LOCUS       NM_011215               4688 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type N
            polypeptide 2 (Ptprn2), mRNA.
ACCESSION   NM_011215 XM_906251
VERSION     NM_011215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4688)
  AUTHORS   Yasui,T., Mashiko,M., Obi,A., Mori,H., Ito-Murata,M., Hayakawa,H.,
            Kikuchi,S., Hosaka,M., Kubota,C., Torii,S. and Gomi,H.
  TITLE     Insulin granule morphology and crinosome formation in mice lacking
            the pancreatic beta cell-specific phogrin (PTPRN2) gene
  JOURNAL   Histochem Cell Biol 161 (3), 223-238 (2024)
   PUBMED   38150052
  REMARK    GeneRIF: Insulin granule morphology and crinosome formation in mice
            lacking the pancreatic beta cell-specific phogrin (PTPRN2) gene.
REFERENCE   2  (bases 1 to 4688)
  AUTHORS   Sokanovic,S.J., Constantin,S., Lamarca Dams,A., Mochimaru,Y.,
            Smiljanic,K., Bjelobaba,I., Previde,R.M. and Stojilkovic,S.S.
  TITLE     Common and female-specific roles of protein tyrosine phosphatase
            receptors N and N2 in mice reproduction
  JOURNAL   Sci Rep 13 (1), 355 (2023)
   PUBMED   36611058
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4688)
  AUTHORS   Torii,S., Kubota,C., Saito,N., Kawano,A., Hou,N., Kobayashi,M.,
            Torii,R., Hosaka,M., Kitamura,T., Takeuchi,T. and Gomi,H.
  TITLE     The pseudophosphatase phogrin enables glucose-stimulated insulin
            signaling in pancreatic beta cells
  JOURNAL   J Biol Chem 293 (16), 5920-5933 (2018)
   PUBMED   29483197
  REMARK    GeneRIF: Relative to wildtype mice, IRS2 levels in phogrin-knockout
            mice islets decreased by 44%. When phogrin was silenced by shRNA in
            pancreatic beta-cell lines, glucose-induced insulin signaling led
            to proteasomal degradation of IRS2 via a negative feedback
            mechanism.
REFERENCE   4  (bases 1 to 4688)
  AUTHORS   Abuhatzira,L., Xu,H., Tahhan,G., Boulougoura,A., Schaffer,A.A. and
            Notkins,A.L.
  TITLE     Multiple microRNAs within the 14q32 cluster target the mRNAs of
            major type 1 diabetes autoantigens IA-2, IA-2beta, and GAD65
  JOURNAL   FASEB J 29 (10), 4374-4383 (2015)
   PUBMED   26148972
  REMARK    GeneRIF: Data show that miRNAs are involved in regulating the
            expression of the major type 1 diabetes (T1D) autoantigens IA-2,
            IA-2beta, and GAD65 enzyme.
REFERENCE   5  (bases 1 to 4688)
  AUTHORS   Xu,H., Abuhatzira,L., Carmona,G.N., Vadrevu,S., Satin,L.S. and
            Notkins,A.L.
  TITLE     The Ia-2beta intronic miRNA, miR-153, is a negative regulator of
            insulin and dopamine secretion through its effect on the Cacna1c
            gene in mice
  JOURNAL   Diabetologia 58 (10), 2298-2306 (2015)
   PUBMED   26141787
REFERENCE   6  (bases 1 to 4688)
  AUTHORS   Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and
            Crompton,M.R.
  TITLE     ICAAR, a novel member of a new family of transmembrane, tyrosine
            phosphatase-like proteins
  JOURNAL   Biochem Biophys Res Commun 229 (2), 402-411 (1996)
   PUBMED   8954911
REFERENCE   7  (bases 1 to 4688)
  AUTHORS   Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.
  TITLE     Molecular cloning and characterization of the human transmembrane
            protein tyrosine phosphatase homologue, phogrin, an autoantigen of
            type 1 diabetes
  JOURNAL   Biochem Biophys Res Commun 227 (2), 440-447 (1996)
   PUBMED   8878534
REFERENCE   8  (bases 1 to 4688)
  AUTHORS   Wasmeier,C. and Hutton,J.C.
  TITLE     Molecular cloning of phogrin, a protein-tyrosine phosphatase
            homologue localized to insulin secretory granule membranes
  JOURNAL   J Biol Chem 271 (30), 18161-18170 (1996)
   PUBMED   8663434
REFERENCE   9  (bases 1 to 4688)
  AUTHORS   Chiang,M.K. and Flanagan,J.G.
  TITLE     PTP-NP, a new member of the receptor protein tyrosine phosphatase
            family, implicated in development of nervous system and pancreatic
            endocrine cells
  JOURNAL   Development 122 (7), 2239-2250 (1996)
   PUBMED   8681804
REFERENCE   10 (bases 1 to 4688)
  AUTHORS   Lu,J., Li,Q., Xie,H., Chen,Z.J., Borovitskaya,A.E., Maclaren,N.K.,
            Notkins,A.L. and Lan,M.S.
