LOCUS       NM_008981               9190 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type G (Ptprg),
            transcript variant 1, mRNA.
ACCESSION   NM_008981 XM_905215
VERSION     NM_008981.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9190)
  AUTHORS   Taki,S., Boron,W.F. and Moss,F.J.
  TITLE     Novel RPTPgamma and RPTPzeta splice variants from mixed
            neuron-astrocyte hippocampal cultures as well as from the
            hippocampi of newborn and adult mice
  JOURNAL   Front Physiol 15, 1406448 (2024)
   PUBMED   38952869
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9190)
  AUTHORS   Hansen,K.B., Staehr,C., Rohde,P.D., Homilius,C., Kim,S.,
            Nyegaard,M., Matchkov,V.V. and Boedtkjer,E.
  TITLE     PTPRG is an ischemia risk locus essential for HCO3--dependent
            regulation of endothelial function and tissue perfusion
  JOURNAL   Elife 9, e57553 (2020)
   PUBMED   32955439
  REMARK    GeneRIF: PTPRG is an ischemia risk locus essential for
            HCO3(-)-dependent regulation of endothelial function and tissue
            perfusion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9190)
  AUTHORS   Brenachot,X., Ramadori,G., Ioris,R.M., Veyrat-Durebex,C.,
            Altirriba,J., Aras,E., Ljubicic,S., Kohno,D., Fabbiano,S.,
            Clement,S., Goossens,N., Trajkovski,M., Harroch,S., Negro,F. and
            Coppari,R.
  TITLE     Hepatic protein tyrosine phosphatase receptor gamma links
            obesity-induced inflammation to insulin resistance
  JOURNAL   Nat Commun 8 (1), 1820 (2017)
   PUBMED   29180649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9190)
  AUTHORS   Nikolaienko,R.M., Hammel,M., Dubreuil,V., Zalmai,R., Hall,D.R.,
            Mehzabeen,N., Karuppan,S.J., Harroch,S., Stella,S.L. and Bouyain,S.
  TITLE     Structural Basis for Interactions Between Contactin Family Members
            and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues
  JOURNAL   J Biol Chem 291 (41), 21335-21349 (2016)
   PUBMED   27539848
  REMARK    GeneRIF: Protein-tyrosine phosphatase receptor type G
            (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6),
            a group of glycophosphatidylinositol-anchored cell adhesion
            molecules involved in the wiring of the nervous system
REFERENCE   5  (bases 1 to 9190)
  AUTHORS   Boedtkjer,E., Hansen,K.B., Boedtkjer,D.M.B., Aalkjaer,C. and
            Boron,W.F.
  TITLE     Extracellular HCO3- is sensed by mouse cerebral arteries:
            Regulation of tone by receptor protein tyrosine phosphatase gamma
  JOURNAL   J Cereb Blood Flow Metab 36 (5), 965-980 (2016)
   PUBMED   26661205
  REMARK    GeneRIF: vasoconstriction promoted through RPTPgamma-dependent
            changes in VSMC Ca(2+)-sensitivity
REFERENCE   6  (bases 1 to 9190)
  AUTHORS   Alexander,R.C., Wright,R. and Freed,W.
  TITLE     Quantitative trait loci contributing to phencyclidine-induced and
            amphetamine-induced locomotor behavior in inbred mice
  JOURNAL   Neuropsychopharmacology 15 (5), 484-490 (1996)
   PUBMED   8914121
  REMARK    Erratum:[Neuropsychopharmacology 1996 Dec;15(6):609]
REFERENCE   7  (bases 1 to 9190)
  AUTHORS   Okumura,M., Matthews,R.J., Robb,B., Litman,G.W., Bork,P. and
            Thomas,M.L.
  TITLE     Comparison of CD45 extracellular domain sequences from divergent
            vertebrate species suggests the conservation of three fibronectin
            type III domains
  JOURNAL   J Immunol 157 (4), 1569-1575 (1996)
   PUBMED   8759740
REFERENCE   8  (bases 1 to 9190)
  AUTHORS   Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S.
