LOCUS       NM_013545               2219 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 6
            (Ptpn6), transcript variant 1, mRNA.
ACCESSION   NM_013545
VERSION     NM_013545.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2219)
  AUTHORS   Zhang,M., Guan,J., Yu,S., Zhang,Y., Cheng,L. and Zhang,Y.
  TITLE     YTHDC1 inhibits osteoclast differentiation to alleviate
            osteoporosis by enhancing PTPN6 messenger RNA stability in an
            m6A-hUR-dependent manner
  JOURNAL   J Leukoc Biol 115 (6), 1154-1164 (2024)
   PUBMED   38289832
  REMARK    GeneRIF: YTHDC1 inhibits osteoclast differentiation to alleviate
            osteoporosis by enhancing PTPN6 messenger RNA stability in an
            m6A-hUR-dependent manner.
REFERENCE   2  (bases 1 to 2219)
  AUTHORS   Xu,S.L., Chen,Z., Yang,J., Fan,Z.Q., Liu,T., Zhang,X.T., Zeng,B.Q.
            and Xing,X.Q.
  TITLE     [Effect of SHP-1 knockout in airway epithelial cells on emphysema
            phenotype in chronic obstructive pulmonary disease in mice]
  JOURNAL   Zhonghua Jie He He Hu Xi Za Zhi 47 (4), 339-345 (2024)
   PUBMED   38599809
  REMARK    GeneRIF: [Effect of SHP-1 knockout in airway epithelial cells on
            emphysema phenotype in chronic obstructive pulmonary disease in
            mice].
REFERENCE   3  (bases 1 to 2219)
  AUTHORS   Lizotte,F., Rousseau,M., Denhez,B., Levesque,D., Guay,A., Liu,H.,
            Moreau,J., Higgins,S., Sabbagh,R., Susztak,K., Boisvert,F.M.,
            Cote,A.M. and Geraldes,P.
  TITLE     Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation
            of podocin and reverses the progression of diabetic kidney disease
  JOURNAL   Kidney Int 104 (4), 787-802 (2023)
   PUBMED   37507049
  REMARK    GeneRIF: Deletion of protein tyrosine phosphatase SHP-1 restores
            SUMOylation of podocin and reverses the progression of diabetic
            kidney disease.
            Erratum:[Kidney Int. 2023 Dec;104(6):1228. doi:
            10.1016/j.kint.2023.10.007. PMID: 37981434]
REFERENCE   4  (bases 1 to 2219)
  AUTHORS   Kumar,A., Schwab,M., Laborit Labrada,B., Silveira,M.A.D.,
            Goudreault,M., Fournier,E., Bellmann,K., Beauchemin,N.,
            Gingras,A.C., Bilodeau,S., Laplante,M. and Marette,A.
  TITLE     SHP-1 phosphatase acts as a coactivator of PCK1 transcription to
            control gluconeogenesis
  JOURNAL   J Biol Chem 299 (9), 105164 (2023)
   PUBMED   37595871
REFERENCE   5  (bases 1 to 2219)
  AUTHORS   Choi,S., Hatzihristidis,T., Gaud,G., Dutta,A., Lee,J., Arya,A.,
            Clubb,L.M., Stamos,D.B., Markovics,A., Mikecz,K. and Love,P.
  TITLE     GRB2 promotes thymocyte positive selection by facilitating
            THEMIS-mediated inactivation of SHP1
  JOURNAL   J Exp Med 220 (7) (2023)
   PUBMED   37067793
REFERENCE   6  (bases 1 to 2219)
  AUTHORS   Davidson,W.F., Morse,H.C. 3rd, Sharrow,S.O. and Chused,T.M.
  TITLE     Phenotypic and functional effects of the motheaten gene on murine B
            and T lymphocytes
  JOURNAL   J Immunol 122 (3), 884-891 (1979)
   PUBMED   221571
REFERENCE   7  (bases 1 to 2219)
  AUTHORS   Sidman,C.L., Shultz,L.D. and Unanue,E.R.
  TITLE     The mouse mutant 'motheaten.' II. Functional studies of the immune
            system
  JOURNAL   J Immunol 121 (6), 2399-2404 (1978)
   PUBMED   363947
REFERENCE   8  (bases 1 to 2219)
  AUTHORS   Ward,J.M.
  TITLE     Pulmonary pathology of the motheaten mouse
  JOURNAL   Vet Pathol 15 (2), 170-178 (1978)
   PUBMED   664185
REFERENCE   9  (bases 1 to 2219)
  AUTHORS   Shultz,L.D. and Green,M.C.
  TITLE     Motheaten, an immunodeficient mutant of the mouse. II. Depressed
            immune competence and elevated serum immunoglobulins
  JOURNAL   J Immunol 116 (4), 936-943 (1976)
   PUBMED   56406
REFERENCE   10 (bases 1 to 2219)
  AUTHORS   Green,M.C. and Shultz,L.D.
  TITLE     Motheaten, an immunodeficient mutant of the mouse. I. Genetics and
            pathology
  JOURNAL   J Hered 66 (5), 250-258 (1975)
   PUBMED   1184950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164157.3, AK151077.1 and AK151623.1.
