LOCUS       NM_001163688            3501 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus protein tyrosine phosphatase receptor type A (Ptpra),
            transcript variant 2, mRNA.
ACCESSION   NM_001163688
VERSION     NM_001163688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Sendo,S., Kiosses,W.B., Yang,S., Wu,D.J., Lee,D.W.K., Liu,L.,
            Aschner,Y., Vela,A.J., Downey,G.P., Santelli,E. and Bottini,N.
  TITLE     Clustering of phosphatase RPTPalpha promotes Src signaling and the
            arthritogenic action of synovial fibroblasts
  JOURNAL   Sci Signal 16 (792), eabn8668 (2023)
   PUBMED   37402225
  REMARK    GeneRIF: Clustering of phosphatase RPTPalpha promotes Src signaling
            and the arthritogenic action of synovial fibroblasts.
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Bai,Y., Yu,G., Zhou,H.M., Amarasinghe,O., Zhou,Y., Zhu,P., Li,Q.,
            Zhang,L., Nguele Meke,F., Miao,Y., Chapman,E., Tao,W.A. and
            Zhang,Z.Y.
  TITLE     PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805
  JOURNAL   Autophagy 19 (5), 1562-1581 (2023)
   PUBMED   36300783
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   Aschner,Y., Correll,K.A., Beke,K.M., Foster,D.G., Roybal,H.M.,
            Nelson,M.R., Meador,C.L., Strand,M., Anderson,K.C., Moore,C.M.,
            Reynolds,P.R., Kopf,K.W., Burnham,E.L. and Downey,G.P.
  TITLE     PTPalpha promotes fibroproliferative responses after acute lung
            injury
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 323 (1), L69-L83 (2022)
   PUBMED   35670474
  REMARK    GeneRIF: PTPalpha promotes fibroproliferative responses after acute
            lung injury.
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Kaji,D.A., Montero,A.M., Patel,R. and Huang,A.H.
  TITLE     Transcriptional profiling of mESC-derived tendon and fibrocartilage
            cell fate switch
  JOURNAL   Nat Commun 12 (1), 4208 (2021)
   PUBMED   34244516
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3501)
  AUTHORS   Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W.
  TITLE     Identification and typing of members of the protein-tyrosine
            phosphatase gene family expressed in mouse brain
  JOURNAL   Mol Biol Rep 16 (4), 241-248 (1992)
   PUBMED   1454056
REFERENCE   7  (bases 1 to 3501)
  AUTHORS   den Hertog,J., Pals,C.E., Jonk,L.J. and Kruijer,W.
  TITLE     Differential expression of a novel murine non-receptor protein
            tyrosine phosphatase during differentiation of P19 embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1241-1249 (1992)
   PUBMED   1590786
REFERENCE   8  (bases 1 to 3501)
  AUTHORS   Yi,T., Cleveland,J.L. and Ihle,J.N.
  TITLE     Identification of novel protein tyrosine phosphatases of
            hematopoietic cells by polymerase chain reaction amplification
  JOURNAL   Blood 78 (9), 2222-2228 (1991)
   PUBMED   1932742
REFERENCE   9  (bases 1 to 3501)
  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
  TITLE     Cloning and expression of a widely expressed receptor tyrosine
            phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6112-6116 (1990)
   PUBMED   2166945
REFERENCE   10 (bases 1 to 3501)
  AUTHORS   Matthews,R.J., Cahir,E.D. and Thomas,M.L.
