LOCUS       NM_001135657            4201 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type J (Ptprj),
            transcript variant 2, mRNA.
ACCESSION   NM_001135657
VERSION     NM_001135657.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Chopra,S., Kadiri,O.L., Ulke,J., Hauffe,R., Jonas,W., Cheshmeh,S.,
            Schmidt,L., Bishop,C.A., Yagoub,S., Schell,M., Rath,M., Kruger,J.,
            Lippert,R.N., Kruger,M., Kappert,K. and Kleinridders,A.
  TITLE     DEP-1 is a brain insulin receptor phosphatase that prevents the
            simultaneous activation of counteracting metabolic pathways
  JOURNAL   Cell Rep 43 (12), 114984 (2024)
   PUBMED   39589923
REFERENCE   2  (bases 1 to 4201)
  AUTHORS   Ulke,J., Schwedler,C., Kruger,J., Stein,V., Geserick,P.,
            Kleinridders,A. and Kappert,K.
  TITLE     High-fat diet alters N-glycosylation of PTPRJ in murine liver
  JOURNAL   J Nutr Biochem 123, 109500 (2024)
   PUBMED   37875230
  REMARK    GeneRIF: High-fat diet alters N-glycosylation of PTPRJ in murine
            liver.
REFERENCE   3  (bases 1 to 4201)
  AUTHORS   Tsoyi,K., Liang,X., De Rossi,G., Ryter,S.W., Xiong,K., Chu,S.G.,
            Liu,X., Ith,B., Celada,L.J., Romero,F., Robertson,M.J.,
            Esposito,A.J., Poli,S., El-Chemaly,S., Perrella,M.A., Shi,Y.,
            Whiteford,J. and Rosas,I.O.
  TITLE     CD148 Deficiency in Fibroblasts Promotes the Development of
            Pulmonary Fibrosis
  JOURNAL   Am J Respir Crit Care Med 204 (3), 312-325 (2021)
   PUBMED   33784491
  REMARK    GeneRIF: CD148 Deficiency in Fibroblasts Promotes the Development
            of Pulmonary Fibrosis.
REFERENCE   4  (bases 1 to 4201)
  AUTHORS   Shalev,M., Arman,E., Stein,M., Cohen-Sharir,Y., Brumfeld,V.,
            Kapishnikov,S., Royal,I., Tuckermann,J. and Elson,A.
  TITLE     PTPRJ promotes osteoclast maturation and activity by inhibiting
            Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis
  JOURNAL   FEBS J 288 (15), 4702-4723 (2021)
   PUBMED   33605542
  REMARK    GeneRIF: PTPRJ promotes osteoclast maturation and activity by
            inhibiting Cbl-mediated ubiquitination of NFATc1 in late
            osteoclastogenesis.
REFERENCE   5  (bases 1 to 4201)
  AUTHORS   Nagy,Z., Mori,J., Ivanova,V.S., Mazharian,A. and Senis,Y.A.
  TITLE     Interplay between the tyrosine kinases Chk and Csk and phosphatase
            PTPRJ is critical for regulating platelets in mice
  JOURNAL   Blood 135 (18), 1574-1587 (2020)
   PUBMED   32016283
REFERENCE   6  (bases 1 to 4201)
  AUTHORS   Kuramochi,S., Matsuda,S., Matsuda,Y., Saitoh,T., Ohsugi,M. and
            Yamamoto,T.
  TITLE     Molecular cloning and characterization of Byp, a murine
            receptor-type tyrosine phosphatase similar to human DEP-1
  JOURNAL   FEBS Lett 378 (1), 7-14 (1996)
   PUBMED   8549806
REFERENCE   7  (bases 1 to 4201)
  AUTHORS   Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y.,
            Takenawa,J., Nakayama,H. and Fujita,J.
  TITLE     Enhanced expression of multiple protein tyrosine phosphatases in
            the regenerating mouse liver: isolation of PTP-RL10, a novel
            cytoplasmic-type phosphatase with sequence homology to cytoskeletal
            protein 4.1
  JOURNAL   Oncogene 10 (2), 407-414 (1995)
   PUBMED   7838537
REFERENCE   8  (bases 1 to 4201)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   9  (bases 1 to 4201)
  AUTHORS   Yi,T., Cleveland,J.L. and Ihle,J.N.