  TITLE     Expression of protein tyrosine phosphatase genes in the developing
            brain of mouse and rat
  JOURNAL   Biochem Mol Biol Int 33 (6), 1221-1227 (1994)
   PUBMED   7804149
REFERENCE   9  (bases 1 to 9190)
  AUTHORS   Wary,K.K., Lou,Z., Buchberg,A.M., Siracusa,L.D., Druck,T.,
            LaForgia,S. and Huebner,K.
  TITLE     A homozygous deletion within the carbonic anhydrase-like domain of
            the Ptprg gene in murine L-cells
  JOURNAL   Cancer Res 53 (7), 1498-1502 (1993)
   PUBMED   8453613
REFERENCE   10 (bases 1 to 9190)
  AUTHORS   Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D.,
            D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al.
  TITLE     Identification of a carbonic anhydrase-like domain in the
            extracellular region of RPTP gamma defines a new subfamily of
            receptor tyrosine phosphatases
  JOURNAL   Mol Cell Biol 13 (3), 1497-1506 (1993)
   PUBMED   8382771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079595.1, L09562.1, AC154682.2 and AK134814.1.
            
            On Nov 21, 2007 this sequence version replaced NM_008981.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09562.1, SRR10223971.13918.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               BC079595.1         1-569
            570-2236            L09562.1           111-1777
            2237-5099           BC079595.1         2113-4975
            5100-7858           AC154682.2         66334-69092         c
            7859-9190           AK134814.1         1-1332
FEATURES             Location/Qualifiers
     source          1..9190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 6.33 cM"
     gene            1..9190
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /note="protein tyrosine phosphatase receptor type G"
                     /db_xref="GeneID:19270"
                     /db_xref="MGI:MGI:97814"
     exon            1..780
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            781..885
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1065
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1214
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1310
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1377
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1535
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1728
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1913
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2022
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2072
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2841
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2974
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3061
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3153
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3245
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3342
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3425
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3560
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3695
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3868
