LOCUS       NM_011211               8972 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type D (Ptprd),
            transcript variant 1, mRNA.
ACCESSION   NM_011211 XM_131462 XM_283979
VERSION     NM_011211.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8972)
  AUTHORS   Emperador-Melero,J., Andersen,J.W., Metzbower,S.R., Levy,A.D.,
            Dharmasri,P.A., de Nola,G., Blanpied,T.A. and Kaeser,P.S.
  TITLE     Distinct active zone protein machineries mediate Ca2+ channel
            clustering and vesicle priming at hippocampal synapses
  JOURNAL   Nat Neurosci 27 (9), 1680-1694 (2024)
   PUBMED   39160372
REFERENCE   2  (bases 1 to 8972)
  AUTHORS   Mishra,I., Feng,B., Basu,B., Brown,A.M., Kim,L.H., Lin,T.,
            Raza,M.A., Moore,A., Hahn,A., Bailey,S., Sharp,A., Bournat,J.C.,
            Poulton,C., Kim,B., Langsner,A., Sathyanesan,A., Sillitoe,R.V.,
            He,Y. and Chopra,A.R.
  TITLE     The cerebellum modulates thirst
  JOURNAL   Nat Neurosci 27 (9), 1745-1757 (2024)
   PUBMED   38987435
REFERENCE   3  (bases 1 to 8972)
  AUTHORS   Cortes,B.I., Meza,R.C., Ancaten-Gonzalez,C., Ardiles,N.M.,
            Aranguiz,M.I., Tomita,H., Kaplan,D.R., Cornejo,F., Nunez-Parra,A.,
            Moya,P.R., Chavez,A.E. and Cancino,G.I.
  TITLE     Loss of protein tyrosine phosphatase receptor delta PTPRD increases
            the number of cortical neurons, impairs synaptic function and
            induces autistic-like behaviors in adult mice
  JOURNAL   Biol Res 57 (1), 40 (2024)
   PUBMED   38890753
  REMARK    GeneRIF: Loss of protein tyrosine phosphatase receptor delta PTPRD
            increases the number of cortical neurons, impairs synaptic function
            and induces autistic-like behaviors in adult mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8972)
  AUTHORS   Matsumoto,Y., Miwa,H., Katayama,K.I., Watanabe,A., Yamada,K.,
            Ito,T., Nakagawa,S. and Aruga,J.
  TITLE     Slitrk4 is required for the development of inhibitory neurons in
            the fear memory circuit of the lateral amygdala
  JOURNAL   Front Mol Neurosci 17, 1386924 (2024)
   PUBMED   38736483
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8972)
  AUTHORS   Cornejo,F., Franchini,N., Cortes,B.I., Elgueta,D. and Cancino,G.I.
  TITLE     Neural conditional ablation of the protein tyrosine phosphatase
            receptor Delta PTPRD impairs gliogenesis in the developing mouse
            brain cortex
  JOURNAL   Front Cell Dev Biol 12, 1357862 (2024)
   PUBMED   38487272
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8972)
  AUTHORS   Sommer,L., Rao,M. and Anderson,D.J.
  TITLE     RPTP delta and the novel protein tyrosine phosphatase RPTP psi are
            expressed in restricted regions of the developing central nervous
            system
  JOURNAL   Dev Dyn 208 (1), 48-61 (1997)
   PUBMED   8989520
REFERENCE   7  (bases 1 to 8972)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   8  (bases 1 to 8972)
  AUTHORS   Mizuno,K., Hasegawa,K., Ogimoto,M., Katagiri,T. and Yakura,H.
  TITLE     Developmental regulation of gene expression for the MPTP delta
            isoforms in the central nervous system and the immune system
  JOURNAL   FEBS Lett 355 (3), 223-228 (1994)
   PUBMED   7988677
REFERENCE   9  (bases 1 to 8972)
  AUTHORS   Kaneko,Y., Takano,S., Okumura,K., Takenawa,J., Higashituji,H.,
            Fukumoto,M., Nakayama,H. and Fujita,J.
