LOCUS       NM_008983               6177 bp    mRNA    linear   ROD 10-MAY-2023
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type K (Ptprk),
            transcript variant 2, mRNA.
ACCESSION   NM_008983
VERSION     NM_008983.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6177)
  AUTHORS   Di Bella DJ, Habibi E, Stickels RR, Scalia G, Brown J, Yadollahpour
            P, Yang SM, Abbate C, Biancalani T, Macosko EZ, Chen F, Regev A and
            Arlotta P.
  TITLE     Molecular logic of cellular diversification in the mouse cerebral
            cortex
  JOURNAL   Nature 595 (7868), 554-559 (2021)
   PUBMED   34163074
  REMARK    Erratum:[Nature. 2021 Aug;596(7873):E11. PMID: 34341543]
REFERENCE   2  (bases 1 to 6177)
  AUTHORS   Nakano Y, Wiechert S and Banfi B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 6177)
  AUTHORS   Casar B, Badrock AP, Jimenez I, Arozarena I, Colon-Bolea P,
            Lorenzo-Martin LF, Barinaga-Rementeria I, Barriuso J, Cappitelli V,
            Donoghue DJ, Bustelo XR, Hurlstone A and Crespo P.
  TITLE     RAS at the Golgi antagonizes malignant transformation through
            PTPRkappa-mediated inhibition of ERK activation
  JOURNAL   Nat Commun 9 (1), 3595 (2018)
   PUBMED   30185827
  REMARK    GeneRIF: Study show that RAS at the Golgi is selectively activated
            by apoptogenic stimuli and antagonizes cell survival by suppressing
            ERK activity through the induction of PTPRkappa, which targets CRAF
            for dephosphorylation. RAS oncogenic potential is strictly
            dependent on its sublocalization, with Golgi complex-located RAS
            antagonizing tumor development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6177)
  AUTHORS   Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y
            and Yoshida Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6177)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 6177)
  AUTHORS   Yang Y, Gil MC, Choi EY, Park SH, Pyun KH and Ha H.
  TITLE     Molecular cloning and chromosomal localization of a human gene
            homologous to the murine R-PTP-kappa, a receptor-type protein
            tyrosine phosphatase
  JOURNAL   Gene 186 (1), 77-82 (1997)
   PUBMED   9047348
REFERENCE   7  (bases 1 to 6177)
  AUTHORS   Huang K, Sommers CL, Grinberg A, Kozak CA and Love PE.
  TITLE     Cloning and characterization of PTP-K1, a novel nonreceptor protein
            tyrosine phosphatase highly expressed in bone marrow
  JOURNAL   Oncogene 13 (7), 1567-1573 (1996)
   PUBMED   8875997
REFERENCE   8  (bases 1 to 6177)
  AUTHORS   Fuchs M, Muller T, Lerch MM and Ullrich A.
  TITLE     Association of human protein-tyrosine phosphatase kappa with
            members of the armadillo family
  JOURNAL   J Biol Chem 271 (28), 16712-16719 (1996)
   PUBMED   8663237
REFERENCE   9  (bases 1 to 6177)
  AUTHORS   Higashitsuji H, Arii S, Furutani M, Imamura M, Kaneko Y, Takenawa
            J, Nakayama H and Fujita J.
  TITLE     Enhanced expression of multiple protein tyrosine phosphatases in
            the regenerating mouse liver: isolation of PTP-RL10, a novel
            cytoplasmic-type phosphatase with sequence homology to cytoskeletal
            protein 4.1
  JOURNAL   Oncogene 10 (2), 407-414 (1995)
   PUBMED   7838537
REFERENCE   10 (bases 1 to 6177)
  AUTHORS   Jiang YP, Wang H, D'Eustachio P, Musacchio JM, Schlessinger J and
            Sap J.
