LOCUS       NM_001291149           12159 bp    mRNA    linear   ROD 22-JAN-2023
DEFINITION  Mus musculus protein tyrosine phosphatase, receptor type, T
            (Ptprt), transcript variant 1, mRNA.
ACCESSION   NM_001291149 XM_006499007
VERSION     NM_001291149.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12159)
  AUTHORS   Liu S, Zhang Z, Li L, Yao L, Ma Z and Li J.
  TITLE     ADAM10- and gamma-secretase-dependent cleavage of the transmembrane
            protein PTPRT attenuates neurodegeneration in the mouse model of
            Alzheimer's disease
  JOURNAL   FASEB J 37 (2), e22734 (2023)
   PUBMED   36583697
  REMARK    GeneRIF: ADAM10- and gamma-secretase-dependent cleavage of the
            transmembrane protein PTPRT attenuates neurodegeneration in the
            mouse model of Alzheimer's disease.
REFERENCE   2  (bases 1 to 12159)
  AUTHORS   Lim SH, Shin S, Kim MH, Kim EC, Lee DY, Moon J, Park HY, Ryu YK,
            Kang YM, Kang YJ, Kim TH, Lee NY, Kim NS, Yu DY, Shim I, Gondo Y,
            Satake M, Kim E, Kim KS, Min SS and Lee JR.
  TITLE     Depression-like behaviors induced by defective PTPRT activity
            through dysregulated synaptic functions and neurogenesis
  JOURNAL   J Cell Sci 133 (20) (2020)
   PUBMED   32938684
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12159)
  AUTHORS   Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L,
            Zampieri N, Landmesser LT and Philippidou P.
  TITLE     Phrenic-specific transcriptional programs shape respiratory motor
            output
  JOURNAL   Elife 9, e52859 (2020)
   PUBMED   31944180
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12159)
  AUTHORS   Ku M, MacKinnon RN, Wall M, Narayan N, Walkley C, Cheng HC,
            Campbell LJ, Purton LE and Nandurkar H.
  TITLE     Hemopoietic Cell Kinase amplification with Protein Tyrosine
            Phosphatase Receptor T depletion leads to polycythemia, aberrant
            marrow erythoid maturation, and splenomegaly
  JOURNAL   Sci Rep 9 (1), 7050 (2019)
   PUBMED   31065022
  REMARK    GeneRIF: Hemopoietic Cell Kinase amplification with Protein
            Tyrosine Phosphatase Receptor T depletion leads to polycythemia,
            aberrant marrow erythoid maturation, and splenomegaly.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12159)
  AUTHORS   Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y
            and Yoshida Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12159)
  AUTHORS   Thuret S, Bhatt L, O'Leary DD and Simon HH.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   7  (bases 1 to 12159)
  AUTHORS   Besco JA, Frostholm A, Popesco MC, Burghes AH and Rotter A.
  TITLE     Genomic organization and alternative splicing of the human and
            mouse RPTPrho genes: Correction
  JOURNAL   BMC Genomics 2, 5 (2001)
   PUBMED   11814386
  REMARK    Correction to:[BMC Genomics. 2001;2:1. PMID: 11423001]
REFERENCE   8  (bases 1 to 12159)
  AUTHORS   Besco JA, Frostholm A, Popesco MC, Burghes AH and Rotter A.
  TITLE     Genomic organization and alternative splicing of the human and
            mouse RPTPrho genes
  JOURNAL   BMC Genomics 2, 1 (2001)
   PUBMED   11423001
  REMARK    Erratum:[BMC Genomics. 2001;2:5. PMID: 11814386]
REFERENCE   9  (bases 1 to 12159)
  AUTHORS   McAndrew PE, Frostholm A, White RA, Rotter A and Burghes AH.
