LOCUS       NM_177081               3295 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 7
            (Ptpn7), transcript variant 1, mRNA.
ACCESSION   NM_177081 XM_915635 XM_923866 XM_923872
VERSION     NM_177081.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   2  (bases 1 to 3295)
  AUTHORS   Inamdar,V.V., Reddy,H., Dangelmaier,C., Kostyak,J.C. and
            Kunapuli,S.P.
  TITLE     The protein tyrosine phosphatase PTPN7 is a negative regulator of
            ERK activation and thromboxane generation in platelets
  JOURNAL   J Biol Chem 294 (33), 12547-12554 (2019)
   PUBMED   31266805
  REMARK    GeneRIF: PTPN7 regulates platelet functional responses downstream
            of GPCR agonists, but not GPVI agonists, through inhibition of ERK
            activation and thromboxane generation.
REFERENCE   3  (bases 1 to 3295)
  AUTHORS   Seo,H., Lee,I.S., Park,J.E., Park,S.G., Lee,D.H., Park,B.C. and
            Cho,S.
  TITLE     Role of protein tyrosine phosphatase non-receptor type 7 in the
            regulation of TNF-alpha production in RAW 264.7 macrophages
  JOURNAL   PLoS One 8 (11), e78776 (2013)
   PUBMED   24265715
  REMARK    GeneRIF: PTPN7 as a negative regulator of TNF-alpha expression and
            the inflammatory response in macrophages
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3295)
  AUTHORS   McAlees,J.W. and Sanders,V.M.
  TITLE     Hematopoietic protein tyrosine phosphatase mediates
            beta2-adrenergic receptor-induced regulation of p38
            mitogen-activated protein kinase in B lymphocytes
  JOURNAL   Mol Cell Biol 29 (3), 675-686 (2009)
   PUBMED   19047375
  REMARK    GeneRIF: beta(2)AR stimulation on a B cell phosphorylates and
            inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release
            bound p38 MAPK, making more available for phosphorylation and
            subsequent IgE regulation.
REFERENCE   5  (bases 1 to 3295)
  AUTHORS   Gronda,M., Arab,S., Iafrate,B., Suzuki,H. and Zanke,B.W.
  TITLE     Hematopoietic protein tyrosine phosphatase suppresses extracellular
            stimulus-regulated kinase activation
  JOURNAL   Mol Cell Biol 21 (20), 6851-6858 (2001)
   PUBMED   11564869
REFERENCE   6  (bases 1 to 3295)
  AUTHORS   Magilavy,D.B., Foys,K.M. and Gajewski,T.F.
  TITLE     Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes
            and accessory cells that support the proliferation of Th2 helper T
            lymphocyte clones
  JOURNAL   Eur J Immunol 22 (9), 2359-2365 (1992)
   PUBMED   1387611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133097.3.
            
            On Oct 4, 2017 this sequence version replaced NM_177081.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC133097.3         111082-111172
            92-265              AC133097.3         112132-112305
            266-449             AC133097.3         112822-113005
            450-534             AC133097.3         113213-113297
            535-611             AC133097.3         114481-114557
            612-749             AC133097.3         115706-115843
            750-860             AC133097.3         116150-116260
            861-1015            AC133097.3         117506-117660
            1016-1129           AC133097.3         120325-120438
            1130-3295           AC133097.3         121543-123708
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.24 cM"
     gene            1..3295
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /note="protein tyrosine phosphatase, non-receptor type 7"
                     /db_xref="GeneID:320139"
                     /db_xref="MGI:MGI:2156893"
     exon            1..91
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            92..265
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1223
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /EC_number="3.1.3.48"
                     /note="hematopoietic protein-tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     7"
                     /protein_id="NP_796055.1"
                     /db_xref="CCDS:CCDS15315.1"
                     /db_xref="GeneID:320139"
                     /db_xref="MGI:MGI:2156893"
                     /translation="MVQACEGRSRAQLPTLSLGADMTQPPPTKAPAKKHVRLQERRGS
                     SVALMLDVQSLGTVEPICSVNTPREVTLHFLRTAGHPLTRWTLQHQPPSPKQLEEEFL
                     KIPSNFVNPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDSDYINANYIRGYDG
                     KEKVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLREGKEKCVHYWPTEEEAYGPF
                     QIRIQDMKEHPEYTVRQLTIQHQQECRSVKHILFSAWPDHQTPESAGPLLRLVAEVET
                     PETAANSGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQ
                     TAEQYQFLHHTLALYAAQLPPEPNP"
     exon            266..449
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            450..534