  TITLE     Identification of novel protein tyrosine phosphatases of
            hematopoietic cells by polymerase chain reaction amplification
  JOURNAL   Blood 78 (9), 2222-2228 (1991)
   PUBMED   1932742
REFERENCE   10 (bases 1 to 4201)
  AUTHORS   Astigiano,S., Barkai,U., Abarzua,P., Tan,S.C., Harper,M.I. and
            Sherman,M.I.
  TITLE     Changes in gene expression following exposure of nulli-SCCl murine
            embryonal carcinoma cells to inducers of differentiation:
            characterization of a down-regulated mRNA
  JOURNAL   Differentiation 46 (1), 61-67 (1991)
   PUBMED   2044862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954341.14.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83203.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL954341.14        101686-101893       c
            209-227             AL954341.14        97690-97708         c
            228-470             AL954341.14        93812-94054         c
            471-698             AL954341.14        92253-92480         c
            699-911             AL954341.14        90969-91181         c
            912-1175            AL954341.14        87183-87446         c
            1176-1433           AL954341.14        85800-86057         c
            1434-1694           AL954341.14        83195-83455         c
            1695-1967           AL954341.14        82161-82433         c
            1968-2258           AL954341.14        80857-81147         c
            2259-2390           AL954341.14        77812-77943         c
            2391-2601           AL954341.14        76002-76212         c
            2602-2726           AL954341.14        75768-75892         c
            2727-2814           AL954341.14        74779-74866         c
            2815-2856           AL954341.14        73534-73575         c
            2857-2865           AL954341.14        72692-72700         c
            2866-2953           AL954341.14        72495-72582         c
            2954-3044           AL954341.14        70778-70868         c
            3045-3118           AL954341.14        69103-69176         c
            3119-3253           AL954341.14        68875-69009         c
            3254-3373           AL954341.14        67139-67258         c
            3374-3534           AL954341.14        63344-63504         c
            3535-3670           AL954341.14        62576-62711         c
            3671-3790           AL954341.14        59168-59287         c
            3791-3910           AL954341.14        52945-53064         c
            3911-4201           AL954341.14        52475-52765         c
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.19 cM"
     gene            1..4201
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /note="protein tyrosine phosphatase receptor type J"
                     /db_xref="GeneID:19271"
                     /db_xref="MGI:MGI:104574"
     exon            1..208
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..3955
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     receptor-type tyrosine-protein phosphatase eta;
                     protein-tyrosine phosphatase eta; susceptibility to colon
                     cancer 1; HPTP beta-like tyrosine phosphatase; colon tumor
                     susceptibility 1"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase eta
                     isoform 2"
                     /protein_id="NP_001129129.1"
                     /db_xref="CCDS:CCDS50629.1"
                     /db_xref="GeneID:19271"
                     /db_xref="MGI:MGI:104574"
                     /translation="MCMDNVLGGFEMPQALLAQGAAASAVQTSDYKDRTQHGSGGIRT
                     MGDPGRRVLCAGAAPNPIFDIEAVVSPTSVLLTWKHNDSGASECRIENKMESNLTFPV
                     KNQTSCNITGLSPGTSYTFSIISVTTNETLNKTITTEPWPVSDLHVTSVGVTQARLTW
                     SNANGTASYRMLIEELTTHSSVNISGLKPGTNNSFAFPESNETQADFAVAEEVPDANG
                     TKRIPVTNLSQLHKNSLVSVDPPSGQDPSLTEILLTDLKPDTQYNATIYSQAANGTEG
                     QPRNKVFKTNSTQVSDVRAMNISASSMTLTWKSNYDGSRTSIVYKIHVAGGTHSVNQT
                     VNKTEAIILGLSSSTLYNITVHPFLGQTEGTPGFLQVYTSPDQVSDFRVTNVSTRAIG