  TITLE     Identification of protein tyrosine phosphatases expressed in murine
            male germ cells
  JOURNAL   Biochem Biophys Res Commun 197 (2), 625-631 (1993)
   PUBMED   8267598
REFERENCE   10 (bases 1 to 8972)
  AUTHORS   Mizuno,K., Hasegawa,K., Katagiri,T., Ogimoto,M., Ichikawa,T. and
            Yakura,H.
  TITLE     MPTP delta, a putative murine homolog of HPTP delta, is expressed
            in specialized regions of the brain and in the B-cell lineage
  JOURNAL   Mol Cell Biol 13 (9), 5513-5523 (1993)
   PUBMED   8355697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954189.5, AL954376.4, AL928645.6, AL845496.5, AL845333.3,
            AL954675.7, AL845508.11, AL845158.5, AL844848.12, AL845517.2 and
            AL929181.2.
            
            On Mar 11, 2019 this sequence version replaced NM_011211.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC086654.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL954189.5         158847-158999       c
            154-208             AL954376.4         56036-56090         c
            209-277             AL928645.6         101989-102057       c
            278-385             AL928645.6         18088-18195         c
            386-427             AL845496.5         25742-25783         c
            428-465             AL845333.3         175309-175346       c
            466-513             AL845333.3         34194-34241         c
            514-547             AL954675.7         79569-79602         c
            548-606             AL845508.11        2782-2840           c
            607-645             AL845158.5         27872-27910         c
            646-811             AL844848.12        133873-134038       c
            812-957             AL844848.12        55446-55591         c
            958-1099            AL844848.12        52338-52479         c
            1100-1288           AL845517.2         138916-139104       c
            1289-1297           AL845517.2         137696-137704       c
            1298-1315           AL845517.2         136958-136975       c
            1316-1426           AL845517.2         135213-135323       c
            1427-1438           AL845517.2         133947-133958       c
            1439-1708           AL845517.2         131465-131734       c
            1709-2290           AL845517.2         126887-127468       c
            2291-2424           AL845517.2         105685-105818       c
            2425-2569           AL845517.2         101357-101501       c
            2570-2667           AL845517.2         83863-83960         c
            2668-2927           AL845517.2         82720-82979         c
            2928-3018           AL845517.2         70346-70436         c
            3019-3228           AL845517.2         64570-64779         c
            3229-3389           AL845517.2         58071-58231         c
            3390-3502           AL845517.2         48729-48841         c
            3503-3600           AL845517.2         37683-37780         c
            3601-3724           AL845517.2         10459-10582         c
            3725-3900           AL929181.2         121183-121358       c
            3901-4020           AL929181.2         105268-105387       c
            4021-4175           AL929181.2         104636-104790       c
            4176-4461           AL929181.2         79778-80063         c
            4462-4640           AL929181.2         78988-79166         c
            4641-4767           AL929181.2         77898-78024         c
            4768-4893           AL929181.2         76755-76880         c
            4894-5048           AL929181.2         73333-73487         c
