LOCUS       NP_033007               1442 aa            linear   ROD 28-APR-2025
DEFINITION  receptor-type tyrosine-protein phosphatase gamma isoform 1
            precursor [Mus musculus].
ACCESSION   NP_033007 XP_910308
VERSION     NP_033007.2
DBSOURCE    REFSEQ: accession NM_008981.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1442)
  AUTHORS   Taki,S., Boron,W.F. and Moss,F.J.
  TITLE     Novel RPTPgamma and RPTPzeta splice variants from mixed
            neuron-astrocyte hippocampal cultures as well as from the
            hippocampi of newborn and adult mice
  JOURNAL   Front Physiol 15, 1406448 (2024)
   PUBMED   38952869
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1442)
  AUTHORS   Hansen,K.B., Staehr,C., Rohde,P.D., Homilius,C., Kim,S.,
            Nyegaard,M., Matchkov,V.V. and Boedtkjer,E.
  TITLE     PTPRG is an ischemia risk locus essential for HCO3--dependent
            regulation of endothelial function and tissue perfusion
  JOURNAL   Elife 9, e57553 (2020)
   PUBMED   32955439
  REMARK    GeneRIF: PTPRG is an ischemia risk locus essential for
            HCO3(-)-dependent regulation of endothelial function and tissue
            perfusion.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1442)
  AUTHORS   Brenachot,X., Ramadori,G., Ioris,R.M., Veyrat-Durebex,C.,
            Altirriba,J., Aras,E., Ljubicic,S., Kohno,D., Fabbiano,S.,
            Clement,S., Goossens,N., Trajkovski,M., Harroch,S., Negro,F. and
            Coppari,R.
  TITLE     Hepatic protein tyrosine phosphatase receptor gamma links
            obesity-induced inflammation to insulin resistance
  JOURNAL   Nat Commun 8 (1), 1820 (2017)
   PUBMED   29180649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1442)
  AUTHORS   Nikolaienko,R.M., Hammel,M., Dubreuil,V., Zalmai,R., Hall,D.R.,
            Mehzabeen,N., Karuppan,S.J., Harroch,S., Stella,S.L. and Bouyain,S.
  TITLE     Structural Basis for Interactions Between Contactin Family Members
            and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues
  JOURNAL   J Biol Chem 291 (41), 21335-21349 (2016)
   PUBMED   27539848
  REMARK    GeneRIF: Protein-tyrosine phosphatase receptor type G
            (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6),
            a group of glycophosphatidylinositol-anchored cell adhesion
            molecules involved in the wiring of the nervous system
REFERENCE   5  (residues 1 to 1442)
  AUTHORS   Boedtkjer,E., Hansen,K.B., Boedtkjer,D.M.B., Aalkjaer,C. and
            Boron,W.F.
  TITLE     Extracellular HCO3- is sensed by mouse cerebral arteries:
            Regulation of tone by receptor protein tyrosine phosphatase gamma
  JOURNAL   J Cereb Blood Flow Metab 36 (5), 965-980 (2016)
   PUBMED   26661205
  REMARK    GeneRIF: vasoconstriction promoted through RPTPgamma-dependent
            changes in VSMC Ca(2+)-sensitivity
REFERENCE   6  (residues 1 to 1442)
  AUTHORS   Alexander,R.C., Wright,R. and Freed,W.
  TITLE     Quantitative trait loci contributing to phencyclidine-induced and
            amphetamine-induced locomotor behavior in inbred mice
  JOURNAL   Neuropsychopharmacology 15 (5), 484-490 (1996)
   PUBMED   8914121
  REMARK    Erratum:[Neuropsychopharmacology 1996 Dec;15(6):609]
REFERENCE   7  (residues 1 to 1442)
  AUTHORS   Okumura,M., Matthews,R.J., Robb,B., Litman,G.W., Bork,P. and
            Thomas,M.L.
  TITLE     Comparison of CD45 extracellular domain sequences from divergent
            vertebrate species suggests the conservation of three fibronectin
            type III domains
  JOURNAL   J Immunol 157 (4), 1569-1575 (1996)
   PUBMED   8759740
REFERENCE   8  (residues 1 to 1442)
  AUTHORS   Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S.
  TITLE     Expression of protein tyrosine phosphatase genes in the developing
            brain of mouse and rat
  JOURNAL   Biochem Mol Biol Int 33 (6), 1221-1227 (1994)
   PUBMED   7804149
REFERENCE   9  (residues 1 to 1442)
  AUTHORS   Wary,K.K., Lou,Z., Buchberg,A.M., Siracusa,L.D., Druck,T.,
            LaForgia,S. and Huebner,K.
  TITLE     A homozygous deletion within the carbonic anhydrase-like domain of
            the Ptprg gene in murine L-cells
  JOURNAL   Cancer Res 53 (7), 1498-1502 (1993)
   PUBMED   8453613
REFERENCE   10 (residues 1 to 1442)
  AUTHORS   Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D.,
            D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al.
  TITLE     Identification of a carbonic anhydrase-like domain in the
            extracellular region of RPTP gamma defines a new subfamily of
            receptor tyrosine phosphatases
  JOURNAL   Mol Cell Biol 13 (3), 1497-1506 (1993)
   PUBMED   8382771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079595.1, L09562.1, AC154682.2 and AK134814.1.
