LOCUS       NM_001291151           12126 bp    mRNA    linear   ROD 22-JAN-2023
DEFINITION  Mus musculus protein tyrosine phosphatase, receptor type, T
            (Ptprt), transcript variant 3, mRNA.
ACCESSION   NM_001291151 XM_006499009
VERSION     NM_001291151.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12126)
  AUTHORS   Liu S, Zhang Z, Li L, Yao L, Ma Z and Li J.
  TITLE     ADAM10- and gamma-secretase-dependent cleavage of the transmembrane
            protein PTPRT attenuates neurodegeneration in the mouse model of
            Alzheimer's disease
  JOURNAL   FASEB J 37 (2), e22734 (2023)
   PUBMED   36583697
  REMARK    GeneRIF: ADAM10- and gamma-secretase-dependent cleavage of the
            transmembrane protein PTPRT attenuates neurodegeneration in the
            mouse model of Alzheimer's disease.
REFERENCE   2  (bases 1 to 12126)
  AUTHORS   Lim SH, Shin S, Kim MH, Kim EC, Lee DY, Moon J, Park HY, Ryu YK,
            Kang YM, Kang YJ, Kim TH, Lee NY, Kim NS, Yu DY, Shim I, Gondo Y,
            Satake M, Kim E, Kim KS, Min SS and Lee JR.
  TITLE     Depression-like behaviors induced by defective PTPRT activity
            through dysregulated synaptic functions and neurogenesis
  JOURNAL   J Cell Sci 133 (20) (2020)
   PUBMED   32938684
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12126)
  AUTHORS   Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L,
            Zampieri N, Landmesser LT and Philippidou P.
  TITLE     Phrenic-specific transcriptional programs shape respiratory motor
            output
  JOURNAL   Elife 9, e52859 (2020)
   PUBMED   31944180
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12126)
  AUTHORS   Ku M, MacKinnon RN, Wall M, Narayan N, Walkley C, Cheng HC,
            Campbell LJ, Purton LE and Nandurkar H.
  TITLE     Hemopoietic Cell Kinase amplification with Protein Tyrosine
            Phosphatase Receptor T depletion leads to polycythemia, aberrant
            marrow erythoid maturation, and splenomegaly
  JOURNAL   Sci Rep 9 (1), 7050 (2019)
   PUBMED   31065022
  REMARK    GeneRIF: Hemopoietic Cell Kinase amplification with Protein
            Tyrosine Phosphatase Receptor T depletion leads to polycythemia,
            aberrant marrow erythoid maturation, and splenomegaly.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12126)
  AUTHORS   Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y
            and Yoshida Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12126)
  AUTHORS   Thuret S, Bhatt L, O'Leary DD and Simon HH.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   7  (bases 1 to 12126)
  AUTHORS   Besco JA, Frostholm A, Popesco MC, Burghes AH and Rotter A.
  TITLE     Genomic organization and alternative splicing of the human and
            mouse RPTPrho genes: Correction
  JOURNAL   BMC Genomics 2, 5 (2001)
   PUBMED   11814386
  REMARK    Correction to:[BMC Genomics. 2001;2:1. PMID: 11423001]
REFERENCE   8  (bases 1 to 12126)
  AUTHORS   Besco JA, Frostholm A, Popesco MC, Burghes AH and Rotter A.
  TITLE     Genomic organization and alternative splicing of the human and
            mouse RPTPrho genes
  JOURNAL   BMC Genomics 2, 1 (2001)
   PUBMED   11423001
  REMARK    Erratum:[BMC Genomics. 2001;2:5. PMID: 11814386]
REFERENCE   9  (bases 1 to 12126)
  AUTHORS   McAndrew PE, Frostholm A, White RA, Rotter A and Burghes AH.