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4004
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4151
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4245
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4322
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..4451
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4452..4598
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4741
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4742..4877
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4878..9190
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5680..5685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /note="hexamer: AATAAA"
     polyA_site      5715
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /note="major polyA site"
ORIGIN      
        1 catggccagt ttccagcccc gcgctctcgg ttcctcccca gcctgcgccg gagccacaac
       61 tttcaggagc atggactgaa ggcgccctcg ccccggcgcc cctctgagat cctttgtgtt
      121 tccctgcgct ccactggccg tttgtgtttt ggggggctct gcgctccgcc ccgccgcttc
      181 cctccctttc caggctcgca gacatgcctc cttccttgcc ggggccctgg aaggagctgc
      241 ccgcctgaag cccggagccg ccgcgccgcg cacagccccg ccgtcgcccg ctggttctcg
      301 ggctgcgctg cgctgccgac tcaacttggg gctcttccgc tgctagccac cgccacccgc
      361 ggtccctgcc tgctccgggc cccgggctct gccgccgtgc gtcttctcct cgccctgcct
      421 gtcggctgga tcgtgtctga gcggaaagca gcccttctcc tccgagagga tcgtccctag
      481 cttggctttg cattcccggt cactttttga ggttttctcg ggagcgcttg gcagcttccc
      541 ggattccagc gggaccggtg gccgagtgtg gggggccccg tgtggcgggc gagccgtgaa
      601 agcctccagg cttagcggag cctcgctcgg aagcaagaac ttattcaaca agtttacccc
      661 ccctgccttt ctcttttcga tgtgcgtttt cggacatgcg gaggttactg gaaccgtgtt
      721 ggtggatttt gttcctgaaa atcaccagtt ctgtgcttca ttatgtggtg tgcttcccgg
      781 cattgactga aggctatgtg gggaccctgc aggagagcag acaggacagc tcagtgcaga
      841 tccgcagacg aaaggcatcc ggagacccat actgggcgta ttctggtgcc tatggtcctg
      901 agcactgggt cacatctagt gtcagctgcg ggggcagcca tcagtctcct atagacattt
      961 tagaccacca tgctcgcgtt ggcgatgaat accaggagct tcaacttgat gggtttgaca
     1021 acgagtcctc taacaaaacc tggatgaaaa atacagggaa aacagttgcc atcctgctga
     1081 aagacgatta ttttgtgagt ggtgccggac tgccgggcag attcaaagct gagaaggtgg
     1141 agtttcactg gggccacagc aatggctccg ctggctcaga gcatagtgtc aatggccgga
     1201 ggtttcctgt ggagatgcag attttctttt acaacccaga cgactttgac agctttcaaa
     1261 cggcaatttc tgagaacaga ataattggag ctatggccat atttttccaa gtcagtccga
     1321 gggacaattc tgcactggat cctattatcc acgggctgaa gggcgtcgta catcacgaga
     1381 aggagacttt cctggatcct ttcattctcc gagacctcct gcccgcatcc ctggggagtt
     1441 attacaggta cacaggctcc ttgactacgc caccctgtag tgaaatagtg gagtggattg
     1501 tcttccggag gcccgttccc atctcctatc accagcttga ggctttttat tctatcttca
     1561 ccacggagca gcaagaccat gtcaagtcag tggagtacct gagaaataac ttccgaccac
     1621 aacaagctct gaatgacaga gtggtgtcaa agtctgctgt ccgggatgcc tggaaccatg
     1681 acctggcaga cttcttggac aacccactag gcacagaagc ctctaaagtt tgcagctctc
     1741 cgcccatcca catgaaggtg cagcctctga accagacagc tctgcaggtg tcctggagcc
