LOCUS       NM_001417180            3592 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 5
            (Ptpn5), transcript variant 3, mRNA.
ACCESSION   NM_001417180 XM_006540715
VERSION     NM_001417180.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3592)
  AUTHORS   Samadi,M., Hales,C.A., Lustberg,D.J., Farris,S., Ross,M.R.,
            Zhao,M., Hepler,J.R., Harbin,N.H., Robinson,E.S.J., Banks,P.J.,
            Bashir,Z.I. and Dudek,S.M.
  TITLE     Mechanisms of mGluR-dependent plasticity in hippocampal area CA2
  JOURNAL   Hippocampus 33 (6), 730-744 (2023)
   PUBMED   36971428
  REMARK    GeneRIF: Mechanisms of mGluR-dependent plasticity in hippocampal
            area CA2.
REFERENCE   3  (bases 1 to 3592)
  AUTHORS   Taylor,D., Kneynsberg,A., van Roijen,M. and Gotz,J.
  TITLE     Tyrosine phosphatase STEP61 in human dementia and in animal models
            with amyloid and tau pathology
  JOURNAL   Mol Brain 16 (1), 6 (2023)
   PUBMED   36639708
  REMARK    GeneRIF: Tyrosine phosphatase STEP61 in human dementia and in
            animal models with amyloid and tau pathology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3592)
  AUTHORS   Durakoglugil,M.S., Wasser,C.R., Wong,C.H., Pohlkamp,T., Xian,X.,
            Lane-Donovan,C., Fritschle,K., Naestle,L. and Herz,J.
  TITLE     Reelin Regulates Neuronal Excitability through Striatal-Enriched
            Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs
            in an NMDAR-Dependent Manner
  JOURNAL   J Neurosci 41 (35), 7340-7349 (2021)
   PUBMED   34290083
  REMARK    GeneRIF: Reelin Regulates Neuronal Excitability through
            Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium
            Permeable AMPARs in an NMDAR-Dependent Manner.
REFERENCE   5  (bases 1 to 3592)
  AUTHORS   Wang,H., Bu,S., Tang,J., Li,Y., Liu,C. and Dong,J.
  TITLE     PTPN5 promotes follicle-stimulating hormone secretion through
            regulating intracellular calcium homeostasis
  JOURNAL   FASEB J 35 (8), e21756 (2021)
   PUBMED   34270805
REFERENCE   6  (bases 1 to 3592)
  AUTHORS   Bult,A., Zhao,F., Dirkx,R. Jr., Raghunathan,A., Solimena,M. and
            Lombroso,P.J.
  TITLE     STEP: a family of brain-enriched PTPs. Alternative splicing
            produces transmembrane, cytosolic and truncated isoforms
  JOURNAL   Eur J Cell Biol 72 (4), 337-344 (1997)
   PUBMED   9127733
REFERENCE   7  (bases 1 to 3592)
  AUTHORS   Bult,A., Zhao,F., Dirkx,R. Jr., Sharma,E., Lukacsi,E., Solimena,M.,
            Naegele,J.R. and Lombroso,P.J.
  TITLE     STEP61: a member of a family of brain-enriched PTPs is localized to
            the endoplasmic reticulum
  JOURNAL   J Neurosci 16 (24), 7821-7831 (1996)
   PUBMED   8987810
REFERENCE   8  (bases 1 to 3592)
  AUTHORS   Li,X., Luna,J., Lombroso,P.J. and Francke,U.
  TITLE     Molecular cloning of the human homolog of a striatum-enriched
            phosphatase (STEP) gene and chromosomal mapping of the human and
            murine loci
  JOURNAL   Genomics 28 (3), 442-449 (1995)
   PUBMED   7490079
REFERENCE   9  (bases 1 to 3592)
  AUTHORS   Sharma,E., Zhao,F., Bult,A. and Lombroso,P.J.
  TITLE     Identification of two alternatively spliced transcripts of STEP: a
            subfamily of brain-enriched protein tyrosine phosphatases
  JOURNAL   Brain Res Mol Brain Res 32 (1), 87-93 (1995)
   PUBMED   7494467
REFERENCE   10 (bases 1 to 3592)
  AUTHORS   Kaneko,Y., Takano,S., Okumura,K., Takenawa,J., Higashituji,H.,
            Fukumoto,M., Nakayama,H. and Fujita,J.
  TITLE     Identification of protein tyrosine phosphatases expressed in murine
            male germ cells
  JOURNAL   Biochem Biophys Res Commun 197 (2), 625-631 (1993)
   PUBMED   8267598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113001.9.
            
            On Feb 28, 2023 this sequence version replaced XM_006540715.4.
