LOCUS       NM_029928              11912 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type B (Ptprb),
            transcript variant 1, mRNA.
ACCESSION   NM_029928 XM_003084841 XM_003085725
VERSION     NM_029928.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11912)
  AUTHORS   Baluk,P., Shirakura,K., Vestweber,D. and McDonald,D.M.
  TITLE     Heterogeneity of endothelial VE-PTP downstream polarization, Tie2
            activation, junctional claudin-5, and permeability in the aorta and
            vena cava
  JOURNAL   Cell Tissue Res 395 (1), 81-103 (2024)
   PUBMED   38032480
  REMARK    GeneRIF: Heterogeneity of endothelial VE-PTP downstream
            polarization, Tie2 activation, junctional claudin-5, and
            permeability in the aorta and vena cava.
REFERENCE   2  (bases 1 to 11912)
  AUTHORS   Shirakura,K., Baluk,P., Nottebaum,A.F., Ipe,U., Peters,K.G.,
            McDonald,D.M. and Vestweber,D.
  TITLE     Shear stress control of vascular leaks and atheromas through Tie2
            activation by VE-PTP sequestration
  JOURNAL   EMBO Mol Med 15 (4), e16128 (2023)
   PUBMED   36740996
  REMARK    GeneRIF: Shear stress control of vascular leaks and atheromas
            through Tie2 activation by VE-PTP sequestration.
REFERENCE   3  (bases 1 to 11912)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 11912)
  AUTHORS   Bernal,F.L., Luque Montoro,M., Arrazola Sastre,A., Lacerda,H.M. and
            Zugaza,J.L.
  TITLE     The Tyrosine Phosphatase hPTPRbeta Controls the Early Signals and
            Dopaminergic Cells Viability via the P2X7 Receptor
  JOURNAL   Int J Mol Sci 22 (23), 12936 (2021)
   PUBMED   34884741
  REMARK    GeneRIF: The Tyrosine Phosphatase hPTPRbeta Controls the Early
            Signals and Dopaminergic Cells Viability via the P2X7 Receptor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11912)
  AUTHORS   Thomson,B.R., Liu,P., Onay,T., Du,J., Tompson,S.W., Misener,S.,
            Purohit,R.R., Young,T.L., Jin,J. and Quaggin,S.E.
  TITLE     Cellular crosstalk regulates the aqueous humor outflow pathway and
            provides new targets for glaucoma therapies
  JOURNAL   Nat Commun 12 (1), 6072 (2021)
   PUBMED   34663817
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11912)
  AUTHORS   Fachinger,G., Deutsch,U. and Risau,W.
  TITLE     Functional interaction of vascular endothelial-protein-tyrosine
            phosphatase with the angiopoietin receptor Tie-2
  JOURNAL   Oncogene 18 (43), 5948-5953 (1999)
   PUBMED   10557082
REFERENCE   7  (bases 1 to 11912)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   8  (bases 1 to 11912)
  AUTHORS   Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S.
  TITLE     Expression of protein tyrosine phosphatase genes in the developing
            brain of mouse and rat
  JOURNAL   Biochem Mol Biol Int 33 (6), 1221-1227 (1994)
   PUBMED   7804149
REFERENCE   9  (bases 1 to 11912)
  AUTHORS   Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W.
  TITLE     Identification and typing of members of the protein-tyrosine
            phosphatase gene family expressed in mouse brain
  JOURNAL   Mol Biol Rep 16 (4), 241-248 (1992)
   PUBMED   1454056
REFERENCE   10 (bases 1 to 11912)
  AUTHORS   Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R.,
            Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H.
  TITLE     Cloning, expression and chromosomal localization of a new putative
            receptor-like protein tyrosine phosphatase
  JOURNAL   FEBS Lett 290 (1-2), 123-130 (1991)
   PUBMED   1655529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147668.1, BC141006.1, AC135862.4, AA790811.1 and AK137255.1.