            
            On Nov 7, 2013 this sequence version replaced NM_013545.2.
            
            Transcript Variant: This variant (1) contains an alternate 5'
            terminal exon and initiates translation at an alternate start
            codon, compared to variant 2. It encodes isoform a, which has a
            shorter and distinct N-terminus, compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169804.1, AK151077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC164157.3         128947-129026       c
            81-625              AK151077.1         2-546
            626-1938            AK151623.1         550-1862
            1939-2219           AK151077.1         1860-2140
FEATURES             Location/Qualifiers
     source          1..2219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..2219
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /note="protein tyrosine phosphatase, non-receptor type 6"
                     /db_xref="GeneID:15170"
                     /db_xref="MGI:MGI:96055"
     exon            1..209
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..332
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..527
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..717
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..834
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..948
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1045
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1125
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1275
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1407
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1562
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1630
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1782
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1874
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2017
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2219
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2209
                     /gene="Ptpn6"
                     /gene_synonym="70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42;
                     SH-PTP1; SHP-1"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcgccc cttcctgtct ccgccctgct ggctgcccca ggccagtaga gtggtagccc
       61 ggggagcagg actgcaggtt ggctttggag gcctgggctc tgagagcctt gcctgaggct
      121 catctctaga gtttgtacgt gcctgcccag acaaactgtt ccctccacat tttctgcagc
      181 caattcagtg agaaccccag gatggtgagg tggtttcacc gggacctcag cgggcctgat
      241 gcagagaccc tgctgaaggg ccggggagtc cctgggagct tcctggctcg gcccagccgc
      301 aagaaccagg gtgacttctc cctctcagtc agggtggatg atcaggtgac tcatattcgg
      361 atccagaact caggggactt ctatgacctg tacggagggg agaagtttgc gacgctgaca
      421 gagctggtcg agtattacac gcagcagcag ggcatcctgc aggaccgaga tggcaccatc
      481 atccacctta agtacccact gaactgctcg gaccccacca gtgagaggtg gtaccacggc
      541 cacatatctg gagggcaggc ggagtcactg ctgcaggcca agggcgagcc ctggacattt
      601 cttgtgcgtg agagtctcag ccaacctggt gattttgtgc tctctgtgct caatgaccag
      661 cccaaggctg gcccaggttc cccgctcagg gtcactcata tcaaggttat gtgtgagggt
      721 ggacgctata ctgtgggtgg ctcagagacg tttgacagcc tcacagacct ggtggagcac
      781 ttcaagaaga cagggattga ggaggcctcg ggtgcctttg tctacctgcg gcagccttac
      841 tacgctactc gggtaaacgc agctgacatt gagaatcggg tcttggaact gaacaagaag
      901 caggagtcgg aggacacagc caaggctggc ttctgggagg agtttgagag tctacaaaag
      961 caggaggtaa agaatctaca ccaacgtctg gaagggcagc ggccagagaa caagagcaag
     1021 aaccgctaca agaacattct tccctttgac cacagccgag tgatcctgca gggacgtgac
     1081 agtaacatcc caggctctga ctacatcaat gccaactacg tgaagaacca gctgctaggt
     1141 ccagatgaga actctaagac ctacatcgcc agccagggct gtctggatgc cacagtcaat
     1201 gacttctggc agatggcttg gcaggagaac actcgtgtca tcgtcatgac taccagagag
     1261 gtggagaaag gccggaacaa atgtgtccca tactggcccg aggtgggcac tcagcgtgtc
     1321 tatggtctct actctgtgac caacagtagg gagcatgaca cagcagaata caaactgcga
     1381 acattacaga tctccccact agacaatggg gacctggttc gggagatatg gcactaccag
     1441 tacctgagct ggcctgacca tggggttccc agtgagcctg ggggtgtcct cagctttctg
     1501 gatcagatca accagcgaca ggaaagtttg cctcatgcag ggcccatcat tgtgcattgc
     1561 agcgctggca tcggccgcac gggcaccatc atcgtcattg atatgcttat ggaaagcatc
     1621 tccaccaagg ggctagactg tgacattgat atccagaaga ccatccagat ggtacgagca
     1681 cagcgctccg gcatggtgca gaccgaggcc cagtacaagt ttatttacgt ggccattgcc
     1741 cagttcatcg aaacgaccaa gaagaaactg gagatcatac aatcccagaa gggccaggag
     1801 tcggagtatg ggaatatcac gtaccctccc gctgtgagga gtgcccacgc caaagcctcg
     1861 cgtacttcct ccaagcacaa ggaggaggtg tacgaaaacg tgcatagcaa gagcaagaag
     1921 gaagagaaag taaagaagca gcggtcggca gacaaggaga agaacaaagg ttctctcaag
     1981 aggaagtgat ctgggcattc gtctgcaggt ggccatgcat cagccttgat ccctgcagag
     2041 gcttccaccc gatagactga gacctgtggc cctcaccaga ccctaggacc acccccatct
     2101 tcttgtaatt taagtgactg tggtcatctg aatctgtata tagcccggca agtccccagg
     2161 gagagccggg cccttctatt cttgtaaata aattccctgg accactgtgt attgcctcc
//
