LOCUS       NM_001161838            2817 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type R (Ptprr),
            transcript variant 3, mRNA.
ACCESSION   NM_001161838
VERSION     NM_001161838.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Erkens,M., Tanaka-Yamamoto,K., Cheron,G., Marquez-Ruiz,J.,
            Prigogine,C., Schepens,J.T., Nadif Kasri,N., Augustine,G.J. and
            Hendriks,W.J.
  TITLE     Protein tyrosine phosphatase receptor type R is required for
            Purkinje cell responsiveness in cerebellar long-term depression
  JOURNAL   Mol Brain 8, 1 (2015)
   PUBMED   25571783
  REMARK    GeneRIF: These findings indicate an important role for PTPRR in
            maintaining low basal mitogen-activated protein kinase activity in
            Purkinje cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Erkens,M., Bakker,B., van Duijn,L.M., Hendriks,W.J. and Van der
            Zee,C.E.
  TITLE     Protein tyrosine phosphatase receptor type R deficient mice exhibit
            increased exploration in a new environment and impaired novel
            object recognition memory
  JOURNAL   Behav Brain Res 265, 111-120 (2014)
   PUBMED   24556203
  REMARK    GeneRIF: The data of this study disclosed a distinct role for PTPRR
            in recognition memory and exploration of a new environment.
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Chesini,I.M., Debyser,G., Croes,H., Ten Dam,G.B., Devreese,B.,
            Stoker,A.W. and Hendriks,W.J.
  TITLE     PTPBR7 binding proteins in myelinating neurons of the mouse brain
  JOURNAL   Int J Biol Sci 7 (7), 978-991 (2011)
   PUBMED   21850207
  REMARK    GeneRIF: Results support the suggested link between PTPRR isoforms
            and cerebellar calcium ion homeostasis, and suggest an additional
            role in the process of cell-cell adhesion
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Reinhard,J., Horvat-Brocker,A., Illes,S., Zaremba,A., Knyazev,P.,
            Ullrich,A. and Faissner,A.
  TITLE     Protein tyrosine phosphatases expression during development of
            mouse superior colliculus
  JOURNAL   Exp Brain Res 199 (3-4), 279-297 (2009)
   PUBMED   19727691
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Pulido,R., Zuniga,A. and Ullrich,A.
  TITLE     PTP-SL and STEP protein tyrosine phosphatases regulate the
            activation of the extracellular signal-regulated kinases ERK1 and
            ERK2 by association through a kinase interaction motif
  JOURNAL   EMBO J 17 (24), 7337-7350 (1998)
   PUBMED   9857190
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H.
  TITLE     Identification and characterization of RPTP rho, a novel RPTP
            mu/kappa-like receptor protein tyrosine phosphatase whose
            expression is restricted to the central nervous system
  JOURNAL   Brain Res Mol Brain Res 56 (1-2), 9-21 (1998)
   PUBMED   9602027
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D.,
            Chiu,I.M., Burghes,A.H. and Rotter,A.
  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
            fibroblast growth factor (FGF-1) transcripts delineate a
            rostrocaudal boundary in the granule cell layer of the murine
            cerebellar cortex
  JOURNAL   J Comp Neurol 391 (4), 444-455 (1998)
   PUBMED   9486824
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T.
  TITLE     cDNA cloning and characterization of a novel receptor-type protein
            tyrosine phosphatase expressed predominantly in the brain
  JOURNAL   J Biol Chem 270 (5), 2337-2343 (1995)
   PUBMED   7836467
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV657487.1, CJ059486.1 and D31898.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_001161838.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (c) is
            shorter at the N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.190013.1,
                                           SRR1660819.190014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                DV657487.1         1-60
            61-492              CJ059486.1         1-432
            493-2233            D31898.1           1105-2845
            2234-2817           D31898.1           2847-3430
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 64.01 cM"
     gene            1..2817
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /note="protein tyrosine phosphatase receptor type R"
                     /db_xref="GeneID:19279"
                     /db_xref="MGI:MGI:109559"
     exon            1..478
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..1714
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /EC_number="3.1.3.48"
                     /note="isoform c is encoded by transcript variant 3;
                     receptor-type tyrosine-protein phosphatase R;
                     protein-tyrosine-phosphatase-SL; R-PTP-R; phosphotyrosine
                     phosphatase 13; STEP-like PTPase"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase R
                     isoform c"