  TITLE     Identification and characterization of RPTP rho, a novel RPTP
            mu/kappa-like receptor protein tyrosine phosphatase whose
            expression is restricted to the central nervous system
  JOURNAL   Brain Res Mol Brain Res 56 (1-2), 9-21 (1998)
   PUBMED   9602027
REFERENCE   10 (bases 1 to 12126)
  AUTHORS   McAndrew PE, Frostholm A, Evans JE, Zdilar D, Goldowitz D, Chiu IM,
            Burghes AH and Rotter A.
  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
            fibroblast growth factor (FGF-1) transcripts delineate a
            rostrocaudal boundary in the granule cell layer of the murine
            cerebellar cortex
  JOURNAL   J Comp Neurol 391 (4), 444-455 (1998)
   PUBMED   9486824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645736.9, AL590415.7, AL591598.8, AL591675.11, AL591586.8,
            AL606841.13 and BM900160.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by
            NM_001291151.2.
            
            On Mar 27, 2014 this sequence version replaced XM_006499009.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site and contains an additional in-frame exon but lacks a
            different in-frame exon in the central coding region, compared to
            variant 1. The encoded isoform (c) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF162857.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AL645736.9         68609-68956         c
            349-474             AL590415.7         11880-12005
            475-746             AL590415.7         96587-96858
            747-828             AL590415.7         106837-106918
            829-944             AL590415.7         121038-121153
            945-1119            AL590415.7         136725-136899
            1120-1413           AL591598.8         186285-186578       c
            1414-1710           AL591675.11        87954-88250         c
            1711-1820           AL591675.11        61920-62029         c
            1821-2022           AL591586.8         157450-157651       c
            2023-2125           AL591586.8         156065-156167       c
            2126-2399           AL591586.8         111739-112012       c
            2400-2436           AL591586.8         78394-78430         c
            2437-2572           AL591586.8         43489-43624         c
            2573-2602           AL591586.8         32584-32613         c
            2603-2751           AL606841.13        196-344
            2752-2939           AL606841.13        49041-49228
            2940-3027           AL606841.13        68852-68939
            3028-3104           AL606841.13        80684-80760
            3105-3141           AL606841.13        90325-90361
            3142-3239           AL606841.13        91762-91859
            3240-3356           AL606841.13        96201-96317
            3357-3511           AL606841.13        97512-97666
            3512-3647           AL606841.13        100937-101072
            3648-3797           AL606841.13        102607-102756
            3798-3971           AL606841.13        104566-104739
            3972-4103           AL606841.13        109071-109202
            4104-4229           AL606841.13        121892-122017
            4230-4393           AL606841.13        122842-123005
            4394-4529           AL606841.13        125914-126049
