LOCUS       NM_011218               6874 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type S (Ptprs),
            transcript variant 1, mRNA.
ACCESSION   NM_011218
VERSION     NM_011218.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6874)
  AUTHORS   Sclip,A. and Sudhof,T.C.
  TITLE     Combinatorial expression of neurexins and LAR-type phosphotyrosine
            phosphatase receptors instructs assembly of a cerebellar circuit
  JOURNAL   Nat Commun 14 (1), 4976 (2023)
   PUBMED   37591863
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6874)
  AUTHORS   Luo,F., Wang,J., Zhang,Z., You,Z., Bedolla,A.,
            Okwubido-Williams,F., Huang,L.F., Silver,J. and Luo,Y.
  TITLE     Inhibition of CSPG receptor PTPsigma promotes migration of newly
            born neuroblasts, axonal sprouting, and recovery from stroke
  JOURNAL   Cell Rep 40 (4), 111137 (2022)
   PUBMED   35905716
REFERENCE   4  (bases 1 to 6874)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6874)
  AUTHORS   Emperador-Melero,J., de Nola,G. and Kaeser,P.S.
  TITLE     Intact synapse structure and function after combined knockout of
            PTPdelta, PTPsigma, and LAR
  JOURNAL   Elife 10, e66638 (2021)
   PUBMED   33656439
  REMARK    GeneRIF: Intact synapse structure and function after combined
            knockout of PTPdelta, PTPsigma, and LAR.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6874)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   7  (bases 1 to 6874)
  AUTHORS   Wagner,J., Boerboom,D. and Tremblay,M.L.
  TITLE     Molecular cloning and tissue-specific RNA processing of a murine
            receptor-type protein tyrosine phosphatase
  JOURNAL   Eur J Biochem 226 (3), 773-782 (1994)
   PUBMED   7529177
REFERENCE   8  (bases 1 to 6874)
  AUTHORS   Ogata,M., Sawada,M., Kosugi,A. and Hamaoka,T.
  TITLE     Developmentally regulated expression of a murine receptor-type
            protein tyrosine phosphatase in the thymus
  JOURNAL   J Immunol 153 (10), 4478-4487 (1994)
   PUBMED   7963522
REFERENCE   9  (bases 1 to 6874)
  AUTHORS   Yan,H., Grossman,A., Wang,H., D'Eustachio,P., Mossie,K.,
            Musacchio,J.M., Silvennoinen,O. and Schlessinger,J.
  TITLE     A novel receptor tyrosine phosphatase-sigma that is highly
            expressed in the nervous system
  JOURNAL   J Biol Chem 268 (33), 24880-24886 (1993)
   PUBMED   8227050
REFERENCE   10 (bases 1 to 6874)
  AUTHORS   Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W.
  TITLE     Identification and typing of members of the protein-tyrosine
            phosphatase gene family expressed in mouse brain
  JOURNAL   Mol Biol Rep 16 (4), 241-248 (1992)
   PUBMED   1454056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177868.1, AK163915.1, D28530.1, BC083188.1 and AI845699.1.
            
            [WARNING] On Jul 22, 2024 this sequence was replaced by
            NM_011218.3.