     1801 aacctgaaac catctaccac ccgcccatca tgaattacat gatctcctat agctggacca
     1861 agaatgagga cgagaaggag aagacattta caaaagacag tgacaaggac ttgaaagcca
     1921 ccatcagcca tgtctcaccc gatagccttt acctattccg agtacaggct gtgtgtagga
     1981 atgacatgcg gagtgacttc agccagacaa tgctctttca agctaatact acccggatct
     2041 tccaagggac caggattgtg aaaacaggag tgccgacagc ctctcctgcc tcttcagcag
     2101 acatggcccc catcagctct ggctcttcca cttggacatc ctccggcatc cccttctcat
     2161 ttgtttccat ggcaactggg atgggccctt cctccagtgg cagccaagct acagtggcct
     2221 ctgtggtcac cagcacactg ttggcaggcc tgggcttcgg tggtggtggc atctcctcct
     2281 tccccagtac cgtgtggccc acgcgccttc ccaccgcatc tgcagccagc aagcaggcag
     2341 ggaggacagt tcttgccacc accgaggcct tagcttcccc tgggccggat gtcgactcgg
     2401 caccgacgaa ggacagcgag ggtacagagg agggagagaa ggaggagaaa agcgagagcg
     2461 aggatggtga gcgagagcat gaggaggaag agaaggactc tgagaagaag gagaagagtg
     2521 aggctactca cacagccgca gagagtgacc ggactgcacc tgcccccacc ccctcttccc
     2581 ctcataggac tgcagcggag ggaggacatc agactatacc tgggcgcagg caggaccact
     2641 ctgcccctgc cacagaccag ccgggccacg ttgccccaga cttggatccc cttgtggaca
     2701 cagccaccca agtgccccca acagccacag aggaacatta ttcagggagt gatcccagga
     2761 ggcccgaaat gccatctaaa aagcctatgt cccgagggga ccgattttct gaggatagca
     2821 aattcatcac agttaaccca gctgagaaga acacctctgg catgctaagc cgcccctccc
     2881 ccgggaggat ggagtggatc atccccctga ttgtggtctc agccttgacc ttcgtgtgcc
     2941 tcgtcctcct cattgccgtg ctggtgtact ggagagggtg taacaaaata aagtccaagg
     3001 gctttccccg acgttcccgt gaagtgcctt cttctgggga gagaggagag aaggggagca
     3061 gaaaatgttt tcagactgct catttctatg tggaagacag cagttcacct cgggtggtcc
     3121 ccaacgaaag tgttcctatt attcccatcc cggatgacat ggaagccatt cctgtcaaac
     3181 agtttggtaa acacatcggt gagctctatt ccaatagcca gcatggcttc tcggaagatt
     3241 ttgaggaagt ccagcgctgt acagctgata tgaacatcac tgcagagcat tccaatcatc
     3301 cggataacaa gcacaaaaac agatacatca acattttagc atatgatcac agtagggtga
     3361 agttaagacc tttaccagga aaggactcta agcacagcga ctacattaat gcaaactatg
     3421 tcgatggtta caacaaagcg aaagcctaca ttgccaccca gggaccttta aaatccacct
     3481 ttgaagactt ctggaggatg atctgggaac aaaacacggg aatcatcatc atgatcacga
     3541 acctcgtgga gaaaggaagg agaaagtgtg atcagtattg gccaacggag aacactgagg
     3601 agtacgggaa cattattgtc acactgaaga gcacaaaagt acatgcctgc tacaccgtcc
     3661 gtcgtctttc agttagaaac acaaaagtga aaaagggcca gaagggcaac cccaaaggtc
     3721 gtcagaatga gcggacggtg atccagtacc actacacaca gtggcctgac atgggtgtcc
     3781 ctgagtacgc cctcccagtc ctgaccttcg tgaggaggtc atctgcggcc cgcatgccag
     3841 acatggggcc cgtgttggtg cactgcagcg ctggtgtggg caggacaggc acctacattg
     3901 taatagacag catgctgcag cagatcaaag acaaaagcac agttaatgtc ctgggcttcc
     3961 tgaagcatat caggacacag aggaactacc tcgtccagac tgaggagcag tacattttca
     4021 tccatgatgc cttgttggaa gccattctcg ggaaggaaac tgaagtatct tcaagtcagc
     4081 tgcatagcta tgttaacagc atcctcatac caggagtagg aggaaagaca cggctggaaa
     4141 agcagtttaa gctgatcacg cagtgtaatg caaagtatgt ggagtgcttc agtgcccaga
     4201 aggagtgcaa caaagagaag aacaggaact cgtctgttgt gccagctgag cgtgctcgag