            4530-11621          AL606841.13        126917-134008
            11622-12126         BM900160.1         1-505               c
FEATURES             Location/Qualifiers
     source          1..12126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 81.91 cM"
     gene            1..12126
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /note="protein tyrosine phosphatase, receptor type, T"
                     /db_xref="GeneID:19281"
                     /db_xref="MGI:MGI:1321152"
     exon            1..348
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..4583
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /EC_number="3.1.3.48"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; receptor-type tyrosine-protein phosphatase T;
                     receptor protein tyrosine phosphatase-rho; receptor-type
                     tyrosine-protein phosphatase rho"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase T
                     isoform c precursor"
                     /protein_id="NP_001278080.1"
                     /db_xref="GeneID:19281"
                     /db_xref="MGI:MGI:1321152"
                     /translation="MGSLGGLALCLLRLLLLGLQRPPLPGAGAQSAAGGCSFDEHYSN
                     CGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKEN
                     DTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTF
                     WPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCI
                     AGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSD
                     GGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTT
                     TGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVH
                     GPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSH
                     YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYI
                     QWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTY
                     SFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADTPLNETDTTITVMLKPAQSRGAP
                     VSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQP
                     FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVE
                     PEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGA
                     QREMGPVASTDKPTAKLGTNRNDEGFSSSSQDVNGFNGSRGELSQPTLTIQTHPYRTC
                     DPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDE
                     NRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVK
                     DFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIR
                     TFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCS
                     AGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
                     CLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPR
                     NHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD
                     FWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF
                     RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTV
                     VHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV
                     ALEYLSSF"
     exon            349..474
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            475..746
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            747..828
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            829..944
