctgtcaacc tgcagaccta
     1141 caagctgtgg catctggacc cagacactga gtatgaaatc agcgtgctgc tcacacgccc
     1201 gggagatgga ggcacaggcc gccctgggcc accactgatc agccggacca agtgcgcaga
     1261 gcccacgagg gcccccaaag gtctggcttt tgctgagatc caggctcgcc agctgaccct
     1321 gcagtgggag cccctgggct ataatgtcac acgttgtcat acctacgctg tgtccctttg
     1381 ctatcgctac accctgggcg gcagccacaa ccagaccatc cgggagtgtg tgaagatgga
     1441 gcggggtgcc agccgctaca ccatcaagaa tctgctgcca ttcagaaaca tccacgtgcg
     1501 tctgattctc acaaaccctg aggggcgcaa ggagggcaag gaggtcacct tccagacaga
     1561 tgaagatgtg cctggtggga ttgcagctga gtccctaacc ttcactccac tggaggacat
     1621 gatctttctc aagtgggagg agccccagga gcccaatggc ctcatcactc agtatgagat
     1681 cagctaccaa agcattgagt cctcagaccc agcagtgaac gtgcccggcc cgagacgcac
     1741 catctccaaa ctccggaatg agacttacca cgtcttctcc aacctgcatc ccggcaccac
     1801 gtatctgttc tccgtgcgtg ctcggacgag caagggcttc ggccaggcgg ctctcactga
     1861 gataaccacc aacatctcag ctcccagctt tgattatgcc gacatgccgt cacccctggg
     1921 cgagtccgag aacaccatca ctgtgctgtt gaggccggcc cagggccgag gagcccccat
     1981 cagcgtctac caggtggttg tggaggaaga gcggccacgg cgcttgcggc gggagcccgg
     2041 agctcaggac tgcttctcgg tacctctgac ctttgagacg gccctggctc gcggcctggt
     2101 gcactacttt ggggctgaac tggctgccag cagcctgctt gaggccatgc ccttcaccgt
     2161 gggtgacaac cagacctatc gtggcttctg gaacccaccg cttgagccca gaaaggccta
     2221 tctcatctat ttccaggcag caagccacct gaaaggggaa acccgactga actgcatccg
     2281 aattgccagg aaagctgcgt gcaaggagag caagcgaccc ctcgaagtgt cccagagatc
     2341 ggaggagatg gggctcatcc tgggcatctg tgcaggtggt cttgccgtcc tcattctcct
     2401 cctgggggcc atcattgtca tcatccgcaa agggagggac cgctatgcct actcttacta
     2461 cccgaagcca gtgaacatga cgaaagccac ggtcaactac cgccaggaga agactcacat
     2521 gatgagtgcc gtggaccgca gcttcacaga tcagagtact ctgcaggagg atgagcggtt
     2581 gggtctgtcc tttatggatg ctcctggcta tagtcctcgt ggagaccagc gaagcggtgg
     2641 tgtcaccgag gccagcagcc tcctgggggg ttctccaagg cgcccatgcg gccggaaggg
     2701 ttctccgtat cataccgggc agctccaccc tgcagtccga gtggctgacc ttctacagca
     2761 catcaaccag atgaagacag ccgagggcta cggcttcaag caggagtacg agagtttctt
     2821 tgagggctgg gacgccacca agaagaaaga caagctcaag ggcggccgac aggagccagt
     2881 gtctgcctat gatcgacacc atgtgaaact acacccgatg ctggcagacc ctgatgccga
     2941 ctacatctct gccaactaca tagacggcta ccacaggtca aaccacttca tagccactca
     3001 agggccaaag cctgagatga tctacgattt ctggcgcatg gtgtggcagg aacagtgtgc
     3061 gagcatcgtc atgatcacca agctggtaga ggtgggcagg gtgaagtgtt ctcgctactg
     3121 gcctgaggac tcagacatgt atggggacat caagatcacg ctggtaaaga cagagacact
     3181 ggctgagtat gtggtgcgca cctttgccct ggagcggaga ggttactcag cccggcatga
     3241 ggtccgccag ttccatttca cagcgtggcc agagcatggt gtcccctacc acgccacggg