            
            On or before Aug 27, 2011 this sequence version replaced
            XM_003084841.1, XM_003085725.1, NM_029928.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147668.1, AK147439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AK147668.1         3-206
            205-6286            BC141006.1         1-6082
            6287-9470           AC135862.4         83130-86313         c
            9471-9830           AA790811.1         32-391
            9831-10441          AK137255.1         61-671
            10442-11112         AC135862.4         81488-82158         c
            11113-11904         AK137255.1         1342-2133
            11905-11912         AC135862.4         80688-80695         c
FEATURES             Location/Qualifiers
     source          1..11912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 64.68 cM"
     gene            1..11912
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /note="protein tyrosine phosphatase receptor type B"
                     /db_xref="GeneID:19263"
                     /db_xref="MGI:MGI:97809"
     exon            1..306
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..6249
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase
                     beta; vascular endothelial protein tyrosine phosphatase;
                     R-PTP-beta; protein-tyrosine phosphatase beta"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase beta
                     isoform 1 precursor"
                     /protein_id="NP_084204.2"
                     /db_xref="CCDS:CCDS36063.1"
                     /db_xref="GeneID:19263"
                     /db_xref="MGI:MGI:97809"
                     /translation="MLRHGALTALWITLSVVQTGVAEQVKCNFTLLESRVSSLSASIQ
                     WRTFASPCNFSLIYSSDTSGPMWCHPIRIDNFTYGCNPKDLQAGTVYNFRIVSLDGEE
                     STLVLQTDPLPPARFEVNREKTASTTLQVRWTPSSGKVSWYEVQLFDHNNQKIQEVQV
                     QESTTWSQYTFLNLTEGNSYKVAITAVSGEKRSFPVYINGSTVPSPVKDLGISPNPNS
                     LLISWSRGSGNVEQYRLVLMDKGAIVQDTNVDRRDTSYAFHELTPGHLYNLTIVTMAS
                     GLQNSRWKLVRTAPMEVSNLKVTNDGRLTSLNVKWQKPPGDVDSYSITLSHQGTIKES
                     KTLAPPVTETQFKDLVPGRLYQVTISCISGELSAEKSAAGRTVPEKVRNLVSYNEIWM
                     KSFTVNWTPPAGDWEHYRIVLFNESLVLLNTTVGKEETHYALDGLELIPGRQYEIEVI
                     VESGNLRNSERCQGRTVPLAVLQLRVKHANETSLGITWRAPLGEWEKYIISLMDRELL
                     VIHKSLSKDAKEFTFTDLMPGRNYKATVTSMSGDLKQSSSIKGRTVPAQVTDLHVNNQ
                     GMTSSLFTNWTKALGDVEFYQVLLIHENVVVKNESVSSDTSRYSFRALKPGSLYSVVV
                     TTVSGGISSRQVVAEGRTVPSSVSGVTVNNSGRNDYLSVSWLPAPGEVDHYVVSLSHE
                     GKVDQFLIIAKSVSECSFSSLTPGRLYNVTVTTKSGNYASHSFTEERTVPDKVQGISV
                     SNSARSDYLKVSWVHATGDFDHYEVTIKNRESFIQTKTIPKSENECEFIELVPGRLYS
                     VTVSTKSGQYEASEQGTGRTIPEPVKDLTLLNRSTEDLHVTWSRANGDVDQYEVQLLF
                     NDMKVFPHIHLVNTATEYKFTALTPGRHYKILVLTISGDVQQSAFIEGLTVPSTVKNI
                     HISANGATDRLMVTWSPGGGDVDSYVVSAFRQDEKVDSQTIPKHASEHTFHRLEAGAK
                     YRIAIVSVSGSLRNQIDALGQTVPASVQGVVAANAYSSNSLTVSWQKALGVAERYDIL