     4261 tgggacttgc accgttgccc gggatgaaag gaacagatta cattaatgct tcttacatca
     4321 tggggtatta tagaagcaac gagttcatca taacccagca tcctctgcca cacactacga
     4381 aagatttctg gagaatgatt tgggatcata atgcacagat cattgtcatg ctgccagaca
     4441 accagagcct ggcagaagat gagtttgtgt actggccgag tcgtgaggaa tccatgaact
     4501 gtgaggcctt tactgtcacc ctcatcagca aagacaggct atgcctctcg aatgaagaac
     4561 aaattatcat ccatgacttc atccttgaag ctacacagga tgactacgta ctagaggttc
     4621 ggcactttca gtgtcccaaa tggcctaacc cagatgcccc tataagtagt accttcgaac
     4681 tgatcaatgt catcaaggaa gaggccttaa cccgggatgg ccccaccatt gttcatgatg
     4741 agtatggagc agtttctgca ggaatgttgt gtgcccttac caccttgtcc cagcagctag
     4801 agaatgaaaa tgctgtggat gtgttccagg tggcaaaaat gatcaatctt atgagacctg
     4861 gagtattcac agacattgaa caataccagt ttgtctacaa agcaatgctc agcttgatca
     4921 gtactaaaga aaatggaaat ggtcccatga ccggggacaa aaacggtgct gtgctaactg
     4981 cagaggaatc agaccctgca gagagcatgg agtctctggt gtgactagtc ccctggaagg
     5041 gcacttcatt tgtaaacttc tgagacttgt aaagacagaa attttttgag gccttttttg
     5101 ccagactcta ggttatacaa taacccagtt acttttttac actgataaaa gttttgatat
     5161 ttattttttg ccattttctg tcttaatggt atcctactga gcatttgcgc ctgttcttca
     5221 tttcacacag tgaaacgcaa ctttacctag tttgcactat atgatcagtg ttaactgcct
     5281 ataatctaat actacagaaa ccctgatgtg acattccatg accacataca tgctattttt
     5341 tagttccgtg cagtgaaggt ctttgttatg acagtgaatc tcagttttac tattattcta
     5401 aagcaactac aatttcttag caggcaacag tgtacttttc tcagtcccct ctatttttta
     5461 ggcactgttc aatactacat gccttctgtt ttaatggagt ggatgggcgt tgtctccttt
     5521 tgcaggacag caggtgactg ggagccctat agatctgttg gcatcagttc catttgtaat
     5581 ggttgaggga ccactaagaa gttaagaggg cttcagagtt acttcatgtg aacatctctt
     5641 attagttacc aagttatatt cacagttgaa atgtgtcaaa ataaagaatc attctgtatt
     5701 acagatttca cagtagctat gtggacagtg tgtgttattt ctatgttgac tctctgaagt
     5761 agcaaaccct aaaatcaggg ctgtctttta caatgggaag atggccttat tttacacaat
     5821 ttacttatga cactctttag ttaactcaac tatagctttt tggtaaatag taccatagta
     5881 gctacaacca caaaataggt attgacattt aaacgtagtc tttgaaaagt ccctactaac
     5941 tactcctata gcaatctaat aaacactacc tatagacagc attttttttg ccaaatgttt
     6001 cataataaat ctcttaatta catccaactc tacttaagat tgaattggaa atatatttgg
     6061 gagtcaattt ttataggtct tactttgaga aagaaatagg aatcttaaag agaaaatcca
     6121 gttcttgaat gaaagatggc atctccattt tagactgggt tttaaggaag agatgcggat
     6181 gctcacaaac aaatgtacat ttataaaaga tggcagtagt cattaggaag cccagaggcc
     6241 agtgtctgga gctactttca gcacgtagta catatgggca aactggaagc attatttcga
     6301 aatttcactt gagtttgttt aaaacaaaac aaaatccact aagctattaa tcaggatctg
     6361 tatcttcctt ctcctctttg cttttgaaag tcaacttctg ccagaattga aatcccccaa
     6421 gattggtttc ttctttatga caaaagcttt ctgaagagga gggcagcatc tcagtgtgaa
     6481 tgcggcttta ttgttcgtgg gttgtttttt ggaactagtc acagaagtgc tggagagcca
     6541 gagctggtaa ggagagagtc acaggccaag cccagagctt tcaacgcatg gaccaggcca
     6601 atagagcccc atgaagatag tgtgtgcaca aagacctaag agaacacaca gagaattggg
     6661 aggctggctt tcaaaactgg tgagcagctg agccgaatcc actaacatat ctgtgctaga