  TITLE     Cloning and characterization of R-PTP-kappa, a new member of the
            receptor protein tyrosine phosphatase family with a proteolytically
            cleaved cellular adhesion molecule-like extracellular region
  JOURNAL   Mol Cell Biol 13 (5), 2942-2951 (1993)
   PUBMED   8474452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159504.5, AC153972.6, AC158646.2, AC129772.3 and AC152983.2.
            
            [WARNING] On Mar 22, 2024 this sequence was replaced by
            NM_008983.3.
            
            On Mar 16, 2007 this sequence version replaced NM_008983.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC159504.5         82886-83243         c
            359-481             AC153972.6         61946-62068         c
            482-753             AC153972.6         4430-4701           c
            754-835             AC158646.2         75085-75166
            836-951             AC158646.2         77031-77146
            952-1126            AC158646.2         95214-95388
            1127-1420           AC158646.2         124040-124333
            1421-1723           AC129772.3         104597-104899
            1724-1833           AC129772.3         111787-111896
            1834-2035           AC129772.3         113924-114125
            2036-2141           AC129772.3         122027-122132
            2142-2415           AC129772.3         131753-132026
            2416-2452           AC129772.3         135748-135784
            2453-2591           AC152983.2         79111-79249
            2592-2752           AC152983.2         87498-87658
            2753-2788           AC152983.2         89600-89635
            2789-2973           AC152983.2         93988-94172
            2974-3061           AC152983.2         95820-95907
            3062-3138           AC152983.2         97390-97466
            3139-3156           AC152983.2         97667-97684
            3157-3193           AC152983.2         100861-100897
            3194-3291           AC152983.2         102312-102409
            3292-3408           AC152983.2         103083-103199
            3409-3563           AC152983.2         107886-108040
            3564-3699           AC152983.2         113053-113188
            3700-3849           AC152983.2         113416-113565
            3850-4023           AC152983.2         114401-114574
            4024-4155           AC152983.2         116421-116552
            4156-4281           AC152983.2         116752-116877
            4282-4445           AC152983.2         119378-119541
            4446-4581           AC152983.2         120263-120398
            4582-6177           AC152983.2         123295-124890
FEATURES             Location/Qualifiers
     source          1..6177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 15.06 cM"
     gene            1..6177
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /note="protein tyrosine phosphatase receptor type K"
                     /db_xref="GeneID:19272"
                     /db_xref="MGI:MGI:103310"
     exon            1..358
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..4635
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; receptor-type tyrosine-protein phosphatase
                     kappa; protein-tyrosine phosphatase kappa; R-PTP-kappa"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase kappa
                     isoform 2 precursor"
                     /protein_id="NP_033009.1"
                     /db_xref="CCDS:CCDS35874.1"
                     /db_xref="GeneID:19272"
                     /db_xref="MGI:MGI:103310"
                     /translation="MDVAAAALPAFVALWLLYPWPLLGSALGQFSAGGCTFDDGPGAC
                     DYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDT
                     HCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWP
                     NEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIAT
                     GRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERG
                     SGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSG
                     SWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTP
                     KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQ
                     HVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL
                     NWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY
                     QFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGA
                     PISAYQIVVEQLHPHRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPEPA
                     PFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI
                     PDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMV
                     NAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVLDENHSATAESSRLL
                     DVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW
                     DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSH
                     YIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVT
                     CVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLS
                     NPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTE
                     EQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPR
                     LQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAF
                     IVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECM
                     SCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEK
                     WQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNM
                     VEAPEQYRFCYDVALEYLESS"
     exon            359..481
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            482..753
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            754..835
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            836..951
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1126
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1420
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1723
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1833
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2035
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2141
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2415
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2452
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2591
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2752
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2788
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2973
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3061
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3138
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3156
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3193
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3291
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3408
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3563
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3699
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3849
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..4023
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4155
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4281
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4445
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4581
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
     exon            4582..6177
                     /gene="Ptprk"
                     /gene_synonym="PTPk; RPTPkappa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcaaact aactctggac taccctgagc agcctctgcc tagcatggag agcggcggcc
       61 gcggctggcg ggcgacgctg gagacgcttt cgcccgcgag gtagttggcc gacgttgcgc
      121 aaggacgaaa gtgctggcgg gtggccgcgg cgtctccgcg agccccccga cgaggccggg
      181 cgggctgctg gctggcggat ttcaccgcga ttcccccgga ggctctttgc aaagctgctt
      241 gaaacttctc ccaaactcgc catggatgtg gcggccgctg cgttgcctgc ttttgtagct
      301 ctctggcttc tgtacccgtg gcctctcctg gggtcggccc ttggccagtt ctcagcaggt
      361 ggctgtactt ttgatgatgg gccaggggct tgtgactacc accaggattt atacgatgac
      421 tttgagtggg tccatgtcag tgcgcaggaa cctcattacc tgccccccga aatgcctcaa
      481 ggttcctata tggttgtgga ctcctcaaat catgatcctg gagaaaaagc cagacttcag
      541 ctgcctacca tgaaggagaa tgacacccac tgcattgatt tcagttacct gttatatagc
      601 cagaaggggt tgaaccctgg cactttgaat atcctagtta gggtgaataa aggacctctt
      661 gctaatccaa tttggaatgt aactggattc actggtcgtg attggcttcg ggctgaacta
      721 gctgtgagca ccttttggcc caatgaatac caggtaatat ttgaagctga agtctcagga
      781 gggagaagtg gttatattgc cattgatgac atccaagtcc tgagttatcc ttgcgataaa
      841 tctcctcatt ttctccgcct tggtgatgtg gaggtcaatg ctgggcagaa tgctacattt
      901 cagtgcattg ctacagggag agatgctgtg cataacaagt tatggctgca gagacgcaat
      961 ggagaagaca tacccgtagc ccagactaag aacataaatc acagaagatt tgctgcctct
     1021 ttcagattgc aagaagtgac aaaaactgac caggatttgt accgctgcgt aactcagtca
     1081 gaacgaggtt ctggggtttc caattttgct caactcattg tgagagaacc acctagaccc
     1141 attgctcctc cccagctgct tggtgttggg cctacttact tgctgatcca actaaatgcc
     1201 aactctatta ttggcgatgg ccccatcatc ctgaaagaag tagagtatcg aatgacatca
     1261 ggatcttgga cagaaaccca tgcagtcaac gcaccaacat ataagttgtg gcatttagac
     1321 ccagatacag aatacgagat ccgcgtcctg cttaccagac ctggcgaagg gggaactggg
     1381 ctgccaggac caccactgat cactagaacg aagtgtgcag aacctatgcg gacaccaaag
     1441 actttaaaga ttgctgaaat ccaggcaagg cgcattgcag tggactggga gtccttgggc
     1501 tacaacatca ctcgttgcca cactttcaac gtcactatct gctaccatta cttccgtggc
     1561 cacaatgaga gcagggcaga ctgcttggac atggacccca aagcccctca gcatgttgtg
     1621 aaccatctgc caccttacac aaatgtcagc ctcaagatga tcctaaccaa cccagaggga
     1681 aggaaggaga gcgaagagac aatcatccaa actgatgaag atgtgcccgg gcctgtgcca
     1741 gtcaaatccc tccaaggaac atcctttgaa aacaagatct tcctgaactg gaaagagcca
     1801 ctggaaccga atggaattat cactcagtat gaggtgagct atagcagcat aagatcattt
     1861 gaccctgctg ttccagtggc tgggccccca cagactgtat caaatttatg gaatagtaca
     1921 caccatgtat ttatgcatct tcaccctgga accacctacc agttttttat aagagccagc
     1981 actgtcaaag gctttggacc agcaacagcc atcaatgtga ccacaaatat ctcagctcca
     2041 agcttacctg actatgaagg agttgatgcc tctctgaatg aaactgccac caccatcaca
     2101 gtactattga ggcctgcaca agccaaaggt gctcctatca gtgcttatca aattgttgtg
     2161 gagcagctac acccacatcg aacgaagcgt gaagcagggg ccatggaatg ctaccaggta
     2221 ccggttacat accagaacgc cctaagtggg ggcgcgccct attactttgc cgcagaactt
     2281 ccccctggga atcttcccga gcctgctccc ttcaccgtgg gtgacaaccg gacctataaa
     2341 ggcttttgga accctcccct ggccccccgc aaaggataca acatctattt ccaagcgatg
     2401 agcagtgtgg agaaggaaac taaaacccaa tgtgtacgaa ttgctacaaa agcagcagca
     2461 acagaagaac cagaagtgat cccagacccg gcaaagcaga cagacagagt ggtgaaaatc
     2521 gcgggcatca gtgctggcat cctagtgttc atccttctcc tgctggttgt catagtaatt
     2581 gtgaaaaaga gcaagcttgc taagaagcgc aaagatgcaa tggggaacac acgtcaggag
     2641 atgacccaca tggtgaatgc tatggaccga agttatgctg accagagcac cctgcatgca
     2701 gaagaccccc tttccctcac cttcatggac caacataact tcagtccaag attgcccaat
     2761 gatccacttg tgccgactgc cgtgttagat gagaaccaca gtgccacagc agagtctagt
     2821 cgtctcctgg atgttcctcg atacctctgt gaagggacag agtcccctta tcagacagga
     2881 cagctgcacc cagccatcag ggtggccgac ttactgcagc acattaacct catgaagaca
     2941 tcagacagct atgggttcaa agaggaatac gagagcttct ttgaaggcca gtcagcctct
     3001 tgggatgtgg ctaaaaagga tcaaaacaga gcaaagaacc gatacggaaa cattatcgca
     3061 tatgatcact ccagagtcat cctgcaacct gtggaagatg acccttcttc agattacatt
