LOCUS       NM_001356382            3351 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 7
            (Ptpn7), transcript variant 2, mRNA.
ACCESSION   NM_001356382 XM_006529697
VERSION     NM_001356382.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3351)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   2  (bases 1 to 3351)
  AUTHORS   Inamdar,V.V., Reddy,H., Dangelmaier,C., Kostyak,J.C. and
            Kunapuli,S.P.
  TITLE     The protein tyrosine phosphatase PTPN7 is a negative regulator of
            ERK activation and thromboxane generation in platelets
  JOURNAL   J Biol Chem 294 (33), 12547-12554 (2019)
   PUBMED   31266805
  REMARK    GeneRIF: PTPN7 regulates platelet functional responses downstream
            of GPCR agonists, but not GPVI agonists, through inhibition of ERK
            activation and thromboxane generation.
REFERENCE   3  (bases 1 to 3351)
  AUTHORS   Seo,H., Lee,I.S., Park,J.E., Park,S.G., Lee,D.H., Park,B.C. and
            Cho,S.
  TITLE     Role of protein tyrosine phosphatase non-receptor type 7 in the
            regulation of TNF-alpha production in RAW 264.7 macrophages
  JOURNAL   PLoS One 8 (11), e78776 (2013)
   PUBMED   24265715
  REMARK    GeneRIF: PTPN7 as a negative regulator of TNF-alpha expression and
            the inflammatory response in macrophages
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3351)
  AUTHORS   McAlees,J.W. and Sanders,V.M.
  TITLE     Hematopoietic protein tyrosine phosphatase mediates
            beta2-adrenergic receptor-induced regulation of p38
            mitogen-activated protein kinase in B lymphocytes
  JOURNAL   Mol Cell Biol 29 (3), 675-686 (2009)
   PUBMED   19047375
  REMARK    GeneRIF: beta(2)AR stimulation on a B cell phosphorylates and
            inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release
            bound p38 MAPK, making more available for phosphorylation and
            subsequent IgE regulation.
REFERENCE   5  (bases 1 to 3351)
  AUTHORS   Gronda,M., Arab,S., Iafrate,B., Suzuki,H. and Zanke,B.W.
  TITLE     Hematopoietic protein tyrosine phosphatase suppresses extracellular
            stimulus-regulated kinase activation
  JOURNAL   Mol Cell Biol 21 (20), 6851-6858 (2001)
   PUBMED   11564869
REFERENCE   6  (bases 1 to 3351)
  AUTHORS   Magilavy,D.B., Foys,K.M. and Gajewski,T.F.
  TITLE     Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes
            and accessory cells that support the proliferation of Th2 helper T
            lymphocyte clones
  JOURNAL   Eur J Immunol 22 (9), 2359-2365 (1992)
   PUBMED   1387611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133097.3.
            
            On Oct 4, 2017 this sequence version replaced XM_006529697.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC133097.3         111691-111837
            148-321             AC133097.3         112132-112305
            322-505             AC133097.3         112822-113005
            506-590             AC133097.3         113213-113297
            591-667             AC133097.3         114481-114557
            668-805             AC133097.3         115706-115843
            806-916             AC133097.3         116150-116260
            917-1071            AC133097.3         117506-117660
            1072-1185           AC133097.3         120325-120438
            1186-3351           AC133097.3         121543-123708
FEATURES             Location/Qualifiers
     source          1..3351
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.24 cM"
     gene            1..3351
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /note="protein tyrosine phosphatase, non-receptor type 7"
                     /db_xref="GeneID:320139"
                     /db_xref="MGI:MGI:2156893"
     exon            1..147
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            148..321
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1279
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /EC_number="3.1.3.48"
                     /note="hematopoietic protein-tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     7"
                     /protein_id="NP_001343311.1"
                     /db_xref="CCDS:CCDS15315.1"
                     /db_xref="GeneID:320139"
                     /db_xref="MGI:MGI:2156893"
                     /translation="MVQACEGRSRAQLPTLSLGADMTQPPPTKAPAKKHVRLQERRGS
                     SVALMLDVQSLGTVEPICSVNTPREVTLHFLRTAGHPLTRWTLQHQPPSPKQLEEEFL
                     KIPSNFVNPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDSDYINANYIRGYDG
                     KEKVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLREGKEKCVHYWPTEEEAYGPF
                     QIRIQDMKEHPEYTVRQLTIQHQQECRSVKHILFSAWPDHQTPESAGPLLRLVAEVET
                     PETAANSGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQ
                     TAEQYQFLHHTLALYAAQLPPEPNP"
     exon            322..505
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..590