                     LAWRSNDSKSFEIFIKQDGGEKHRNASTGNQSYMVEDLKPGTSYHFEIIPRGPDGTEG
                     LSSTVNGSTDPSAVTDIRVVNISTTEMQLEWQNTDDASGYTYHLVLESKSGSIIRTNS
                     SQKWITVGSLTPGTLYNVTIFPEVDQIQGISNSITQYTRPSSVSHIEVNTTTTTAAIR
                     WKNEDAASASYAYSVLILKTGDGSNVTSNFTKDPSILIPELIPGVSYTVKILTQVGDG
                     TTSLVPGWNLFCTEPEPVTSFHCEVVPKEPALVLKWACPFGMYTGFELGVRSDSWDNM
                     TRLENCTSDDDTECRTEVAYLNFSTSYNISIATLSCGKMALPAQNICTTGITDPPTPD
                     GSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAAQPSADVLKYTYEDFKRGA
                     SDTYVTYLIRIEEKGQSQGLSEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFT
                     NITYNLQNDGLINGDESYVSFSPYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFI
                     FWRKKRTDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIG
                     ISLPKYTAEIAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFI
                     ATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAM
                     TSEVVLPEWTIRDFVVKNMQNSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYM
                     KQIPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQT
                     EDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMTIYENLEPSSLNVTMLLHPQLNDFG
                     CWVLGPGCCWSARIQGLVDIWEDVNCPAESLSFRCGH"
     exon            209..227
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..470
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..698
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..911
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1175
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1433
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1694
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1967
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2258
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2390
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2601
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2726
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2814
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2856
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2865
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2953
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3044
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3118
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3253
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3373
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3534
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3670
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3790
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3910
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4201
                     /gene="Ptprj"
                     /gene_synonym="BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2;
                     R-PTP-eta; R-PTP-J; RPTPJ; Scc-1; Scc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaacagaa acgaacgtcc gcagataact acctgttctg gctcttgtta gttctatgtg
       61 tatggataat gtcttgggag gttttgaaat gccacaagcc ttgctggccc agggtgcagc
      121 tgcctctgct gttcagacct cagattataa ggacagaaca cagcacggaa gtggggggat
      181 cagaaccatg ggagatccag gacgaagggt cctgtgcgca ggtgcggcac cgaatcctat
      241 atttgacatt gaagctgtcg tcagcccaac tagtgtgtta ttaacatgga agcacaatga
      301 ctcaggcgct tcagaatgta gaatagagaa taagatggag agcaatctga cgtttcctgt
      361 taaaaaccag acatcatgta acattacagg cttaagccca ggcacttcgt atacattctc
      421 catcatctct gtaacaacca atgagacctt gaacaaaact atcacaacag agccctggcc
      481 agtgtctgat ctccatgtca cctctgtggg tgtgacacag gctcgtctca cctggagcaa
      541 tgcaaatggc actgcctcct accggatgct gattgaagag ttgaccacac attcctcagt
      601 caatatttca ggtctgaagc cggggaccaa taatagcttc gctttcccag aatcaaatga
      661 gacacaggct gactttgcag ttgcagagga ggtcccggat gccaatggta ccaagagaat
      721 cccagtgacc aacctatccc aactacacaa gaattctctt gtctctgtgg acccaccctc
      781 tggccaggat ccctccctca cagagatctt gcttactgac ctaaagcctg atactcagta
      841 caatgccacc atctattctc aagcagcaaa tggcactgaa ggacagccca ggaacaaagt
