LOCUS       NM_011217               3466 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type R (Ptprr),
            transcript variant 1, mRNA.
ACCESSION   NM_011217
VERSION     NM_011217.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3466)
  AUTHORS   Erkens,M., Tanaka-Yamamoto,K., Cheron,G., Marquez-Ruiz,J.,
            Prigogine,C., Schepens,J.T., Nadif Kasri,N., Augustine,G.J. and
            Hendriks,W.J.
  TITLE     Protein tyrosine phosphatase receptor type R is required for
            Purkinje cell responsiveness in cerebellar long-term depression
  JOURNAL   Mol Brain 8, 1 (2015)
   PUBMED   25571783
  REMARK    GeneRIF: These findings indicate an important role for PTPRR in
            maintaining low basal mitogen-activated protein kinase activity in
            Purkinje cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3466)
  AUTHORS   Erkens,M., Bakker,B., van Duijn,L.M., Hendriks,W.J. and Van der
            Zee,C.E.
  TITLE     Protein tyrosine phosphatase receptor type R deficient mice exhibit
            increased exploration in a new environment and impaired novel
            object recognition memory
  JOURNAL   Behav Brain Res 265, 111-120 (2014)
   PUBMED   24556203
  REMARK    GeneRIF: The data of this study disclosed a distinct role for PTPRR
            in recognition memory and exploration of a new environment.
REFERENCE   3  (bases 1 to 3466)
  AUTHORS   Chesini,I.M., Debyser,G., Croes,H., Ten Dam,G.B., Devreese,B.,
            Stoker,A.W. and Hendriks,W.J.
  TITLE     PTPBR7 binding proteins in myelinating neurons of the mouse brain
  JOURNAL   Int J Biol Sci 7 (7), 978-991 (2011)
   PUBMED   21850207
  REMARK    GeneRIF: Results support the suggested link between PTPRR isoforms
            and cerebellar calcium ion homeostasis, and suggest an additional
            role in the process of cell-cell adhesion
REFERENCE   4  (bases 1 to 3466)
  AUTHORS   Reinhard,J., Horvat-Brocker,A., Illes,S., Zaremba,A., Knyazev,P.,
            Ullrich,A. and Faissner,A.
  TITLE     Protein tyrosine phosphatases expression during development of
            mouse superior colliculus
  JOURNAL   Exp Brain Res 199 (3-4), 279-297 (2009)
   PUBMED   19727691
REFERENCE   5  (bases 1 to 3466)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   6  (bases 1 to 3466)
  AUTHORS   Pulido,R., Zuniga,A. and Ullrich,A.
  TITLE     PTP-SL and STEP protein tyrosine phosphatases regulate the
            activation of the extracellular signal-regulated kinases ERK1 and
            ERK2 by association through a kinase interaction motif
  JOURNAL   EMBO J 17 (24), 7337-7350 (1998)
   PUBMED   9857190
REFERENCE   7  (bases 1 to 3466)
  AUTHORS   McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H.
  TITLE     Identification and characterization of RPTP rho, a novel RPTP
            mu/kappa-like receptor protein tyrosine phosphatase whose
            expression is restricted to the central nervous system
  JOURNAL   Brain Res Mol Brain Res 56 (1-2), 9-21 (1998)
   PUBMED   9602027
REFERENCE   8  (bases 1 to 3466)
  AUTHORS   McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D.,
            Chiu,I.M., Burghes,A.H. and Rotter,A.
  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
            fibroblast growth factor (FGF-1) transcripts delineate a
            rostrocaudal boundary in the granule cell layer of the murine
            cerebellar cortex
  JOURNAL   J Comp Neurol 391 (4), 444-455 (1998)
   PUBMED   9486824
REFERENCE   9  (bases 1 to 3466)
  AUTHORS   Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T.
  TITLE     cDNA cloning and characterization of a novel receptor-type protein
            tyrosine phosphatase expressed predominantly in the brain
  JOURNAL   J Biol Chem 270 (5), 2337-2343 (1995)
   PUBMED   7836467
REFERENCE   10 (bases 1 to 3466)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028054.1 and D31898.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_011217.3.