            
            Transcript Variant: This variant (3) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1283698.1,
                                           SRR7345562.2406227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC113001.9         201178-201631       c
            455-836             AC113001.9         200200-200581       c
            837-887             AC113001.9         199432-199482       c
            888-964             AC113001.9         180643-180719       c
            965-1158            AC113001.9         159299-159492       c
            1159-1266           AC113001.9         158649-158756       c
            1267-1350           AC113001.9         158343-158426       c
            1351-1592           AC113001.9         157699-157940       c
            1593-1782           AC113001.9         156412-156601       c
            1783-1867           AC113001.9         153963-154047       c
            1868-1947           AC113001.9         151008-151087       c
            1948-2085           AC113001.9         150683-150820       c
            2086-2196           AC113001.9         149785-149895       c
            2197-2357           AC113001.9         147369-147529       c
            2358-2471           AC113001.9         147168-147281       c
            2472-3592           AC113001.9         145720-146840       c
FEATURES             Location/Qualifiers
     source          1..3592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.7 cM"
     gene            1..3592
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /note="protein tyrosine phosphatase, non-receptor type 5"
                     /db_xref="GeneID:19259"
                     /db_xref="MGI:MGI:97807"
     exon            1..454
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            455..836
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            837..887
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            888..964
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     CDS             940..2565
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /EC_number="3.1.3.48"
                     /note="neural-specific protein-tyrosine phosphatase;
                     striatum-enriched protein-tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     5"
                     /protein_id="NP_001404109.1"
                     /db_xref="GeneID:19259"
                     /db_xref="MGI:MGI:97807"
                     /translation="MCCSERLLGLPQPVEMEAPDEAEGLPSKQKEMPPPPPPSPPSEP
                     AQKLPPQGAGSHSLTVRSSLCLFAASQFLLACGVLWLSGHGHSWLQNTTDLISSSLTV
                     LNHLGPVAWLGSGTWGIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPEDRRQS
                     VSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPETDPASLTVKSMGLQER
                     RGSNVSLTLDMCTPGCNEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDPFLL
                     QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANY
                     IRGYSGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQ
                     VVHDGVEITVQKVIHTEDYRLRLISLRRGTEERSLKHYWFTSWPDQKTPDRAPPLLHL
                     VREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQLR
                     QDRGGMIQTCEQYQFVHHAMSLYEKQLSLQSSE"
     exon            965..1158
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1266
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1350
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1592
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1782
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1867
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1947
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2085
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2196
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2357
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2471
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..3592
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3568..3573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /note="hexamer: AATAAA"
     polyA_site      3592
                     /gene="Ptpn5"
                     /gene_synonym="Step"
                     /note="major polyA site"
ORIGIN      
        1 gccatcttgg ttatggccac agattgggag gaaggagtga agggcaggaa gtgaagttag
       61 agcattaaag gacgcctgct catgaagacc ctcccaggct ataacgggcg ctttggtgaa
