LOCUS       NM_008985               3511 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type N (Ptprn),
            transcript variant 1, mRNA.
ACCESSION   NM_008985
VERSION     NM_008985.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3511)
  AUTHORS   Sokanovic,S.J., Constantin,S., Lamarca Dams,A., Mochimaru,Y.,
            Smiljanic,K., Bjelobaba,I., Previde,R.M. and Stojilkovic,S.S.
  TITLE     Common and female-specific roles of protein tyrosine phosphatase
            receptors N and N2 in mice reproduction
  JOURNAL   Sci Rep 13 (1), 355 (2023)
   PUBMED   36611058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3511)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3511)
  AUTHORS   Shah,K., King,G.D. and Jiang,H.
  TITLE     A chromatin modulator sustains self-renewal and enables
            differentiation of postnatal neural stem and progenitor cells
  JOURNAL   J Mol Cell Biol 12 (1), 4-16 (2020)
   PUBMED   31065682
REFERENCE   4  (bases 1 to 3511)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 3511)
  AUTHORS   Abuhatzira,L., Xu,H., Tahhan,G., Boulougoura,A., Schaffer,A.A. and
            Notkins,A.L.
  TITLE     Multiple microRNAs within the 14q32 cluster target the mRNAs of
            major type 1 diabetes autoantigens IA-2, IA-2beta, and GAD65
  JOURNAL   FASEB J 29 (10), 4374-4383 (2015)
   PUBMED   26148972
  REMARK    GeneRIF: Data show that miRNAs are involved in regulating the
            expression of the major type 1 diabetes (T1D) autoantigens IA-2,
            IA-2beta, and GAD65 enzyme.
REFERENCE   6  (bases 1 to 3511)
  AUTHORS   Magistrelli,G., Toma,S. and Isacchi,A.
  TITLE     Substitution of two variant residues in the protein tyrosine
            phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic
            activity
  JOURNAL   Biochem Biophys Res Commun 227 (2), 581-588 (1996)
   PUBMED   8878556
REFERENCE   7  (bases 1 to 3511)
  AUTHORS   Notkins,A.L., Lu,J., Li,Q., VanderVegt,F.P., Wasserfall,C.,
            Maclaren,N.K. and Lan,M.S.
  TITLE     IA-2 and IA-2 beta are major autoantigens in IDDM and the
            precursors of the 40 kDa and 37 kDa tryptic fragments
  JOURNAL   J Autoimmun 9 (5), 677-682 (1996)
   PUBMED   8933284
REFERENCE   8  (bases 1 to 3511)
  AUTHORS   Magistrelli,G., Covini,N., Mosca,M., Lippoli,G. and Isacchi,A.
  TITLE     Expression of PTP35, the murine homologue of the protein tyrosine
            phosphatase-related sequence IA-2, is regulated during cell growth
            and stimulated by mitogens in 3T3 fibroblasts
  JOURNAL   Biochem Biophys Res Commun 217 (1), 154-161 (1995)
   PUBMED   8526904
REFERENCE   9  (bases 1 to 3511)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   10 (bases 1 to 3511)
  AUTHORS   Lu,J., Notkins,A.L. and Lan,M.S.
  TITLE     Isolation, sequence and expression of a novel mouse brain cDNA,
            mIA-2, and its relatedness to members of the protein tyrosine
            phosphatase family
  JOURNAL   Biochem Biophys Res Commun 204 (2), 930-936 (1994)
   PUBMED   7980563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166150.2.
