LOCUS       NM_207270               4020 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type H (Ptprh),
            mRNA.
ACCESSION   NM_207270
VERSION     NM_207270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Mori,S., Kamei,N., Murata,Y., Takayama,K., Matozaki,T. and
            Takeda-Morishita,M.
  TITLE     Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a
            Role in Regulating the Intestinal Paracellular Transport of
            Macromolecules
  JOURNAL   J Pharm Sci 106 (9), 2904-2908 (2017)
   PUBMED   28431964
  REMARK    GeneRIF: The results of this study suggest the partial contribution
            of SAP-1 to the regulated transport of hydrophilic macromolecules
            through paracellular tight junctions.
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Shintani,T., Higashi,S., Takeuchi,Y., Gaudio,E., Trapasso,F.,
            Fusco,A. and Noda,M.
  TITLE     The R3 receptor-like protein tyrosine phosphatase subfamily
            inhibits insulin signalling by dephosphorylating the insulin
            receptor at specific sites
  JOURNAL   J Biochem 158 (3), 235-243 (2015)
   PUBMED   26063811
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Murata,Y., Kotani,T., Supriatna,Y., Kitamura,Y., Imada,S.,
            Kawahara,K., Nishio,M., Daniwijaya,E.W., Sadakata,H., Kusakari,S.,
            Mori,M., Kanazawa,Y., Saito,Y., Okawa,K., Takeda-Morishita,M.,
            Okazawa,H., Ohnishi,H., Azuma,T., Suzuki,A. and Matozaki,T.
  TITLE     Protein tyrosine phosphatase SAP-1 protects against colitis through
            regulation of CEACAM20 in the intestinal epithelium
  JOURNAL   Proc Natl Acad Sci U S A 112 (31), E4264-E4271 (2015)
   PUBMED   26195794
  REMARK    GeneRIF: SAP-1 and CEACAM20 thus constitute a regulatory system
            through which the intestinal epithelium contributes to intestinal
            immunity.
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Murata,Y., Mori,M., Kotani,T., Supriatna,Y., Okazawa,H.,
            Kusakari,S., Saito,Y., Ohnishi,H. and Matozaki,T.
  TITLE     Tyrosine phosphorylation of R3 subtype receptor-type protein
            tyrosine phosphatases and their complex formations with Grb2 or Fyn
  JOURNAL   Genes Cells 15 (5), 513-524 (2010)
   PUBMED   20398064
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Sadakata,H., Okazawa,H., Sato,T., Supriatna,Y., Ohnishi,H.,
            Kusakari,S., Murata,Y., Ito,T., Nishiyama,U., Minegishi,T.,
            Harada,A. and Matozaki,T.
  TITLE     SAP-1 is a microvillus-specific protein tyrosine phosphatase that
            modulates intestinal tumorigenesis
  JOURNAL   Genes Cells 14 (3), 295-308 (2009)
   PUBMED   19170756
  REMARK    GeneRIF: These results thus suggest that SAP-1 is a
            microvillus-specific receptor-type protein tyrosine phosphatase
            that regulates intestinal tumorigenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618721.1, AK078884.1, AC161197.9 and BY755543.1.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_207270.3.