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..611
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            612..749
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            750..860
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1015
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1129
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..3295
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3269..3274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /note="hexamer: AATAAA"
     polyA_site      3292
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /note="major polyA site"
ORIGIN      
        1 tgaaacctct cagtcctcaa agatagacgg actgacagac agctggcaag aggcagcctg
       61 ggggacatag cttcttcagt aagtacttga agcatgcctc atggctgaat gagcctccct
      121 tgggcccagc aacctacccc agcatggtcc aggcctgtga ggggcgctcc agagcacagc
      181 tgccgacctt gtctttgggg gcagacatga ctcagcctcc acccaccaaa gctccagcca
      241 agaagcatgt gcggctgcag gagagaaggg gctccagtgt ggctctgatg ctggatgtac
      301 agtctctggg cacggttgaa cccatctgct cagtgaacac accccgggaa gtcaccctac
      361 acttcctgcg cacggctgga caccccctta cacgctggac gctacagcac caacctccca
      421 gccccaagca gctagaggag gaattcttga agattccctc aaactttgtc aaccctgaag
      481 acctggatat ccctggccac gcctccaaag accgctacaa gaccatcttg ccaaatcccc
      541 agagccgtgt ctgtcttggc cgggcacaga gccaggagga cagtgactac atcaatgcca
      601 actacatccg gggctatgac gggaaggaga aggtctacat tgccacccag ggccccatgc
      661 ccaacactgt agcagacttc tgggagatgg tgtggcaaga agacgtatcc ctcattgtca
      721 tgctcaccca gctccgagag ggcaaggaga aatgtgtaca ctactggccc acagaagagg
      781 aagcctatgg gcccttccag atccgcatcc aggacatgaa agagcaccca gaatacactg
      841 tgaggcaact caccatccag caccaacagg aatgccgttc agtgaagcac atcctcttct
      901 cagcctggcc agaccaccag actccagaat cagcggggcc cctgctgcgc ctggtggccg
      961 aggtggagac tccagagaca gctgccaact ccgggcctat agtggttcac tgcagtgcag
     1021 ggatcggccg gaccggctgc ttcatcgcca cccgcatcgg ctgccagcag ctgaaggccc
     1081 gaggggaggt ggatattctg ggcatcgtgt gccaacttcg actagacaga ggaggcatga
     1141 tccagacggc cgagcagtac cagtttctgc accacacttt ggccctatat gcagcccagc
     1201 tgcccccgga gcccaacccc tgaccctcca ccagctcatg ggtctctcag gcctgagaca
     1261 gtgggtctgg ggaagtgggc tgtgagctct ggcatggctt ctgcatccgc acaggaaaag
     1321 gatccctgga atactttaca gtctcaggaa actgccccag caagcaacag gagccaggcc
     1381 acgggtcttc acctccaacc acgactctgc cttcttcagt ggcccccagt ggaacatgcg
     1441 ggagcgtcct gtggctctga acttacagat aggagctggt ccttgcaatg gattgagaga
     1501 gcagctggag tgctggctta tttaggtgct ttcggtgagc tcccttcctt gtccatgaca
     1561 caaagagtca gtcaaacaga atgttcctga aagccattcc agatgtagcc ctgctgatgc
     1621 ggctgcagag atggtgattg caagatcctc ttccattaag gcctttccca cacacaggcc
     1681 agatgcaaca gcagggaaaa tcctggtctg accttggtca aatcttctct atcctacata
     1741 gactgctcct ccccatacac ccgtgagtgc tggaggaccg gctcagaaga gaataagggc
     1801 cttgattggc ctgcctccat acatatcata aaaggagatg cagaggtaac cagctctagc
     1861 cgttgggatc actgtatgag cccagaagtg atgatgtacc tgtcatccta gcactcagga
     1921 gtagaagcag gtgggttgct gcgagtttga ggtcagctag atctacattt tgagtaccag
     1981 gctagccagg acaacatagc aagatttttt ttaaggcaat cttgagctct ctgctctctg
     2041 gaggagatga gggttgcctc tgcttctatg gcttccttcc tgtcatctgc tcccaaccac
     2101 tctctggggg aaaacccagc actctctgct ttgcttctgt gacttcagag catcctttgg
     2161 gtacccatga agtatcaaag aaagaggaga gaagagacaa agagctatgt ctgcttcaag
     2221 aaaacctacc tgccgtacct cccctggctt gtatttcttt gcagagtgct tatctggttc
     2281 cagaagcagg ctgggtggtc accactccaa gcagcatggg gctaagacct tcagccctca
     2341 tcatcatcac ttcacagaat ttccagggaa ctcatgatct atctcaggga tgaactatga
     2401 atcccagaaa gccagacaaa ccctgagtct cccttgaccc ggattgggct gcctgtgggg
     2461 gggaaggcag aatactattc ctactgtctg gtcctcagct cctggatgtg ctaagtgaca
     2521 caagtcctcc atgaaaaccc caaggagttg gaggagtgac tgcctccttg cttcctggca
     2581 tctctctgga gaactcgaag tgcttctgga catagtgtcg aaagcctgtg agccgcactt
     2641 ggacagggaa gacaggagaa tcgggagttc cagaccagcc ttggcgatgt gagacccaat
     2701 ctcaaaagca agcaaacaaa aagaaactaa gcagcggggc atggtggtgc atacctttaa
     2761 ttccagcact cgggaggcag aggcaggcgg atttctgagt tcaaggccag cctggtctac
     2821 aaagtgagtt ccaggacagc cagggctata cagagaaacc ctgcctcgaa agaaaaaaaa
     2881 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaag
     2941 aaacgaaact aaacaaacaa acaaacaaac aaaaataatg tgaggctaca actgaggtta
     3001 acatttttaa tgctcgacct gagctgagta ggtgctctgc ttctttagtc ttggggtggt
     3061 ggcttgcact tccacttttt ttttaagtcc cctgaaaggt ctgcactgct gcccaggata
     3121 ggcttctaaa gtacaggatg ctacatgagc tcagagactg tatagaaggg tgcaagggag
     3181 caattgtaca gccctatggg ctccctccct atacagtcac cccaaccctg ttctagaggg
     3241 cacaggctct ggaaaagcat aataaataaa taaataacct cttggatgcc caccc
//
