LOCUS       NM_019933               4707 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 4
            (Ptpn4), mRNA.
ACCESSION   NM_019933
VERSION     NM_019933.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4707)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   2  (bases 1 to 4707)
  AUTHORS   Chen,C., Wang,Y., Zhao,Q., Li,G.D., Wang,Y.H., Xu,L.C., Huang,H.Z.,
            Song,G., Li,W.T. and He,X.H.
  TITLE     E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and
            Metastasis by Activating STAT3 via Degradation of PTPN4
  JOURNAL   Pancreas 52 (4), e224-e234 (2023)
   PUBMED   37747937
  REMARK    GeneRIF: E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer
            Growth and Metastasis by Activating STAT3 via Degradation of PTPN4.
REFERENCE   3  (bases 1 to 4707)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4707)
  AUTHORS   Espinoza,S., Arredondo,S.B., Barake,F., Carvajal,F., Guerrero,F.G.,
            Segovia-Miranda,F., Valenzuela,D.M., Wyneken,U.,
            Rojas-Fernandez,A., Cerpa,W., Massardo,L., Varela-Nallar,L. and
            Gonzalez,A.
  TITLE     Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR
            stability through ubiquitination of tyrosine phosphatase PTPMEG
  JOURNAL   BMC Biol 18 (1), 164 (2020)
   PUBMED   33158444
  REMARK    GeneRIF: Neuronal surface P antigen (NSPA) modulates postsynaptic
            NMDAR stability through ubiquitination of tyrosine phosphatase
            PTPMEG.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4707)
  AUTHORS   Huai,W., Song,H., Wang,L., Li,B., Zhao,J., Han,L., Gao,C.,
            Jiang,G., Zhang,L. and Zhao,W.
  TITLE     Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4
            pathway by dephosphorylating TRAM
  JOURNAL   J Immunol 194 (9), 4458-4465 (2015)
   PUBMED   25825441
  REMARK    GeneRIF: our results provide new insight into the TLR4 pathway and
            identify PTPN4 as a specific inhibitor of TRIF-dependent TLR4
            pathway.
REFERENCE   6  (bases 1 to 4707)
  AUTHORS   Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T.
  TITLE     The protein-tyrosine phosphatase PTPMEG interacts with glutamate
            receptor delta 2 and epsilon subunits
  JOURNAL   J Biol Chem 275 (21), 16167-16173 (2000)
   PUBMED   10748123
REFERENCE   7  (bases 1 to 4707)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 4707)
  AUTHORS   Celler,J.W., Luo,X. and Bohmer,F.D.
  TITLE     Protein tyrosine phosphatase gene expression analysis in Swiss 3T3
            fibroblasts
  JOURNAL   Mol Cell Biochem 178 (1-2), 157-162 (1998)
   PUBMED   9546595
REFERENCE   9  (bases 1 to 4707)
  AUTHORS   Huang,K., Sommers,C.L., Grinberg,A., Kozak,C.A. and Love,P.E.
  TITLE     Cloning and characterization of PTP-K1, a novel nonreceptor protein
            tyrosine phosphatase highly expressed in bone marrow
  JOURNAL   Oncogene 13 (7), 1567-1573 (1996)
   PUBMED   8875997
REFERENCE   10 (bases 1 to 4707)
  AUTHORS   Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S.
  TITLE     Expression of protein tyrosine phosphatase genes in the developing
            brain of mouse and rat
  JOURNAL   Biochem Mol Biol Int 33 (6), 1221-1227 (1994)
   PUBMED   7804149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE985496.1, AK046683.1, AF106702.1, AK166169.1 and AC123955.5.