  TITLE     Identification of a second transmembrane protein tyrosine
            phosphatase, IA-2beta, as an autoantigen in insulin-dependent
            diabetes mellitus: precursor of the 37-kDa tryptic fragment
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2307-2311 (1996)
   PUBMED   8637868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160634.2, AK138655.1, BC133678.1 and AC164641.5.
            
            On Apr 1, 2009 this sequence version replaced NM_011215.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133678.1, U57345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC160634.2         129768-129776
            10-2940             AK138655.1         2-2932
            2941-3202           BC133678.1         2825-3086
            3203-4688           AC164641.5         187581-189066
FEATURES             Location/Qualifiers
     source          1..4688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 62.65 cM"
     gene            1..4688
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /note="protein tyrosine phosphatase receptor type N
                     polypeptide 2"
                     /db_xref="GeneID:19276"
                     /db_xref="MGI:MGI:107418"
     exon            1..254
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            255..305
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            306..419
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            420..522
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..685
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1034
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1235
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1276
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1659
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1746
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1826
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1891
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2104
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2299
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2447
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2521
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2599
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2719
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2886
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2940
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3005
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3079
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..4688
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4668..4673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /note="hexamer: ATTAAA"
     polyA_site      4686
                     /gene="Ptprn2"
                     /gene_synonym="4930425H11Rik; IA2beta; mKIAA0387; phogrin;
                     Phol; PTP-NP"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcgctg tccggtgctg aagctcggcc ggcgccgccg caggagcgct gagagcgccg
       61 cgaaaggagc tggcgccgcc tcgctaagtc cctatcggtc cttgctcccg cgcggccatg
      121 gactgagcgc caaccggctg cggggatggg gccgccgctc ccgcttttgc tgctgctgct
      181 gctaccgccg ccgctgcctc gcgctctgcc cgcccccgcg tctgcccgcg gccggcagct
      241 cccggggcgc ctgggatgct tgtttgagga tggcttgtgt ggatcactgg agacctgtgt
      301 gaacgatggt gtgtttggaa gatgtcaaaa ggttccggtg atggacactt accgatatga
      361 ggtaccacca ggagccctgc tgcacctgaa ggtcacctta cagaagctct cccgtacagg
      421 tttcacgtgg caagatgact atacccagcg tgtgattgcc caggagcttg caaacctccc
      481 caaggcctac ctatggcatg gggaagcgtc cggcccagcc aggtccttac aacagaatgc
      541 tgacaatgaa aaatggttca gtctggagag ggaggtggcc ctggccaaga cccttcggcg
      601 ctatctgccc tacctggagc ttctgtccca gaccccaaca gcaaatgcac actctaggat
      661 agaccatgag actcgtccag ccaagggtga agactcttcc cctgagaaca tcctgaccta
      721 cgtggcccac acatcagcac tgacctatcc tcctgcaacc cgggccaagt atcctgataa
      781 ccttctgcgg ccctttagcc ggctccagcc agatgagctc agccccaagg tagacggtga
      841 catagacaaa cagaagctga ttgcagcact gggcgcctac actgctcaga ggcttcctgg
      901 agaaaatgac ccagagccac ggtaccttgt acatggttcc gcgagagcac caaggccatt
      961 ctcagcaact gctttgtctc agagatggcc tccacctcct ggagacgcca aagactcccc
     1021 gagtatggat gatgacacac tcctgcagag tctcctgaag gatttgcagc agaactctga
     1081 agtggaccgc ctgggccccc tgaaggagga gaaagcagac tcagttgctg gagccataca
     1141 aagtgatcct gcagagggaa gccaagaaag ccacgggaga ggggctgaag gacagccaag