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1119
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1413
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1710
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1820
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2022
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2125
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2399
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2436
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2572
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2602
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2751
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2939
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3027
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3104
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3141
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3239
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3356
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3511
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3647
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3797
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3971
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4103
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4229
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..4393
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4529
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..12111
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaggactc tggggacacc gccccccggc ccccgcgtcc cgcccccgcc cagcctcgcg
       61 cctcagttcg cgccgcgcct gggctcggag cgcagcggcg ccggctcccg cagccggaga
      121 ggagccagcc ccgggagccc agcggcgcgc actgcctgca gccgcgctgg cgatgcgggg
      181 ccgccccgcg cccgcccgag tcccggcccc ggcgccctcg ggaaggggct gagccgcttg
      241 ccgcccggat ggggagcctt ggcgggctcg ccctctgcct gctccggctc ctgctcctgg
      301 ggctgcagcg gccgccgttg cccggcgccg gagcgcagag cgccgcaggt ggctgttctt
      361 ttgacgaaca ttacagcaac tgcgggtata gcgtggctct gggaaccaat gggtttacct
      421 gggagcagat taacacatgg gagaagccaa tgctggaccc agctgtgccc acagggtcct
      481 tcatgatggt gaacagctct ggaagggctt caggccagaa agcccatctt cttctgccaa
      541 ccttgaagga gaatgacact cactgcattg acttccatta ctacttctcc agtcgagatc
      601 gctccagccc gggagccttg aatgtctacg tgaaggtgaa tggtggaccc caagggaacc
      661 ctgtctggaa cgtatctggc gtcgtcactg agggctgggt gaaggcagag cttgccatca
      721 gcaccttctg gcctcatttc tatcaggtga tatttgaatc cgtctctttg aaaggtcatc
      781 ctggttacat cgctgtggac gaagttcggg tccttgctca tccatgcaga aaagcacctc
      841 atttcctgcg actccaaaac gttgaggtga atgtggggca gaacgccacg tttcagtgca
      901 ttgctggtgg aaagtggtcc cagcatgaca aactttggct ccagcaatgg aatggcagag
      961 acacagccct catggtcacc cgggtggtca accacagacg cttctcagcc acagtgagtg
     1021 tggcagacac ctctcaacgc agtatctcca agtatcgctg cgtgatccgc tcagatggtg
     1081 ggtctggtgt gtccaactat gcagagctga ttgtgaaaga gcctcccacg cccattgctc
     1141 ccccggaact actggccgtg ggtgccacct acctgtggat taaaccaaat gccaactcca
     1201 ttattgggga tggccccatc atactgaagg aggtagaata ccgcacaacc acaggaacct
     1261 gggccgagac ccacatcgtg gactctccca actacaagct ctggcatctg gaccctgatg
     1321 tggagtatga gatccgggtg ctgctcacac gaccaggaga ggggggcaca ggaccaccag
     1381 gaccacccct aactaccagg accaagtgtg ccgatcccgt gcatggcccg cagaatgtgg