            5049-5184           AL929181.2         69725-69860         c
            5185-8972           AL929181.2         63921-67708         c
FEATURES             Location/Qualifiers
     source          1..8972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 36.94 cM"
     gene            1..8972
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /note="protein tyrosine phosphatase receptor type D"
                     /db_xref="GeneID:19266"
                     /db_xref="MGI:MGI:97812"
     exon            1..153
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            154..208
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            209..277
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            278..385
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            386..427
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            428..465
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            466..513
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            514..547
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            548..606
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            607..645
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            646..811
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            812..957
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1099
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1288
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1297
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1315
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1426
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1438
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1708
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..2290
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2424
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2569
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2667
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2927
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3018
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3228
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3389
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3502
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3600
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3724
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3900
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4020
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4175
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4461
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4640
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            4641..4767
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            4768..4893
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..5048
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5184
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..8972
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6912..6917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /note="hexamer: ATTAAA"
     polyA_site      6936
                     /gene="Ptprd"
                     /gene_synonym="1110002J03Rik; 3000002J10Rik;
                     B230219D21Rik; R-PTP-delta"
                     /note="major polyA site"
ORIGIN      
        1 accgacgccg agcgagcgct gccggctgag gccgttgctc tccctgtctg cagttgagcc
       61 cggaccctgg gacagaaaga cagttctcgg ttggactgga agaaagggaa ggaagactcc
      121 tctgttcccg aggagagcgg agcggctgcc ctagtgaaga aatgaagaat caaagaagta
      181 aaggacttat ctcataatca cataactagg gaaccttgag gagttgcaca ctttccatcc
