LOCUS       NM_016933                853 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type C
            polypeptide-associated protein (Ptprcap), mRNA.
ACCESSION   NM_016933
VERSION     NM_016933.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 853)
  AUTHORS   Leitenberg,D., Falahati,R., Lu,D.D. and Takeda,A.
  TITLE     CD45-associated protein promotes the response of primary CD4 T
            cells to low-potency T-cell receptor (TCR) stimulation and
            facilitates CD45 association with CD3/TCR and lck
  JOURNAL   Immunology 121 (4), 545-554 (2007)
   PUBMED   17428310
REFERENCE   2  (bases 1 to 853)
  AUTHORS   Takeda,A., Matsuda,A., Paul,R.M. and Yaseen,N.R.
  TITLE     CD45-associated protein inhibits CD45 dimerization and up-regulates
            its protein tyrosine phosphatase activity
  JOURNAL   Blood 103 (9), 3440-3447 (2004)
   PUBMED   14715639
  REMARK    GeneRIF: results support a model in which binding of CD45-AP to
            inactive CD45 dimers converts them to active monomers
REFERENCE   3  (bases 1 to 853)
  AUTHORS   Fortin,M., Steff,A.M., Felberg,J., Ding,I., Schraven,B., Johnson,P.
            and Hugo,P.
  TITLE     Apoptosis mediated through CD45 is independent of its phosphatase
            activity and association with leukocyte phosphatase-associated
            phosphoprotein
  JOURNAL   J Immunol 168 (12), 6084-6089 (2002)
   PUBMED   12055218
  REMARK    GeneRIF: The association of LPAP with CD45 is dispensable for
            CD45-mediated apoptosis signaling, as shown in studies of LPAP
            knocked-out thymocytes.
REFERENCE   4  (bases 1 to 853)
  AUTHORS   Ding,I., Bruyns,E., Li,P., Magada,D., Paskind,M., Rodman,L.,
            Seshadri,T., Alexander,D., Giese,T. and Schraven,B.
  TITLE     Biochemical and functional analysis of mice deficient in expression
            of the CD45-associated phosphoprotein LPAP
  JOURNAL   Eur J Immunol 29 (12), 3956-3961 (1999)
   PUBMED   10602004
REFERENCE   5  (bases 1 to 853)
  AUTHORS   Kung,C., Okumura,M., Seavitt,J.R., Noll,M.E., White,L.S.,
            Pingel,J.T. and Thomas,M.L.
  TITLE     CD45-associated protein is not essential for the regulation of
            antigen receptor-mediated signal transduction
  JOURNAL   Eur J Immunol 29 (12), 3951-3955 (1999)
   PUBMED   10602003
REFERENCE   6  (bases 1 to 853)
  AUTHORS   Takai,S., Kozak,C.A., Kitamura,K. and Takeda,A.
  TITLE     Assignment of the CD45-AP gene to the centromeric end of mouse
            chromosome 19 and human chromosome 11q13.1-q13.3
  JOURNAL   Genomics 38 (3), 429-431 (1996)
   PUBMED   8975722
REFERENCE   7  (bases 1 to 853)
  AUTHORS   Bruyns,E., Mincheva,A., Bruyns,R.M., Kirchgessner,H., Weitz,S.,
            Lichter,P., Meuer,S. and Schraven,B.
  TITLE     Sequence, genomic organization, and chromosomal localization of the
            human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes
  JOURNAL   Genomics 38 (1), 79-83 (1996)
   PUBMED   8954783
REFERENCE   8  (bases 1 to 853)
  AUTHORS   Cahir McFarland,E.D. and Thomas,M.L.
  TITLE     CD45 protein-tyrosine phosphatase associates with the WW
            domain-containing protein, CD45AP, through the transmembrane region
  JOURNAL   J Biol Chem 270 (47), 28103-28107 (1995)
   PUBMED   7499298
REFERENCE   9  (bases 1 to 853)
  AUTHORS   Shimizu,Y., Ogawa,H., Oka,Y., Mizuno,R., Sakoda,S., Kishimoto,T.
            and Sugiyama,H.