                     LLNENGLLLSNVSEPATARQHKFEDLTPGKKYKMQILTVSGGLFSKESQAEGRTVPAA
                     VTNLRITENSSRYLSFGWTASEGELSWYNIFLYNPDRTLQERAQVDPLVQSFSFQNLL
                     QGRMYKMVIVTHSGELSNESFIFGRTVPAAVNHLKGSHRNTTDSLWFSWSPASGDFDF
                     YELILYNPNGTKKENWKEKDVTEWRFQGLVPGRKYTLYVVTHSGDLSNKVTGEGRTAP
                     SPPSLLSFADVANTSLAITWKGPPDWTDYNDFELQWFPGDALTIFNPYSSRKSEGRIV
                     YGLHPGRSYQFSVKTVSGDSWKTYSKPISGSVRTKPDKIQNLHCRPQNSTAIACSWIP
                     PDSDFDGYSIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSE
                     VVEDSTITMIDRPPQPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVR
                     EADSMDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAESPDSSSKSFNIKLGAE
                     MDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSMPI
                     TTESEPLFGVIEGVSAGLFLIGMLVALVAFFICRQKASHSRERPSARLSIRRDRPLSV
                     HLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLP
                     ENRGKNRYNNILPYDASRVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGPLPGTK
                     DDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLPEW
                     TIREFKICSEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGP
                     TVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLH
                     QCVRDVLRAKKLRNEQENPLFPIYENVNPEYHRDAIYSRH"
     exon            307..580
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            581..859
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1117
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1381
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1651
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1912
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2179
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2443
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2707
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2971
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3235
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3505
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3769
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..4033
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4315
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            4316..4594
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4744
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4988
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5095
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5096..5195
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5196..5279
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5280..5297
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5298..5379
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5380..5470
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5547
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5548..5682
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5683..5805
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5806..5969
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            5970..6105