            
            On Jun 19, 2009 this sequence version replaced NM_011217.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D31898.1, SRR1660815.249956.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AK028054.1         2-49
            49-2882             D31898.1           12-2845
            2883-3466           D31898.1           2847-3430
FEATURES             Location/Qualifiers
     source          1..3466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 64.01 cM"
     gene            1..3466
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /note="protein tyrosine phosphatase receptor type R"
                     /db_xref="GeneID:19279"
                     /db_xref="MGI:MGI:109559"
     exon            1..450
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..2363
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /EC_number="3.1.3.48"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase R;
                     protein-tyrosine-phosphatase-SL; R-PTP-R; phosphotyrosine
                     phosphatase 13; STEP-like PTPase"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase R
                     isoform a precursor"
                     /protein_id="NP_035347.1"
                     /db_xref="CCDS:CCDS24182.1"
                     /db_xref="GeneID:19279"
                     /db_xref="MGI:MGI:109559"
                     /translation="MRRAVGFPALCLLLNLHAAGCFSRNNDHFLAIRQKKSWKPVFIY
                     DHSQDIKKSLDIAQEAYKHNYHSPSEVQISKHHQIINSAFPRPAYDPSLNLLAESDQD
                     LEIENLPIPAANVIVVTLQMDITKLNITLLRIFRQGVAAALGLLPQQVHINRLIEKKN
                     QVELFVSPGNRKPGETQALQAEEVLRSLNVDGLHQSLPQFGITDVAPEKNVLQGQHEA
                     DKIWSKEGFYAVVIFLSIFIIIVTCLMIIYRLKERLQLSLRQDKEKNQEIHLSPIARQ
                     QAQSEAKTTHSMVQPDQAPKVLNVVVDPQGQCTPEIRNSTSTSVCPSPFRMKPIGLQE
                     RRGSNVSLTLDMSSLGSVEPFVAVSTPREKVAMEYLQSASRVLTRSQLRDVVASSHLL
                     QSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNITDSLSTYINANY
                     IRGYSGKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKR
                     GIYGKVEVLVTGVTECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQL
                     MLDVEEDRLASEGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRV
                     DRGGMVQTSEQYEFVHHALCLFESRLSPETVE"
     exon            451..746
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            747..860
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1016
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1127
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1396
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1583
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1668
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1748
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1886
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1997
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2155
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2269
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..3466
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcctcgg tgtgtctcgg ctgctgctag ctgcacaggc agcagaggcg ctgcctggct
       61 cggaggctgg cactagagtc caccccactg tcaccaccgg ctgcgggctt ccagaaggcc
      121 aaactctcac ctcttctgag cgtcttgccc ccatcagcct cgagtcccca tctcccgcag
      181 catcctactc tcgtatctcc ccatcccttg cggagaggaa gcaggtgctc ggttctgtag
      241 gcacgccaca gactgctctg tgtaccccag cggaggaccc tgtcatcgga tgcccgggat
      301 caaaggactc ttggcagtgg ttctctcaaa tagcacttag cctagagtgg ggttgcggcg
      361 gagtttctcc tctgaccctc aatgcacaca ctatgaggag agcggtcggc ttccctgcgc
      421 tgtgcctgct tcttaatctt catgctgcag gttgtttttc cagaaacaat gatcactttt