     1201 agagcagaca gatgccccag agacaatgct tcaagatcac agactatcag aggtggatga
     1261 cccagtgtac aaggaggtca accgtctgag cttccagctt ggggacctct tgaaggacta
     1321 tgggtctcct ctcttacctg aaggtcccct tctagaaaaa tcctccagag aagagattaa
     1381 gaaatcagag cagccagagg aggtcttgtc ttcagaagag gagactgctg gggtggagca
     1441 tgtgaggagc cggacttact ccaaagacct atttgaaagg aaaccaaact cagagcccca
     1501 gcccaggagg cttgaggatc agttccaaaa ccgagctcca gagttgtggg aggatgaaga
     1561 aagcctcaaa ttggcagcac agggaccccc tagtggaggc ctacagctgg aagtgcagcc
     1621 ttctgaggaa cagcagggat acatcctcac aggaaacaac cctctaagtc cagagaaggg
     1681 gaagcagctg atggaccaag ttgcccacat cctccgggta ccttccagct tctttgcaga
     1741 tatcaaagtt ttgggaccag cagtgacctt caaagtaagt gccaacatcc aaaacatgac
     1801 aactgccgat gtcatcaagg ctgcagctga caacaaagac cagctggaga aggcaactgg
     1861 actgacaatc cttcaaagtg gaatcaggcc gaagggaaag ctcaaactcc tgccgcatca
     1921 ggaagagcaa gaggactcta ccaagttcat tttgctcacc ttcctctcca ttgcctgcat
     1981 cctgggggtt ctcctggctt ccagccttgc ctactgcctc cgccacaact cacactacaa
     2041 gctgaaggac aagttgtctg gactaggcgc tgaccccagt gcagatgcca ctgaagccta
     2101 ccaggagcta tgccgccagc gtatggctat tcgtccacag gaccgctctg agggaccaca
     2161 tacatcacgc atcaacagcg tctcatccca gttcagcgat gggccgatgc ctagtccttc
     2221 ggctcggagc agcacttcat cctggtctga ggagcctgtc cagtccaaca tggacatctc
     2281 tactggccac atgatcctgg cctacatgga agaccatctg aagaacaaga accgcctgga
     2341 gaaggagtgg gaagcactgt gcgcctacca agcagagccc aacagctcac ttgtggccca
     2401 gagagaggag aatgcaccca agaaccgttc cctggctgtg ctgacctatg accactccag
     2461 gatcctgttg aagtctcaaa acagccatgg cagttccgac tacatcaatg ccagccccat
     2521 tatggaccat gacccacgaa accccgcata cattgccacc caaggcccac ttcccgccac
     2581 ggtggccgac ttctggcaga tggtgtggga aagcggctgt gcagtcattg tcatgctgac
     2641 acccctctcc gagaacggcg tccggcagtg ccatcactac tggcccgatg aaggctccaa
     2701 cctctaccat gtctacgagg tcaatctagt ctctgagcac atatggtgcc aggatttcct
     2761 ggtgagaagc ttttacctga agaacctgca gaccaacgag actcgcacgg tgacccagtt
     2821 ccacttcctg agttggtatg accagggagt cccttcctcc acgaggtcac tcctggattt
     2881 ccgcagaaaa gtgaacaaat gctaccgagg ccgctcttgt ccgatcattg tccattgcag
     2941 tgacggcgcc ggcaggagtg gaacctacgt cctgattgac atggttctca ataagatggc
     3001 caaaggtgct aaagagattg atatcgcagc gaccctggag cacttgaggg accagagacc
     3061 aggcatggtc cagacaaagg agcagtttga gtttgcgctg acagctgtgg ctgaggaggt
     3121 gaatgccatc ctgaaggccc ttccccagta ggcgctgaag ctggagctgg cgggacccca
     3181 ccacgagtgc ttccagaacc gcaacaggat atcagtcctg catcttctgt gtagtaacag
     3241 ggtccttcgg gctccacagt cagtgcaggt ggctagtcat gtgtacttct gattgaccaa
     3301 atagcacatg tgtggaaaca cccagttagg atggaaggaa ggaatgaagg aaggatggga
     3361 gggaggaagg gagggaggga gggagggagg gagggaggaa ggaaggaagg aaggaaggaa
     3421 ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa agactcagct tacttgtatc
     3481 acagtcttga caaaattcct tttccctaaa gcacactttg acattgtcac attattgaca
     3541 cagtaattag aaacccactg tggcctcttc aggagtgtgc ttatgtctgt aaattgctgg
     3601 agagggggta gatgggccag gacaaccagc aagacacctg ttgggaagca ccgggtatag
     3661 aatcatattt ggtgtttgcc tgtaagacaa ctaggggagc cctttaagga aaagatcagt
     3721 gtcctgcacc cctggggcaa atgacaaggg tattatcatg gagttctgcc tattcctact
     3781 ggtgtccacc agtcacacat ttggaatgta gattccaaag acagaaaaga taaagggttt
     3841 cccaagggta gacaccttga ccatcctgaa gtatgggtgc tgtacctgtt ccagaagcga
     3901 ggacccaggt gacagcctca cctttgcaaa gttatagagg aacctgccct ggtacatctt
     3961 taatattagg attctgtttt ctacattgca agcacaggca cccatagtac acttttgttg
     4021 aagttacaaa accagaatga gtatggcaag ttccaagggt ccccagtgct tcccattcag
     4081 catccccagg gagcccccaa aggtactgaa aagtctctga tgctcctact cctggaaaga
     4141 agtctgggaa gcccctttcg ctctgcctcc tgcatcctcc cagataacaa aacacattaa
     4201 cacattctta ctggataatc caatttgcca aaacatttgg gcattgtgcc caccacctgc
     4261 ccacacatag gaagtccact tcagtaagtg caaggcgcta gcacccatcg aggtagagga
     4321 cattgcttta agccccagtt tgtttgtagg gttgagtatg aaaaagccca tctcctgtgt
     4381 ccccattgct ccttcccctt agcctcgaca tttcaagttg cggtgtgtga cggaggtggc
     4441 tgccgaacga gaagagatgc cacagtgtat cgtgtctcta gttgtattgt atacctgctt
     4501 aacatctgcg acatttctct cccaagtcat ttgccccttc ccggaattta aacaataatt
     4561 aatagaaatg aatttatctg aatataggaa gcatatactt aattgtaact tcttatgttt
     4621 aaaggaaaat tctcagtgtg atatacagat atatttaatt gtgtcatatt aaaccttctg
     4681 atttcata
//