  TITLE     Identification of an additional member of the
            protein-tyrosine-phosphatase family: evidence for alternative
            splicing in the tyrosine phosphatase domain
  JOURNAL   Proc Natl Acad Sci U S A 87 (12), 4444-4448 (1990)
   PUBMED   2162042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010458.1, AK031690.1 and AK162387.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. This results
            in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031690.1, BC050930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK010458.1         1-4
            5-260               AK031690.1         3-258
            261-2947            AK031690.1         260-2946
            2948-2948           AK162387.1         354-354
            2949-3292           AK031690.1         2948-3291
            3293-3501           AK031690.1         3293-3501
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.23 cM"
     gene            1..3501
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /note="protein tyrosine phosphatase receptor type A"
                     /db_xref="GeneID:19262"
                     /db_xref="MGI:MGI:97808"
     exon            1..281
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            282..360
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..2669
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; receptor-type tyrosine-protein phosphatase
                     alpha; PTPTY-28; R-PTP-alpha; LCA-related phosphatase;
                     protein-tyrosine phosphatase alpha"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase alpha
                     isoform 2 precursor"
                     /protein_id="NP_001157160.1"
                     /db_xref="CCDS:CCDS50712.1"
                     /db_xref="GeneID:19262"
                     /db_xref="MGI:MGI:97808"
                     /translation="MDSWFILVLFGSGLIHVSANNATTVSPSLGTTRLIKTSTTELAK
                     EENKTSNSTSSVISLSVAPTFSPNLTLEPTYVTTVNSSHSDNGTRRAASTESGGTTIS
                     PNGSWLIENQFTDAITEPWEGNSSTAATTPETFPPADETPIIAVMVALSSLLVIVFII
                     IVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLE
                     EEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT
                     PVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLK
                     ERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQRLIT
                     QFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
                     DMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH
                     LQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRV
                     IIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT
                     ELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQ
                     FHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVL
                     ERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK"
     exon            361..702
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            703..787
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            788..861
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            862..998
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1089
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1166
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1203
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1301
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1421
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1588
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1724
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1874
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1968
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2045
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2180
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2306
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2458
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2594
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..3501
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /note="hexamer: ATTAAA"
     regulatory      2894..2899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /note="hexamer: AATGAA"
     polyA_site      2900
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /note="major polyA site"
     polyA_site      2915
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /note="major polyA site"
     regulatory      3200..3205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
                     /note="hexamer: AATAAA"