     1441 agattgtgga cattcgggct cggcagctga ccctgcagtg ggaacccttt ggctatgcag
     1501 tgacccgctg ccacagctac aacctcacag tgcagtacca gtacgtgttc aaccagcagc
     1561 agtatgaagc tgaagaggtg atccagacat cttcccacta tacccttcgg ggtctacggc
     1621 ccttcatgac catcagactg cggctgctac tgtccaaccc tgagggccgg atggagagtg
     1681 aggagttggt ggtacagaca gaagaggatg ttccaggagc tgttcctctc gagtccatcc
     1741 aagggggtcc ctttgaggag aagatctaca tccagtggaa acctcccaat gagaccaatg
     1801 gggtcatcac actctatgag attaactaca aggctgtggg ctcactggat ccaagtgctg
     1861 acctctccag ccagagggga aaggtgttca aactccggaa tgaaacccac cacctctttg
     1921 tgggtctgta ccctgggact acctactctt tcaccatcaa ggccagcaca gccaagggct
     1981 ttggaccccc agtcactact cggattgcca ccaagatttc agctccatca atgcctgaat
     2041 atgacgcaga taccccactc aatgaaacag atacaaccat cacggtgatg ctcaaacccg
     2101 cccagtccag gggagcccca gtcagtgttt accagctggt tgtcaaggag gagcgactcc
     2161 agaagtctcg gagagcagct gacatcattg agtgtttctc agtacctgtg agctaccgga
     2221 acgcctccaa cctcgattcg ctacactact ttgctgctga gctgaagccc tccaacctgc
     2281 ctgtcaccca gccatttaca gtgggagaca acaagaccta caatggctac tggaaccctc
     2341 ctctctcccc attgaagagc tacagcatct acttccaggc cctcagcaaa gcaaatggag
     2401 agacaaaaat caactgtgtg cgtctggcta caaaaggtgc ttccactcag aattctaaca
     2461 ctgtggagcc ggagaagcag gtcgacaaca cggtgaagat ggctggcgtg attgctggcc
     2521 tcctcatgtt catcatcatt ctcctggggg tgatgctgac catcaaaagg agaagaaatg
     2581 cttattcgta ctcctattac ttgaagctgg ctaagaagca gaaggagacc cagagtggag
     2641 cccagaggga gatgggtcct gtggcctcga ctgacaagcc taccgccaag ctcggcacca
     2701 accgcaatga tgaaggcttc tcctccagct ctcaggatgt taatggattc aatggcagcc
     2761 gtggggagct gtctcagcct accctcacca ttcagactca tccctaccgg acttgtgacc
     2821 ctgtagagat gagctatccc cgggaccagt tccagcctgc catccgggtg gcggacctgc
     2881 ttcaacacat cacccagatg aagagaggcc agggctacgg gttcaaggag gaatacgagg
     2941 ccttaccaga aggacagaca gcttcgtggg acacagccaa ggaagatgaa aaccgcaata
     3001 agaatcgata cggaaacatc atatcttatg accactctcg agtaaggctg ttggtgctgg
     3061 atggagaccc tcactcagac tacatcaatg ccaactacat tgacgggtac caccgacccc
     3121 ggcactacat tgcaacccaa ggtccaatgc aagagacggt gaaggacttt tggagaatga
     3181 tctggcagga aaactctgcc agcatcgtca tggtcacaaa ccttgtggaa gtgggcaggg
     3241 tgaagtgtgt ccgatactgg ccagatgaca cagaggtcta tggagacatt aaagtcaccc
     3301 taatagaaac agagcccctg gcagaatacg tcatccgcac cttcacagtc cagaagaaag
     3361 gctaccatga gatccgggag ctccgcctct tccacttcac cagctggcct gaccacggtg
     3421 ttccctgcta tgccactggc cttctgggct ttgtccgcca ggtcaagttt ctcaatcccc
     3481 cagaagctgg gcccatagtg gtccattgca gtgctggagc cgggaggact ggctgcttca
     3541 ttgcgattga caccatgctc gacatggctg agaatgaagg ggttgtggac atcttcaact
     3601 gtgtgcgtga gctccgggca cagagggtca acctggtgca gacagaggag cagtacgtgt
     3661 ttgtgcacga tgccatcctg gaagcatgcc tctgcggcaa tactgccatc ccagtgtgtg
     3721 agttccgctc tctctactac aacatcagca ggctggaccc gcagaccaac tccagccaga
     3781 tcaaagacga gtttcagaca ctcaacattg tgacacctcg agtgcggcct gaagactgca
     3841 gcattgggct cttaccccgg aaccatgata agaatcggag catggatgtc ctgcctctgg
     3901 accgctgtct acccttcctc atctcagtag atggagagtc cagcaactac atcaatgcag
     3961 cactgatgga tagccacaag cagcctgccg ccttcgtggt cacccagcat cctctaccca
     4021 acacggtggc agacttctgg aggctggtgt ttgattataa ttgttcatct gtggtgatgc
     4081 tgaacgagat ggatactgct cagctctgta tgcagtactg gcctgagaag acctccgggt
