LOCUS       NM_008982               7582 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type J (Ptprj),
            transcript variant 1, mRNA.
ACCESSION   NM_008982 XM_485033
VERSION     NM_008982.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7582)
  AUTHORS   Chopra,S., Kadiri,O.L., Ulke,J., Hauffe,R., Jonas,W., Cheshmeh,S.,
            Schmidt,L., Bishop,C.A., Yagoub,S., Schell,M., Rath,M., Kruger,J.,
            Lippert,R.N., Kruger,M., Kappert,K. and Kleinridders,A.
  TITLE     DEP-1 is a brain insulin receptor phosphatase that prevents the
            simultaneous activation of counteracting metabolic pathways
  JOURNAL   Cell Rep 43 (12), 114984 (2024)
   PUBMED   39589923
REFERENCE   2  (bases 1 to 7582)
  AUTHORS   Ulke,J., Schwedler,C., Kruger,J., Stein,V., Geserick,P.,
            Kleinridders,A. and Kappert,K.
  TITLE     High-fat diet alters N-glycosylation of PTPRJ in murine liver
  JOURNAL   J Nutr Biochem 123, 109500 (2024)
   PUBMED   37875230
  REMARK    GeneRIF: High-fat diet alters N-glycosylation of PTPRJ in murine
            liver.
REFERENCE   3  (bases 1 to 7582)
  AUTHORS   Tsoyi,K., Liang,X., De Rossi,G., Ryter,S.W., Xiong,K., Chu,S.G.,
            Liu,X., Ith,B., Celada,L.J., Romero,F., Robertson,M.J.,
            Esposito,A.J., Poli,S., El-Chemaly,S., Perrella,M.A., Shi,Y.,
            Whiteford,J. and Rosas,I.O.
  TITLE     CD148 Deficiency in Fibroblasts Promotes the Development of
            Pulmonary Fibrosis
  JOURNAL   Am J Respir Crit Care Med 204 (3), 312-325 (2021)
   PUBMED   33784491
  REMARK    GeneRIF: CD148 Deficiency in Fibroblasts Promotes the Development
            of Pulmonary Fibrosis.
REFERENCE   4  (bases 1 to 7582)
  AUTHORS   Shalev,M., Arman,E., Stein,M., Cohen-Sharir,Y., Brumfeld,V.,
            Kapishnikov,S., Royal,I., Tuckermann,J. and Elson,A.
  TITLE     PTPRJ promotes osteoclast maturation and activity by inhibiting
            Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis
  JOURNAL   FEBS J 288 (15), 4702-4723 (2021)
   PUBMED   33605542
  REMARK    GeneRIF: PTPRJ promotes osteoclast maturation and activity by
            inhibiting Cbl-mediated ubiquitination of NFATc1 in late
            osteoclastogenesis.
REFERENCE   5  (bases 1 to 7582)
  AUTHORS   Nagy,Z., Mori,J., Ivanova,V.S., Mazharian,A. and Senis,Y.A.
  TITLE     Interplay between the tyrosine kinases Chk and Csk and phosphatase
            PTPRJ is critical for regulating platelets in mice
  JOURNAL   Blood 135 (18), 1574-1587 (2020)
   PUBMED   32016283
REFERENCE   6  (bases 1 to 7582)
  AUTHORS   Kuramochi,S., Matsuda,S., Matsuda,Y., Saitoh,T., Ohsugi,M. and
            Yamamoto,T.
  TITLE     Molecular cloning and characterization of Byp, a murine
            receptor-type tyrosine phosphatase similar to human DEP-1
  JOURNAL   FEBS Lett 378 (1), 7-14 (1996)
   PUBMED   8549806
REFERENCE   7  (bases 1 to 7582)
  AUTHORS   Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y.,
            Takenawa,J., Nakayama,H. and Fujita,J.
