LOCUS       NM_019651               4087 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 9
            (Ptpn9), mRNA.
ACCESSION   NM_019651
VERSION     NM_019651.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4087)
  AUTHORS   Li,X., Wang,J., Liao,C., Yang,X., Zhao,Z., Liu,Y., Xue,Q., Luo,Y.,
            Liu,X. and Liu,Z.
  TITLE     The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated
            microglial hyperalgesia during inflammatory pain
  JOURNAL   FASEB J 38 (8), e23590 (2024)
   PUBMED   38656553
  REMARK    GeneRIF: The binding of PKCepsilon and MEG2 to STAT3 regulates
            IL-6-mediated microglial hyperalgesia during inflammatory pain.
REFERENCE   2  (bases 1 to 4087)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4087)
  AUTHORS   Yoon,S.Y., Yu,J.S., Hwang,J.Y., So,H.M., Seo,S.O., Kim,J.K.,
            Jang,T.S., Chung,S.J. and Kim,K.H.
  TITLE     Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase
            MEG2 Relevant to Insulin Resistance
  JOURNAL   Molecules 26 (6), 1612 (2021)
   PUBMED   33799458
  REMARK    GeneRIF: Phloridzin Acts as an Inhibitor of Protein-Tyrosine
            Phosphatase MEG2 Relevant to Insulin Resistance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4087)
  AUTHORS   Reinhard,J., Wiemann,S., Joachim,S.C., Palmhof,M., Woestmann,J.,
            Denecke,B., Wang,Y., Downey,G.P. and Faissner,A.
  TITLE     Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation
            and Progressive Glaucomatous Neurodegeneration
  JOURNAL   Mol Neurobiol 56 (6), 4322-4345 (2019)
   PUBMED   30315478
  REMARK    GeneRIF: the heterozygous loss of Meg2 in mice is sufficient to
            cause intraocular pressure elevation and glaucomatous
            neurodegeneration.
REFERENCE   5  (bases 1 to 4087)
  AUTHORS   Zhang,D., Marlin,M.C., Liang,Z., Ahmad,M., Ashpole,N.M.,
            Sonntag,W.E., Zhao,Z.J. and Li,G.
  TITLE     The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and
            Signal Transduction of Tropomyosin Receptor Kinase A
  JOURNAL   J Biol Chem 291 (46), 23895-23905 (2016)
   PUBMED   27655914
  REMARK    GeneRIF: As a result, overexpression of PTP-MEG2 down-regulates
            NGF/TrkA signaling and blocks neurite outgrowth and differentiation
REFERENCE   6  (bases 1 to 4087)
  AUTHORS   Reinhard,J., Horvat-Brocker,A., Illes,S., Zaremba,A., Knyazev,P.,
            Ullrich,A. and Faissner,A.
  TITLE     Protein tyrosine phosphatases expression during development of
            mouse superior colliculus
  JOURNAL   Exp Brain Res 199 (3-4), 279-297 (2009)
   PUBMED   19727691
REFERENCE   7  (bases 1 to 4087)
  AUTHORS   Cho,C.Y., Koo,S.H., Wang,Y., Callaway,S., Hedrick,S., Mak,P.A.,
            Orth,A.P., Peters,E.C., Saez,E., Montminy,M., Schultz,P.G. and
            Chanda,S.K.
  TITLE     Identification of the tyrosine phosphatase PTP-MEG2 as an
            antagonist of hepatic insulin signaling
  JOURNAL   Cell Metab 3 (5), 367-378 (2006)
   PUBMED   16679294
  REMARK    GeneRIF: role in the negative regulation of hepatic insulin
            signaling
REFERENCE   8  (bases 1 to 4087)
  AUTHORS   Wang,Y., Vachon,E., Zhang,J., Cherepanov,V., Kruger,J., Li,J.,
            Saito,K., Shannon,P., Bottini,N., Huynh,H., Ni,H., Yang,H.,
            McKerlie,C., Quaggin,S., Zhao,Z.J., Marsden,P.A., Mustelin,T.,
            Siminovitch,K.A. and Downey,G.P.
  TITLE     Tyrosine phosphatase MEG2 modulates murine development and platelet
            and lymphocyte activation through secretory vesicle function
  JOURNAL   J Exp Med 202 (11), 1587-1597 (2005)
   PUBMED   16330817
REFERENCE   9  (bases 1 to 4087)
  AUTHORS   Huynh,H., Bottini,N., Williams,S., Cherepanov,V., Musumeci,L.,
            Saito,K., Bruckner,S., Vachon,E., Wang,X., Kruger,J., Chow,C.W.,
            Pellecchia,M., Monosov,E., Greer,P.A., Trimble,W., Downey,G.P. and
            Mustelin,T.