     4141 gttatggtcc catccaggtg gagtttgtct ctgcagacat cgatgaggac atcatccaca
     4201 gaatcttccg gatctgtaac atggctcggc cacaggatgg ttatcgtatt gtccagcacc
     4261 tccagtacat cggctggcct gcataccggg acacgccccc ctctaagcgc tctctgctca
     4321 aagtggtccg acggctggag aaatggcagg agcaatacga cggaagagag gggcgcactg
     4381 tggtccactg cctaaatggg ggaggccgca gtggaacctt ctgtgctatc tgcagtgtgt
     4441 gtgagatgat ccagcagcag aacattattg acgtgttcca cattgtgaaa accctccgca
     4501 acaacaagtc caacatggtg gagacgctgg aacagtataa atttgtatat gaggtggcac
     4561 tggaatattt aagctccttt tagactgatt ggatggggag cctgccagag ttcagcggcg
     4621 gctgcagctg cccctctatt tctgtgactg acaatgactg gtctcaggag ctccgaggtg
     4681 gtacacctgc tcagctccag gaagaagact gctggtctca tgctctgcag cttctgtggg
     4741 ggtctgtagc tgtgggagat gcggttctga tggggactag catcccttct acacctgaca
     4801 gcatcaggcc cacagaagtc tacccacaag caaggccctg gacttccgat tcccagacct
     4861 cttgcttttg ttcgttctga gtttgttact ctcatggcaa gctgactgtg caggtgctgg
     4921 ggtgtgggga gatggccagt ccttccctta ccatccttag gagtatcagg ggtggaagtt
     4981 cttctccatg ctatcctgca aaagcatgga ttgtagtttg agggatcact gtgttattgg
     5041 ttcctataat ctcccacagg ggcctctggc atgagacagc tgccaatctg gatcagtgtg
     5101 actcctggat accccctagg ccaagcagaa agctttttca tcttacacct aacccatcct
     5161 gggttctact cactacaacc atctccagcc aggccttgac cctctgtaat ctcccggcca
     5221 acctgctgta tctgtatcac acttcggcaa aggtttcctt tgcttttcca tagtctgtag
     5281 ggagaggagg gctcatagga aatgttacag tatctcttta atctttgtag aaaaagccac
     5341 tctcatgggg cagggctctt gctggccttt acagtacaac cctgcgcttc ttaggtggtg
     5401 ctttctgtgg gaaagacaaa caaaaaaagc tttgagtgtt ttcccaagta catgtgaaaa
     5461 gaaactcttg tgagagtgta aaattctgta ttctcttatg tcaaaagaag aaaaggatag
     5521 gatgggagtt tggatgtgtg gctgtcagat aactctcttg gacttttatt tcctggtcat
     5581 acccataaaa agacccactg taggatgaca cagccattga acacatgaaa tgggacctct
     5641 gggatcagtc cctgggttgt gggtgtggaa atacagaagc acctttataa tttgtctctc
     5701 caaatttgaa ctctttcctt aaaaaaaaaa atccagctgc cattttgaaa ttggctactg
     5761 gggccccagc ttggtttatg atagaataag caggtttagg ctgggggcca agtcttgctc
     5821 aaagcatgaa ttaagggaaa ggagagaaca ttagtgaagt gtttcctgca agccaagtgc
     5881 catggttacc accttccatg tgacatctca tatagtcagt agcaccccta ggaaccccta
     5941 gagaatgctc tcatcatatc catttggtaa ttgaagaaac ctgagcatct tcttcagtga
     6001 tggaattctg ggttccaaag acaggtaatg gcaccgaaac ccccccccca ccattttcct
     6061 catgctttct cagccaagca attattttta tggaaccaaa ataaggctag aaactttgga
     6121 gcagagagag agaactccag gagtagaaat ttaattcttt ctttctgata gcagttcttc
     6181 ttggtagccc acactttcag atatatttta ttaactcatt cgcagttccc cagaaaagct
     6241 agtcttatct aatttcatca ttgctaaaaa caattcccgt gctccctcag gctacaaggg
     6301 agccagcttg ggaagctctg tagcctgggt tgagccacaa tatctgacag ccttaatagc
     6361 cagaggtcta ggaaggtcta tcttgcagac tgatccagtc tcggtgtatg agggacacag
     6421 aatccaataa ggtacacatc ttgcccttca ggcccactgt attgtagaga agctgagcca
     6481 cattgtaaca gtggagcata caagcatttg atgagctttg gtgtgagagt gacttgctct
     6541 gcctagagct tcctaggcaa catccattcc aggcagggct caacagacag aaaagaagaa
     6601 aaaggaattc aagccaaggt ggtcaacatg cacaatggta aaggcaggtg agaaggtatc
     6661 tggagggaca gatggtggga ggtcagccca gctagaaggt agcaagacag ggatggtggc
     6721 aggaaggtag ccagagccag ggaggaaatg taaagggcac agtcactgcc ctgcaggcaa