  TITLE     Identification and characterization of RPTP rho, a novel RPTP
            mu/kappa-like receptor protein tyrosine phosphatase whose
            expression is restricted to the central nervous system
  JOURNAL   Brain Res Mol Brain Res 56 (1-2), 9-21 (1998)
   PUBMED   9602027
REFERENCE   10 (bases 1 to 12159)
  AUTHORS   McAndrew PE, Frostholm A, Evans JE, Zdilar D, Goldowitz D, Chiu IM,
            Burghes AH and Rotter A.
  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
            fibroblast growth factor (FGF-1) transcripts delineate a
            rostrocaudal boundary in the granule cell layer of the murine
            cerebellar cortex
  JOURNAL   J Comp Neurol 391 (4), 444-455 (1998)
   PUBMED   9486824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645736.9, AL590415.7, AL591598.8, AL591675.11, AL591586.8,
            AL606841.13 and BM900160.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by
            NM_001291149.2.
            
            On Mar 28, 2014 this sequence version replaced XM_006499007.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY026863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AL645736.9         68609-68956         c
            349-474             AL590415.7         11880-12005
            475-746             AL590415.7         96587-96858
            747-828             AL590415.7         106837-106918
            829-944             AL590415.7         121038-121153
            945-1119            AL590415.7         136725-136899
            1120-1413           AL591598.8         186285-186578       c
            1414-1710           AL591675.11        87954-88250         c
            1711-1820           AL591675.11        61920-62029         c
            1821-2022           AL591586.8         157450-157651       c
            2023-2125           AL591586.8         156065-156167       c
            2126-2399           AL591586.8         111739-112012       c
            2400-2436           AL591586.8         78394-78430         c
            2437-2572           AL591586.8         43489-43624         c
            2573-2721           AL606841.13        196-344
            2722-2912           AL606841.13        49038-49228
            2913-3000           AL606841.13        68852-68939
            3001-3077           AL606841.13        80684-80760
            3078-3114           AL606841.13        90325-90361
            3115-3212           AL606841.13        91762-91859
            3213-3272           AL606841.13        95498-95557
            3273-3389           AL606841.13        96201-96317
            3390-3544           AL606841.13        97512-97666
            3545-3680           AL606841.13        100937-101072
            3681-3830           AL606841.13        102607-102756
            3831-4004           AL606841.13        104566-104739
            4005-4136           AL606841.13        109071-109202
            4137-4262           AL606841.13        121892-122017
            4263-4426           AL606841.13        122842-123005
            4427-4562           AL606841.13        125914-126049
            4563-11654          AL606841.13        126917-134008
            11655-12159         BM900160.1         1-505               c
FEATURES             Location/Qualifiers
     source          1..12159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 81.91 cM"