  TITLE     Control of vesicle fusion by a tyrosine phosphatase
  JOURNAL   Nat Cell Biol 6 (9), 831-839 (2004)
   PUBMED   15322554
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053017.1.
            
            On Mar 13, 2005 this sequence version replaced NM_019651.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053017.1, AK089069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.7 cM"
     gene            1..4087
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /note="protein tyrosine phosphatase, non-receptor type 9"
                     /db_xref="GeneID:56294"
                     /db_xref="MGI:MGI:1928376"
     exon            1..689
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..2408
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /EC_number="3.1.3.48"
                     /note="PTPase MEG2; protein-tyrosine phosphatase MEG2;
                     Protein-tyrosine phosphatase, non-receptor type 9
                     (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2)"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     9"
                     /protein_id="NP_062625.2"
                     /db_xref="CCDS:CCDS23215.1"
                     /db_xref="GeneID:56294"
                     /db_xref="MGI:MGI:1928376"
                     /translation="MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSW
                     NVAVKFLMARKFDVLRAVELFHCYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVR
                     DPTGASIALFTARLHHPHKSAQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNY
                     ANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILK
                     TSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILSSLPPALDWD
                     SVHVPGPHAMTIQELVDYVNTRQKRGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYG
                     DVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWE
                     QKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIH
                     NTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSMAVGNLGARSKGQCPE
                     PPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYF
                     CYKAILEFAEREGMVPSGHSLLAMDGQ"
     exon            690..833
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..923
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1048
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1154
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1265
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1594
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1688
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1755
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1834
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1985
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2193
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..4057
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /note="hexamer: AGTAAA"
     polyA_site      4002
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
     regulatory      4052..4057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /note="hexamer: ATTAAA"
     polyA_site      4057
                     /gene="Ptpn9"
                     /gene_synonym="MEG2"
                     /note="major polyA site"
ORIGIN      
        1 agatgctcag tttctcaatg gagccgtggg gggctcgggc ggacgcggcg caggccgcag
       61 cgctggccct gagccgggag ggggacgcct tttcctcgct cgctcgcgcc cgccctccct
      121 gtctccgcgg cggcttttga ggaactgggc cgcgaggcca cggagcagtt cgcagggccc
      181 gcatccccgt ggacgcccgg gctgggcggt ctcgaggcgc cggcgagctc tgccccgggg
      241 gttaagcggc tcggaaggcc gacggcctcc aactcccgcc aggcgccttc gcggtggctg
      301 taaaagttgt ggactcctaa aaaagaaaga aagccaagca gacctcgaac tgctgttagt
      361 tcctcgcccg cactttctcc tcctcaggac aggaggggtg gcgtgaggaa aggagtgaag
      421 caaacaggag gcatttcctc tccgcgggga gcgacagcgg gctctccccg gccagcagga
      481 gcggcgttgg cagccgccgc gggcgccggg cgctcgcacc atgcgcgagc cgaccgagag
      541 ctgctgaggc gccgggccac agaagcggag cgcgagtgca gcgggttctg gcgctcgccc
      601 accagacctg ccccggcggc ggcgggatgg agccggcgac cgcgccccgg ccggacatgg
      661 cgccggagct gacccccgag gaggagcagg ctaccaagca gtttcttgaa gagatcaaca