     6781 caggaagttg gcagagttca acagctatgc actcagttta gttttggaga cggctctctc
     6841 tggaccagca ggacagccta ttttcctttc atcagacact gtgaaaatgt tccctcagtg
     6901 tgtgctttta atatgttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgctca ctattttgtt
     6961 gctggaacaa aatatggagt gaatcatgag actgagctct tacgtaaaac ccagggtctc
     7021 tgttctacca tggagcaggg tcaacaacct tggcctctga gccttcaagg acagaatatg
     7081 aaaggaaatc agggagccag ctcccattgg tgtgggccca ggagccgtct agaagtctaa
     7141 aaacaccaga gttgatcaag gaaggctgtc actttggagg ttcaaaagga gcatctcaaa
     7201 gaaaaggcac gaaaaggaaa tctatgagtt actattctct tttgatgggc ctcttcccag
     7261 gtatatttga gcatatcccc aggccccaga ccccactggt ccgtctggat tcctatggct
     7321 ctagtctcct atctctgaat ggacttccag gtagccttca ggagtctata gcatagccaa
     7381 tcagcatgtt gcattctatt tcttcagatc ttggccactt ctaacagaga gtggatagag
     7441 gggagaggat taactacaaa tcctaggatt cattctgctg aggaaagaat tgaagagctg
     7501 acagataaag atgacagtgg tatctgtcat tataaatggc gggaatttaa aaaaaaaatt
     7561 ccaagggaaa ggaagtgtgt gaaaattcag gccatgctga gggaagggct aatttatatc
     7621 cttattttct cataatccaa ctgttcttaa agaaggtgat cttaaaacag tgcacacaaa
     7681 aagaaagtgg ggtacatgga tggaagtaac attcttcagg tccggggggg gggagggtag
     7741 gggttgggga ggcatgcaga agagcttaga tgatatggga aatggtccta agaaatttag
     7801 atgatatttt ccccaggaaa tctcccaaga aaacccactt tcttctcacc cgacctactt
     7861 atggggtagg cttattttga gacaagcaaa ggaaagatgc caaaatgaat cctcacttag
     7921 ctaatatctt cctgttggtc accagtggaa tccaaatgga aaaggtataa ggtacaaatg
     7981 agataccatg aaaactgccc caagttggcc atgtttatga tggcttcagg ttggaacaca
     8041 gctacatctc aatctcatgt tcttttatcc ctactgatat gattatcatg gatgaggtat
     8101 gggtctgtta gcttctagaa agccacagca ggtccctttt ataggaacaa aagaggctgc
     8161 ttgcttcagg tgactctcag tgtggttctt agcaatcaaa gaccagccag atgtcaccta
     8221 ctccatggaa ccagtagatt cagtgctgtg gactctaaaa cgtgagctca ctcttctaca
     8281 ttcttgaaat atctgtgact atggccagca ctactttact atcaagtaaa cagatccaaa
     8341 gggagaattc atttgcccat acaagcaaac ttgtcctggc tttctgacca cagagacaaa
     8401 attcttccat cattgtatct gagattttcc cacatgatta ctcttagcaa cagagacaag
     8461 agcaaaacta atgactcagt agatattggt aaagcccagt gcagacaatg ataagcttca
     8521 aatttctcta gagcctcgtg gtttacattc atgatatatt cggattccat tttctaattt
     8581 attcttagta gtttaaatat gactgtataa attcattttt aaatctgtcc tttatctcat
     8641 gtatctttct gatcaatctt agggaatatc tctgaccaag gcatagtgcc tgaccatgtt
     8701 ccttcctcct gaggttaatt ctaaactcac attcacacca acttacattc cccttggagc
     8761 atctgttgct gtggaggtat cctgactgta ctgctcctga ggttcagcaa aggtctcgtc
     8821 ttcttatgga gggttctgca agatgcccac taacagacta gaataatgag aacttacctg
     8881 catggcatgg taaaggttga gcccacaaaa ccctaaaaac aaaggggaag ccagatgcag
     8941 atttactcag aggatccttg aatgctgaac gatgtctgtt gtctctgtag agttccatgg
     9001 cttctgatgt gggaaaatct taggacacac ttcatgaatt ttaaataccc ttcccttcac
     9061 atagctcaat acaatccctg gatcctatag cattcagcat tcaagacaga taccactagg
     9121 aagtacaaac tactatggca tggtacgcca tggtaagtag gataagaact tgctcattgg
     9181 tttgaactcc aactgcacca tttctggaat ataaaatatc aggctgaaca aggcatggaa
     9241 aaggaaacat acacacatct ttggccaggt ttaaaggggt taatctggaa ggctaggaca
     9301 ggaaaacaag aattcaattg aaacccagca tctactcaga aacaaggatg cttatagact
     9361 gttgagctca gtgataaatt ccatggggaa aaaataaaga aggccaaccc tccttaacct
     9421 gtagctggcc acccctgcta tcatagcagg tcatcagcac caagctaaag caagctcagt