  TITLE     Enhanced expression of multiple protein tyrosine phosphatases in
            the regenerating mouse liver: isolation of PTP-RL10, a novel
            cytoplasmic-type phosphatase with sequence homology to cytoskeletal
            protein 4.1
  JOURNAL   Oncogene 10 (2), 407-414 (1995)
   PUBMED   7838537
REFERENCE   8  (bases 1 to 7582)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   9  (bases 1 to 7582)
  AUTHORS   Yi,T., Cleveland,J.L. and Ihle,J.N.
  TITLE     Identification of novel protein tyrosine phosphatases of
            hematopoietic cells by polymerase chain reaction amplification
  JOURNAL   Blood 78 (9), 2222-2228 (1991)
   PUBMED   1932742
REFERENCE   10 (bases 1 to 7582)
  AUTHORS   Astigiano,S., Barkai,U., Abarzua,P., Tan,S.C., Harper,M.I. and
            Sherman,M.I.
  TITLE     Changes in gene expression following exposure of nulli-SCCl murine
            embryonal carcinoma cells to inducers of differentiation:
            characterization of a down-regulated mRNA
  JOURNAL   Differentiation 46 (1), 61-67 (1991)
   PUBMED   2044862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935132.13 and AL954341.14.
            
            On Dec 5, 2019 this sequence version replaced NM_008982.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147556.1, AK147318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               AL935132.13        24608-25047         c
            441-459             AL954341.14        97690-97708         c
            460-702             AL954341.14        93812-94054         c
            703-930             AL954341.14        92253-92480         c
            931-1143            AL954341.14        90969-91181         c
            1144-1407           AL954341.14        87183-87446         c
            1408-1665           AL954341.14        85800-86057         c
            1666-1926           AL954341.14        83195-83455         c
            1927-2199           AL954341.14        82161-82433         c
            2200-2490           AL954341.14        80857-81147         c
            2491-2622           AL954341.14        77812-77943         c
            2623-2833           AL954341.14        76002-76212         c
            2834-2958           AL954341.14        75768-75892         c
            2959-3046           AL954341.14        74779-74866         c
            3047-3088           AL954341.14        73534-73575         c
            3089-3097           AL954341.14        72692-72700         c
            3098-3185           AL954341.14        72495-72582         c
            3186-3276           AL954341.14        70778-70868         c
            3277-3350           AL954341.14        69103-69176         c
            3351-3485           AL954341.14        68875-69009         c
            3486-3605           AL954341.14        67139-67258         c
            3606-3766           AL954341.14        63344-63504         c
            3767-3902           AL954341.14        62576-62711         c
            3903-7582           AL954341.14        55608-59287         c
FEATURES             Location/Qualifiers
     source          1..7582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.19 cM"
     gene            1..7582
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /note="protein tyrosine phosphatase receptor type J"
                     /db_xref="GeneID:19271"