      241 ccagtcactg ctccccttcg ggggagggtc ttacttgctc gaaatagaag gcaagcagtt
      301 cttggcctgt gaaatctgag tggcagtgcc tggctgtcag tatgctggcc ccaatgttga
      361 tggacatgat tagctttggc tccaggttcc tgtcctgaga ccacagcaga aagtgccttg
      421 gatgaaggct tggactctgg atcgtctggt gacttcaact gtctggtctc agggtggaga
      481 actttctttg tatgcctaac ctgtgagtcg atgatgatgg tgcctgtcca ctaactgaac
      541 aactgtggtg ttcaacattc tgaggccagg aactgtttct gaaacactct acagagctca
      601 tagatgggag aagtctggtg agcacccagg ggatctaact agcaagctct aaaagggttc
      661 cagctgaagt ttctgagcgg agcagtcgct gtggctccct aggctgagtt tccaagctgc
      721 tggttcatgc cgttgacaaa ctgcaggatg gtgcccgtgg ccaggccgct gtcgctgctc
      781 ctcaccttct tcctctgcgc ctgtgctgag acacccccca ggtttacacg aactccggtt
      841 gatcagacag gggtctctgg aggagttgca tcattcattt gtcaagctac aggagaccca
      901 agacctaaaa ttgtctggaa caaaaaagga aagaaagtca gcaaccagag atttgaggta
      961 atagaatttg acgatggatc tggatcagta ctcagaatac agcccttaag gactccacgg
     1021 gatgaggcca tttatgaatg tgtggcctcg aataatgtgg gagaaatcag tgtgtccaca
     1081 agactcacag ttttacgtga ggatcagatt cctagagggt tccctacgat tgatatgggc
     1141 ccgcagttga aggtggtgga acggacccgc accgccacca tgctgtgtgc agccagcggt
     1201 aatccggatc cagaaatcac ttggtttaaa gatttcttac ctgttgacac aagcaacaac
     1261 aatggtcgta ttaagcagtt acgatcagaa tctattggtg gtacaccaat aagaggagcg
     1321 ctgcagatcg aacagagcga agaatccgac caaggaaaat acgagtgtgt tgccaccaac
     1381 agcgcgggca ctcgctactc tgcccctgcc aatttatatg tcagagagct gcgagaagtt
     1441 cgccgtgtcc caccaagatt ctctatccca cccactaatc atgaaatcat gccaggtgga
     1501 agtgtaaata tcacctgtgt ggcagtgggg tcaccaatgc cttatgtgaa gtggatgttg
     1561 ggggcagaag atctgacacc agaagatgat atgccgatag gacgaaatgt cctagaactg
     1621 aatgacgtaa gacagtcagc aaattacacc tgtgttgcta tgtcgacgtt gggggtcatt
     1681 gaagcaatag cccagatcac tgtcaaagcc ttacccaagc ctccaggaac tcctgtagtg
     1741 accgagagca cagctacaag catcacacta acatgggact ctgggaatcc tgagcctgtc
     1801 tcttactaca tcattcagca taagcctaaa aattctgaag aaccatataa agaaattgat
     1861 gggatagcca ccacacgcta cagtgttgcc ggattaagtc cctactcgga ttatgaattt
     1921 agagttgttg ctgtcaataa cattggacga ggcccagcaa gtgagcctgt gttaactcag
     1981 acctcagaac aagcaccatc cagtgcccca cgggatgttc aggcacgcat gttgagctct
     2041 accaccattc tggtacaatg gaaggaacct gaggagccaa atggacagat ccaagggtat
     2101 agagtttatt atacaatgga ccccactcag catgtcaaca actggatgaa acacaatgta
     2161 gctgatagcc aaatcactac tattggcaat ttagtacccc aaaaaacata ctctgtcaaa
     2221 gtcctggctt ttacctcaat tggagatgga cctctttcta gtgatataca agtcatcact
     2281 cagacaggag taccagggca gccactaaac ttcaaagcag aacctgaatc tgaaacaagt
     2341 attttgctgt cttggacacc gccacgatca gataccattg ccagctatga actagtctac
     2401 agagatgggg atcaaggaga agagcagcga atcaccattg agccaggcac atcttatagg
     2461 cttcaagggc tgaaaccaaa cagcctgtac tacttccgtc tgtctgcacg ctctcctcaa
     2521 ggcctgggtg cttctacagc tgaaatatca gctagaacca tgcaatcaat gtttgcaaaa
     2581 aattttcatg tcaaagcagt tatgaagact tcagtgctgc tgtcttggga gattccagag
     2641 aattataatt ctgctatgcc tttcaaaatt ctttatgatg atgggaaaat ggtggaagaa
     2701 gtggatggcc gagctaccca gaagctgatt gttaacctga agcctgagaa gtcatattcc
     2761 tttgtgttaa ccaatcgtgg gaacagtgct ggtggattgc agcatagggt gacagcaaag
     2821 actgccccag atgtgctccg caccaagcct gccttcattg ggaagacaaa cttggatggc
     2881 atgattactg tgcaactgcc tgatgttcct gcaaatgaaa acataaaggg ttactacatt
     2941 ataattgtgc ctttgaagaa gtcgcgtggg aaattcatca agccctggga gagccctgat
     3001 gagatggagt tagatgagct gcttaaggag atatctagaa aacgcagaag cattcgttat
     3061 ggaagagaag ttgaattaaa gccatatatt gctgctcact ttgatgtcct tcccactgag
     3121 ttcaccctgg gggatgacaa acattatggt ggatttacga acaaacagct ccaaagtgga