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            591..667
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            668..805
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            806..916
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1071
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1185
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..3351
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /note="hexamer: AATAAA"
     polyA_site      3348
                     /gene="Ptpn7"
                     /gene_synonym="BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP"
                     /note="major polyA site"
ORIGIN      
        1 caactgatct tggagtggaa ctgccgacaa tgagaagacc cttctagaag ttggagcgtg
       61 cctggatccc tgactggatc cagtgcttct caaggcctcc atttctcatt atagagaagc
      121 ctgctagctg gctagactca gagagctgca tgcctcatgg ctgaatgagc ctcccttggg
      181 cccagcaacc taccccagca tggtccaggc ctgtgagggg cgctccagag cacagctgcc
      241 gaccttgtct ttgggggcag acatgactca gcctccaccc accaaagctc cagccaagaa
      301 gcatgtgcgg ctgcaggaga gaaggggctc cagtgtggct ctgatgctgg atgtacagtc
      361 tctgggcacg gttgaaccca tctgctcagt gaacacaccc cgggaagtca ccctacactt
      421 cctgcgcacg gctggacacc cccttacacg ctggacgcta cagcaccaac ctcccagccc
      481 caagcagcta gaggaggaat tcttgaagat tccctcaaac tttgtcaacc ctgaagacct
      541 ggatatccct ggccacgcct ccaaagaccg ctacaagacc atcttgccaa atccccagag
      601 ccgtgtctgt cttggccggg cacagagcca ggaggacagt gactacatca atgccaacta
      661 catccggggc tatgacggga aggagaaggt ctacattgcc acccagggcc ccatgcccaa
      721 cactgtagca gacttctggg agatggtgtg gcaagaagac gtatccctca ttgtcatgct
      781 cacccagctc cgagagggca aggagaaatg tgtacactac tggcccacag aagaggaagc
      841 ctatgggccc ttccagatcc gcatccagga catgaaagag cacccagaat acactgtgag
      901 gcaactcacc atccagcacc aacaggaatg ccgttcagtg aagcacatcc tcttctcagc
      961 ctggccagac caccagactc cagaatcagc ggggcccctg ctgcgcctgg tggccgaggt
     1021 ggagactcca gagacagctg ccaactccgg gcctatagtg gttcactgca gtgcagggat
     1081 cggccggacc ggctgcttca tcgccacccg catcggctgc cagcagctga aggcccgagg
     1141 ggaggtggat attctgggca tcgtgtgcca acttcgacta gacagaggag gcatgatcca
     1201 gacggccgag cagtaccagt ttctgcacca cactttggcc ctatatgcag cccagctgcc
     1261 cccggagccc aacccctgac cctccaccag ctcatgggtc tctcaggcct gagacagtgg
     1321 gtctggggaa gtgggctgtg agctctggca tggcttctgc atccgcacag gaaaaggatc
     1381 cctggaatac tttacagtct caggaaactg ccccagcaag caacaggagc caggccacgg
     1441 gtcttcacct ccaaccacga ctctgccttc ttcagtggcc cccagtggaa catgcgggag
     1501 cgtcctgtgg ctctgaactt acagatagga gctggtcctt gcaatggatt gagagagcag
     1561 ctggagtgct ggcttattta ggtgctttcg gtgagctccc ttccttgtcc atgacacaaa
     1621 gagtcagtca aacagaatgt tcctgaaagc cattccagat gtagccctgc tgatgcggct
     1681 gcagagatgg tgattgcaag atcctcttcc attaaggcct ttcccacaca caggccagat
     1741 gcaacagcag ggaaaatcct ggtctgacct tggtcaaatc ttctctatcc tacatagact
     1801 gctcctcccc atacacccgt gagtgctgga ggaccggctc agaagagaat aagggccttg
     1861 attggcctgc ctccatacat atcataaaag gagatgcaga ggtaaccagc tctagccgtt
     1921 gggatcactg tatgagccca gaagtgatga tgtacctgtc atcctagcac tcaggagtag
     1981 aagcaggtgg gttgctgcga gtttgaggtc agctagatct acattttgag taccaggcta
     2041 gccaggacaa catagcaaga ttttttttaa ggcaatcttg agctctctgc tctctggagg
     2101 agatgagggt tgcctctgct tctatggctt ccttcctgtc atctgctccc aaccactctc
     2161 tgggggaaaa cccagcactc tctgctttgc ttctgtgact tcagagcatc ctttgggtac
     2221 ccatgaagta tcaaagaaag aggagagaag agacaaagag ctatgtctgc ttcaagaaaa
     2281 cctacctgcc gtacctcccc tggcttgtat ttctttgcag agtgcttatc tggttccaga
     2341 agcaggctgg gtggtcacca ctccaagcag catggggcta agaccttcag ccctcatcat
     2401 catcacttca cagaatttcc agggaactca tgatctatct cagggatgaa ctatgaatcc
     2461 cagaaagcca gacaaaccct gagtctccct tgacccggat tgggctgcct gtggggggga
     2521 aggcagaata ctattcctac tgtctggtcc tcagctcctg gatgtgctaa gtgacacaag
     2581 tcctccatga aaaccccaag gagttggagg agtgactgcc tccttgcttc ctggcatctc
     2641 tctggagaac tcgaagtgct tctggacata gtgtcgaaag cctgtgagcc gcacttggac
     2701 agggaagaca ggagaatcgg gagttccaga ccagccttgg cgatgtgaga cccaatctca
     2761 aaagcaagca aacaaaaaga aactaagcag cggggcatgg tggtgcatac ctttaattcc
     2821 agcactcggg aggcagaggc aggcggattt ctgagttcaa ggccagcctg gtctacaaag
     2881 tgagttccag gacagccagg gctatacaga gaaaccctgc ctcgaaagaa aaaaaaaaga
     2941 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaaagaaac
     3001 gaaactaaac aaacaaacaa acaaacaaaa ataatgtgag gctacaactg aggttaacat
     3061 ttttaatgct cgacctgagc tgagtaggtg ctctgcttct ttagtcttgg ggtggtggct
     3121 tgcacttcca cttttttttt aagtcccctg aaaggtctgc actgctgccc aggataggct
     3181 tctaaagtac aggatgctac atgagctcag agactgtata gaagggtgca agggagcaat
     3241 tgtacagccc tatgggctcc ctccctatac agtcacccca accctgttct agagggcaca
     3301 ggctctggaa aagcataata aataaataaa taacctcttg gatgcccacc c
//