                     /db_xref="MGI:MGI:104574"
     exon            1..440
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..4061
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase eta;
                     protein-tyrosine phosphatase eta; susceptibility to colon
                     cancer 1; HPTP beta-like tyrosine phosphatase; colon tumor
                     susceptibility 1"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase eta
                     isoform 1 precursor"
                     /protein_id="NP_033008.4"
                     /db_xref="CCDS:CCDS50630.1"
                     /db_xref="GeneID:19271"
                     /db_xref="MGI:MGI:104574"
                     /translation="MKPAARETRTPPRSPGLRWALLPLLLLLRQGQVLCAGAAPNPIF
                     DIEAVVSPTSVLLTWKHNDSGASECRIENKMESNLTFPVKNQTSCNITGLSPGTSYTF
                     SIISVTTNETLNKTITTEPWPVSDLHVTSVGVTQARLTWSNANGTASYRMLIEELTTH
                     SSVNISGLKPGTNNSFAFPESNETQADFAVAEEVPDANGTKRIPVTNLSQLHKNSLVS
                     VDPPSGQDPSLTEILLTDLKPDTQYNATIYSQAANGTEGQPRNKVFKTNSTQVSDVRA
                     MNISASSMTLTWKSNYDGSRTSIVYKIHVAGGTHSVNQTVNKTEAIILGLSSSTLYNI
                     TVHPFLGQTEGTPGFLQVYTSPDQVSDFRVTNVSTRAIGLAWRSNDSKSFEIFIKQDG
                     GEKHRNASTGNQSYMVEDLKPGTSYHFEIIPRGPDGTEGLSSTVNGSTDPSAVTDIRV
                     VNISTTEMQLEWQNTDDASGYTYHLVLESKSGSIIRTNSSQKWITVGSLTPGTLYNVT
                     IFPEVDQIQGISNSITQYTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVLILK
                     TGDGSNVTSNFTKDPSILIPELIPGVSYTVKILTQVGDGTTSLVPGWNLFCTEPEPVT
                     SFHCEVVPKEPALVLKWACPFGMYTGFELGVRSDSWDNMTRLENCTSDDDTECRTEVA
                     YLNFSTSYNISIATLSCGKMALPAQNICTTGITDPPTPDGSPNITSVSHNSVKVKFSG
                     FEASHGPIKAYAVILTTGEAAQPSADVLKYTYEDFKRGASDTYVTYLIRIEEKGQSQG
                     LSEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYV
                     SFSPYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFIFWRKKRTDAKNNEVSFSQI
                     KPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEIAENRGKNRY
                     NNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWE
                     KNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTIRDFVVKNM
                     QNSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGR
                     TGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQK
                     DSKVDLIYQNTTAMTIYENLEPVSMFGKTNGYIA"
     exon            441..459
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..702
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..930
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1143
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1407
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1665
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1926
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2199
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2490
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2622
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2833
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2958
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3046
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3088
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3097
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3185
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3276