     3121 aatgccaact acatcgacat ttggctgtac agggatggct accagagacc aagccactac
     3181 attgcaactc aaggcccagt tcatgaaacc gtatatgatt tttggaggat ggtgtggcaa
     3241 gagcagtctg cctgtattgt gatggtcact aatttagtgg aagttggccg ggtgaaatgc
     3301 tataaatatt ggcctgatga tactgaggtt tatggtgact tcaaagtcac ctgcgtagaa
     3361 atggagccac ttgctgagta tgtcgttagg acattcacct tggaaaggag gggctataat
     3421 gaaatccgtg aagtcaaaca gttccacttc actggctggc ctgaccatgg tgttccatac
     3481 cacgcaacag ggctcctgtc atttatccgg agagtcaagc tatctaaccc tcccagtgct
     3541 gggcccattg tcgtacactg cagtgctggt gctgggcgca caggctgtta cattgttatt
     3601 gacataatgc tggacatggc tgaaagagag ggtgtggttg acatctacaa ctgtgtgaaa
     3661 gccttacgat ctcggcgcat taatatggta cagacagagg aacagtacat ttttattcat
     3721 gatgccattt tagaagcctg cttatgtgga gaaactgcca tccctgtgtg tgaatttaaa
     3781 gctgcatatt ttgatatgat tcgaatagac tctcagacta actcctctca tctcaaagat
     3841 gaatttcaga ctctgaattc ggtcacccct cgactacaag ctgaagactg cagcatagcc
     3901 tgcctgccaa ggaaccatga caagaaccgt ttcatggata tgctcccacc tgacagatgt
     3961 ctgccttttt taattacaat tgatggggag agcagtaact acatcaatgc tgctcttatg
     4021 gatagctata ggcagccagc agctttcatc gtcacacaat acccactgcc aaacactgtg
     4081 aaagacttct ggagattagt atatgattac ggatgtacct ccatcgtgat gctaaatgaa
     4141 gtggacctgt ctcagggctg cccacagtac tggccagaag aaggaatgct gcgatatggt
     4201 cctatccaag tggaatgtat gtcttgttca atggactgtg atgtgatcaa tcgaattttt
     4261 agaatatgca acctaacgag accacaggag ggctatctga tggtacaaca gttccagtac
     4321 ctaggctggg cttctcatcg agaagtgcct ggctccaaac gctcgttttt gaaattgata
     4381 ctgcaggtgg aaaaatggca agaggaatgt gaagaagggg aaggccggac aatcatccac
     4441 tgcttgaatg gcggtgggcg cagtggcatg ttctgtgcca taggcattgt tgtggagatg
     4501 gtgaagcggc aaaatgtggt ggatgttttc catgcagtaa agacgctgag gaacagcaag
     4561 ccaaacatgg tggaagcccc ggagcagtat cgtttttgct atgatgtggc gttagagtac
     4621 ctggagtcct catagttcgc tgagactatt tgcagagcat ccaagcagaa atccattcgt
     4681 ctgttgagcc agcagctgtt gtacctgtta ctgcaccgag agattttaat gtacggggtg
     4741 ggaggctttt acattggaga ggcaaatgta tttttcttat aaagttgtgt atcttaataa
     4801 aaaggacttg atcagtttct gtgactgtat gagagcatcc acatttcatg ccacctaatt
     4861 ttatctttaa tcagaggcag atttggatga gaagtggtct gtgtctgtcc agtgaccaca
     4921 cagccttttc tctcctgctt tctgtagagc agctaccaca cattgcatgc actttgtaag
     4981 tggcatttcc ctctcttttt aaaataaaaa ctgtgggacc ttaagaatgg ggaaggaaac
     5041 aagctgtgca aagtcatggt aaatttcatt ttatatgttc caagtgtacc agattctata
     5101 taaatgtgtg tgtgtgtata tatatatata tatatatata tatatatata tatatatata
     5161 catacataca tatatacata tgtgtgtata tatacataca tacatacata tatatggctt
     5221 attttctttt aatgtgcaat gatggctgga tcatttaaag ttccttttag aaaataacat
     5281 aagccaaaga ctgaagtgta catatgtcta tatggaagaa gcacattata tttattggtt
     5341 acttacatta cttttttgat ggataaaata ctaccgccac acaatcattt ttgttgttgt
     5401 tgttgtttta ggagagttag ctaaaaatca atggtaaaca attttttgta gattattttt
     5461 tgtatgttta gtgtaagtaa aggataaact ttttattcat aaaccaggaa gcaatgtttt
     5521 ctgtagtggt tcccttgtgt acatgcctgt gaattaaatt tatgtaaaac atcttggcaa
     5581 ttgtctttga atagaggacc aaattaaaac atttcactga aaatgtagtt ctcccccagt
     5641 ttcattaggt aaatgatggc ttgatggttg cctatgagaa atctgcacag cagaggacat
     5701 tgcaggtagc ttgcccaatg tggaatatta cctttaagca ttgtttaaac attaaagagt
     5761 tagtctctgc ctatggcctg acactgttca ggatcaccag atgacaacat tgctgcttgc
     5821 aggatcaagt tttagcagag tataaactgc caccgtagcg gcgcagtgtt ctttttgatg
     5881 tttccaagca caagctttgg gtttctacaa tagacagtgc aaatagatgt gtggtctcat
     5941 tcatgtgccc cacatagctg tagtgtcaca tcctcatcag cttgcagttt gtgattaact
     6001 gaagcattat ggtgtcctct tcctacattg cctgtctatg acatggtgct tataaagatt
     6061 taatgagagt aagagtgaaa taaagttttt ataattgtaa catttactga ttgaacatca
     6121 ttttctcttc taaattttca tgcctttatt cccaaataaa taatctctct atgactc
//