            
            On Apr 12, 2007 this sequence version replaced NM_207270.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849380 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               BB618721.1         1-576
            577-913             AK078884.1         251-587
            914-1100            AC161197.9         186802-186988
            1101-1367           AC161197.9         194321-194587
            1368-1634           AC161197.9         195829-196095
            1635-1776           AK078884.1         1312-1453
            1777-1913           AC161197.9         198279-198415
            1914-3486           AK078884.1         1591-3163
            3487-4020           BY755543.1         152-685
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.63 cM"
     gene            1..4020
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /note="protein tyrosine phosphatase receptor type H"
                     /db_xref="GeneID:545902"
                     /db_xref="MGI:MGI:3026877"
     exon            1..255
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..421
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..455
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..566
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..833
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1100
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1367
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1634
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1913
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2180
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2259
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2307
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2398
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2489
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2566
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2701
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2824
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2985
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3121
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..4020
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactcagggc tgcctggtgt ggaccctgcc tgagctgaat ctcagggaaa gaacaggaga
       61 gaggccttgc tagagggcag tgggagactg catctgtgct acagagaaaa tatacaaagg
      121 ccacgggttg aggaacatgc aggcgtcacc tgatggagct gcaaaggtct acgggagaca
      181 ggaaaaggaa acagaataca gagcccccgt caactcaagt gctccagtag gatatgagga
      241 gataccgttt tcaggcctca gcctctggcc tcaccaatgg gctggcaaaa ggaaaatctt
      301 aagtcgaaag tccatccagt agaggttgca gagccgggac tcctgcatcc cctgcgcagt
      361 atcgggacat atggccagag ctggtgggaa ctgtggggtt tggaggagct tggtgctatt
      421 gggtttgtat ggttgttctg tggtcagggc agctggtacc agtgtcacag tggacaggca
      481 tgctcctgct tcttcatacg agttttccat gtgggtagag aaagatggcg tcagcagctc
      541 cccacagatt cctgtaacca ccgcagcccc aaacccagtg agaaacctga gggtcgaagg
      601 tcaaaacaac atctccatca gcctgagctg ggagcctcct gatcagtcct ccctgcaggg
      661 cctcacctac tggacccagt gcagtagaca tggtggccaa actgagaccc ggaacacaac
      721 agacaccagt gtcaccgtgg atggccttga tcctgggtct tcatatgaat gttctgtgtg
      781 ggtggaaaag gatggactct atagcaaaaa tgagactctc aataccagca cagctccaaa
      841 cccagtgaga aacctgaggg tcgaaggtca aaacaacatc tccatcagcc tgagctggga
      901 gcctcctgat cagccctccc tgcagggcct cacctactgg gcccagtgca gtagacatgg
      961 tggccaaact gagacccgga acacagcaga caccagtgtc accgtggatg gacttgatcc
     1021 tgggtcttca tatgaatgtt ctgtgtgggt ggaaaaggat ggagtctata gcaccaatga
     1081 gactctcaat accagcacag ccccaaaccc agtgagaaac ctgagggtcg aaggtcaaaa