     6721 tggatttacc aacccctgca gccccaccag aggggtcacc tctgcacaat acaaaggatt
     6781 gaccataaga aacataactc ttagaggctg tgggaaataa ggaaggaaaa ggtttcagat
     6841 tgtggtatga gcttcccagt caatcgagca gattcttttt gctgtgcaca gatctgatct
     6901 tagctaatgc ttttcagtta gatgctcagt ggaattaaca tttgaattgg agttcagtct
     6961 ctcaattgtc tcgtagtaaa aataacattg tctagaagac aaatggcaag tattacttct
     7021 gtgctgttta cacaagattc aattcatgaa aatgcatact ctacagttct ggggctctct
     7081 cttacacgag tgaaagaaga atgggagaaa gggagaaaga agtacaacag aagtacaatc
     7141 aaggcggggg agaggcttcc tgtgggcagc ctacatgtct acagcaggct tgagccaaag
     7201 cctacagatg ccagcctact ggactacatg cagttgctat gtgcccattt tgccaaagtg
     7261 gtccacacgc cctttactgg gggtgatagt taccttcagc tctcttcagt cctcacattc
     7321 accacaattt gtatgttcac tattctttgc tattggcaaa aatgtttttg catctttcca
     7381 gaggcaaaga gttccaaaga tgttttcttt gagacataag cacgtggctt aagtatataa
     7441 ggttagtact atttacagtc gagggaaaag atataactat tggtaaagct agtgtgaaag
     7501 tttatgagat atgctggttt tatgaattta cctctaggga aatgaaatat acaaaccaaa
     7561 tgaagcggaa ttgttataat ttgatcaggt ggatgtgcag gatatcacag atgtattaga
     7621 gacacccgaa aagtttcttg tacctcaaac cataatatca tctttgatag ttcatatata
     7681 tataaatata tatatatata tatatatata tatccttctg agtttcaaga ataagtacag
     7741 cttagtttgg tggttttcct aaactttata tgagctttga gagcctgtgt taaatagaag
     7801 agtccagcaa ggtcaaaaac cccaaaagtt atatatagtg ttcaaggtaa aaagaagggt
     7861 tctggtgttg aaagtctggt ttgtagcttt taccccagag tgacagtgaa gccagtgagt
     7921 aaccatcatt gttttataat aacatagcac aactgccttc tcatgacctt ttcataaatg
     7981 catatatact atgtttaaaa tatagatacc actttaccaa agatacacat tactaattct
     8041 aagcaaaaaa agaaaaaaaa agatattaaa aaaaacctcg aactcataat acttttaaaa
     8101 agtaatcaaa atgtagttct gttatcgctt tgcagttatg ctggtgaatg ccttctcaac
     8161 cccggtgttc taaagtttct gttcaaacgg tgccagtaca tttttatatg aagggaatgc
     8221 ctgctttttt cctccatagc agctgtaatt catgtagccc tttgtacttt cccttagtcc
     8281 ccacttaaca cacagcattg gctttattta tctctataaa gaaggcatgg taaaaaaaaa
     8341 taactaataa aaaattataa tgacatttgg cctctacttt tgtcttagct gttaaaatgt
     8401 ttttagtatt tttgttaaat atttgcaaag ggaagaattt tctacagagg ataattaatt
     8461 tcaagaaaaa tatcttgagt tttaaggaat aaacatctcc agaaaaggag acagtcaatt
     8521 ttataaaatg tcgtaactct ccaacatttg gggtagtgac tccttttttg ttaggacatt
     8581 tgaaactagc aagtagccgt tgtttctaaa gagccccact tcatgtcaac tcctgtttct
     8641 ttaacttcat tttcaaacag tttaaaacat taaacctgta aatattttgt tgcttgagta
     8701 agcatcttct ggaagctttg tatctatggt atataatcat agaattttat attttcatat
     8761 aaagctaatt tttttctagt ttcaactatg tcatagttct tttagttgtt ggtgcccctc
     8821 tcccccgtgg tggatatgtg aacttctgtg tattgaagta gcaagaacca tctttgcatt
     8881 ccaaaagaat ccgtgtgttc ttcctttggg gtagtgattg tgaaaatcgg gtgttctttt
     8941 taattccatt gatcattagt gcaatagcaa ttagacatca ctagtcactg aatacatttg
     9001 tcacatggac ccattttgga aaaagtgatt ttttttttta aagaattgtt ctgtgggggg
     9061 aggggtttta taacctgaaa ttttttccct ttttccttct gtttaaaact atatcaaatc
     9121 attctattat agtgttattt aatatgtaaa ttgtattgct atacataaaa taaagtatgg
     9181 tttttgatgt
//