            
            On Oct 26, 2007 this sequence version replaced NM_011218.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CJ177868.1         4-39
            37-915              AK163915.1         2-880
            916-4727            D28530.1           805-4616
            4728-6854           BC083188.1         3457-5583
            6855-6874           AI845699.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..6874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.32 cM"
     gene            1..6874
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /note="protein tyrosine phosphatase receptor type S"
                     /db_xref="GeneID:19280"
                     /db_xref="MGI:MGI:97815"
     exon            1..141
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            142..327
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..5960
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tissue-specific protein tyrosine phosphatase;
                     R-PTP-sigma; Receptor-type tyrosine-protein phosphatase
                     sigma; Receptor-type tyrosine-protein phosphatase S"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase S
                     isoform 1 precursor"
                     /protein_id="NP_035348.2"
                     /db_xref="CCDS:CCDS37664.1"
                     /db_xref="GeneID:19280"
                     /db_xref="MGI:MGI:97815"
                     /translation="MAPTWSPSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIG
                     VSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIDFDESSGAVLRIQPLRTPRDE
                     NVYECVAQNSVGEITIHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASG
                     NPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYS
                     SPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPED
                     DMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTENTATS
                     ITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAV
                     NSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVY
                     YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ
                     QGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYELLFREGDRGREVGRTFDPTTAF
                     VVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILV
                     SWRPPPPETHNGALVGYSVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVT
                     AVAYTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQI
                     RGYQVHYVRMEGAEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGAR
                     SKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPADAAEDPVLGYRLQFGREDAAPA
                     TLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEAAAALSIPEDAPRGFPQILGAA
                     GNVSAGSVLLRWLPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALT
                     LRGLRPETAYELRVRAHTRRGPGPFSPPLRYRLARDPVSPKNFKVKMIMKTSVLLSWE
                     FPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTV
                     TARTAFNMLSGKPSVAPKPDNDGFIVVYLPDGQSPVTVQNYFIVMVPLRKSRGGQFPV
                     LLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHPGNQKQYG
                     GFDNRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVI
                     GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRIN
                     FQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHSNLEANKPK
                     NRYANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWR
                     MVWEQRSATVVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTMELATFCVRTFS
                     LHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGV
                     GRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGC