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            6106..6226
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     exon            6227..11912
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11887..11892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /note="hexamer: AATAAA"
     polyA_site      11909
                     /gene="Ptprb"
                     /gene_synonym="3230402H02Rik; C130094E24; Ptpz; Rptpb;
                     VE-PTP; Veptp"
                     /note="major polyA site"
ORIGIN      
        1 ttgcggaagt cccggacggg gctttggggg cgaggcagcg cgggtcagaa tggcagcgtg
       61 ggaagggccg cgcgccgcgg gtccccgccg cctgtcgtgt ccgctgcccg cccggggcgg
      121 cagcagaagc agcggctgcc acggcccttg agcatcgcca gccccgaggg tagcgcgctg
      181 cgcccgcccg cagggcgcgc tgagcgctca acaagtggta cccagaagtg ccctggctgg
      241 cctcccagcg agatgctgag gcatggagcc ctaacggcct tgtggataac actgagcgtc
      301 gtgcagactg gagtggcaga gcaagtgaaa tgtaacttca cactgttgga gtccagggtc
      361 tctagcttgt cagcgtctat ccagtggagg actttcgcgt caccctgtaa ctttagcctc
      421 atctacagca gtgatacctc ggggcccatg tggtgccatc ctattcggat agacaacttt
      481 acctacggat gtaaccccaa ggatttacaa gcagggaccg tctataactt caggattgtt
      541 tctctggatg gagaagagag cactctggtc ttacagacag atccgttgcc tcctgccagg
      601 tttgaagtca atcgggagaa aacagcatca accaccctgc aggtccggtg gactccctct
      661 tctggaaaag tctcctggta tgaggtgcaa ttatttgatc ataacaatca aaagatacaa
      721 gaagtccaag ttcaagaaag taccacctgg agccaatata cttttctgaa cctcactgag
      781 ggtaacagtt acaaagttgc catcacagct gtttcgggag aaaagcgctc ctttccggtg
      841 tatatcaatg gctctacagt accatctcca gtgaaagatc ttggcatttc ccccaatcct
      901 aattctctcc taatttcctg gtctcgtggt tctgggaatg tggaacaata caggctggtg
      961 ctaatggata aaggggccat cgttcaagac acaaacgtgg acaggcgtga tacttcttat
     1021 gcttttcacg agctgacccc tggccacctc tacaacctca ctattgtcac catggcctcg
     1081 ggactgcaaa actccaggtg gaaactggtg aggaccgctc ccatggaagt ctcaaatctg
     1141 aaggtgacaa atgacgggag gttgacctct ctaaatgtga agtggcagaa accccctggg
     1201 gatgtagatt cctacagcat taccctgtct caccaaggga ccatcaaaga atccaaaaca
     1261 ttagcacctc ctgttactga aactcaattt aaggacttag tccctggacg gctttaccaa
     1321 gtgaccatca gctgcatctc tggtgagctc tctgctgaga agtcagcagc ggggagaaca
     1381 gttccagaaa aagtgaggaa tctggtttcc tacaacgaga tttggatgaa gtcctttaca
     1441 gtgaactgga cgccccctgc tggagattgg gagcattatc gtatcgtgct cttcaatgaa
     1501 tccttggtct tgctcaacac cacagtggga aaggaagaaa cgcactatgc cttggatggc
     1561 ttggagctca taccaggaag acagtatgag atagaagtca ttgttgagag cggaaatctg
     1621 cggaattccg agcgctgtca aggcaggaca gtacccctgg ctgtcctcca gcttcgcgtc
     1681 aaacacgcta acgaaacttc actgggcatc acgtggcggg cccctctagg cgaatgggag
     1741 aaatacatca tttcgttgat ggacagagag ctcttggtca tccacaagtc actctccaaa
     1801 gatgccaaag aattcacttt tacagacctg atgcctggac ggaattacaa ggctactgtc
     1861 actagcatga gtggagattt aaaacagtca tcttcaatca aaggaagaac agtgcctgcc
     1921 caggtgactg acctgcacgt caacaaccaa gggatgacca gtagtctgtt cactaactgg
     1981 acaaaggcac tgggagatgt agagttctac caagttttac tgatccatga aaatgtggtt