     gene            1..12159
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /note="protein tyrosine phosphatase, receptor type, T"
                     /db_xref="GeneID:19281"
                     /db_xref="MGI:MGI:1321152"
     exon            1..348
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..4616
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /EC_number="3.1.3.48"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase T;
                     receptor protein tyrosine phosphatase-rho; receptor-type
                     tyrosine-protein phosphatase rho"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase T
                     isoform a precursor"
                     /protein_id="NP_001278078.1"
                     /db_xref="CCDS:CCDS71182.1"
                     /db_xref="GeneID:19281"
                     /db_xref="MGI:MGI:1321152"
                     /translation="MGSLGGLALCLLRLLLLGLQRPPLPGAGAQSAAGGCSFDEHYSN
                     CGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKEN
                     DTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTF
                     WPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCI
                     AGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSD
                     GGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTT
                     TGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVH
                     GPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSH
                     YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYI
                     QWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTY
                     SFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADTPLNETDTTITVMLKPAQSRGAP
                     VSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQP
                     FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVE
                     PEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQREMGPVAST
                     DKPTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPR
                     DQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGN
                     IISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQE
                     NSASIVMVTNLVEVGRHPAEHTVGTATLGRAASPGMVKCVRYWPDDTEVYGDIKVTLI
                     ETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNP
                     PEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ
                     YVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVR
                     PEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVV
                     TQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSA
                     DIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQ
                     EQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVE
                     TLEQYKFVYEVALEYLSSF"
     exon            349..474
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            475..746
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            747..828
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            829..944
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1119
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1413
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1710