                     GNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAHTSRFITASLPCNKFKN
                     RLVNILPYESSRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRA
                     LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV
                     TDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG
                     VGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLG
                     SFDHYAT"
     exon            328..473
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            474..615
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            616..804
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            805..915
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1185
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1767
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1901
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2046
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2352
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2546
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2664
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..3264
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3362
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3616
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3710
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3926
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4084
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4096
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4209
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4307
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4431
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4607
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4727
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4882
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..5168
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5347
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5348..5474
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5475..5600
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5601..5755
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5756..5891
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     exon            5892..6859
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6834..6839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /note="hexamer: ATTAAA"
     polyA_site      6858
                     /gene="Ptprs"
                     /gene_synonym="PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9;
                     R-PTP-S; RPTPsigma"
                     /note="major polyA site"
ORIGIN      
        1 aggggtgacg tcaccggctg ggggcgcgcg agccgcagtg gggttttgcc ccgcccgcca
       61 ggcagctcgg gccgcgcgca cacgcggagc cgccggagcc cgggccgacc cggtgccggg
      121 agcagcatgc ggagcccgca gacgctgccc ctctggacac ctcagcctga ggcctctccg
      181 tgagtcacgg gggtaccatc ccccaccagg gcagaggctg gaggccactg ccaagcatgg
      241 cgcccacctg gagtcccagc gtggtgtctg tggtgggtcc tgtggggctc ttcctcgtac
      301 tgctggccag aggatgcttg gctgaagaac cacccaggtt tatcagagag cccaaggatc
      361 agattggagt gtcgggaggc gtggcctcct tcgtgtgcca ggccacgggt gatcctaagc
      421 cacgggtgac ctggaacaag aagggcaaga aagtgaactc acagcgcttc gagaccattg
      481 actttgacga gagctctggg gcggtcctga ggatccagcc acttcggacg cctcgggatg
      541 agaacgtgta cgagtgtgtg gcccagaact cggtgggcga aatcacaatt catgcaaagc
      601 tcaccgtcct tcgagaggac cagctgcctc ctggcttccc caacattgac atgggccccc
      661 agttgaaggt tgtagagcgc acacgcacag ccaccatgct ctgtgctgcc agcgggaacc
      721 cggaccctga gatcacctgg tttaaggact tcctgcctgt ggaccccagt gccagcaacg
      781 ggcggatcaa gcagcttcga tcaggtgccc tgcagattga gagcagcgag gagacagacc