  TITLE     Isolation of a cDNA clone encoding a novel membrane protein
            expressed in lymphocytes
  JOURNAL   FEBS Lett 355 (1), 30-34 (1994)
   PUBMED   7957956
REFERENCE   10 (bases 1 to 853)
  AUTHORS   Takeda,A., Maizel,A.L., Kitamura,K., Ohta,T. and Kimura,S.
  TITLE     Molecular cloning of the CD45-associated 30-kDa protein
  JOURNAL   J Biol Chem 269 (4), 2357-2360 (1994)
   PUBMED   8300558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA265746.1, BB840651.1, AI323196.1, AI627045.1 and AW049152.1.
            
            On Mar 4, 2005 this sequence version replaced NM_016933.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA265746.1, AK165203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AA265746.1         1-65
            66-361              BB840651.1         64-359
            362-498             AI323196.1         334-470
            499-755             AI627045.1         134-390
            756-853             AW049152.1         10-107              c
FEATURES             Location/Qualifiers
     source          1..853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.86 cM"
     gene            1..853
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
                     /note="protein tyrosine phosphatase receptor type C
                     polypeptide-associated protein"
                     /db_xref="GeneID:19265"
                     /db_xref="MGI:MGI:97811"
     exon            1..58
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..649
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
                     /note="CD45-associated protein; CD45-AP; PTPRC-associated
                     protein"
                     /codon_start=1
                     /product="protein tyrosine phosphatase receptor type
                     C-associated protein"
                     /protein_id="NP_058629.2"
                     /db_xref="CCDS:CCDS37884.1"
                     /db_xref="GeneID:19265"
                     /db_xref="MGI:MGI:97811"
                     /translation="MALPGTLRFGVLMALPGALASGADPEDGVGSSVVTIVLLLLLLL
                     LLVTALALAWRRLSHASGGYYHPARLGAALWGHTCRLLWASPAGRWLRARTELESPEE
                     SGPPEDEEDAEDFVIDGGPEEAAAKEEEQRCQAEQTRDPRDTDSDGGLGLSSQGPVGS
                     GSSAEALLSDLHAFSGSAAWDDSAGGAGGQGLRVTAL"
     exon            59..846
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      823..828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
     regulatory      829..834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
     polyA_site      846
                     /gene="Ptprcap"
                     /gene_synonym="CD-45-AP; LPAP; LSM-1"
ORIGIN      
        1 ctcacttctc actaaacagt cagaggtggg tgcccgtgca aaagccatcg gatcaatggc
       61 tctgcctggt accctcagat ttggggtgct gatggccctg ccaggggcac tggcctctgg
      121 ggcagaccca gaggacggtg tgggctccag tgtggtcacc attgtcctgc tgctcttgct
      181 cctgctgctg ctggtcactg ccctagcctt ggcttggcgt cgcctcagcc atgcctcagg
      241 ggggtactac cacccagctc gcctgggtgc tgccttgtgg ggccacacct gccgcctgct
      301 ctgggccagc cctgcaggcc gctggcttcg cgcccgcact gagctggaat ccccagaaga
      361 atcagggccg ccggaggatg aagaggatgc agaagatttt gtgatagatg gtggccccga
      421 ggaagctgcc gccaaggaag aggagcagcg gtgtcaagca gagcagaccc gagatccacg
      481 tgacacagac agtgacgggg gcctgggcct gagctctcag ggtcctgtgg gctcaggcag
      541 cagcgccgag gccctgctga gtgacctgca tgccttttct ggtagtgctg cctgggatga
      601 cagcgctgga ggagcagggg gccagggcct ccgggtcact gcactatagg agtcagcttg
      661 tcctgttcct gccccagcct ctgacttttc ccatgcatgt tatggtgaaa cacaagctgc
      721 cctggacctt cgtcacccca cccttacatc agcttcttag actgacaccc caaccagttc
      781 cccagagtgt gtgtgtgcat cccagacagg cactgggcaa acattaaaaa taaaactttg
      841 taagcaaaaa aaa
//