      721 agtggacagt acagtataat gtttctccac tctcctggaa tgtggctgtc aagttcctca
      781 tggccagaaa gtttgatgtg ctccgtgctg tagagttgtt ccactgctac agagaaacaa
      841 gaagaaagga aggcattgtg aagctgaaac ctcatgagga gcctctccgt tctgagatcc
      901 tcagtgggaa gtttactatc ttgaatgttc gagacccaac tggagcctcc attgccctct
      961 tcactgccag gttacaccac ccccacaagt ctgcccagca cgtggtgctc caagctctgt
     1021 tttatctgct ggacagagct gtggacagct ttgaaactca aagaaatgga ctggtgttca
     1081 tctatgacat gtgcgggtct aattatgcca actttgagct agatcttggc aagaaagtcc
     1141 taaacctgct gaagggagca tttccagctc gactgaagaa agtgctgatt gtaggagcac
     1201 ccatatggtt ccgagtgccc tattcaatca tcagcctgct cttgaaggat aaagtccggg
     1261 aaaggattca gatattaaag acatctgaag ttacccagca cctgcctagg gagtgccttc
     1321 cagaaaatct gggtgggtac gtcaaaattg acctggctac ttggaatttc cagttcctgc
     1381 cccaagtaaa cggccaccca gatcccttcg atgagatcat cctgtcttcc ctacctcctg
     1441 ccttagactg ggactcagta catgttccag gtcctcatgc catgaccatc caagagttgg
     1501 tagactatgt taacaccagg caaaagcggg gcatctatga ggagtatgaa gacattcgtc
     1561 gtgagaaccc tgttggcact ttccactgtt ccatgtctcc aggaaaccta gaaaaaaaca
     1621 gatatggaga tgtaccctgc ctagaccaaa cccgagtgaa gctgacaaaa cggagtggcc
     1681 acactcagac agattacatc aatgccagtt tcatggatgg ttacaagcag aagaatgctt
     1741 atattggtac acaaggtcct ttggagaaca cctatcgtga cttctggctt atggtttggg
     1801 agcaaaaagt tttggtgatt gtcatgacta cccgctttga ggaaggcggc aggagaaaat
     1861 gtggccagta ctggccttta gaaaaagact cccggatccg atttggcttc ctcacggtga
     1921 ctaatctagg agtggaaaac atgaaccatt ataagaaaac aactctagaa attcacaaca
     1981 cagaggagcg gcagaaacgc caggttaccc acttccagtt cctaagctgg ccagattatg
     2041 gtgtcccttc ctcagctgct tccctcattg acttcctgag agtggtcaga aaccagcaga
     2101 gtatggctgt aggcaacctg ggagctcgct ccaaagggca gtgccctgag ccacccattg
     2161 tggtccactg cagtgctggc atcggcagga caggtacctt ctgctcactg gacatctgcc
     2221 tggcacagct ggaggagctt ggcaccctta atgtgttcca gacggtgtca cgcatgagga
     2281 cccaaagggc cttcagtatc cagacccctg agcagtacta cttttgctac aaggcaattc
     2341 tggagtttgc agagagggaa ggcatggttc cctctggtca cagcctgttg gccatggacg
     2401 gtcaataact gctccacaag tttccacctg ctggtcagcc ttccttaaac taccctggac
     2461 actgctgagc ctataggttg ccatcagtta tgctgaagcc atggatcaac ctctttcctg
     2521 tgtctcccag cgcacatgtg cacgcaaggc agcctttccc tttggctaga taaatgtggt
     2581 gaacttgcca ctagaaaggg ccagcagcaa tgtgttctta attcctagca cctgctatcg
     2641 aactgtgcct tatcaaaacc aaattgtggc tattgatttt tgccagggtc cctgaggtaa
     2701 gtggggaagg acccctcccc ccacccccat ctcccagttc ctctggacat ctcctccttc
     2761 cctttgctat gatttgacag ggaggtctgg tgagcattca ccttcctacc cagaaagctt
     2821 gaccaagtta catattctag agaatgtccc gagtgccaag cacgtttata catagggcgt
     2881 gtattccagt cttttctgtc attctgtgtg tgtgtgtgtg tacgtatgtg cacttacgtg
     2941 tatggatcca tatgtatgtg tgtacataat atatactctg tgataattat ggccgtatac
     3001 tataaataca tatacacaca gatactcttt gtagaagtct ctggggattt atgttgcagt
     3061 tcagcattcc ttgcttcttg gaccctgctg attattctgg actggctggg gttagggatc
     3121 atggctcatg ttgtcagaca gcagagtgat agaagaaaac acatactttt ttcctgggcc
     3181 acaggtcttc ttccttaatg aaaattttcc ctctggactc tatgcttgtt ggagccaaaa
     3241 atactgactt atggtaacac tggttcaatt tagcatgggt gtctttcatc taacaaattc
     3301 tctgttgtct ttgctgattt ggggaacaga cctccactgt gattccagac tctgtcttat
     3361 gaccccattg atggggacca aggctagaaa taaatttaca gagctgccag agtccaaagt
     3421 aatcggtacg aagttttaaa aggaataaag gagagcccag agtgaacaag aggaacctac
     3481 catgaaatcc ccttcttggg aggacaaact ggggcctctt tttcttgtgt tggaagacac
     3541 ctttctttat gcaactcttc cttgtctact gaatgcccag ctctccctgc ctgctagcct
     3601 gccagatcct agactgcaaa ctgggtgggc ctatgtcttt ataaaacata aactgggtgg
     3661 gtctatgtct ttatgaagca taatcccttt ggctgcatga gtccgttcct tggaatcact
     3721 ggtccactgc ccgtacaact tgttcctgtc ttttcccagt ctgattcgcc aggaatggaa
     3781 tcaagagttc ccaacactgt gttcccacaa aaccctacag aacccctaaa ccttccctta
     3841 ctccacacga tgaggttggc agctggtcag agctcaataa ttttatactg taataagatc
     3901 tttgaatgtg tatattctta ttttttacaa tcatttcatt ttgtatttaa catcaatgga
     3961 ctgagtcaag attcagtaaa taattgtaat gttcatatgc gatatcttat agtggtacaa
     4021 ttttgtattt acctataaat ataccaacat gattaaaaaa aaaaaaaaaa aaaaaaaaaa
     4081 aaaaaaa
//