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1820
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2022
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2125
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2399
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2436
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2572
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2721
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2912
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3000
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3077
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3114
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3212
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3272
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3389
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3544
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3680
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3830
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4004
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4136
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4262
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4263..4426
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4427..4562
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..12144
                     /gene="Ptprt"
                     /gene_synonym="mKIAA0283; mRPTPrho; R-PTP-T; RPTP-rfo;
                     RPTP-rho; RPTPmam4; RPTPrho"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaggactc tggggacacc gccccccggc ccccgcgtcc cgcccccgcc cagcctcgcg
       61 cctcagttcg cgccgcgcct gggctcggag cgcagcggcg ccggctcccg cagccggaga
      121 ggagccagcc ccgggagccc agcggcgcgc actgcctgca gccgcgctgg cgatgcgggg
      181 ccgccccgcg cccgcccgag tcccggcccc ggcgccctcg ggaaggggct gagccgcttg
      241 ccgcccggat ggggagcctt ggcgggctcg ccctctgcct gctccggctc ctgctcctgg
      301 ggctgcagcg gccgccgttg cccggcgccg gagcgcagag cgccgcaggt ggctgttctt
      361 ttgacgaaca ttacagcaac tgcgggtata gcgtggctct gggaaccaat gggtttacct
      421 gggagcagat taacacatgg gagaagccaa tgctggaccc agctgtgccc acagggtcct
      481 tcatgatggt gaacagctct ggaagggctt caggccagaa agcccatctt cttctgccaa
      541 ccttgaagga gaatgacact cactgcattg acttccatta ctacttctcc agtcgagatc
      601 gctccagccc gggagccttg aatgtctacg tgaaggtgaa tggtggaccc caagggaacc
      661 ctgtctggaa cgtatctggc gtcgtcactg agggctgggt gaaggcagag cttgccatca
      721 gcaccttctg gcctcatttc tatcaggtga tatttgaatc cgtctctttg aaaggtcatc
      781 ctggttacat cgctgtggac gaagttcggg tccttgctca tccatgcaga aaagcacctc
      841 atttcctgcg actccaaaac gttgaggtga atgtggggca gaacgccacg tttcagtgca
      901 ttgctggtgg aaagtggtcc cagcatgaca aactttggct ccagcaatgg aatggcagag
      961 acacagccct catggtcacc cgggtggtca accacagacg cttctcagcc acagtgagtg
     1021 tggcagacac ctctcaacgc agtatctcca agtatcgctg cgtgatccgc tcagatggtg
     1081 ggtctggtgt gtccaactat gcagagctga ttgtgaaaga gcctcccacg cccattgctc
     1141 ccccggaact actggccgtg ggtgccacct acctgtggat taaaccaaat gccaactcca
     1201 ttattgggga tggccccatc atactgaagg aggtagaata ccgcacaacc acaggaacct
     1261 gggccgagac ccacatcgtg gactctccca actacaagct ctggcatctg gaccctgatg
     1321 tggagtatga gatccgggtg ctgctcacac gaccaggaga ggggggcaca ggaccaccag
     1381 gaccacccct aactaccagg accaagtgtg ccgatcccgt gcatggcccg cagaatgtgg