      841 agggcaagta cgagtgtgtg gccaccaaca gcgctggggt gcgctactca tcacctgcca
      901 acctctacgt gcgagtccgc cgtgtggccc cacgcttctc catcctgccc atgagccacg
      961 agatcatgcc cggtgggaat gtgaatatca cttgtgtggc cgtgggctca cccatgccct
     1021 acgtgaaatg gatgcagggg gccgaggacc tgacgcctga ggatgacatg cccgtgggtc
     1081 ggaatgttct agaactcacg gatgtcaagg actcagctaa ctacacttgt gtggccatgt
     1141 ccagcctggg tgtgatcgag gccgtggccc agatcactgt aaaatctctc cccaaagccc
     1201 ctgggactcc tgtggtgacg gagaacactg ccaccagtat cactgtcaca tgggactcgg
     1261 gcaaccctga ccccgtgtcc tactacgtaa ttgagtataa gtccaaaagc caggatgggc
     1321 cgtatcagat caaagaagac atcaccacca cgcgctacag catcggaggc ctgagcccca
     1381 attctgagta tgagatctgg gtgtcagctg tcaactccat tggccagggc cctcccagtg
     1441 aatcggtggt gacccgcaca ggtgagcagg caccagccag cgctcccagg aatgttcagg
     1501 cccgcatgct cagcgccacc accatgatcg tgcagtggga ggagcctgtg gagcccaatg
     1561 gcctgatccg tggctaccgt gtctactata ccatggagcc ggaacaccca gtgggcaact
     1621 ggcagaaaca caatgtggac gacagtctcc tgaccactgt gggcagcctg ctggaagacg
     1681 agacctacac cgtgcgcgtg ctcgccttca cgtcggtggg cgacggacca ctgtcagacc
     1741 ccatccaggt caagacccag cagggagttc ctggccagcc catgaacttg cgggctgagg
     1801 ccaagtcaga gaccagcatt gggctctcgt ggagtgcacc acgacaggag agtgtcatta
     1861 agtatgaact gctcttccgg gagggcgacc gaggccgaga ggtggggcga accttcgacc
     1921 caaccacagc ctttgtggtg gaggacctca agcccaatac ggagtatgcg ttccggctgg
     1981 cggcgcgctc gccgcagggc ctgggcgcct tcaccgcggt cgtgcgccag cgcacgctgc
     2041 aggccaaacc gtcagccccc cctcaagacg ttaagtgcac cagcttgcgc tccacggcca
     2101 tattggtaag ttggcgcccg ccaccgccag aaactcacaa cggggccctc gtgggctaca
     2161 gcgtccgcta ccgaccgctg ggctcagagg acccggaccc caaggaggtg aacaacatac
     2221 ccccgaccac cactcagatc cttctggaag ctttggagaa atggacggag taccgtgtca
     2281 ccgccgtggc ttacacagag gtgggaccag ggcccgagag ctcgcccgtg gtcgtccgca
     2341 ccgatgagga cgtgcccagc gcgcccccgc ggaaggtgga ggcggaggcg ctcaacgcca
     2401 cagccatccg agtgctgtgg cgctcgccca cgcccggccg gcagcacggg cagatccgcg
     2461 gctaccaggt ccactatgtg cgcatggagg gtgccgaggc ccgcgggcca ccgcgcatca
     2521 aggacatcat gctggcggat gcccaggaaa tggtgataac gaacctccag cctgagactg
     2581 cttactctat cacagtagcc gcgtatacca tgaaaggcga tggcgctcgc agcaaaccga
     2641 aggtggtggt gaccaaggga gcagtgctgg gccgccccac cctgtcggtg cagcagaccc
     2701 ccgagggcag cctgctggcg cgctgggagc cccccgcgga cgcggccgag gacccggtgc
     2761 ttggctaccg cctgcagttt gggcgcgaag acgcggcccc ggccacgttg gagctggctg
     2821 cgtgggagcg gcggttcgcg gcgcctgcac acaagggcgc cacctatgtg ttccggctgg
     2881 cagcgcgggg ccgcgcgggg ttgggcgagg aggccgcggc agcgctgagc atccccgagg
     2941 acgctccgcg cggcttcccg cagatcttgg gcgccgcggg caacgtgtcc gcgggctccg
     3001 tgctactgcg ctggctgcca cccgtgcccg ccgagcgcaa cggcgccatc atcaagtaca
     3061 cggtgtccgt gcgggaggcc ggcgcccctg ggcccgcgac cgagacggag ctggcggcgg
     3121 ccgcccagcc gggggccgag acagcgctca cgctgcgagg gctgcggccg gagacggcct
     3181 acgagttacg cgtgcgcgca cacacgcgtc gcggcccggg ccccttctca cccccgctgc
     3241 gctacaggct cgcgcgggac ccagtctccc caaagaactt caaggtgaag atgatcatga
     3301 agacttcagt gctgctgagc tgggagttcc ccgacaacta taactcaccc acaccctaca
     3361 agattcagta caatgggctc accctggatg tggacggccg cacgaccaag aagctgatca
     3421 cacacctcaa gccacacacc ttctataatt tcgtgctcac caaccgtggc agcagcctgg
     3481 ggggcctgca gcagacggtc actgccagga ccgcctttaa catgctcagt ggcaagccta
     3541 gcgtcgcccc gaagcccgac aatgacggtt tcatcgtggt ctacctgcct gatggccaga
     3601 gtcctgtgac cgtgcagaac tacttcattg tgatggtccc acttcggaag tctcgaggtg
     3661 gccagttccc tgtcctacta ggtagtccag aggacatgga tctggaggag ctcatccagg
     3721 acatctcccg gctgcagagg cgcagcctgc gccactccag acagctggag gtgcctcggc
     3781 cctacatcgc cgctcgattc tccatcctgc cagctgtctt ccatcctggg aaccagaagc