     2041 gtcaagaacg agagtgtttc cagtgatacc agcagataca gcttccgcgc cctgaaaccc
     2101 ggcagcctct actccgtggt ggtgaccacg gtgagtggag ggatctcctc ccggcaggtg
     2161 gtggcggaag gaagaacagt cccgtccagc gtgagtgggg tgacagtcaa caattctggc
     2221 cggaatgact acctcagcgt ttcctggctg ccggcgcctg gagaagtgga tcactacgtg
     2281 gtgagcctct cccacgaggg caaggtggat cagttcctca tcatcgccaa atctgtcagc
     2341 gagtgttcct tcagctccct caccccgggc cgcctctaca acgtcactgt aaccaccaag
     2401 agcggcaatt atgcaagcca ctccttcacc gaggaacgga cagtgccaga caaggtccag
     2461 ggaatcagtg ttagcaactc tgccagaagc gactacttaa aggtgtcctg ggtgcatgcc
     2521 actggagact ttgaccacta tgaagtcacc atcaaaaaca gagaaagctt cattcaaacc
     2581 aaaaccatcc ccaagtcaga aaatgagtgt gaatttattg agctggttcc tggacgcctg
     2641 tacagcgtca ctgtcagtac aaagagtgga caatatgaag ccagtgaaca ggggacaggg
     2701 agaacgatcc cagagcctgt gaaggatctc acccttctca acaggagtac ggaggatctc
     2761 catgtgactt ggtcaagagc caatggggat gttgatcagt acgaggtcca gctgctcttc
     2821 aacgacatga aagtcttccc tcatattcac cttgtgaaca cagcaactga gtataagttc
     2881 acggcgctca cgccggggcg ccattacaaa atcctcgtcc tgaccatcag tggcgatgtc
     2941 cagcagtcag ccttcattga aggcctcaca gttcccagca ctgtcaaaaa cattcacatt
     3001 tctgccaatg gagccacgga taggctgatg gtaacctgga gccctggtgg cggggatgtg
     3061 gactcctatg tggtgtctgc attcagacag gacgagaagg ttgactctca gaccattccc
     3121 aagcatgcct cggagcacac gttccacagg ctggaggccg gagccaagta caggatcgcc
     3181 attgtttctg tcagtgggtc cctgagaaac cagatagatg cgctcggaca gacagtccca
     3241 gcgtctgtcc agggagtcgt cgcagccaat gcatacagca gtaattcctt aacagtaagt
     3301 tggcagaaag cccttggtgt ggcagaaaga tacgatatcc tgcttctaaa cgagaatggg
     3361 cttcttttga gcaacgtgtc agagccagct acggcaagac agcacaaatt tgaagatcta
     3421 acgccaggca agaaatacaa gatgcagatc ctgactgtca gcggaggcct cttcagtaaa
     3481 gaatctcagg ctgaaggccg aacagtccca gcagctgtca ccaatctgag gatcacagag
     3541 aactccagta gatacctgtc cttcggctgg accgcctcgg agggtgaact cagctggtac
     3601 aacatcttcc tctacaaccc agacaggact cttcaggagc gagctcaagt tgacccgcta
     3661 gtccagagct tctctttcca gaacttgcta caaggcagaa tgtacaagat ggtgattgtc
     3721 actcacagtg gggagctgtc caatgagtca tttatattcg gcagaacagt tcctgctgcc
     3781 gtgaaccatc tcaaaggctc ccatcggaac acgacagaca gcctgtggtt cagctggagc
     3841 ccagcctccg gggactttga cttctatgag ctgattcttt acaatcccaa cggcacgaag
     3901 aaggagaact ggaaagaaaa ggacgtgaca gagtggcgtt tccaaggtct tgttcctgga
     3961 aggaaataca ccctgtatgt ggtgactcac agtggggacc tcagcaataa agtcacaggg
     4021 gagggcagaa cagccccaag tcctccgagt cttttgtcat tcgctgatgt tgcaaacacc
     4081 tccttggcta tcacctggaa gggaccccca gactggacag attacaatga ctttgagctg
     4141 cagtggttcc ctggagatgc acttaccatc ttcaacccct acagcagcag aaagtcagaa
     4201 ggacgcattg tgtacgggct tcacccaggg aggtcctatc aattcagtgt caagactgtg
     4261 agcggggact cctggaaaac ctacagcaaa ccaatttctg ggtctgtgag gacaaagcca
     4321 gacaagatac aaaacctgca ttgccgcccc cagaactcca cggccattgc ctgctcttgg
     4381 atacctcctg actccgactt tgatggctac agcattgagt gccgaaaaat ggatacccaa
     4441 gaaatcgagt tttccagaaa gctggagaaa gaaaaatcac tgctcaacat catgatgtta