            
            On Apr 19, 2022 this sequence version replaced NM_008985.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ832283.1, BC068165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC166150.2         101734-101914
            182-232             AC166150.2         103545-103595
            233-346             AC166150.2         103778-103891
            347-443             AC166150.2         105251-105347
            444-702             AC166150.2         107281-107539
            703-1054            AC166150.2         107622-107973
            1055-1186           AC166150.2         108494-108625
            1187-1224           AC166150.2         109038-109075
            1225-1499           AC166150.2         110017-110291
            1500-1586           AC166150.2         110707-110793
            1587-1666           AC166150.2         111060-111139
            1667-1731           AC166150.2         111269-111333
            1732-1950           AC166150.2         111777-111995
            1951-2151           AC166150.2         112458-112658
            2152-2299           AC166150.2         112759-112906
            2300-2373           AC166150.2         113074-113147
            2374-2451           AC166150.2         113373-113450
            2452-2571           AC166150.2         113543-113662
            2572-2738           AC166150.2         114001-114167
            2739-2792           AC166150.2         117139-117192
            2793-2857           AC166150.2         117752-117816
            2858-2931           AC166150.2         118008-118081
            2932-3511           AC166150.2         118298-118877
FEATURES             Location/Qualifiers
     source          1..3511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.64 cM"
     gene            1..3511
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /note="protein tyrosine phosphatase receptor type N"
                     /db_xref="GeneID:19275"
                     /db_xref="MGI:MGI:102765"
     exon            1..181
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3003
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase-like
                     N"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase-like
                     N isoform 1 precursor"
                     /protein_id="NP_033011.2"
                     /db_xref="CCDS:CCDS35625.1"
                     /db_xref="GeneID:19275"
                     /db_xref="MGI:MGI:102765"
                     /translation="MRRPRRPGGSGGSGGSGGLRLLVCLLLLSGRPGGCSAISAHGCL
                     FDRRLCSHLEVCIQDGLFGQCQAGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHD
                     DLTQHVISQEMERIPRLRPPEPHPRDRSGLVPRKPGPAGELLTQGNPTGSSPAAQGFP
                     RPAGGGDGAGAGSPLSSLQAELLPPLLEHLLMPPQPPHPALTYEPALLQPYLFHQFGS
                     RDGSRGSESSSGVVGVGHLSKAEGPALFSRSASKAILGTHSGHSFGDLTGPSPAQLFQ
                     DSGLLYMAQELPVPGRARAPRLPENGGNRAEDSSEGHEEEVLGGRGEKSPPQAAQPEL
                     SLQRLTAVLAGYGVELRQLTPEQFSTLLTLLQLLPKGTGRNLEGAVNVGGADVKKTIQ
                     QMQRGDPAEALPPTPSLPGYLTASPASSEVQQVLSPGFPEPPHTPSPLGSSSVLLEKK
                     SPLGQSQPTVVGRPSARPSAEEYGYIVTDQKPLSLVAGVRLLEILAEHVHMSSGSFIN
                     ISVVGPAVTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAEVL
                     PRQAHGISPMRSVLLTLVALAGVAGLLVALAVALCMRHHSRQRDKERLAALGPEGAHG
                     DTTFEYQDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCE
                     EPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCAAAQDESNIKKN
                     RHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQ
                     MVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGSSLYHVYEVNLVSEHIWCEDFLVRSF
                     YLKNLQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDG
                     AGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
                     NAILKALPQ"
     exon            182..232
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            233..346
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            347..443
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            444..702
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1054
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1186
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1224
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1499
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1586
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1666
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1731
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1950
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2151
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2299
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2373
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2451
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2571
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2738