      121 tgcaatggcc atcggctgtg ggagttctga caaaggatag atgcaacctg gtgcgcattt
      181 ctttctttct tccttttttt cctggtgcgc ttttcaaaag gatcgctcgg agtactctgt
      241 aaagaaacag ctgcaggtgg ccagggacgg aagactagta aagaggctac tgcggaaatt
      301 taagctacag aggagagcag tggctggaac cattcttttt agtagccgcg tcctgcttct
      361 cattttcgcc atgtaaaact gctgcgtgtg cgatccactc tgcccccaca gagcctgcag
      421 tggggtgaaa tgtcaggaac aagccccgga gaagagccct aggcgatgct ggagctcccc
      481 acccccaccc cgccaagcgg gcgagccctg cgcaattccc ggggagcggc gcaagcccgt
      541 ccgggggcgg ggcggagccc gggctggggg tgcccagcag acccggcagc tgcacccgcg
      601 actctgcagt tcaggcgcat ttggtggggc gattgggcag ggagcacgca aggagagcgg
      661 gactgagggc tccgcggaca gaccgacaga cggacgcccc cgcacacgca gacgcaccga
      721 gctccgcacg gcccctgtca cacacagaca gggacacacg cagacacgca cactcgcgcg
      781 ctcacatcct cccgccagcc tgcttgtccg ccggcgcctg gagcccgctc tggccgacct
      841 aatccccagg aaaccccaga gcccagaaat tcacgtgagt acgccaggag tgagagagag
      901 agccaggctg ctgatgactc cgagggagga accctggaca tgtgctgtag tgagaggctg
      961 ttgggtctcc cccagccggt agagatggaa gcaccggacg aggccgaagg actccccagc
     1021 aagcagaaag agatgccacc acccccgcca ccctcaccgc cctctgagcc agctcagaag
     1081 ctgccacctc aaggcgctgg gagccactcc ctcaccgtca gaagcagcct gtgcctgttt
     1141 gctgcctctc agttcctgct tgcctgtggg gtgctctggc tcagtggcca tggccactcc
     1201 tggctgcaga acaccacaga cctcatctcc tcctcgctca cagtgttgaa ccatctggga
     1261 cctgtggcct ggctgggttc tgggacctgg gggataccaa gtctgctgct agtctctctg
     1321 actgtgagcc tggtcatcgt caccaccctg gtgtggcacc tcctcaaggc acccccagag
     1381 ccacctgccc cactgccccc agaggacagg cgtcaatcag tgagccggca gccttccttc
     1441 acctactcag agtggatgga ggagaaggta gaggatgact tcctggacct ggacgcggtg
     1501 cccgagacac ctgtgtttga ctgtgtgatg gacatcaagc ctgagactga tcctgcctca
     1561 ttgactgtca agtccatggg tctacaggag aggagaggat ccaatgtctc cttgaccctg
     1621 gacatgtgta ctcctggctg caatgaggag ggcttcggct acctggtgtc tccacgagaa
     1681 gagtcagccc atgagtatct gctcagcgcc tcccgtgtcc tccgggcaga agagctacat
     1741 gaaaaggctc tggacccttt cttgctgcag gcggaattct ttgaaatccc catgaacttt
     1801 gtggatccaa aagagtatga catcccaggg ctggtgcgga agaatcggta caaaaccatc
     1861 cttcccaatc ctcacagcag ggtacgtctg acgtcaccag accctgaaga tcctctgagt
     1921 tcctacatca atgccaacta catccggggc tacagtgggg aggagaaggt gtacatcgcc
     1981 acgcagggac ccatcgtcag cactgtggcc gacttttggc gcatggtgtg gcaggagcgc
     2041 acacccatca tcgtcatgat caccaacatc gaggagatga acgagaagtg cacagaatac
     2101 tggccagaag agcaggtggt ccatgacggc gtggagatca ccgtgcagaa agtcatccac
     2161 acggaggact accggctgcg actcatctcc ctcaggagag ggactgaaga gcgaagcttg
     2221 aagcattact ggttcacatc ctggcctgac cagaagaccc ccgaccgggc tcccccactc
     2281 ctgcacctgg tacgggaagt ggaggaggca gcccaacaag agggacccca ttgttcccca
     2341 atcatcgttc actgcagtgc agggattggg agaactggct gcttcattgc caccagcatc
     2401 tgctgccagc agctgcgacg tgagggcgtg gtggacatcc tgaagaccac gtgccagctc
     2461 cgtcaggaca ggggtggcat gatccagaca tgcgaacagt accagtttgt gcaccacgcc
     2521 atgagcctct atgagaagca gctgtccctc cagtcctcag agtgaccacg ctcttcctct
     2581 gagatccact gggtactgcc aagcctgagg ctgggtcttt accccaacta cccaagatct
     2641 tgccttgggt cctgggccta ttccctggcc ctccccctca tcctcccctc tcttcagtct
     2701 gttccccatc tattgtcctg gcctggtccc taccccaagc ctagctctcc tactgtatat
     2761 actgcagagt tggggagggc aggggaggaa tgtgccaggc caggcctggg gcccctgggc
     2821 ctgacccaca ccatatagac ctgagggcct cagttttaac catggttcca cagctacttg
     2881 gtccaaaatg tttccatgcc acaccccaag tgtcctacca taatgtgttc tgtctgtcca
     2941 tctatcacag ctatttgtac caaacactgt gtcccctcag ccaggaaagg agcactgaac
     3001 taagctctca cccctcagcc ctcacccaca tccccacacc agactcccac cctgctcccc
     3061 aggcagagat actgaccttc ctctggcccc actggctcct ctgcaaaggc agagtgcatt
     3121 ttgctaccag gatgtggatg gcagagacca ggcaggggag cacatgatgg ttgacagaga
     3181 gatcccagct aagacagttc ctgggcaaag atgagtatct ccagtctatg tggcactgga
     3241 gaggaagagg acagatatag tggggaaccc caaagatctg agccctgagg ggggcctcca
     3301 agagtaggat gtggacagct ccagacctgt gagacatctt tctgtgtcac tatgggaaac
     3361 cgcaagtgtc tccctacatg ttgctctgtg tgtgttccct tgtccatgcg tgtgttgaga
     3421 gcccatgaac agggcatgca tgactctttg gcaacatgtg ttatcttgga gccacgtgtt
     3481 tttattgctg actttaaata tttattccac ggcaaacgga gacatttggt gtcttttttt
     3541 aatccgctcg tggtcattga atagagcaat aaacagagca ttttgagcaa aa
//