     3841 aatatggtgg ctttgacaac aggggcttgg agccaggcca ccgctatgtc ctctttgtgc
     3901 ttgctgtgtt gcagaagaat gagcctacat ttgcagccag tcccttctca gaccccttcc
     3961 agctggacaa cccggaccct cagcccattg tggacggcga ggagggcctc atctgggtga
     4021 ttgggcctgt gctggccgtg gtcttcatca tctgcatcgt gattgccatc ctgctgtaca
     4081 agaacaaacc tgacagcaaa cgcaaggact cagagccccg caccaaatgc ttactgaaca
     4141 atgccgacct tgccccccat caccccaagg accctgtgga aatgcgacgc atcaacttcc
     4201 agacaccagg tatgctcagc cacccaccca tccccatcac agacatggcg gagcacatgg
     4261 agagactcaa agccaacgac agcctgaagc tctcccagga gtacgagtcc attgaccccg
     4321 ggcagcaatt cacgtgggaa cattcgaacc tggaggccaa caagcccaag aaccgctatg
     4381 ccaacgtcat cgcctatgac cactcacgag tcatcctgca gcccctagaa ggcatcatgg
     4441 gtagtgatta catcaatgcc aactatgtgg acggctaccg gcggcagaat gcatacattg
     4501 ccacgcaggg gcccctgcct gagacctttg gggacttctg gcggatggtg tgggagcagc
     4561 gatcggccac tgtggtcatg atgacgcgac tggaggagaa atcacggatc aaatgtgacc
     4621 aatactggcc taaccgaggc accgagacat acggcttcat ccaggtcacc ctactagata
     4681 ccatggagct ggctaccttc tgcgtcagga ctttttctct acacaagaat ggctctagcg
     4741 agaagcgtga ggtgcgacat ttccagttca cggcatggcc cgaccacggg gtacctgagt
     4801 accccacgcc cttcctggca ttcctgcgaa gagtcaagac ctgcaacccg cctgatgctg
     4861 gccccattgt ggtccactgc agcgcgggtg tggggcgcac tggctgcttc atcgtaattg
     4921 acgccatgct agagcgcatc aagacagaga agaccgtgga tgtgtatgga catgtgacac
     4981 tcatgcggtc gcagcgcaac tacatggtgc agacagagga tcagtatggc ttcatccacg
     5041 aggcgctgct ggaggctgtg ggctgcggca ataccgaggt ccctgctcgc agcctctaca
     5101 cctacatcca gaagctggcc caggtggagc ctggcgagca cgtcacgggc atggagcttg
     5161 agttcaagag gctcgccagt tccaaggcac acacttcgcg cttcatcacc gccagcctgc
     5221 cttgcaacaa gtttaagaac cgactggtga acatcctgcc gtacgagagc tcgcgtgtct
     5281 gcctgcagcc catccgcggt gtggagggct ctgactacat caatgccagc tttatcgacg
     5341 gctatagaca gcagaaagcc tacattgcaa cacaggggcc actggcagag accacagagg
     5401 acttctggcg agctctgtgg gagaacaact ctactattgt cgtaatgctc accaagctcc
     5461 gagaaatggg ccgggaaaag tgccaccagt actggccagc cgagcgctct gcccgctacc
     5521 agtactttgt ggttgacccg atggcagagt ataacatgcc acagtacatt ctgcgtgagt
     5581 ttaaggtcac agatgcccgg gatggccagt cccggaccgt ccgacagttc cagttcacgg
     5641 actggccaga gcagggtgca cccaagtcag gggaaggctt cattgacttc atcggccaag
     5701 tgcataagac caaggagcag tttggccagg acggacccat ctcagtgcac tgcagcgccg
     5761 gagtgggcag gaccggagtg ttcatcaccc tgagcatcgt gcttgagcgg atgcgctacg
     5821 agggcgtggt ggacattttc cagacagtga aggtgcttcg gacccagagg cctgccatgg
     5881 tgcagacaga ggacgagtac cagttctgct tccaggcggc tttggaatac ctgggcagtt
     5941 ttgatcatta tgcaacataa gccatgggcc ccgcccaaca cctcagccct gcgccaagtg
     6001 ccctggatgt gagcctaggc ccgccgctgg gcaggatgcg gcccagggag acctcctctt
     6061 cgcggagaca ggcgctgcct tcctcattcc cttctgattc caaaacgagg ttccagggtg
     6121 gggggttggg gtggagagag aaggagccac tgctccccag gctggggtca cacagggacc
     6181 gacctctgct tccgcactcc cctgcctgcc ttttggcaac attttttttc ttattttttt
     6241 ttaatagtgt atattttttt tctttttctt tttttctttt ttttttttaa gaaaaaaaca
     6301 aaatcgtgcc ggtcaaaact ttgaaaaaga aacaagatca ctgtttgtgc ctctgtggga
     6361 ggcctatttt ttcatagtta gtgtgccgtg tggcggctat gtgcggccac ttcgacggct
     6421 tctgtgtgtg catctttccc acatgcccga cactgccccc atccccatgt gaatggtgcg
     6481 cttagttttt atttttaacc tttttacttt ttttttaatc aatcttcaga catatcagat
     6541 atggagggtg aggcgctggg ggcactcggg ccagactaca gggacatggc caccaaggac
     6601 acagtggctg gccttgctgc tccagtccct ggcacaccag ggagggtcct cgtctactca
     6661 tgacctctgt gccccgcatg gaggacctgg gactacggga cacttggggg atatccaacc
     6721 ccctggagca actgaggtct ctctttgtag gagagtgggt cagtactcgt ccccgctgtt
     6781 ttttgggcag aagcagcagg tgacgcccct gtatgtagat aaaccaactt tgtattaaag
     6841 aaagattcgt ccgacctaga aaaaaaaaaa aaaa
//
