LOCUS       NP_997153                971 aa            linear   ROD 15-JUN-2024
DEFINITION  receptor-type tyrosine-protein phosphatase H precursor [Mus
            musculus].
ACCESSION   NP_997153
VERSION     NP_997153.2
DBSOURCE    REFSEQ: accession NM_207270.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 971)
  AUTHORS   Mori,S., Kamei,N., Murata,Y., Takayama,K., Matozaki,T. and
            Takeda-Morishita,M.
  TITLE     Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a
            Role in Regulating the Intestinal Paracellular Transport of
            Macromolecules
  JOURNAL   J Pharm Sci 106 (9), 2904-2908 (2017)
   PUBMED   28431964
  REMARK    GeneRIF: The results of this study suggest the partial contribution
            of SAP-1 to the regulated transport of hydrophilic macromolecules
            through paracellular tight junctions.
REFERENCE   2  (residues 1 to 971)
  AUTHORS   Shintani,T., Higashi,S., Takeuchi,Y., Gaudio,E., Trapasso,F.,
            Fusco,A. and Noda,M.
  TITLE     The R3 receptor-like protein tyrosine phosphatase subfamily
            inhibits insulin signalling by dephosphorylating the insulin
            receptor at specific sites
  JOURNAL   J Biochem 158 (3), 235-243 (2015)
   PUBMED   26063811
REFERENCE   3  (residues 1 to 971)
  AUTHORS   Murata,Y., Kotani,T., Supriatna,Y., Kitamura,Y., Imada,S.,
            Kawahara,K., Nishio,M., Daniwijaya,E.W., Sadakata,H., Kusakari,S.,
            Mori,M., Kanazawa,Y., Saito,Y., Okawa,K., Takeda-Morishita,M.,
            Okazawa,H., Ohnishi,H., Azuma,T., Suzuki,A. and Matozaki,T.
  TITLE     Protein tyrosine phosphatase SAP-1 protects against colitis through
            regulation of CEACAM20 in the intestinal epithelium
  JOURNAL   Proc Natl Acad Sci U S A 112 (31), E4264-E4271 (2015)
   PUBMED   26195794
  REMARK    GeneRIF: SAP-1 and CEACAM20 thus constitute a regulatory system
            through which the intestinal epithelium contributes to intestinal
            immunity.
REFERENCE   4  (residues 1 to 971)
  AUTHORS   Murata,Y., Mori,M., Kotani,T., Supriatna,Y., Okazawa,H.,
            Kusakari,S., Saito,Y., Ohnishi,H. and Matozaki,T.
  TITLE     Tyrosine phosphorylation of R3 subtype receptor-type protein
            tyrosine phosphatases and their complex formations with Grb2 or Fyn
  JOURNAL   Genes Cells 15 (5), 513-524 (2010)
   PUBMED   20398064
REFERENCE   5  (residues 1 to 971)
  AUTHORS   Sadakata,H., Okazawa,H., Sato,T., Supriatna,Y., Ohnishi,H.,
            Kusakari,S., Murata,Y., Ito,T., Nishiyama,U., Minegishi,T.,
            Harada,A. and Matozaki,T.
  TITLE     SAP-1 is a microvillus-specific protein tyrosine phosphatase that
            modulates intestinal tumorigenesis
  JOURNAL   Genes Cells 14 (3), 295-308 (2009)
   PUBMED   19170756
  REMARK    GeneRIF: These results thus suggest that SAP-1 is a
            microvillus-specific receptor-type protein tyrosine phosphatase
            that regulates intestinal tumorigenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161197.9 and AC161218.10.
            
            On Apr 12, 2007 this sequence version replaced NP_997153.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849380 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.63 cM"
     Protein         1..971
                     /product="receptor-type tyrosine-protein phosphatase H
                     precursor"
                     /EC_number="3.1.3.48"
                     /note="receptor type protein tyrosine phosphatase sap-1;
                     stomach cancer-associated protein tyrosine phosphatase 1;
                     receptor-type tyrosine-protein phosphatase H"
                     /calculated_mol_wt=104162
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2809
     mat_peptide     28..971
                     /product="Receptor-type tyrosine-protein phosphatase H.
                     /id=PRO_5007654674"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q0N2.1)"
                     /calculated_mol_wt=104162
     Region          67..146
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(67,128,143)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            80
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Region          113..>589
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            169
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            293
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            382
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            440
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            520
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            605..625
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Region          699..931
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Site            945
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:20398064; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     Site            953
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:20398064; propagated from
                     UniProtKB/Swiss-Prot (E9Q0N2.1)"
     CDS             1..971
                     /gene="Ptprh"
                     /gene_synonym="R-PTP-H; sap-1"
                     /coded_by="NM_207270.3:378..3293"
                     /db_xref="CCDS:CCDS51974.1"
                     /db_xref="GeneID:545902"
                     /db_xref="MGI:MGI:3026877"
ORIGIN      
        1 maraggncgv wrslvllgly gcsvvraagt svtvdrhapa ssyefsmwve kdgvssspqi
       61 pvttaapnpv rnlrvegqnn isislswepp dqsslqglty wtqcsrhggq tetrnttdts
      121 vtvdgldpgs syecsvwvek dglysknetl ntstapnpvr nlrvegqnni sislsweppd
      181 qpslqgltyw aqcsrhggqt etrntadtsv tvdgldpgss yecsvwvekd gvystnetln
      241 tstapnpvrn lrvegqnnis islsweppdq pslqgltywa qcsrhggqte trnttdtsit
      301 vdgldpgssy ecsvwvekdg vystnetlsn ttapnpvrnl rvksqnnfsi slsweppdqp
      361 slqgliywaq csrhggqtet rnttdtsvtv dgldpgflyk csvwvekdgv ystnetlnts
      421 tvpisasnpv rnlrvegqnn fsislswepp dqsslqglty waqcsrhggq tetrntadts
      481 vtvdgldpgs syecsvwvek dgvystnetl ntstvpaavn itscistsgg ygvlltwscp
      541 sggyesfevk vgrkwrseng slcgkgvtvs dlepaqsyta tvttvfkdlk aqslsttcht
      601 esaaiiagai vgilllfilv gllivflkrr rkkrqpkevp kdlvcscpgd ilakdfadhv
      661 renekdsncg faeeyqqlal egqgqsqita salenrsknr yrnvlpydws rvplqplqee
      721 pgsdyinasf mpglwspkef iatqgplpnt vgdfwrmvwe qqshtlvmlt ncmesgrvkc
      781 ehywpldaqp cihgqlqvml iseeasenwt vrhlqlfhmk eqqtlslrqf hylawpdhgv
      841 pyspdpllaf rkmlrqwmdq ttdggppivh csagvgrtgt lialdvllrq leceglvgpf
      901 sfvkkmresr plmvqteaqy vflhqcilks lqkpapalvp eeamyenvas lvyenasaim
      961 ahesefsasg c
//