     4501 gtacctcata agaggtacct ggtgtccatc aaggtgcagt cggccggcat gaccagtgag
     4561 gtggttgaag atagcaccat caccatgata gaccgcccgc ctcaaccgcc tccacacatc
     4621 cgtgtgaatg aaaaggatgt gctaatcagc aaatcttcca tcaactttac tgtcaactgc
     4681 agctggttca gcgacaccaa cggagcggtt aaatactttg ctgtggtggt gagagaggcc
     4741 gacagcatgg atgagttgaa gccagaacag cagcaccctc tcccttccta cctggagtac
     4801 agacacaacg cctccatccg agtctaccag accaattatt ttgccagcaa atgtgctgaa
     4861 agtcccgaca gcagttctaa aagtttcaac attaagcttg gagcagagat ggacagcctc
     4921 ggtggcaaat gtgatcccag tcagcagaaa ttctgtgatg gaccgctgaa gccacacacc
     4981 gcctacagaa tcagcatccg ggcttttaca cagctatttg acgaggactt gaaagagttc
     5041 accaaacctc tctactcgga tacgttcttc tctatgccca tcaccacaga gtcagagccc
     5101 ttgtttggag ttattgaagg tgtgagtgct ggcctgtttc taattggcat gctggtggcc
     5161 cttgttgcct tcttcatctg cagacagaaa gctagccaca gcagggaaag gccatctgcc
     5221 cggctcagca ttcgtaggga ccggcctttg tctgtccatc tgaatctggg ccagaaaggc
     5281 aaccggaaaa cttcttgccc cataaagatc aatcagtttg aagggcattt catgaagctg
     5341 caggcagact ccaactacct tctatccaag gaatatgagg acttaaaaga cgtgggtaga
     5401 agccagtcat gtgacattgc cctcttgcct gagaatcgag ggaaaaatcg atacaacaac
     5461 atattgcctt atgatgcctc aagagtgaag ctctgcaatg tcgatgacga cccttgctct
     5521 gactacatca acgccagcta catccccggt aacaacttca gacgagaata catcgccact
     5581 cagggaccgc ttccaggcac caaggatgac ttctggaaga tggcgtggga gcagaacgtt
     5641 cacaacatcg tcatggtgac ccagtgtgtt gaaaagggcc gagtgaagtg tgaccattac
     5701 tggccagcag accaggaccc cctctactac ggtgatctca tcctacagat ggtctcggag
     5761 tccgtgctcc ccgagtggac catcagggag tttaagatat gcagtgaaga acagttggat
     5821 gcacacagac tcatccgtca ctttcactac acggtgtggc cagaccatgg ggtcccagag
     5881 accacccagt ccctgatcca atttgtgagg acagtcaggg actacatcaa cagaagcccc
     5941 ggggctgggc ccaccgtagt gcactgcagc gctggtgtgg gcagaacagg gacgttcgtt
     6001 gccctggacc ggatcctcca gcagttggac tctaaggact ccgtggacat ttatggggca
     6061 gtgcatgacc taagactcca cagggttcac atggtccaga ccgagtgtca atatgtgtat
     6121 ctgcatcagt gtgtaagaga cgtcctcaga gcaaagaaac tgcggaacga gcaagagaac
     6181 cccctgtttc cgatttatga gaatgtgaat ccagagtatc acagagatgc aatctactcg
     6241 agacattaag aattcacctg aagatcccct ggataaaagc gtttcactgt gtgactttaa
     6301 aaaaaaacaa aaacaaaaaa acaaaaacaa aaccttgctt catgccctgt gggggtgcca
     6361 gccatttctg ttgatactat gtataattta ttaatctgga gaatgttaaa gaatttatgt
     6421 aatttaaagg taacagatat tattgtacat acttgtattt tgtagtttct cctgtaaata
     6481 tgtatttttc ataatgttta aaattaagct ttatatattt tcacactaaa gtgttcatgg
     6541 cttgttgtac atagacccat acagcctgta tgacagggcc acgggtgaaa agtgtgtaga
     6601 ggaagtcgca aggacagtcc ccgggggtgt ttcttacctg tccttatagt cactgggtaa
     6661 gcgaacgtca gagctgaaga gagcatacca tgaggctagc tatgttgagc tgctttctta
     6721 tgaatggacc ctgggatcta aggaatataa tagtcaaaaa agattagggc tgtggccaaa
     6781 cctttgtggt aggccatatg ccaagaaatt aaaaataaat gaagtgaatt aaaaggagga
     6841 ttcgacagca ccaaagctga gcttgctgtt gtctaagcta gaagcttttt gtctgactcc
     6901 tcccagggtc ccagggtccc tcccagggtc aacttgaagc ttgcagtgac cacggggtta