     3181 caagaatatg tcttctttgt gttagcagtg atggaccatg cagagtctaa gatgtatgca
     3241 accagcccat actccgaccc tgttgtgtca atggatctgg atccacagcc aatcacagac
     3301 gaagaggaag gcttgatatg ggtcgtaggt cctgtccttg cagtggtgtt tatcatctgt
     3361 attgtgattg ctattcttct ttataaaagg aagagggcag agtcggagtc cagaaagagc
     3421 agcttaccaa acagtaagga ggtcccttca caccacccaa ccgacccagt agaactgagg
     3481 cgccttaact ttcaaacacc aggtatggct agccatcctc caatacctat cttggaactt
     3541 gcagatcata ttgagaggtt gaaagcaaat gataacctga agttttccca ggaatatgag
     3601 tcaattgacc ctggccagca gttcacatgg gaacactcaa acttggaagt aaacaaacca
     3661 aagaacagat atgcaaatgt cattgcatac gatcactccc gggttctctt atcagcaata
     3721 gaaggaatcc caggaagtga ctatgtgaat gccaactaca tagatggcta taggaaacaa
     3781 aatgcctata ttgcaaccca gggatctctt cctgaaacat ttggggactt ttggagaatg
     3841 atatgggagc aacgaagtgc cacagttgtc atgatgacaa agctagaaga aaggtcgagg
     3901 gtgaagtgtg accagtattg gcccagcaga ggcacagaaa ctcacgggct ggtccaggtg
     3961 acgctgctgg atactgtgga gcttgccaca tactgtgtcc ggacatttgc actttataag
     4021 aatggatcga gtgagaagag ggaagtgaga caattccagt tcaccgcctg gcctgatcat
     4081 ggtgttccag agcaccccac acctttccta gctttcttac ggagagtcaa aacctgcaat
     4141 cctccagatg cagggccaat ggtggtacac tgcagtgctg gtgttggcag aactggctgc
     4201 ttcattgtaa tagatgccat gttagaaaga ataaagcatg aaaaaactgt agatatttat
     4261 ggccatgtaa ctttaatgag agcccagagg aattacatgg tacaaacaga agaccagtac
     4321 atctttatcc atgatgcact gttagaagca gtgacatgtg gaaataccga agtgccggct
     4381 agaaacttgt atgcctacat tcagaagctg acacaaatag aaacagggga gaatgtcacc
     4441 ggaatggagc tcgaatttaa gcgtctagcc agctcaaaag ctcacacctc aagattcatc
     4501 agtgccaatc ttccatgtaa taaattcaaa aaccgccttg ttaatattat gccatatgaa
     4561 tccacaaggg tgtgcctgca gcctatccga ggagttgaag gctctgatta catcaatgcc
     4621 agtttccttg atggatatag acaacagaaa gcctacattg ctacccaggg gcccttagca
     4681 gagacaactg aagacttttg gcgcatgctt tgggaacaca attccaccat cgttgtgatg
     4741 ctcaccaagc tgagagaaat gggcagagag aaatgtcacc agtactggcc agctgaacga
     4801 tctgcaagat accagtattt tgttgtagat cccatggctg aatataacat gcctcagtat
     4861 atcctgaggg aattcaaggt cacggatgcc agggatggcc agtcccgaac agtgaggcag
     4921 ttccagttca ctgactggcc agaacaagga gtgccaaagt ctggagaagg atttattgac
     4981 ttcattggcc aagtccataa aacaaaggag cagtttggcc aagatgggcc catttccgtg
     5041 cattgcagtg ccggcgttgg aagaactgga gttttcataa cattgagtat tgtgttggaa
     5101 agaatgagat atgaaggggt ggtagatatc ttccagactg tcaaaatgtt aagaacacaa
     5161 cgaccagcca tggtacaaac agaggatcaa taccagttct gctatcgagc cgcactagaa
     5221 tacctgggca gctttgatca ctatgcaacg tagaaacccc tgaccccttc tggattttta
     5281 ctacaggccc ttcgctatcc atggagtctc ttctgagcca tacagggcac ttgagaagtc
     5341 cttcttaact tctagctaac aaccacttag tgggactatt acaaaaaaca aacaaaaaaa
     5401 aaaaacaaca aaaaaaaaaa aaacaaaacc aaactcttcc aagtggacca agaattcaca
     5461 gtttaatcat ctaacctgaa aaataataac aagaatcctg acttaggagg catctgaaga
     5521 attctattta cagatacctc aaggattcaa aataaaggga agaagaaatg acagcaaaga
     5581 accaccatct tgttcaggat tgcttgatag ggacagagag agcttgcctg tgggcctcag
     5641 gccagcacaa ggaattcgct gctgtggctg ctcacataag gtggactctg cctcaacatc
     5701 accctttccc cgtgccactc atacttacat tttaggggga agggtgggga tgtttaaaaa
     5761 aagaaagtcc ttgattgcat ttttatgttg taaagattct gctgacctgt gcttcatttc
     5821 taactatgta aacttttttt ttttaaatgt atcattcgat aaagtaaact tataacgtta
     5881 agtaattctt catatttttt ttatttctaa attctaggtc tttttaagct atagaatggt
     5941 tatctgtaat atcttactgt agaaatattg aataatctga aactttgcac atttttgtgc
     6001 aatgctcagt ctacagtacc tgtctcaaca gctattactc acatgttttg ttttgtataa