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2792
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2857
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2931
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3511
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /note="hexamer: AATAAA"
     polyA_site      3511
                     /gene="Ptprn"
                     /gene_synonym="IA-2; mIA-A; mKIAA4064; PTP IA-2; R-PTP-N"
                     /note="major polyA site"
ORIGIN      
        1 gactcccacc aacgtcgccg agactctggc cggagagaga gctcagagcc gggaaggatg
       61 aggcgcccgc ggcggcccgg gggctccggg ggctccgggg gctccggggg cctccggctg
      121 ctggtctgcc tgctgttgct gagcggccgc cccgggggct gcagcgccat cagtgcccac
      181 ggctgtctgt ttgaccgcag actttgttcg catctggaag tctgtattca ggatggcttg
      241 tttggacagt gccaggcagg agtggggcag gcacggcccc tcttacaagt cacttcccca
      301 gttctccagc gcctacaagg tgtgctccgg caactcatgt cccaaggctt gtcctggcat
      361 gatgacctta cccagcatgt gatctcccag gagatggaac gcatccccag gcttcgcccc
      421 ccagagcccc atccaaggga caggtctggt ttggtgccca ggaaaccagg ccctgcaggg
      481 gaattgctaa ctcagggcaa tcctactggc tcctctcctg ctgcccaggg ctttccaagg
      541 cctgcagggg gtggggacgg agctggggcg ggctccccac tgtcctctct gcaggctgag
      601 ttgttacccc ctctcttgga gcatctgcta atgcccccac agcctccaca ccctgctctg
      661 acctatgaac ctgcactgct acagccttac ctcttccacc agtttggctc ccgagatggc
      721 tcccggggct cagagagctc ctctggggta gttggtgttg gtcacctgtc caaggctgaa
      781 ggtcctgcac tcttcagcag aagtgcctcc aaggccattt tggggactca ctctggacac
      841 tcttttgggg accttacagg tccctcacct gctcaacttt tccaagattc agggctgctc
      901 tacatggccc aagagttgcc agtgcctggc agagcccggg caccaaggtt gccagagaat
      961 gggggcaaca gggcagagga ctcttcagag ggccatgagg aggaagtact agggggtcgt
     1021 ggggagaagt cccctcccca agcagcacaa ccagaattga gtctgcagag attgactgct
     1081 gtactggcag gctatggagt agagctgcgt cagttgaccc cggagcagtt ttctaccctc
     1141 ttgaccctgc tgcagttgct gcccaagggc acaggaagaa atcttgaagg ggctgtaaat
     1201 gttggaggag ccgatgtcaa gaaaacaata caacagatgc agagaggaga cccagcagaa
     1261 gctctgcccc ccacaccctc gcttcctggg tacctcactg ccagccctgc ctccagcgaa
     1321 gttcagcagg tgctgagccc tggtttccct gaacctcccc acacacccag ccctctgggc
     1381 tcctcctcag tccttctgga gaagaaaagt cccttgggcc agagccagcc cacagtggtg
     1441 ggacggccat cagctcgacc atcggccgag gagtatggct atatcgtcac tgaccagaaa
     1501 cccctgagcc tggtggctgg agtgaggctg ctggagattc tggctgagca cgtgcatatg
     1561 tcctccggta gctttatcaa catcagtgtg gtgggaccag ctgtcacctt ccgaatccgg
     1621 cacaatgagc agaacctgtc tttggcagat gtgacccagc aagctgggct ggtgaagtct
     1681 gaactggaag cgcagacagg gctccagatt ttgcagacag gggtgggaca gagggaggaa
     1741 gcagctgaag tccttccccg acaagcccat ggcatatctc ccatgcgctc agtgctgctt
     1801 actctagtgg ccctggcagg cgtcgctggg ctgctagtgg ctttggcagt ggccttgtgt
     1861 atgcgccatc attcgagaca gcgggataag gagcgcctgg cagcgctggg gccggagggg
     1921 gcccatggtg acactacttt tgagtaccag gacctgtgtc gccagcacat ggccacaaag
     1981 tccctgttta accgggcgga gggtcagcca gagccttcta gggtgagcag tgtgtcctcc
     2041 cagttcagcg acgcggccca ggccagcccc agttcccaca gcagcacacc atcttggtgc
     2101 gaggagcccg cccaggccaa catggacatc tccacaggac acatgattct ggcatacatg
     2161 gaggatcacc ttcggaaccg ggaccggttg gccaaggagt ggcaggctct gtgcgcctac
     2221 caagcagagc caaacacctg tgccgccgca caggatgaga gcaacatcaa gaagaaccgc
     2281 catcctgact tcctacccta tgaccatgcc cgaatcaagc tgaaagtgga gagcagccct
     2341 tctcggagtg attacatcaa cgccagcccc atcatcgagc atgaccctcg gatgccggcc
     2401 tacatagcca cacagggacc actgtcccac accatcgcgg acttctggca gatggtgtgg
     2461 gagagtggct gcactgtcat cgttatgctg accccgttgg tggaggacgg tgtcaaacag
     2521 tgtgaccgct actggccgga tgaaggatct tccctctacc acgtctatga ggtgaacctg
     2581 gtgtcggagc acatctggtg cgaggacttc ctggtgcgga gcttctacct taagaacctg
     2641 cagacccagg agacgcgcac gctcactcag ttccacttcc tcagctggcc ggcagagggc
     2701 actccggcct ccacccggcc gctgctggac ttccgcagga aagtgaacaa gtgctacaga
     2761 ggccgctcct gccccatcat agtgcactgc agtgacggtg cagggaggac aggcacctac
     2821 atccttattg acatggtcct gaatcgcatg gccaaaggag tgaaggagat tgatattgct
     2881 gccaccctgg agcatgtccg tgaccagcgg cctggacttg tccgttctaa ggaccagttt
     2941 gagtttgcgc tgacagccgt ggcagaggag gtgaatgcta tcctcaaggc cctgccccag
     3001 tgagcccccc tgggcgcctc agtgggcatc ctggcctcgg ctccttctgc ctgtgtgagc
     3061 atctgtgcac ccactcttca gcccctaccc atctgccacc ttggtctgac ttggccatgg
     3121 gagcctttcc caacccagtg tggaagggag tcgggaggga aggaaggggt aggctcgccc
     3181 tgctttatcc atgctagaac catggtatcc catgggaagc agacagcagg caaggagagg
     3241 cgtggacacc ggccacaggt gtgcccgagc cccatcctac ctgagtctct gtctccctct
     3301 ctggatatgt gcgtccccac tcccaccagc ctaccaccta tagacaaagc agaacgagga
     3361 aaccccagct cccccaaccc tgctaccact ggcctgccac cttgaccctg ctcaaccttc
     3421 tccctctagc acaagggaac atttctagaa aagtaaaatc tacttttgta tcagtgtgaa
     3481 taaagttagt gtgttgtctg tgcagctgca a
//