      901 gtttaaaaca aattccaccc aggtttctga cgtccgagct atgaacatca gtgcctcaag
      961 catgaccctg acctggaaaa gcaattacga tgggtcccgt acttcaattg tctacaaaat
     1021 acacgtggct ggggggaccc actccgtcaa ccaaactgtc aataagactg aggccatcat
     1081 cctcggactc agctccagca ccttgtacaa catcacagtt catcctttcc tgggtcagac
     1141 ggagggcaca ccaggcttcc tccaagtgta cacttccccc gatcaggtct ctgacttccg
     1201 agtgacaaat gtcagcacaa gggcaattgg tttggcttgg aggagcaatg actccaagtc
     1261 cttcgagatt ttcatcaagc aggacggagg tgagaagcat cgaaatgctt cgacgggaaa
     1321 ccagagctat atggttgaag atttaaagcc tggaaccagt taccattttg agataattcc
     1381 acgaggacca gacgggacag aagggctgtc cagtacagtg aatgggagca ctgaccccag
     1441 tgctgtgact gacatccggg tggtcaacat tagcaccact gaaatgcagt tggagtggca
     1501 gaatacggac gatgcctctg gatacactta ccatttagtt ctagagtcta aaagtggctc
     1561 catcatcagg accaacagtt ctcagaagtg gatcacagta gggagcctca ccccaggcac
     1621 cttatacaat gtcacaatct ttccagaagt ggaccagatc cagggaatct ccaactccat
     1681 tacccagtac acacggccca gcagtgtgtc ccacattgaa gtaaacacca ccaccaccac
     1741 ggcagccatc cgatggaaga acgaggacgc agcctctgct tcctatgcct actccgtcct
     1801 tatcttgaag actggagatg gcagcaatgt aaccagcaac ttcacaaaag acccttctat
     1861 tctaatccct gagttaatcc ctggtgtctc ttacacagtg aagatcctta cacaagttgg
     1921 ggatggtaca acatcactgg tacctggttg gaatctgttc tgtacggaac ctgaaccagt
     1981 gacctccttc cactgtgaag tggtccctaa ggagccagca ttggttctca agtgggcctg
     2041 cccctttggc atgtacacag gcttcgagct gggggtcagg agtgattcct gggacaatat
     2101 gacacgccta gagaactgca cttcggatga tgacacagag tgcaggacgg aagtcgccta
     2161 tttgaatttt tctacctcgt acaacatcag catcgccacc ttgtcatgtg ggaagatggc
     2221 gcttcccgcc cagaacatct gcaccactgg catcacagac ccacctactc cggatggatc
     2281 ccctaatatt acatcggtca gtcacaattc agtaaaggtt aagttcagcg ggtttgaagc
     2341 cagccacgga cctatcaaag cctatgctgt catcctcacc accggggaag ctgcccaacc
     2401 ttctgcagat gttttgaagt acacgtatga ggatttcaaa aggggagcct cggatactta
     2461 tgtcacatac ctcataagaa tagaagagaa gggacagtct cagggcttgt ctgaagtctt
     2521 gaactatgaa attgatgtgg ggaaccaatc cactaccctc ggctactaca acgggaggct
     2581 ggagcctctg ggctcctacc gggcttgtgt tgctggcttt accaatatta cctacaacct
     2641 tcagaatgac ggcctcatca atggggatga gagctatgtg tctttcagtc catattcaga
     2701 ggccgtgttc ttgccccagg acccaggtgt catctgcgga gcagtgtttg gatgtatctt
     2761 tggtgccctg gccatcacag ctgtgggagg cttcatcttc tggagaaaga aaaggacaga
     2821 tgccaagaat aatgaagtgt ccttttctca aattaaacct aaaaaatcca agttaatccg
     2881 agtggagaat tttgaggcct actttaagaa gcagcaagct gactctaact gtgggtttgc
     2941 agaggaatat gaggacctga agctgattgg gataagttta cctaaataca cagctgagat
     3001 agccgagaac agagggaaga accgctacaa caatgttctg ccctatgata tttctcgagt
     3061 caaactttca gtccagaccc attcgacaga tgactacatc aatgccaact atatgcctgg
     3121 ctaccattcc aagaaagatt tcattgccac acaaggacct ttacccaaca ctttgaaaga
     3181 tttctggcgt atggtttggg agaaaaacgt atatgccatt gttatgttga ccaaatgcgt
     3241 ggagcaggga aggaccaaat gtgaggagta ctggccttcc aagcaggctc aggactacgg
     3301 ggacataact gtggcgatga catcagaagt cgttcttcca gaatggacca tcagagattt
     3361 tgtggtgaaa aatatgcaga atagcgagag ccatcctctg cggcagttcc atttcacctc
     3421 ctggcctgac cacggtgttc ctgacaccac tgacctgctc atcaactttc ggtacctggt
     3481 ccgggattac atgaagcaga taccccccga gtcaccaatt ctggtgcatt gcagtgctgg
     3541 ggttggaagg acgggcactt tcatcgccat cgatcgcctg atctatcaga tagagaatga
     3601 gaacaccgtg gacgtgtatg ggattgtcta tgaccttcgg atgcacaggc ctctgatggt
     3661 gcagacagag gaccagtatg ttttcctcaa tcagtgtgtt ttggatatta tcagagccca
     3721 gaaagactca aaagttgatc tcatctatca gaacacaacg gcaatgacaa tctatgaaaa
     3781 cctcgagcca agttccttga atgtgactat gttgcttcat ccacagctga acgattttgg
     3841 atgttgggtt ctaggtcctg gctgttgctg gtctgctagg atccagggcc ttgttgacat
     3901 ctgggaagat gtaaattgtc ccgctgaaag cctcagtttt agatgtggcc actagatgga
     3961 gccagagcac tggtatgaag gagcaccagg gccgtgtaag gcaaaagagg acccagaaaa
     4021 agaaacttaa cttgttcact cctgagaaac ctgcaagtca acaagccaag gaagtgcctt
     4081 tgcatgcatt tggtagcctt tccaatcccg cttattacat aatatgttca tgttcatggc
     4141 aaaaaaaaaa aaataaaata aataaaaaag gaaaacaaaa taaaaaaaat cttagaacat
     4201 t
//