      481 tggctattcg tcaaaagaag agttggaagc cggtgttcat ttatgaccat tcacaggata
      541 tcaagaagag cctggacatc gcacaagagg catacaaaca taactaccac tccccttccg
      601 aagttcaaat aagcaaacat caccagatta ttaattcagc atttcctaga cctgcatatg
      661 acccgtctct taatctgttg gctgagtctg atcaagatct tgaaatagaa aatctcccaa
      721 ttccagcagc aaatgtgatt gtggtgacac tgcaaatgga tataaccaag ctgaacataa
      781 ccctgcttcg gatcttccgc caaggagtag ctgcagccct gggactctta cctcagcaag
      841 tgcacattaa ccggctcatt gaaaagaaga accaggttga gttgtttgtg tctcccggaa
      901 accggaaacc aggagaaacg caggccctgc aggctgagga agtgctgcgt tccctcaatg
      961 tggatggttt gcatcagagt ttaccacagt ttggaattac agacgtcgcc cctgagaaaa
     1021 atgttttaca agggcagcac gaagcagaca agatctggag caaagaagga ttttacgctg
     1081 tcgtcatctt cctcagcatc tttatcatca tagtaacctg tttgatgatt atttacaggt
     1141 taaaagaaag gcttcagctt tccttaagac aagataaaga gaaaaaccag gagatccacc
     1201 tatcacccat tgcacggcag caagcacaat cggaggccaa gacgacccac agcatggtcc
     1261 agcccgatca ggcgccaaag gtgctgaacg tggttgtgga ccctcaaggc caatgcactc
     1321 ctgagattcg aaacagcacc tccacctctg tctgcccttc tcccttcaga atgaagccca
     1381 taggactcca ggagcgacga ggttccaatg tatctcttac gctggacatg agtagcctgg
     1441 gcagtgtgga accctttgtg gccgtctcaa ccccccggga gaaggtagcc atggaatacc
     1501 tgcagtcagc cagccgagtt ctcacacggt cacagctgag ggacgtcgtg gcaagttccc
     1561 acctacttca aagtgaattc atggaaatac caatgaattt tgtggatccc aaagaaattg
     1621 atattccacg tcacggaact aaaaatcgtt ataagaccat tttgccaaat cccctcagca
     1681 gagtgtgctt aagaccaaaa aatataaccg attccttgag tacttacata aatgctaact
     1741 atattcgggg ctacagtggt aaggagaaag ccttcattgc cacccagggc cccatgatca
     1801 acactgtgaa tgacttctgg cagatggtgt ggcaagaaga cagtcccgtg attgtgatga
     1861 tcacgaaact caaagagaaa aatgagaaat gtgtgctcta ctggccagaa aagagaggga
     1921 tttacggcaa ggttgaggtt ctggtcaccg gtgtgaccga atgtgataac tacaccatcc
     1981 gcaacctcgt cttaaagcaa ggaagtcaca cccaacatgt gaagcactac tggtacactt
     2041 catggccgga tcataagact ccagacagtg cccagcccct tctgcagctc atgttggatg
     2101 tggaagaaga cagactggcc tctgaaggcc gagggcctgt ggttgtccac tgcagtgcgg
     2161 ggattgggag aactgggtgt ttcatcgcta catccattgg ctgtcaacaa ttgaaagaag
     2221 aaggagttgt agacgcacta agtattgtct gccagcttcg tgtagacagg ggtggtatgg
     2281 tccaaaccag cgagcagtat gaatttgtgc accatgctct gtgcctgttc gagagcagac
     2341 tttcaccaga aactgtcgag tgactccgaa gatttaccag agtgtcaatc tctcaccggg
     2401 tgattcatca aattacctac caagagctcc aagaggggct ccctgcaatg gacgaggagg
     2461 ctctaaagcc agcctaaggc actgattgtg gaagatctgg caacatgaaa gattgccagc
     2521 ctttgtgtat aggactgcgt tcgtaggcat ccccccagtt attctgaagg tcctgtgctg
     2581 atggaggcat gacagtcctc tcgcagcctg aggagggttt tgttctgtct gtgtcgcctc
     2641 tccgccgcac agaatcgatg tgtgtgatat tcagagactg gaggagctgc tgacattatc
     2701 ctgtgtttag atgctttaat gttcataaag cctgtcttgt gactggactg tcagctgtcc
     2761 aactgtccct gttgtaagtg ctattaacta tctcagttac cagaatcttg ctgctcaagt
     2821 ttcgagtgat cgacaatgga tttttaacca agacattttt gtttttggaa aaaaaaaaaa
     2881 aatcaaatgc agtgactatt ttatatggac atgtgtcttg attatatcta ttaagtgtgc
     2941 atttatagta tctcctatgg atcaattaca gagcacaatg actgtcgttg gatatatatg
     3001 tatatgtata tgtatattat atgtatatgt acacatatat attctattat taggcataca
     3061 agtggctcct gttccacaat actaactact atatttctac attgtgactt gttttacttt
     3121 aaaaggggat aaacaaattt atagcaacta taaagtatca ataattttaa atactcatct
     3181 ctcttttact aagaagggat ttttaaatat ggtgtctacc tggtatctct ctcccaataa
     3241 gaagcaggtg cctttgggga atgctccaac ctgtttcatc cccaaaagtt tttccgagga
     3301 cactgtcatg cacgacctca catttctaaa agacctcctt cctcaagaga caaatgaagg
     3361 caaaataatc acactcagca aacaggagat gttctgctca gatatgaatt ttcaatgcag
     3421 caaagctgac tttctttcgt actcccaata aatgactctt aacagt
//