     1441 agattgtgga cattcgggct cggcagctga ccctgcagtg ggaacccttt ggctatgcag
     1501 tgacccgctg ccacagctac aacctcacag tgcagtacca gtacgtgttc aaccagcagc
     1561 agtatgaagc tgaagaggtg atccagacat cttcccacta tacccttcgg ggtctacggc
     1621 ccttcatgac catcagactg cggctgctac tgtccaaccc tgagggccgg atggagagtg
     1681 aggagttggt ggtacagaca gaagaggatg ttccaggagc tgttcctctc gagtccatcc
     1741 aagggggtcc ctttgaggag aagatctaca tccagtggaa acctcccaat gagaccaatg
     1801 gggtcatcac actctatgag attaactaca aggctgtggg ctcactggat ccaagtgctg
     1861 acctctccag ccagagggga aaggtgttca aactccggaa tgaaacccac cacctctttg
     1921 tgggtctgta ccctgggact acctactctt tcaccatcaa ggccagcaca gccaagggct
     1981 ttggaccccc agtcactact cggattgcca ccaagatttc agctccatca atgcctgaat
     2041 atgacgcaga taccccactc aatgaaacag atacaaccat cacggtgatg ctcaaacccg
     2101 cccagtccag gggagcccca gtcagtgttt accagctggt tgtcaaggag gagcgactcc
     2161 agaagtctcg gagagcagct gacatcattg agtgtttctc agtacctgtg agctaccgga
     2221 acgcctccaa cctcgattcg ctacactact ttgctgctga gctgaagccc tccaacctgc
     2281 ctgtcaccca gccatttaca gtgggagaca acaagaccta caatggctac tggaaccctc
     2341 ctctctcccc attgaagagc tacagcatct acttccaggc cctcagcaaa gcaaatggag
     2401 agacaaaaat caactgtgtg cgtctggcta caaaaggtgc ttccactcag aattctaaca
     2461 ctgtggagcc ggagaagcag gtcgacaaca cggtgaagat ggctggcgtg attgctggcc
     2521 tcctcatgtt catcatcatt ctcctggggg tgatgctgac catcaaaagg aggaagctgg
     2581 ctaagaagca gaaggagacc cagagtggag cccagaggga gatgggtcct gtggcctcga
     2641 ctgacaagcc taccgccaag ctcggcacca accgcaatga tgaaggcttc tcctccagct
     2701 ctcaggatgt taatggattc acagatggca gccgtgggga gctgtctcag cctaccctca
     2761 ccattcagac tcatccctac cggacttgtg accctgtaga gatgagctat ccccgggacc
     2821 agttccagcc tgccatccgg gtggcggacc tgcttcaaca catcacccag atgaagagag
     2881 gccagggcta cgggttcaag gaggaatacg aggccttacc agaaggacag acagcttcgt
     2941 gggacacagc caaggaagat gaaaaccgca ataagaatcg atacggaaac atcatatctt
     3001 atgaccactc tcgagtaagg ctgttggtgc tggatggaga ccctcactca gactacatca
     3061 atgccaacta cattgacggg taccaccgac cccggcacta cattgcaacc caaggtccaa
     3121 tgcaagagac ggtgaaggac ttttggagaa tgatctggca ggaaaactct gccagcatcg
     3181 tcatggtcac aaaccttgtg gaagtgggca ggcacccagc ggaacacact gtgggaactg
     3241 ccacgctagg ccgtgctgca tcccccggaa tggtgaagtg tgtccgatac tggccagatg
     3301 acacagaggt ctatggagac attaaagtca ccctaataga aacagagccc ctggcagaat
     3361 acgtcatccg caccttcaca gtccagaaga aaggctacca tgagatccgg gagctccgcc
     3421 tcttccactt caccagctgg cctgaccacg gtgttccctg ctatgccact ggccttctgg
     3481 gctttgtccg ccaggtcaag tttctcaatc ccccagaagc tgggcccata gtggtccatt
     3541 gcagtgctgg agccgggagg actggctgct tcattgcgat tgacaccatg ctcgacatgg
     3601 ctgagaatga aggggttgtg gacatcttca actgtgtgcg tgagctccgg gcacagaggg
     3661 tcaacctggt gcagacagag gagcagtacg tgtttgtgca cgatgccatc ctggaagcat
     3721 gcctctgcgg caatactgcc atcccagtgt gtgagttccg ctctctctac tacaacatca
     3781 gcaggctgga cccgcagacc aactccagcc agatcaaaga cgagtttcag acactcaaca
     3841 ttgtgacacc tcgagtgcgg cctgaagact gcagcattgg gctcttaccc cggaaccatg
     3901 ataagaatcg gagcatggat gtcctgcctc tggaccgctg tctacccttc ctcatctcag
     3961 tagatggaga gtccagcaac tacatcaatg cagcactgat ggatagccac aagcagcctg
     4021 ccgccttcgt ggtcacccag catcctctac ccaacacggt ggcagacttc tggaggctgg
     4081 tgtttgatta taattgttca tctgtggtga tgctgaacga gatggatact gctcagctct