     1141 caacatctcc atcagcctga gctgggagcc tcctgatcag ccctccctgc agggcctcac
     1201 ctactgggcc cagtgcagta gacatggtgg ccaaactgag acccggaaca caacagacac
     1261 cagtattacc gtggatggac ttgatcctgg gtcttcatat gaatgttctg tgtgggtgga
     1321 aaaggatgga gtctatagca ccaatgagac tctcagtaac accacagccc caaacccagt
     1381 gagaaacctg agggtcaaaa gtcagaacaa cttctccatc agcctgagct gggagcctcc
     1441 tgatcagccc tccctgcagg gcctcatcta ctgggcccag tgcagtagac atggtggcca
     1501 aactgagacc cggaacacaa cagacaccag tgtcaccgtg gatggacttg atcctgggtt
     1561 tttatataaa tgttctgtgt gggtggaaaa ggatggagtc tatagcacca atgagactct
     1621 caataccagc acagtcccca tttcagcctc aaacccagtg agaaacctga gggtcgaagg
     1681 tcagaacaac ttctccatca gcctgagctg ggagcctcct gatcagtcct ccctgcaggg
     1741 cctcacctac tgggcccagt gcagtagaca tggtggccaa actgagaccc ggaacacagc
     1801 agacaccagt gtcaccgtgg atggccttga tcctgggtct tcatatgaat gttctgtgtg
     1861 ggtggaaaag gatggagtct atagcaccaa tgagactctc aataccagca cagtaccagc
     1921 tgctgtcaac atcacctcct gcatcagcac ttctggggga tatggggtcc tcctgacctg
     1981 gtcctgccca tctgggggtt atgagagctt tgaggtaaaa gtgggtagga aatggcgctc
     2041 tgaaaatgga tctttgtgtg ggaagggcgt gaccgtgtca gatcttgagc cagctcagtc
     2101 ctacacagcc accgtcacga ctgtcttcaa ggacctgaag gcccagtctc tctctacaac
     2161 ttgccacaca gagagtgcag ccatcattgc tggagccatt gtgggcatcc tcctgctttt
     2221 catcctggtg ggtctgctga ttgtcttcct gaagaggagg agaaagaaga gacagcccaa
     2281 ggaagtgccc aaggatctgg tgtgcagctg cccaggggat atcctggcca aagactttgc
     2341 tgaccatgtc agggagaatg agaaggacag caactgtgga tttgctgagg agtatcagca
     2401 actggctctg gagggccaag gccagtctca aataacggca tcggctctag agaacagatc
     2461 caagaaccgc tacaggaatg tactgcccta tgactggtcc cgggttcccc tgcagcccct
     2521 ccaagaggaa ccaggctctg actatatcaa cgccagcttt atgcctggtc tctggagccc
     2581 caaggagttc attgcaaccc agggtcccct gcctaacact gtgggtgatt tttggagaat
     2641 ggtctgggaa cagcagagcc acaccctggt tatgctgacc aactgcatgg agtctggacg
     2701 ggtgaagtgt gagcactact ggcccttgga tgctcagcct tgcattcatg ggcagctgca
     2761 ggtaatgttg attagtgagg aggcgtcaga aaactggaca gtgaggcatc ttcaactctt
     2821 ccatatgaaa gaacagcaga ctctctcgtt gcgccaattc cactacctgg cctggccaga
     2881 ccatggagtt ccttactccc cagaccccct gctggctttc cgaaagatgc ttcggcaatg
     2941 gatggatcag accacggatg gaggtccacc cattgtgcat tgcagtgctg gtgtgggccg
     3001 gacgggcacc ctaattgcac tggatgtcct gctgcggcag ctggagtgtg aggggctggt
     3061 gggtcccttc agctttgtga agaagatgag agagagccgg ccactgatgg tgcagacaga
     3121 ggcccagtat gtgttcctcc accagtgcat cttgaaatcc ctccagaagc cagctccagc
     3181 ccttgtccca gaggaggcaa tgtatgagaa cgtggcaagc ttagtttatg agaatgcatc
     3241 tgctatcatg gcccatgagt ctgagttctc agcttctggg tgctgaaccc agacacagaa
     3301 atacccaggc cagatctgga cctgtgctga agcccagata tgtggacctt caagacaaca
     3361 ggattgaagt cccagcctcc ccaaccccat gggaggaggt cactggaaac gcatctcctg
     3421 tggtccaagt gcaggaaggg ctggtatact tcaactgtga gccctgtgag tggtggagct
     3481 tgaggacagg gtggctgaca ggtaggggtg acggggtgac tgacaggtag gggtgacggg
     3541 gtgactgaca ggtaggggtg atggggtgac tgacaggtag gggtgacggg gtgactgaca
     3601 ggtaggggtg acggggtgac tgacaggtag gggtgacggg gtgactgaca ggtaggggtg
     3661 atggggtgac tgacaggtag gggtgacggg gtgactgaca ggtaggggtg acggggtgac
     3721 tgacaggtag gggtgactga cagctaggtt ttctcttctt tgagtggaga tagctaccgc
     3781 ctgggtgtgc aggctctcaa aaaaacaggc tggaacctgg attcgaaaga aggaatcagg
     3841 gtctggaatt gtactacctg agcagcaaag gcaggcaggt acttgtcccc tttttacctc
     3901 agaaaccgaa tcagtctcct ttactccgag gctgaaggga gtcccctgtg cttgtggtct
     3961 ccctgggccc cgtggctgta cattctttcc ttctatataa tttattaaac tgtcctcccg
//