     6961 aggggtgcca tagcgagcaa tactaacagg gatgaggaac ctccagcaca cagcagcggg
     7021 ccacctgcaa cagtcccagc tggttctcct ctggaaagag ttacagtggc aggtgatgtt
     7081 cctgatcaga gaaagcatgg tatgccaaca tgtccataga aatagctaca tcatatataa
     7141 tgagttaaag agtggtggta aaacacacac acacacacac acacacacac acacacacac
     7201 acacacacac acacaccagc tctccttagt ctaaaaaccc ttcaaatgct ctttctaagt
     7261 aagttgatgc agttaaaatg ttatcaagtt ctcacctgaa gctcagttta ctgtaagcaa
     7321 cgccacacac cctaccaatt ttatcattaa gatttatgct ttatttgact ataaataatc
     7381 ccaagtgact cagagagtgg acattggcca gatcaaggtc tgattcgtag atgtttcctg
     7441 aggaaggtct agagagagtc ctgtgggtgc ctgagtgtga cgtcacattt tctgacctca
     7501 gagcttcatt tccagaaaca gcagcttctc tcgaacatag gcatctttgc catgtatcat
     7561 aaattcccac aataaaatgg atataattgg cataacaatt gaaaataatt aacgatacct
     7621 attgtatagg tgtttatcac tgtaacctta gtttgtaaat ataatgtgat acagataatt
     7681 acataactcc acacccagcc tggaaatgtt tttagggagt gttcgaagtt tatagaaaca
     7741 gaggagctgt gtcctaagga tccctgtgaa caacattcag agttctcccg atgtccctgt
     7801 gctctgtgcc cccatgacaa tgatactgag cagctctggc cctgcggcca gaaacatggc
     7861 ggatcttggg aacaggaaaa agagggggag aggtgtaagc atatagcggt aactagggag
     7921 aaaatggagg ccaggcatgg tttgggtgtg ttgtgtgtta ggaatggttt tcttagagga
     7981 aaaagaaaaa aagctaggtc gagggagcag ctcagaggta gcaagcttgt gtgtgtatct
     8041 ctccctcctc ccctctgaga agagaaaaga aaggggaggg ggtagagttg taaaacgatg
     8101 ttgcttggtg caaagcatgc tcatgacctg gaaaaggaag tccattttca ttttaagaaa
     8161 agttccagca agggcctgga acctgttggg ccctgttccg aaatctgttt ctctgtgtcc
     8221 tcaaggagag aagcaaggtg cagtgaaatt aatgttgtta ttgttttcaa taggaagtgg
     8281 aagagggtct gggtgagggc aggggaccag agcgatgcct tccttgaggc acctgccagc
     8341 aagggctgga gctgtttcta tggcaagtca ctagatgcag aagagaaagc agttcgttgc
     8401 acacgcaggg actaccacca caaagcccct gcaggtctgt agccgtaact cacacacctc
     8461 tcaaagcagc ttgggtgaag tcagaggtac agaaatgagc acagccatgc agcccaggga
     8521 caccatgcat tcttgctctc tattccaggg aatactaata cctcctctat acaagtttta
     8581 aagccccctt agcaacaaat acttctgtgt aatttctctc ttgaaaagat ctaatacaaa
     8641 tctagttgat ctacccatca aacttagcgg agagctggac tgaaaatgta actaccgata
     8701 ggatgcttgc caggcacatg ggaggccctg ggtttagtct caggtaccac aaaataagta
     8761 aggagaaaaa gaaagaaagg tttctttggc ccttccttct gttgggtgca tctcccctta
     8821 attgcttcac atggctgtgc ctcggtaaac actccactta ctaccgtgtc ggacatcctg
     8881 tctgcacctg agagcagctc tgtactcaac taaagctgtc aagtacttca aggctctcag
     8941 actttgagag agtctgtttt gcatcttaat aattatttac ccaggttcct tataattaac
     9001 tcctctagtc tttcagatta aatcaatttc acattgcaag tctgcgttac tctggaaagc
     9061 tgccaacttt cccactcttg aatcagattg ttcaaagatg catctatctc cctgtctggg
     9121 cttgcaaacg ttcatcttga ggaacttcca ccctttagtg cccggccttc caccctcccc
     9181 ttgcttgctg ctgcttcctg gtgaatggct cactgtgctg ggcgaatgtg cctttatctt
     9241 ctattcatct catcttccac acactgctag catctcataa cctcaacacc atacaggagt
     9301 gattaagact ttaatttttc aacattgaaa cggcaacaac atagcaatct ggggtcagtt
     9361 atatttagga ggctctgtaa ttaattttgt tattacctct tggaggaaag cccaaaatga