            
            On Jul 25, 2007 this sequence version replaced NP_033007.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09562.1, SRR10223971.13918.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 6.33 cM"
     Protein         1..1442
                     /product="receptor-type tyrosine-protein phosphatase gamma
                     isoform 1 precursor"
                     /EC_number="3.1.3.48"
                     /note="receptor-type tyrosine-protein phosphatase gamma;
                     R-PTP-gamma; Protein-tyrosine phosphatase gamma precursor
                     (R-PTP-gamma)"
                     /calculated_mol_wt=158918
     sig_peptide     1..19
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
                     /calculated_mol_wt=2393
     mat_peptide     20..1442
                     /product="Receptor-type tyrosine-protein phosphatase
                     gamma. /id=PRO_0000025442"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05909.1)"
                     /calculated_mol_wt=158918
     Region          67..319
                     /region_name="alpha_CARP_receptor_like"
                     /note="Carbonic anhydrase alpha related protein,
                     receptor_like subfamily. Carbonic anhydrase related
                     proteins (CARPs) are sequence similar to carbonic
                     anhydrases. Carbonic anhydrases are zinc-containing
                     enzymes that catalyze the reversible hydration of
                     carbon...; cd03122"
                     /db_xref="CDD:239396"
     Site            109
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Site            113
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Site            156
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Region          348..438
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            359
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Site            order(432..433,435..436)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            444
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Region          461..480
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05909.1)"
     Region          557..726
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05909.1)"
     Region          <613..689
                     /region_name="PRK12495"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:183558"
     Site            719
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Site            734..759
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05909.1)"
     Region          769..788
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05909.1)"
     Region          845..1118
                     /region_name="R-PTPc-G-1"
                     /note="catalytic domain of receptor-type tyrosine-protein
                     phosphatase G, repeat 1; cd17667"
                     /db_xref="CDD:350505"
     Site            1179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P23470; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Region          1202..1406
                     /region_name="R-PTP-G-2"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase G, repeat 2; cd17670"
                     /db_xref="CDD:350508"
     Site            1348
                     /site_type="other"
                     /note="Ancestral active site; propagated from
                     UniProtKB/Swiss-Prot (Q05909.1)"
     Region          1412..1442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05909.1)"
     CDS             1..1442
                     /gene="Ptprg"
                     /gene_synonym="5430405N12Rik; RPTPgamma"
                     /coded_by="NM_008981.3:696..5024"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS26816.1"
                     /db_xref="GeneID:19270"
                     /db_xref="MGI:MGI:97814"
ORIGIN      
        1 mrrllepcww ilflkitssv lhyvvcfpal tegyvgtlqe srqdssvqir rrkasgdpyw
       61 aysgaygpeh wvtssvscgg shqspidild hharvgdeyq elqldgfdne ssnktwmknt
      121 gktvaillkd dyfvsgaglp grfkaekvef hwghsngsag sehsvngrrf pvemqiffyn
      181 pddfdsfqta isenriigam aiffqvsprd nsaldpiihg lkgvvhheke tfldpfilrd
      241 llpaslgsyy rytgslttpp cseivewivf rrpvpisyhq leafysiftt eqqdhvksve
      301 ylrnnfrpqq alndrvvsks avrdawnhdl adfldnplgt easkvcsspp ihmkvqplnq
      361 talqvswsqp etiyhppimn ymisyswtkn edekektftk dsdkdlkati shvspdslyl
      421 frvqavcrnd mrsdfsqtml fqanttrifq gtrivktgvp taspassadm apissgsstw
      481 tssgipfsfv smatgmgpss sgsqatvasv vtstllaglg fggggissfp stvwptrlpt
      541 asaaskqagr tvlatteala spgpdvdsap tkdsegteeg ekeeksesed gereheeeek
      601 dsekkeksea thtaaesdrt apaptpssph rtaaegghqt ipgrrqdhsa patdqpghva
      661 pdldplvdta tqvpptatee hysgsdprrp empskkpmsr gdrfsedskf itvnpaeknt
      721 sgmlsrpspg rmewiipliv vsaltfvclv lliavlvywr gcnkikskgf prrsrevpss
      781 gergekgsrk cfqtahfyve dsssprvvpn esvpiipipd dmeaipvkqf gkhigelysn
      841 sqhgfsedfe evqrctadmn itaehsnhpd nkhknryini laydhsrvkl rplpgkdskh
      901 sdyinanyvd gynkakayia tqgplkstfe dfwrmiweqn tgiiimitnl vekgrrkcdq
      961 ywptenteey gniivtlkst kvhacytvrr lsvrntkvkk gqkgnpkgrq nertviqyhy
     1021 tqwpdmgvpe yalpvltfvr rssaarmpdm gpvlvhcsag vgrtgtyivi dsmlqqikdk
     1081 stvnvlgflk hirtqrnylv qteeqyifih dalleailgk etevsssqlh syvnsilipg
     1141 vggktrlekq fklitqcnak yvecfsaqke cnkeknrnss vvpaerarvg laplpgmkgt
     1201 dyinasyimg yyrsnefiit qhplphttkd fwrmiwdhna qiivmlpdnq slaedefvyw
     1261 psreesmnce aftvtliskd rlclsneeqi iihdfileat qddyvlevrh fqcpkwpnpd
     1321 apisstfeli nvikeealtr dgptivhdey gavsagmlca lttlsqqlen enavdvfqva
     1381 kminlmrpgv ftdieqyqfv ykamlslist kengngpmtg dkngavltae esdpaesmes
     1441 lv
//