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3350
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3485
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3605
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3766
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3902
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..7582
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7511
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /note="major polyA site"
     regulatory      7563..7568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /note="hexamer: TATAAA"
     polyA_site      7582
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
ORIGIN      
        1 ggagccgcat gacgcgcgga ggaggcagag ggagcagccg gggccgcggg agccgggagc
       61 tgggagccac gcgcggaggg tgggcgccgc tcgctccgcc ccgcgaagcc cctgcgagtc
      121 taaggccgcg gccgctccgc gccaggcgcg ctaggctccg ccgtgtggcc gccgccgccg
      181 ccgctgccat gtccccgggg aagcccgggg cgggcggagc ggggactagg cggaccggct
      241 ggcggagaag gaggcggagg cgtcggctgg agacggagac gagggcgccc ggcttcgggc
      301 acacggcggg gcgcgtcccg ggcacgttcc agggcgcgca gggcatgaag cccgcggcgc
      361 gggagacgcg gacacccccg cgctcgcccg ggctccgctg ggcgctgctg ccgctgctgc
      421 tgttgctacg ccagggccag gtcctgtgcg caggtgcggc accgaatcct atatttgaca
      481 ttgaagctgt cgtcagccca actagtgtgt tattaacatg gaagcacaat gactcaggcg
      541 cttcagaatg tagaatagag aataagatgg agagcaatct gacgtttcct gttaaaaacc
      601 agacatcatg taacattaca ggcttaagcc caggcacttc gtatacattc tccatcatct
      661 ctgtaacaac caatgagacc ttgaacaaaa ctatcacaac agagccctgg ccagtgtctg
      721 atctccatgt cacctctgtg ggtgtgacac aggctcgtct cacctggagc aatgcaaatg
      781 gcactgcctc ctaccggatg ctgattgaag agttgaccac acattcctca gtcaatattt
      841 caggtctgaa gccggggacc aataatagct tcgctttccc agaatcaaat gagacacagg
      901 ctgactttgc agttgcagag gaggtcccgg atgccaatgg taccaagaga atcccagtga
      961 ccaacctatc ccaactacac aagaattctc ttgtctctgt ggacccaccc tctggccagg
     1021 atccctccct cacagagatc ttgcttactg acctaaagcc tgatactcag tacaatgcca
     1081 ccatctattc tcaagcagca aatggcactg aaggacagcc caggaacaaa gtgtttaaaa
     1141 caaattccac ccaggtttct gacgtccgag ctatgaacat cagtgcctca agcatgaccc
     1201 tgacctggaa aagcaattac gatgggtccc gtacttcaat tgtctacaaa atacacgtgg
     1261 ctggggggac ccactccgtc aaccaaactg tcaataagac tgaggccatc atcctcggac
     1321 tcagctccag caccttgtac aacatcacag ttcatccttt cctgggtcag acggagggca
     1381 caccaggctt cctccaagtg tacacttccc ccgatcaggt ctctgacttc cgagtgacaa
     1441 atgtcagcac aagggcaatt ggtttggctt ggaggagcaa tgactccaag tccttcgaga
     1501 ttttcatcaa gcaggacgga ggtgagaagc atcgaaatgc ttcgacggga aaccagagct
     1561 atatggttga agatttaaag cctggaacca gttaccattt tgagataatt ccacgaggac
     1621 cagacgggac agaagggctg tccagtacag tgaatgggag cactgacccc agtgctgtga
     1681 ctgacatccg ggtggtcaac attagcacca ctgaaatgca gttggagtgg cagaatacgg
     1741 acgatgcctc tggatacact taccatttag ttctagagtc taaaagtggc tccatcatca
     1801 ggaccaacag ttctcagaag tggatcacag tagggagcct caccccaggc accttataca
     1861 atgtcacaat ctttccagaa gtggaccaga tccagggaat ctccaactcc attacccagt
     1921 acacacggcc cagcagtgtg tcccacattg aagtaaacac caccaccacc acggcagcca
     1981 tccgatggaa gaacgaggac gcagcctctg cttcctatgc ctactccgtc cttatcttga
     2041 agactggaga tggcagcaat gtaaccagca acttcacaaa agacccttct attctaatcc
     2101 ctgagttaat ccctggtgtc tcttacacag tgaagatcct tacacaagtt ggggatggta