     polyA_site      3227
                     /gene="Ptpra"
                     /gene_synonym="Ptpa; Ptpalpha; Rptpalpha; Rptra;
                     Rptralpha"
ORIGIN      
        1 ggccgcgacg ggagagaggc tgcggcgagt gaggcgctga cagggactcg cgggggcatc
       61 ttgcacagac ccctggacca cgccgccatc gcagcctcca gcccagtcct ctctctgccg
      121 cttctcctcg ccatggaggc gaggccgccg ccgccgccgc ggggcttcga gcagcggacc
      181 gggcggcggc cctgagggga gcggcgggcc gagacgccgc cgcggtcctg aggcggagct
      241 gccgtgcgcg tcccccgcgg tcccgcccag cgccgggctc ggtcagcatg gattcctggt
      301 tcattcttgt cctgtttggc agtggtctaa tacatgttag tgccaacaat gctactacag
      361 tttcaccttc tttaggaacg acaagattaa ttaaaacatc aacaacagaa ttggctaagg
      421 aagagaataa aacctcaaat tcaacctctt cagtaatttc tctttctgtg gcaccaacat
      481 tcagcccaaa cctgactctg gagcccacct atgtgactac tgttaattct tcacactctg
      541 acaatgggac caggagggca gccagcacgg aatctggagg cactaccatt tccccgaacg
      601 gaagctggct tattgagaac cagttcacgg atgccataac agaaccctgg gaggggaact
      661 ccagcactgc agcaaccact ccagaaacct tccccccggc agatgagaca ccaattattg
      721 cggtgatggt ggccctgtcc tctctgctag taatcgtgtt tattatcata gttctgtaca
      781 tgttaaggtt taagaaatac aagcaagctg ggagtcattc caactctttc cgcctgtcaa
      841 atggccgcac ggaggatgtg gagccccaaa gtgtaccact tctggccagg tccccaagca
      901 ccaacaggaa gtacccacca ctgcctgtgg acaagctgga agaggagatt aaccggagaa
      961 tggctgatga caataagctc ttcagagaag aattcaacgc tctccctgct tgtcctatcc
     1021 aggccacctg tgaggctgcc tccaaggaag aaaacaagga aaaaaaccgc tatgtaaaca
     1081 tcctgcccta tgaccactct agagtgcacc tgacacctgt tgaaggggtc ccagattctg
     1141 attacatcaa cgcttcattc attaatggct accaggaaaa gaacaaattc atcgctgcac
     1201 aaggaccaaa agaagaaaca gtgaatgact tctggagaat gatatgggaa caaaacacag
     1261 ctactattgt catggtgacc aacctgaagg agagaaagga gtgtaaatgt gcccaatact
     1321 ggccagacca aggctgctgg acctatggga atgtccgtgt gtctgtcgag gatgtgactg
     1381 ttctggtgga ctacacagta cggaaattct gcatccagca ggtgggcgac gtgaccaaca
     1441 ggaaaccaca gcgcctcatc actcagttcc acttcaccag ctggccagac tttggggtgc
     1501 ctttcacccc aattggcatg ctcaagttcc tcaagaaggt gaaggcctgt aaccctcagt
     1561 acgcaggggc tatcgtggtc cactgcagtg caggtgtagg gcgcactggc acctttgttg
     1621 tcatcgatgc catgctggac atgatgcatt cggaacgcaa agtggatgta tacgggtttg
     1681 tgagccggat ccgggcccag cgctgccaga tggtacagac agacatgcag tacgtcttca
     1741 tataccaggc ccttctggag cattatctgt atggggacac agaactggaa gtgacttctc
     1801 tagaaaccca cctacaaaaa atttataaca agatcccagg gacgagcaac aacgggttag
     1861 aggaggagtt taagaaatta acttcaatca aaatccagaa tgacaagatg cgcacgggaa
     1921 accttccagc caacatgaag aagaaccggg ttttacagat cattccatat gaatttaaca
     1981 gagtgatcat tccagtcaaa cgaggcgaag agaacacaga ctatgtgaac gcatccttca
     2041 ttgatggata ccggcagaaa gactcctaca ttgccagcca gggccctctt ctccacacga
     2101 ttgaggactt ctggcgaatg atctgggagt ggaagtcctg ttctatcgta atgctgacag
     2161 aactggaaga gagaggccag gagaagtgtg cccagtactg gccatctgat ggcctggtgt
     2221 cctatggaga catcacagtt gagctgaaga aggaggagga atgtgaaagc tacactgtcc
     2281 gagacctcct ggtcaccaac accagggaga acaagagtcg gcaaatccgg cagttccact
     2341 tccacggctg gcctgaggtg ggcatcccca gcgacggcaa gggcatgatc aacatcattg
     2401 cagcagtgca gaagcagcag cagcagtcgg ggaaccatcc catcactgtg cactgcagtg
     2461 ccggggcagg acggacagga accttctgtg ccttgagcac agtcctggaa cgtgtgaaag
     2521 cagaaggaat tttagatgtc ttccaaactg tcaagagcct gcggctgcag aggccacaca
     2581 tggtccagac actggaacag tatgaattct gctacaaggt ggtacaggag tacattgacg
     2641 ccttttcaga ttatgccaac ttcaagtgac aggtgacaag gcccacagac aggagaattg
     2701 cctttaatat tttgtaatat tctgtttttg ttaatatacc caaaattgta tatatcttat
     2761 aactgtttta gaaatggcac ataggcttct attacctgtt aggtggagat tttgtatgta
     2821 aatgtgttag cactgatagt ccttttccag tgttttattg ggaaattaaa tagtgtgata
     2881 tttgggttga tataatgaaa tcctcagcct ggaaactggg ccagattgtt ccttgcttca
     2941 aatatctttt cctaaagaag ataaacctaa gactcattcc aggtagctca gtgccaacta
     3001 aaacaaagca caaagttctc agagctcttg aggaaatggt tgtctccctg tccccaggca
     3061 ggcctcttcc cctccctgtc ctgtaaatat ccctcccctc tccagtccac cctcatctcc
     3121 caccaagatc agccacctca ggcatgggga gtaatgagac cagagcgcct ctctggcacc
     3181 acagcaggga tcgtcaggta ataaacactc ttgattccct gaggaaatat cggtcccttt
     3241 gtcttgggca gagcagtctt atgaagctgg ggctctcctg ggttgttcct agccctgctg
     3301 ttggctggtg tcttccaggt cctcttttct atcaagtata attatcccag ccacccaccc
     3361 agctttgctc cctgggacag acagcaaggg tctcactgag tttctctaca gaaagagaca
     3421 ccagggacag aggagctgct gcaggcttga gctgaggcca ttttggcctc tctagtttct
     3481 gtccagaata agttttaaat g
//