     3301 gctgctggcc ttcatccggc gtgtgaaggc ttccactcca cctgatgccg ggcccattgt
     3361 cattcactgc agtgcaggaa ctggccgcac aggctgctac atcgtcctgg atgtgatgct
     3421 ggacatggct gaatgtgagg gggtcgtgga catttacaac tgtgtgaaga ccctctgttc
     3481 ccgacgggtc aacatgatcc agacggagga acaatatatc ttcatccacg atgcaatctt
     3541 ggaggcctgc ctgtgtgggg agaccaccat ccctgtcaac gagttcaagg ccacctacag
     3601 ggagatgatc cgcattgacc ctcagagcaa ttcctcccag cttcgggaag agttccagac
     3661 gctgaactcg gtcacgccgc cgctggatgt ggaggagtgt agcattgccc tgctgccccg
     3721 gaatcgagac aagaaccgta gcatggatgt gctgccacca gaccgctgcc tgcccttcct
     3781 catctccagt gatggggacc ccaataacta catcaatgca gcactgactg acagctacac
     3841 acggagcgcc gccttcatcg tgaccctgca cccgctgcag agtaccacgc ccgacttctg
     3901 gcggctggtc tacgactacg ggtgcacctc catcgtcatg ctgaaccaac ttaaccagtc
     3961 caactccgcc tggccctgct tgcagtactg gccggagcca ggccgacagc agtatgggct
     4021 catggaggtg gagtttgtgt ctggcacagc aaacgaggat ttggtgtccc gagtgttccg
     4081 ggtgcagaac tcttctcggc tgcaggaggg tcacctgctg gtacggcact tccagtttct
     4141 gcgttggtct gcttatcggg acacgcctga ctccaggaag gcctttctgc acctgttggc
     4201 tgaggtggac aagtggcagg cagagagtgg ggatgggcgc accgtggtgc attgtctcaa
     4261 cgggggtggc cgcagtggca ccttctgcgc ctgtgccacg gtcttggaga tgatccgctg
     4321 tcacagcctg gtggatgttt tctttgctgc caaaacactt cggaactaca agcccaatat
     4381 ggtggagacc atggatcagt atcatttctg ctacgacgtg gccctggagt acctggaggc
     4441 tctggagttg agatagcagg cgcctgacct ggggcaccca gtgaacaccc agggcatggc
     4501 ccatcatccc agatgaggag ggcctgtggc cccaactttg ctcagccata attccacagg
     4561 gacaacactg gaacggacgg acactgcacc atcttggtga cccccacggg aaggctgcag
     4621 gccaaggaga agctttgcaa gactgtatca gccccacctc tagagggccc tgcagacctg
     4681 tgcagagaag ctcgcctgga ccaaaatagc tagtgctgga gagcccaggc caggcccctc
     4741 tgctccatca cagtccttgg ccagaaatga atgagtgtct gcagagagca cccatggttt
     4801 gcacccagta tggtcctttc tgcacgtggt ggaggctcac tgggacttgg caggggctga
     4861 gtccccgaga gtcctgaagc tgggactctt ccccgtctcg ccggtgggac ccgctgagca
     4921 tcctgcagct ccattctcca tcccactgcc cctacagacc tggggtgctt tgctcgcttt
     4981 cctcctgctt ctgagctttt cctgcaacag gacccgtgcc tccctcctgg gctccatccc
     5041 tgcctggccc agtatatgca gaatgatata cttcagctcc ctcttccctg gcctttgggt
     5101 ctccatggct cagtcctgct cagcttgggc ctgtgacaat ccacaaggct gaatcacagc
     5161 ccctggggtt gaggtccctg tggctcttgg tgaggctgcc actggatcgg ggcaggctag
     5221 aacagggctg gtgtcagctc ctagagtaca gaggaagaag ggatactttg gaatggagga
     5281 ccagtgcttt ttttgttgtt gttattttgt tatttttttg atgggagggt gggaagttct
     5341 ctttataatg gggtaggcca cacccccatt tcgtgcctca atttccccat ctgtaaactg
     5401 tagatatgac tactgaccta cctcacaggg ggctgtgggg aggtgtaagg taatgtttgt
     5461 aaagcgcttt gtaaataaat gtgctctctg aatgcca
//