     2161 caacatcact ggtacctggt tggaatctgt tctgtacgga acctgaacca gtgacctcct
     2221 tccactgtga agtggtccct aaggagccag cattggttct caagtgggcc tgcccctttg
     2281 gcatgtacac aggcttcgag ctgggggtca ggagtgattc ctgggacaat atgacacgcc
     2341 tagagaactg cacttcggat gatgacacag agtgcaggac ggaagtcgcc tatttgaatt
     2401 tttctacctc gtacaacatc agcatcgcca ccttgtcatg tgggaagatg gcgcttcccg
     2461 cccagaacat ctgcaccact ggcatcacag acccacctac tccggatgga tcccctaata
     2521 ttacatcggt cagtcacaat tcagtaaagg ttaagttcag cgggtttgaa gccagccacg
     2581 gacctatcaa agcctatgct gtcatcctca ccaccgggga agctgcccaa ccttctgcag
     2641 atgttttgaa gtacacgtat gaggatttca aaaggggagc ctcggatact tatgtcacat
     2701 acctcataag aatagaagag aagggacagt ctcagggctt gtctgaagtc ttgaactatg
     2761 aaattgatgt ggggaaccaa tccactaccc tcggctacta caacgggagg ctggagcctc
     2821 tgggctccta ccgggcttgt gttgctggct ttaccaatat tacctacaac cttcagaatg
     2881 acggcctcat caatggggat gagagctatg tgtctttcag tccatattca gaggccgtgt
     2941 tcttgcccca ggacccaggt gtcatctgcg gagcagtgtt tggatgtatc tttggtgccc
     3001 tggccatcac agctgtggga ggcttcatct tctggagaaa gaaaaggaca gatgccaaga
     3061 ataatgaagt gtccttttct caaattaaac ctaaaaaatc caagttaatc cgagtggaga
     3121 attttgaggc ctactttaag aagcagcaag ctgactctaa ctgtgggttt gcagaggaat
     3181 atgaggacct gaagctgatt gggataagtt tacctaaata cacagctgag atagccgaga
     3241 acagagggaa gaaccgctac aacaatgttc tgccctatga tatttctcga gtcaaacttt
     3301 cagtccagac ccattcgaca gatgactaca tcaatgccaa ctatatgcct ggctaccatt
     3361 ccaagaaaga tttcattgcc acacaaggac ctttacccaa cactttgaaa gatttctggc
     3421 gtatggtttg ggagaaaaac gtatatgcca ttgttatgtt gaccaaatgc gtggagcagg
     3481 gaaggaccaa atgtgaggag tactggcctt ccaagcaggc tcaggactac ggggacataa
     3541 ctgtggcgat gacatcagaa gtcgttcttc cagaatggac catcagagat tttgtggtga
     3601 aaaatatgca gaatagcgag agccatcctc tgcggcagtt ccatttcacc tcctggcctg
     3661 accacggtgt tcctgacacc actgacctgc tcatcaactt tcggtacctg gtccgggatt
     3721 acatgaagca gatacccccc gagtcaccaa ttctggtgca ttgcagtgct ggggttggaa
     3781 ggacgggcac tttcatcgcc atcgatcgcc tgatctatca gatagagaat gagaacaccg
     3841 tggacgtgta tgggattgtc tatgaccttc ggatgcacag gcctctgatg gtgcagacag
     3901 aggaccagta tgttttcctc aatcagtgtg ttttggatat tatcagagcc cagaaagact
     3961 caaaagttga tctcatctat cagaacacaa cggcaatgac aatctatgaa aacctcgagc
     4021 cagtgagcat gtttggaaag actaatggtt acatcgccta gttccaaagc aaaccctttc
     4081 tgaagctaac cggaccgtca cacccacagt gaaggagagc gccctgacgg gacatgtttt
     4141 atatgtctcc tttctcagtt ctttgttctg ttctgttaga actacttgga gggcatgggg
     4201 ctgtgcgtgc aaaagcatgg cagatagcca gtggggtgtc aggggctgtg gacgggtggt
     4261 gtggaaatca gctgccttcc tgatcactaa tgggatgggt tcactttttg tttttttcct
     4321 tgagaattgt ggaaaaccag gaaaagtgag ctatgttttg ttttccaaac tggtttgttc
     4381 tcctcttttc tccccttgtc tcccccctct ctctcccccc tacctctctg tttttttttt
     4441 ttttcaagac ttttatatga ttcacatgct aaagccagga ttatgttggg ttgaatatat
     4501 tttaagtatc agaggtctat ttttacctac tgtatcttgg aatctagccg atggaaatgc
     4561 gtgactgtgg gtgtttctca cgcagggagg ggcacatggc gcctcttctg cgtgggtttc
     4621 tatttgaaca tgtgcctttt ctgaattatg cttccatggg caaaactcag tagatgtctc
     4681 tatttttata ttgaatctca gaattggaat atacagacta tttaagcagt agcttagcat
     4741 cagagagtcg cctcctcagt aacattccgg ctcccattcg attagaggag gctctctctg
     4801 cggcccaccc ttgacacacg tttgtgcccc acagtcccct tccctttctt tcttttcccc