     9421 tatgagaaaa tactgtgaaa cgttttaaca gatgtccagc aatacaaaaa tagggcactc
     9481 atgatccact gcacagtgct tctcttagct ccgtgttaag gctctaactc cttatattaa
     9541 acactttctg atcccctcac aaaaagaagg aaggaagaaa gagagagaga gaaaaagaaa
     9601 gatctgtcat gtaataaatt cttgttcagt ttagtttatg ggcgttttag aaggttgaat
     9661 cctaaagtta ctagatattt gcctcagagc cccagcgatg gaacactcta gaatttttgt
     9721 tcacacaagc tgaccaaacc tgaccatgcc aagctgagta agtaataaac ggtggcagct
     9781 tgtttgtaga aacagttcgg aggttttctg agttctgttt cattgtgtgt tggggggggg
     9841 gggggggaga atgtgattga ctagataaaa gttgtaagga ggcatgagct gacacggaga
     9901 gtgaactccc atccccgagg agtcggcgga agcggaagtg tggcacacct gcctgaatcc
     9961 ccgttaccac tccaaggatc gctaatccaa gcttgagaag ttcggtgttc aaagaatctt
    10021 tcacggcaaa ggaagctggg ccacggctgc ggagaggaag tgaaatgatg agaggaagga
    10081 aactgctgga gaagagacca ccaaggcaga catcgggaag gcagactgcc ccgtttcctt
    10141 catgggacgg tttttgaaca tttcatcatg tatttctatt aggacaggta gactgagcat
    10201 cccgaacccc caaatctgaa actcaaaatg ctcccaagtg caagacttga cttgagcact
    10261 gacttgactc cacggctggc ctcgtgcaat ctctaagaaa acacagatcc attaaaaact
    10321 accatgtaaa cttaccgtca gccatgcgca caaggtacat gagagactga aaagaacttc
    10381 atgtttagac ttgggattca ccttcaagac tcctatttat tcaaatattc caaatttatt
    10441 ttaaaatcag attctggtgg aaatcatttc aggtaaagga cctctgactt gtgtgcctgt
    10501 tgatgggatt caccgtgacc acggaggtca ggctatctag ctgattcagc cattggactg
    10561 gctcccttgg cttttgaatt aaccaggtgt gtgactaagt ttacagggct tggctttgtc
    10621 actgcagaca cagcacctta gagtcttata atgtaggata actgtatagg atacagtgtt
    10681 tggccatttc ggttaaaact cagggtgcca tttgatgcag ctatgataac agcacagatt
    10741 ctggtctctt ctaaaactgt gtgtagccct gaaaacactt ctgactgaaa atacttgact
    10801 gaagatggct tccttggaat aactacatgc attttatttt tttttttaag aattgtctat
    10861 atagatagca ttcgctaagt aaagacattg ttggtgaatg ctccccaaaa tagaagtgta
    10921 cataatggaa atataaaaga tctattgaaa gatatgccaa agattatttt ttaacctata
    10981 tgccaataat gcacatgatc ttacgtaaga aaccaaagaa agttgttcaa aactgtaaat
    11041 agtgtcagag aaatgttaca tgtctcctct cagaatagtt gcaagaaggg ttagtttggg
    11101 ttattctctg cctcaagtaa ttttctttaa aaaaaaaaat gccatcctca ccccaaggca
    11161 agtaagcatt tccattaagt ctgagatgtg ttttaggagc tatgtgtgta aatatgcctt
    11221 gagaaaggag ccggagtgat tgtggcttta aatatccaac agcctccatc tgccagttag
    11281 tgggaaggtc tacaccagag gtcagagtct tctggcctca gccacactga caagagaggc
    11341 cacaaggtcc ccacttaaag agcacttcat cttggccatt gtctgtgagg ctcagttctc
    11401 caagaacaaa gagcaagtct ctcttgctta acctccatca cacagagaac agttcacggc
    11461 tcacataccc tgcatgcacg gtttagagca gaagtcgctt ctggctgtgt gctttggatg
    11521 tttggttgta cctactaatt ctgaagtcca cagaggtgca tttagctgct ctgccgcgtg
    11581 tgtgaagggt aatagatcat gtaaataaac ccagcaactg aacctgttat gttctataat
    11641 agagcacttc cctggtttca aaatcattta cgttctctgc aaatctagta aaatggcagt
    11701 aaatgtattt tttttccaca ctacagcatc tacccacacg attgcattgt aaccagcatt
    11761 gtttgagcaa agaacctcat cagtctttct atttaaataa tgtatgtgct taatatattt
    11821 tcagatatgt aaccatggtt aaaggaaacc tatatggaat cttgcacaaa ccctcaccaa
    11881 tgtaggaata aaactgctgc tcattgaaag ag
//