     4141 gtatgcagta ctggcctgag aagacctccg ggtgttatgg tcccatccag gtggagtttg
     4201 tctctgcaga catcgatgag gacatcatcc acagaatctt ccggatctgt aacatggctc
     4261 ggccacagga tggttatcgt attgtccagc acctccagta catcggctgg cctgcatacc
     4321 gggacacgcc cccctctaag cgctctctgc tcaaagtggt ccgacggctg gagaaatggc
     4381 aggagcaata cgacggaaga gaggggcgca ctgtggtcca ctgcctaaat gggggaggcc
     4441 gcagtggaac cttctgtgct atctgcagtg tgtgtgagat gatccagcag cagaacatta
     4501 ttgacgtgtt ccacattgtg aaaaccctcc gcaacaacaa gtccaacatg gtggagacgc
     4561 tggaacagta taaatttgta tatgaggtgg cactggaata tttaagctcc ttttagactg
     4621 attggatggg gagcctgcca gagttcagcg gcggctgcag ctgcccctct atttctgtga
     4681 ctgacaatga ctggtctcag gagctccgag gtggtacacc tgctcagctc caggaagaag
     4741 actgctggtc tcatgctctg cagcttctgt gggggtctgt agctgtggga gatgcggttc
     4801 tgatggggac tagcatccct tctacacctg acagcatcag gcccacagaa gtctacccac
     4861 aagcaaggcc ctggacttcc gattcccaga cctcttgctt ttgttcgttc tgagtttgtt
     4921 actctcatgg caagctgact gtgcaggtgc tggggtgtgg ggagatggcc agtccttccc
     4981 ttaccatcct taggagtatc aggggtggaa gttcttctcc atgctatcct gcaaaagcat
     5041 ggattgtagt ttgagggatc actgtgttat tggttcctat aatctcccac aggggcctct
     5101 ggcatgagac agctgccaat ctggatcagt gtgactcctg gataccccct aggccaagca
     5161 gaaagctttt tcatcttaca cctaacccat cctgggttct actcactaca accatctcca
     5221 gccaggcctt gaccctctgt aatctcccgg ccaacctgct gtatctgtat cacacttcgg
     5281 caaaggtttc ctttgctttt ccatagtctg tagggagagg agggctcata ggaaatgtta
     5341 cagtatctct ttaatctttg tagaaaaagc cactctcatg gggcagggct cttgctggcc
     5401 tttacagtac aaccctgcgc ttcttaggtg gtgctttctg tgggaaagac aaacaaaaaa
     5461 agctttgagt gttttcccaa gtacatgtga aaagaaactc ttgtgagagt gtaaaattct
     5521 gtattctctt atgtcaaaag aagaaaagga taggatggga gtttggatgt gtggctgtca
     5581 gataactctc ttggactttt atttcctggt catacccata aaaagaccca ctgtaggatg
     5641 acacagccat tgaacacatg aaatgggacc tctgggatca gtccctgggt tgtgggtgtg
     5701 gaaatacaga agcaccttta taatttgtct ctccaaattt gaactctttc cttaaaaaaa
     5761 aaaatccagc tgccattttg aaattggcta ctggggcccc agcttggttt atgatagaat
     5821 aagcaggttt aggctggggg ccaagtcttg ctcaaagcat gaattaaggg aaaggagaga
     5881 acattagtga agtgtttcct gcaagccaag tgccatggtt accaccttcc atgtgacatc
     5941 tcatatagtc agtagcaccc ctaggaaccc ctagagaatg ctctcatcat atccatttgg
     6001 taattgaaga aacctgagca tcttcttcag tgatggaatt ctgggttcca aagacaggta
     6061 atggcaccga aacccccccc ccaccatttt cctcatgctt tctcagccaa gcaattattt
     6121 ttatggaacc aaaataaggc tagaaacttt ggagcagaga gagagaactc caggagtaga
     6181 aatttaattc tttctttctg atagcagttc ttcttggtag cccacacttt cagatatatt
     6241 ttattaactc attcgcagtt ccccagaaaa gctagtctta tctaatttca tcattgctaa
     6301 aaacaattcc cgtgctccct caggctacaa gggagccagc ttgggaagct ctgtagcctg
     6361 ggttgagcca caatatctga cagccttaat agccagaggt ctaggaaggt ctatcttgca
     6421 gactgatcca gtctcggtgt atgagggaca cagaatccaa taaggtacac atcttgccct
     6481 tcaggcccac tgtattgtag agaagctgag ccacattgta acagtggagc atacaagcat
     6541 ttgatgagct ttggtgtgag agtgacttgc tctgcctaga gcttcctagg caacatccat
     6601 tccaggcagg gctcaacaga cagaaaagaa gaaaaaggaa ttcaagccaa ggtggtcaac
     6661 atgcacaatg gtaaaggcag gtgagaaggt atctggaggg acagatggtg ggaggtcagc
     6721 ccagctagaa ggtagcaaga cagggatggt ggcaggaagg tagccagagc cagggaggaa
     6781 atgtaaaggg cacagtcact gccctgcagg caacaggaag ttggcagagt tcaacagcta