     6061 ccgatgagaa agtgcccatt ctctgcaagc ttcaagggga attttgtttt gctttgtttt
     6121 ctttttggaa tcaacaggga ggcgcaaagt aaaaagctgc tgctaacatg tatatataca
     6181 tagatatcta tattttaagg gtatctatgt atatatagac agtatgtcca cacaaagatt
     6241 taactgccat tcggttcttc catggtttag gttttggggg gttttttgtt tgtttgtttt
     6301 aattttttta tttttaagta tagaaagcga ttgtaaacat ctttttcaag ttacttttag
     6361 tattgtgaaa ctttaatttg taaagggaat tgaggagtgc acatcattga ttattgagcc
     6421 tcgcccctaa ctttccagcc tcgtattccc ccatctatcc aaccatatcc acaaatactg
     6481 ttttgttagc caggcttccg acaaaattca atatttctaa cactctagtg caataacaat
     6541 tgttaaatat ctaaaaggtg tgcatgtggg aaaggtcagt gcatatccct ttaggaggga
     6601 agaatgttgt aatatatcag ctatcaagtt gttggttttt tttttttaaa gtatattcaa
     6661 tcatatattg tctatagtac gtgctatgaa atttgcattt atgatatgta acaggggcaa
     6721 agccaaactc atgttactct tttcagtcag aaacatgttg tgtcagccgc gttcctggga
     6781 ggcgctgtgc tgtttcattc ggttttagtt ctgcatttag agtgccttat aattgatacc
     6841 tattttaata acatttcttt ttatctttcg gttctgattt ccattagatg ttcacatttg
     6901 tttctctttc aattaaaaca ttgtctgtcc accacatgta tataaactct ttgaataata
     6961 tgcattccta gttttcagcc aagtggggga tgttagtgac tgtaccagcc caaagcactt
     7021 ggataatcag ggcctctcct ttcctcattg tcacatcagg aagagcaact tggtttactt
     7081 cagatccctt ccaaatctgc tccagagtgg gcagtaacca ccagtcttac ttatagaaac
     7141 aacttcggga tatatttgat attccattag gatttttctg aaaggggcaa taaattacat
     7201 atatatatat atatatatat atatatatat atatatatat atatatatat atatatatat
     7261 ctccccaaac atttccacag gaagccatgg atgatggcat gaatttgcca catgctatat
     7321 gattttaaaa taccctccac aaatactgag tactctgaaa gagttttgat acaggtgtaa
     7381 tattttggtt taattttagc ttcatgatgg tctgcatgga agggtatttg gtttcacatc
     7441 ttcccatcac tagcagaata aaatcctaga gaccaaacac ttgcaactat catatctgag
     7501 catttttttt tgtaaaaaaa aaaaaaaaaa aaacaaaaaa caaaaaataa aaattaaaaa
     7561 aaaatgaaca aaaacaaaaa aatagaaaaa atagaagtat atataatact aaaaagaaac
     7621 tagaaggcta cctcagaatg agactctcta acctacatca gaaccagata gaatgtgcac
     7681 tgtgtgagtc tattgttttc ttttcacttg taccattgaa ggtttatcca agtgcccggt
     7741 tgctcagtgc tgtgaatttt gttttaagtg aaacaaggaa ggtcagatag gttattgtgt
     7801 cacctagaca tgccattttg gacatgttgg atctaatgga atatcacaca ccagaatgac
     7861 tggccagtga gctgtttgtc tcttggcaac aaaactgcct gtatggcagg aacaatgaca
     7921 gtaatcagca aaagaaatgg atgggacgtg tcctgcagga ggatgaggtg ggcgttactc
     7981 ctgaatcagg agctggtcct agaactaact ccccactgtc actgatgtgc attccactct
     8041 gctttgcttt atgaccattc aagtttaatt tcccaggcaa acatcagtat ctaccattac
     8101 catagacatc aaagtttcca gttattttca tcatcataac cagtacggtg ctattattta
     8161 cctatgtatg tgtagttatg tataattttg taattagtta caatggtaaa atatcaaata
     8221 tataaaagtg atttgtacag aactttattt tagctctttt ttaaaaatgg tttgcatggt
     8281 tagacaaggc aaggacagcc aggggaggga agggcctcta gggaacttcg cactttctac
     8341 acctttgtac tatgcactgc tctattgatt ctacacccaa taatgttatt acttgaaccc
     8401 atctgtaagg aactgcttca gaagttcatt tctgtgtctg tggataacaa cacatcacag
     8461 caggaaagga aaacatgcct agtagcacac acagtttttt tttttctttc ctgttgagtt
     8521 ttgggttagc tttgtttcag tctttcttgt cattttaaaa ttcccttccc atttttttct
     8581 cctttgcttt tgatttccat tgggtatatg ggtgccctga tactccagca gaggtcagaa
     8641 ggctacagat ccatcctatc catccgttac atggctttgc catacaagct tggagtgtct
     8701 ttacaaagat aacagttgtg ttctttgctc tcgttttgga tgcatagact gaaaattcaa
     8761 aaaaaaaata acttgtaaaa tggcttgtta aaaaaaatac aattacctct aattagtagt
     8821 acgcgtaagt gttttacaga atgaaaggcg tgctttttat tttcttactt cgttacattg
     8881 gtggcgaaag aagtctgtat gaaaatcagt tctttgctga cacaggttcc atttgttaca
     8941 aatgaattct aataaaaatg tcagtgttat gc
//