     4861 tcccagtttt cgccaaagac ttgtgttggt gagattttca tcccattggt tgggtgagaa
     4921 tagaaatgta aaccatcatc atgagactct ctgtgggtgg gggtggggag gaagagagga
     4981 atcaacatac catggtgtgc accccttctc atcccgtctc ctcctttctc tcctttctgt
     5041 ctttggtaag aaggattatt taaaggtgca atatgtgacg tagtggttca cgatgctctg
     5101 ggttcttagt aatgttttac tcaggttgtc attttatgta tgtgtgtgtg tctgtgtgtc
     5161 tgtgtgtgtc tctgtgtgtt ttatagcgtg gtgatctgtg aacatttcag tgtgaactca
     5221 gaataacccc ttttcccctc gaagtccact ggctttagtc tatctgcagt gacacacatc
     5281 agtatctact gtatatataa atactaaact cttacaccag tcattcctat gaattgaggt
     5341 gtacaaagtt tgatttgtat caaagatgta attattattt ttaaaacctc ttttcactac
     5401 actgctgctg taattacttt gaatttttaa agaaaaaaaa tgtagttttt tttttttttt
     5461 tggcttcagg tgtgtattca ccaagaattt cagaatttat gtggttttat tttattggta
     5521 cataatctgt aaacttctca aggcattaac atgacaagat ttgtgtcttt tattttatct
     5581 tgtggctcag gttatatttg aagaagtttc aagtttatct tctagtaggc aatgaagtct
     5641 atataaggtc ttatgaagga atcgccaggt ccctggactc ctgtggctgt tttccacagt
     5701 aacaacacat cctgctgtat gtttgggaca atggtatcct gttgaagatg agggtgggtc
     5761 ttctccaagg acctggccac tgtgggcccc ggaactgcct tctgatgttc tgccttctct
     5821 gttcctcgtg tcaccagcac tttgatggct gactggacct gatcatgagt atttgtaggg
     5881 ttagagaggg tgacccataa ttgaaagtcc cctgctgtgt ttcagcgctg tagtgctgtg
     5941 gtgtgtaccc ccccccccct tttcctttgc ggtactgaaa ggattgaaag aagagggtca
     6001 tggcattgtc atgctttggg ggagaatttt acttctcaca tggaaactgc actttttttt
     6061 ttctaaatcc tttgcatttt gatgttcatt tagtgtacag ccctacagag aatgggctgg
     6121 cccaggtagc ttgggcccct tgactcaact tcactgggga acttgactct gcagttgtga
     6181 atcagggaag ccatgctgtc tccaggtgtg gagtgaagct gaccttgggc tcattatttc
     6241 caaatgccct gtcaggtctg tctaggatgt gctgacttcg gggtgctata cagaggggcc
     6301 tgtcctggca atagttctgt gcaccacctc tctgcctcct cagtttgtta ggaaccattg
     6361 tagagggtgg tgaggggtcc aatcccatgc agcgcctatg ccctgcctca tctgccagaa
     6421 agcatgagga aaggacttgc ccctaaagta gtcctgtaga agattagagt cccttaaaaa
     6481 aatcaaagca acataatcat aatcacacca tataaaattg caaaacccag agccgtctcc
     6541 acttcttccc gtgtgggtct gcaaagtctt taggcctcag ccccaacaag ccattcccag
     6601 tcccaggagg aaggctagtg gcagagaggt ctggagttcc aaatgggcag gtcacaagaa
     6661 ggtcaccatg ccattccaca tctggaggag gactgtgtgg tggagtttgc atagcacagc
     6721 cattggaaag ggaagattaa tgacagaggc tagggttggc cagaggcaga aggcccttct
     6781 tactgtctgc cccaagccct cagtggaact gtgaacaaaa gttggaagag cctggagaaa
     6841 tttgaatgat ggagttcccc cgctaagaca ctgagaaaag cagccaggat gagacttgct
     6901 gtcagtgaaa gggctacaga ctggtggtca actgctttgg aggacttgag ccattgactg
     6961 gtgtcttcta aggagaaaaa ggctttgcca ccagagctga atctagcaac gattggcacc
     7021 agtgggacat ttggtgtcca ttctctgagg ccactttgtg atctccagcc agactttggc
     7081 acaatggacc tgctggcttt gtgctttgtg aagttggagg ctctgggggg tgggggtggg
     7141 agtggggagg aagcagggaa gggtcaacta tgcagctggt tcattcatac ttgttttctg
     7201 ggatggagaa gcctggaatt atcccccacc cccacccccg aaatgcttga ttgtgcttgt
     7261 tgagctaaac aagccggtga ctgaagctag ttcacctcaa aacagagttg ggatgccgca
     7321 tttttcagat tgctgcgtag caactgtgtg tttaacacct gtggcttttt ctccctgggg
     7381 cacagaatag aagtgttgat gtggactcta aactgtactt ttcttgtaac tattttggaa
     7441 tgatgcacat ttctaatgtc tgttatactt gtacagagta ttgctcttgg ttgctttttt
     7501 ttttttttaa aggaaaaaaa tggcctgaaa aacttttttt ttaaagactt acaaatacca
     7561 aatataaaaa tatgtcaaca ca
//