     6841 tgcactcagt ttagttttgg agacggctct ctctggacca gcaggacagc ctattttcct
     6901 ttcatcagac actgtgaaaa tgttccctca gtgtgtgctt ttaatatgtt gtgtgtgtgt
     6961 gtgtgtgtgt gtgtgtgtgc tcactatttt gttgctggaa caaaatatgg agtgaatcat
     7021 gagactgagc tcttacgtaa aacccagggt ctctgttcta ccatggagca gggtcaacaa
     7081 ccttggcctc tgagccttca aggacagaat atgaaaggaa atcagggagc cagctcccat
     7141 tggtgtgggc ccaggagccg tctagaagtc taaaaacacc agagttgatc aaggaaggct
     7201 gtcactttgg aggttcaaaa ggagcatctc aaagaaaagg cacgaaaagg aaatctatga
     7261 gttactattc tcttttgatg ggcctcttcc caggtatatt tgagcatatc cccaggcccc
     7321 agaccccact ggtccgtctg gattcctatg gctctagtct cctatctctg aatggacttc
     7381 caggtagcct tcaggagtct atagcatagc caatcagcat gttgcattct atttcttcag
     7441 atcttggcca cttctaacag agagtggata gaggggagag gattaactac aaatcctagg
     7501 attcattctg ctgaggaaag aattgaagag ctgacagata aagatgacag tggtatctgt
     7561 cattataaat ggcgggaatt taaaaaaaaa attccaaggg aaaggaagtg tgtgaaaatt
     7621 caggccatgc tgagggaagg gctaatttat atccttattt tctcataatc caactgttct
     7681 taaagaaggt gatcttaaaa cagtgcacac aaaaagaaag tggggtacat ggatggaagt
     7741 aacattcttc aggtccgggg ggggggaggg taggggttgg ggaggcatgc agaagagctt
     7801 agatgatatg ggaaatggtc ctaagaaatt tagatgatat tttccccagg aaatctccca
     7861 agaaaaccca ctttcttctc acccgaccta cttatggggt aggcttattt tgagacaagc
     7921 aaaggaaaga tgccaaaatg aatcctcact tagctaatat cttcctgttg gtcaccagtg
     7981 gaatccaaat ggaaaaggta taaggtacaa atgagatacc atgaaaactg ccccaagttg
     8041 gccatgttta tgatggcttc aggttggaac acagctacat ctcaatctca tgttctttta
     8101 tccctactga tatgattatc atggatgagg tatgggtctg ttagcttcta gaaagccaca
     8161 gcaggtccct tttataggaa caaaagaggc tgcttgcttc aggtgactct cagtgtggtt
     8221 cttagcaatc aaagaccagc cagatgtcac ctactccatg gaaccagtag attcagtgct
     8281 gtggactcta aaacgtgagc tcactcttct acattcttga aatatctgtg actatggcca
     8341 gcactacttt actatcaagt aaacagatcc aaagggagaa ttcatttgcc catacaagca
     8401 aacttgtcct ggctttctga ccacagagac aaaattcttc catcattgta tctgagattt
     8461 tcccacatga ttactcttag caacagagac aagagcaaaa ctaatgactc agtagatatt
     8521 ggtaaagccc agtgcagaca atgataagct tcaaatttct ctagagcctc gtggtttaca
     8581 ttcatgatat attcggattc cattttctaa tttattctta gtagtttaaa tatgactgta
     8641 taaattcatt tttaaatctg tcctttatct catgtatctt tctgatcaat cttagggaat
     8701 atctctgacc aaggcatagt gcctgaccat gttccttcct cctgaggtta attctaaact
     8761 cacattcaca ccaacttaca ttccccttgg agcatctgtt gctgtggagg tatcctgact
     8821 gtactgctcc tgaggttcag caaaggtctc gtcttcttat ggagggttct gcaagatgcc
     8881 cactaacaga ctagaataat gagaacttac ctgcatggca tggtaaaggt tgagcccaca
     8941 aaaccctaaa aacaaagggg aagccagatg cagatttact cagaggatcc ttgaatgctg
     9001 aacgatgtct gttgtctctg tagagttcca tggcttctga tgtgggaaaa tcttaggaca
     9061 cacttcatga attttaaata cccttccctt cacatagctc aatacaatcc ctggatccta
     9121 tagcattcag cattcaagac agataccact aggaagtaca aactactatg gcatggtacg
     9181 ccatggtaag taggataaga acttgctcat tggtttgaac tccaactgca ccatttctgg
     9241 aatataaaat atcaggctga acaaggcatg gaaaaggaaa catacacaca tctttggcca
     9301 ggtttaaagg ggttaatctg gaaggctagg acaggaaaac aagaattcaa ttgaaaccca
     9361 gcatctactc agaaacaagg atgcttatag actgttgagc tcagtgataa attccatggg
     9421 gaaaaaataa agaaggccaa ccctccttaa cctgtagctg gccacccctg ctatcatagc