     9481 actgtaaacg gtaggtctag atccaaagct gaacatgaac aggatgctaa tcttatgcta
     9541 caaggtcaat gagccaagat ccctaagaag gagttgacaa cccaaagtaa aagtcaagtg
     9601 aaaagataaa acagaaattg caatgtcctc tataagcctt gatttgcctt tctttccaat
     9661 tgaccaatca aagtgaggcc ctctgtagta tctcactagt tcttactcag agacaataaa
     9721 acagaagagt agagtaaatt cggccataga caaatgagac ttaacctggt ttgcatacgg
     9781 ttgtgtacag gtttcttatg tgaggttgtc cctagagacc tatcaaaaat tatgaaatgc
     9841 aaaggcttcc tttaactgaa tgtgggatca cctttgaaat cctatccttt ttgaacaaca
     9901 aagagagagc aagtgagagc aagagcgaga gcttgagagt gagagagtga gagagagtga
     9961 gagagagtga gagagagaga gagagagaga gagagagaga gagggagaga gagagggagg
    10021 gagggagagg tggaaaatag aaagtggggg agaaagagaa tagttctaaa ccgagttttc
    10081 tctgacacat aatttagagt catggagctg atatcctgag aaacacagca caaatatctc
    10141 tgacatatct acatacgaat aagctctttc aaattcttgg taaccacaga tagacttttg
    10201 catgacagtg gctatataac tgtattgtgg agaccaagaa ctatctcttg cgtatatcct
    10261 gccaacttct acaagaggta gaaaagctat caaagggccc acattcaccc ctaaaatcca
    10321 tccatgaata ttagtgtcca acaggtggag tcggtaccca cattcctacc ccgccccaga
    10381 cctggcacta ctttatctag cacgaataca cctaagagct tagtggtggt gcacagcagc
    10441 tggtacagag gacgggtaag aattgggagg ggagacaacc ttctagaaag gacttcagaa
    10501 agtgattaat catggggctt ccttttggat tggagagcca cgctaggtag taaaatgcta
    10561 accccggttc tttgttggac tgtttagaga atgaagtgta ggagtcttag aatattgaac
    10621 agcaaagtga tggtattcag ggtatttaat gtagattgtg agtcttcagt gagaaccatt
    10681 tctagggcct ttgtgagcag aattgtgtta gttccccccg cccccaatca gtctcctaaa
    10741 gggacagcag aatactagca tccatagtct tcttaagact gtgggtgata agacaaagtc
    10801 aaacatagtt tgctaccctg gttacccctg tgagcggtgc tgaggtggat gtggagactg
    10861 agtacctgta agaaagagct gagtgctagg gaggatcgct gcctgtttga gtagcttccc
    10921 aacagaagcc aggcatcccc atctcctggc ctagggtgaa gaaacagagt agccaaggta
    10981 gatagacttc agaccacttt cactttcagt gggtgagtcc ttgaaacttg aaggtcacat
    11041 ttgaactggg aacctccaaa ctgcaaacta agtaggtagg tcatgcttgg tttgggaagt
    11101 ggaagccctc tgtttttcta atcaaatcat ctcctcctgt caatcaaaag gcagctccag
    11161 ctgcatctcc tagccttatc caggatggtt agcaccagtc acagggagca gttccttggc
    11221 catacatctg atgcttactg ccatcactga gaagggcagc cagcacccag actcactggc
    11281 caccagggcc ctcaatgaca gacagaacca ataaacatcg aggcaggagt caaaacaagg
    11341 ctttgcttca tgcgtattgt ctccaaaggt taattcagcc atcattccct attcaaggcc
    11401 tgtaggaaaa gacttcaaaa gcacagggat tctgttgaca ccttatcata atcattccca
    11461 gtacatatat ttcatcacca actggttctt gggctggccc aggttagcct aggctaactc
    11521 agatttgtaa tcaggatcaa aaattatatt ctcccttctc tcttcactct atatccaagt
    11581 agccaattaa aggtacagtt gtagcctctg tggttgcctt ggctacagat gaccatactg
    11641 gtacacctct ccaggaccta tcatggcatt cccagtctac actagggaag cttacatttt
    11701 cattgtccgg tggcatatga tatcacatga gaccaaagtc tccacactat ctgaaatctc
    11761 cacaaatccc agtggcctgc acttgtacag tttgggtgtt tgatagataa agcacgtatg
    11821 agaagagaaa acaaaataaa tcaacttcag caaaaagaaa gccagcactg tgctgtcaat
    11881 gtctttcccc cctttccctt tttatttcca gttctagctt caaaaagcag aaggtaaata
    11941 atgtcaggtc aatgaatatc agatatattt tttgactgta cattaaagtg acgtgtaatc
    12001 tttttacacc tgcaagtcca tcttatttat tcttgtaaat gttccctgac aatgtttgta
    12061 atatggctgt gtttaaaaaa aaatctatac aataaagctg tgaccctgag aaaaaaaaaa
    12121 aaaaaa
//