                     /protein_id="NP_001155310.1"
                     /db_xref="CCDS:CCDS48693.1"
                     /db_xref="GeneID:19279"
                     /db_xref="MGI:MGI:109559"
                     /translation="MIIYRLKERLQLSLRQDKEKNQEIHLSPIARQQAQSEAKTTHSM
                     VQPDQAPKVLNVVVDPQGQCTPEIRNSTSTSVCPSPFRMKPIGLQERRGSNVSLTLDM
                     SSLGSVEPFVAVSTPREKVAMEYLQSASRVLTRSQLRDVVASSHLLQSEFMEIPMNFV
                     DPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNITDSLSTYINANYIRGYSGKEKAFI
                     ATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVTG
                     VTECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASE
                     GRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRVDRGGMVQTSEQY
                     EFVHHALCLFESRLSPETVE"
     exon            479..747
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            748..934
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1019
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1099
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1237
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1348
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1506
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1620
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..2817
                     /gene="Ptprr"
                     /gene_synonym="Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggagggg actcggagta cagagagctt tggtaacagt tcctcggcac agaaaagcac
       61 agagctccct cacctgtgaa ccaggtagtt tccaggagag gttgtgccgg acctggagga
      121 aggcaagaac tcaggagcct gtcccccatg cccacccctg cccttacagg atctcctgac
      181 atcgaggaca gctgtccatc catccgtgcc tgagcagtta gggcagcagc tgtggcagcg
      241 ctgggtggag gtgtgtttta ctacaccgag tggaatcgag ctaaaaaaaa ctatgttgac
      301 agtctgataa gagcttgttt cccccggctc tcctttaacc ccgggctttc tgttttgctt
      361 tcgaaagaaa aatgttttac aagggcagca cgaagcagac aagatctgga gcaaagaagg
      421 attttacgct gtcgtcatct tcctcagcat ctttatcatc atagtaacct gtttgatgat
      481 tatttacagg ttaaaagaaa ggcttcagct ttccttaaga caagataaag agaaaaacca
      541 ggagatccac ctatcaccca ttgcacggca gcaagcacaa tcggaggcca agacgaccca
      601 cagcatggtc cagcccgatc aggcgccaaa ggtgctgaac gtggttgtgg accctcaagg
      661 ccaatgcact cctgagattc gaaacagcac ctccacctct gtctgccctt ctcccttcag
      721 aatgaagccc ataggactcc aggagcgacg aggttccaat gtatctctta cgctggacat
      781 gagtagcctg ggcagtgtgg aaccctttgt ggccgtctca accccccggg agaaggtagc
      841 catggaatac ctgcagtcag ccagccgagt tctcacacgg tcacagctga gggacgtcgt
      901 ggcaagttcc cacctacttc aaagtgaatt catggaaata ccaatgaatt ttgtggatcc
      961 caaagaaatt gatattccac gtcacggaac taaaaatcgt tataagacca ttttgccaaa
     1021 tcccctcagc agagtgtgct taagaccaaa aaatataacc gattccttga gtacttacat
     1081 aaatgctaac tatattcggg gctacagtgg taaggagaaa gccttcattg ccacccaggg
     1141 ccccatgatc aacactgtga atgacttctg gcagatggtg tggcaagaag acagtcccgt
     1201 gattgtgatg atcacgaaac tcaaagagaa aaatgagaaa tgtgtgctct actggccaga
     1261 aaagagaggg atttacggca aggttgaggt tctggtcacc ggtgtgaccg aatgtgataa
     1321 ctacaccatc cgcaacctcg tcttaaagca aggaagtcac acccaacatg tgaagcacta
     1381 ctggtacact tcatggccgg atcataagac tccagacagt gcccagcccc ttctgcagct
     1441 catgttggat gtggaagaag acagactggc ctctgaaggc cgagggcctg tggttgtcca
     1501 ctgcagtgcg gggattggga gaactgggtg tttcatcgct acatccattg gctgtcaaca
     1561 attgaaagaa gaaggagttg tagacgcact aagtattgtc tgccagcttc gtgtagacag
     1621 gggtggtatg gtccaaacca gcgagcagta tgaatttgtg caccatgctc tgtgcctgtt
     1681 cgagagcaga ctttcaccag aaactgtcga gtgactccga agatttacca gagtgtcaat
     1741 ctctcaccgg gtgattcatc aaattaccta ccaagagctc caagaggggc tccctgcaat
     1801 ggacgaggag gctctaaagc cagcctaagg cactgattgt ggaagatctg gcaacatgaa
     1861 agattgccag cctttgtgta taggactgcg ttcgtaggca tccccccagt tattctgaag
     1921 gtcctgtgct gatggaggca tgacagtcct ctcgcagcct gaggagggtt ttgttctgtc
     1981 tgtgtcgcct ctccgccgca cagaatcgat gtgtgtgata ttcagagact ggaggagctg
     2041 ctgacattat cctgtgttta gatgctttaa tgttcataaa gcctgtcttg tgactggact
     2101 gtcagctgtc caactgtccc tgttgtaagt gctattaact atctcagtta ccagaatctt
     2161 gctgctcaag tttcgagtga tcgacaatgg atttttaacc aagacatttt tgtttttgga
     2221 aaaaaaaaaa aaatcaaatg cagtgactat tttatatgga catgtgtctt gattatatct
     2281 attaagtgtg catttatagt atctcctatg gatcaattac agagcacaat gactgtcgtt
     2341 ggatatatat gtatatgtat atgtatatta tatgtatatg tacacatata tattctatta
     2401 ttaggcatac aagtggctcc tgttccacaa tactaactac tatatttcta cattgtgact
     2461 tgttttactt taaaagggga taaacaaatt tatagcaact ataaagtatc aataatttta
     2521 aatactcatc tctcttttac taagaaggga tttttaaata tggtgtctac ctggtatctc
     2581 tctcccaata agaagcaggt gcctttgggg aatgctccaa cctgtttcat ccccaaaagt
     2641 ttttccgagg acactgtcat gcacgacctc acatttctaa aagacctcct tcctcaagag
     2701 acaaatgaag gcaaaataat cacactcagc aaacaggaga tgttctgctc agatatgaat
     2761 tttcaatgca gcaaagctga ctttctttcg tactcccaat aaatgactct taacagt
//