     9481 aggtcatcag caccaagcta aagcaagctc agtactgtaa acggtaggtc tagatccaaa
     9541 gctgaacatg aacaggatgc taatcttatg ctacaaggtc aatgagccaa gatccctaag
     9601 aaggagttga caacccaaag taaaagtcaa gtgaaaagat aaaacagaaa ttgcaatgtc
     9661 ctctataagc cttgatttgc ctttctttcc aattgaccaa tcaaagtgag gccctctgta
     9721 gtatctcact agttcttact cagagacaat aaaacagaag agtagagtaa attcggccat
     9781 agacaaatga gacttaacct ggtttgcata cggttgtgta caggtttctt atgtgaggtt
     9841 gtccctagag acctatcaaa aattatgaaa tgcaaaggct tcctttaact gaatgtggga
     9901 tcacctttga aatcctatcc tttttgaaca acaaagagag agcaagtgag agcaagagcg
     9961 agagcttgag agtgagagag tgagagagag tgagagagag tgagagagag agagagagag
    10021 agagagagag agagagggag agagagaggg agggagggag aggtggaaaa tagaaagtgg
    10081 gggagaaaga gaatagttct aaaccgagtt ttctctgaca cataatttag agtcatggag
    10141 ctgatatcct gagaaacaca gcacaaatat ctctgacata tctacatacg aataagctct
    10201 ttcaaattct tggtaaccac agatagactt ttgcatgaca gtggctatat aactgtattg
    10261 tggagaccaa gaactatctc ttgcgtatat cctgccaact tctacaagag gtagaaaagc
    10321 tatcaaaggg cccacattca cccctaaaat ccatccatga atattagtgt ccaacaggtg
    10381 gagtcggtac ccacattcct accccgcccc agacctggca ctactttatc tagcacgaat
    10441 acacctaaga gcttagtggt ggtgcacagc agctggtaca gaggacgggt aagaattggg
    10501 aggggagaca accttctaga aaggacttca gaaagtgatt aatcatgggg cttccttttg
    10561 gattggagag ccacgctagg tagtaaaatg ctaaccccgg ttctttgttg gactgtttag
    10621 agaatgaagt gtaggagtct tagaatattg aacagcaaag tgatggtatt cagggtattt
    10681 aatgtagatt gtgagtcttc agtgagaacc atttctaggg cctttgtgag cagaattgtg
    10741 ttagttcccc ccgcccccaa tcagtctcct aaagggacag cagaatacta gcatccatag
    10801 tcttcttaag actgtgggtg ataagacaaa gtcaaacata gtttgctacc ctggttaccc
    10861 ctgtgagcgg tgctgaggtg gatgtggaga ctgagtacct gtaagaaaga gctgagtgct
    10921 agggaggatc gctgcctgtt tgagtagctt cccaacagaa gccaggcatc cccatctcct
    10981 ggcctagggt gaagaaacag agtagccaag gtagatagac ttcagaccac tttcactttc
    11041 agtgggtgag tccttgaaac ttgaaggtca catttgaact gggaacctcc aaactgcaaa
    11101 ctaagtaggt aggtcatgct tggtttggga agtggaagcc ctctgttttt ctaatcaaat
    11161 catctcctcc tgtcaatcaa aaggcagctc cagctgcatc tcctagcctt atccaggatg
    11221 gttagcacca gtcacaggga gcagttcctt ggccatacat ctgatgctta ctgccatcac
    11281 tgagaagggc agccagcacc cagactcact ggccaccagg gccctcaatg acagacagaa
    11341 ccaataaaca tcgaggcagg agtcaaaaca aggctttgct tcatgcgtat tgtctccaaa
    11401 ggttaattca gccatcattc cctattcaag gcctgtagga aaagacttca aaagcacagg
    11461 gattctgttg acaccttatc ataatcattc ccagtacata tatttcatca ccaactggtt
    11521 cttgggctgg cccaggttag cctaggctaa ctcagatttg taatcaggat caaaaattat
    11581 attctccctt ctctcttcac tctatatcca agtagccaat taaaggtaca gttgtagcct
    11641 ctgtggttgc cttggctaca gatgaccata ctggtacacc tctccaggac ctatcatggc
    11701 attcccagtc tacactaggg aagcttacat tttcattgtc cggtggcata tgatatcaca
    11761 tgagaccaaa gtctccacac tatctgaaat ctccacaaat cccagtggcc tgcacttgta
    11821 cagtttgggt gtttgataga taaagcacgt atgagaagag aaaacaaaat aaatcaactt
    11881 cagcaaaaag aaagccagca ctgtgctgtc aatgtctttc ccccctttcc ctttttattt
    11941 ccagttctag cttcaaaaag cagaaggtaa ataatgtcag gtcaatgaat atcagatata
    12001 ttttttgact gtacattaaa gtgacgtgta atctttttac acctgcaagt ccatcttatt
    12061 tattcttgta aatgttccct gacaatgttt gtaatatggc tgtgtttaaa aaaaaatcta
    12121 tacaataaag ctgtgaccct gagaaaaaaa aaaaaaaaa
//