            
            On Nov 2, 2006 this sequence version replaced NM_019933.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.104848.1,
                                           SRR7345562.4564481.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               BE985496.1         1-141
            142-1496            AK046683.1         417-1771
            1497-1821           AF106702.1         1325-1649
            1822-1843           AK046683.1         2097-2118
            1844-2408           AF106702.1         1672-2236
            2409-3054           AK166169.1         346-991
            3055-4707           AC123955.5         141117-142769
FEATURES             Location/Qualifiers
     source          1..4707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.39 cM"
     gene            1..4707
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /note="protein tyrosine phosphatase, non-receptor type 4"
                     /db_xref="GeneID:19258"
                     /db_xref="MGI:MGI:1099792"
     exon            1..170
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            171..325
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2968
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /EC_number="3.1.3.48"
                     /note="testis-enriched protein tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     4"
                     /protein_id="NP_064317.2"
                     /db_xref="CCDS:CCDS15227.1"
                     /db_xref="GeneID:19258"
                     /db_xref="MGI:MGI:1099792"
                     /translation="MTARFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFR
                     VNKHDQGQVLLDIVFKHLDLTERDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYN
                     LNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLSCPCNTAALLASFAVQSELGD
                     YNQSENLAGYLSDYSFIPNQPQDFEKEIAKLHQQHVGLSPAEAEFNYLNAARTLELYG
                     VEFHYARDQSNNEILIGVMSGGILIYKNRVRMNTFLWLKIVKISFKCKQFFIQLRKEL
                     HESRETLLGFNMVNYRACKTLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYC
                     GRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSLSDDRLETQSLPSRS
                     PPGTPNHRNSSFTQEATRVRPSSVGHLVDHVVHMSPSEDFVSQRSPSSTQANSIVLES
                     SPSQETPEDGQPPALPPKQSKKNSWNQIHFSNSQQDLVTHTNESFDVPSSPEKSTPNG
                     GIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQV
                     VLINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEKLESEPDFQYIP
                     EKAPLDSVHQDDHSLRESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNISK
                     NRYRDISPYDATRVLLKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCKDFWQM
                     TWEQGSSMVVMLTTQVERGRVKCHQYWPEPSESSSYGCYQVTCHSEEGNPAYIFRKMT
                     LFNQEKNESRQLTQIQYTAWPDHGVPDDSSDFLDFVCHVRDQRAGKEEPIIVHCSAGI
                     GRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE
                     GFVKPLTTSSNK"
     exon            326..433
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            434..476
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            477..555
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            556..600
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            601..653
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            654..774
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            775..862
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            863..951
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1015
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1188
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1257
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1383
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1542
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1702
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1786
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1843
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2000
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2167
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2258
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2320
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2467
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2596
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2745
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2881
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..4707
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /note="hexamer: AACAAA"
     polyA_site      2990
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /note="major polyA site"
     regulatory      4081..4086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /note="hexamer: AATATA"
     polyA_site      4099
                     /gene="Ptpn4"
                     /gene_synonym="hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG"
                     /note="major polyA site"
ORIGIN      
        1 cggccgctgt ggcggcggct gttctcggga cgctgagggc gagcacctcg acgcggacca
       61 cgcgcttctt tcacccggcc gcgagcccgg ggcctcctgc ctttttgtat ttggattccc
      121 cccccccccc ccctttctcc agccgggagg acgcggctgt gataacgaag gttttgtgtg
      181 gacagtaatg accgcacgtt tccgattgcc tgctggcaga acctacaatg tccgagcatc
      241 agagttggcc cgagacagac agcatacaga ggtcgtttgc aacattcttc ttctggataa
      301 cactgtacag gctttcagag ttaacaaaca tgatcagggg caagttctgt tggatatagt
      361 cttcaagcat cttgatttga ctgagcgaga ctattttggt ttacagttgg ctgacgattc
      421 cacagataac ccaaggtggc tggatccaaa caaaccaata aggaagcagc taaagagagg
      481 atcaccttac aatttgaact ttagagtcaa attctttgta agtgacccca acaagttaca
      541 agaagagtat acaaggtatc agtacttttt gcaaattaag caagacattc ttactggaag
      601 attatcctgt ccttgtaaca ctgctgccct tttagcatca tttgctgttc agtctgaact
      661 tggagactac aatcagtcag aaaacttggc aggctacctc tcagattatt ctttcattcc
      721 taatcaacct caagattttg agaaagaaat tgcaaagtta catcagcagc acgttggcct
      781 atctcctgca gaagcagaat ttaattacct aaacgcggca cgtaccttag aactctatgg
      841 agttgaattt cactatgcaa gggatcaaag taacaatgaa atcctgattg gagtgatgtc
      901 aggaggaatt ctgatttata agaacagggt acggatgaat acttttctgt ggttgaagat
      961 tgtaaaaatt tcttttaaat gcaaacagtt ttttattcaa cttagaaaag agttgcatga
     1021 atctagagaa acattactgg gatttaatat ggtgaattat agagcatgta aaactttgtg
     1081 gaaagcgtgt gtagaacatc atacattctt ccgcctggat agaccacttc cacctcaaaa
     1141 aaattttttt gcacattatt ttacattggg ttccaaattc cggtactgtg ggagaactga
     1201 agtccagtca gttcaatatg gcaaagaaaa ggcaaataaa gacagggtat ttgcaagatc
     1261 tccaagtaag cctttggcac ggaaattaat ggattgggaa gtagtcagca gaaattcatt
     1321 atctgatgac aggttagaaa cacaaagcct cccatcccgg tctccacctg gaactcccaa
     1381 ccatcggaat tcttcattca cacaagaggc aacccgggtt cggccgtctt cagttggtca
     1441 tttggtagac catgtggttc acatgtcccc cagtgaggat tttgtaagtc agagatctcc
     1501 atcatcaacg caagctaata gcatagttct ggagtcatca ccatcacaag agacccctga
     1561 agatgggcag ccaccagctt taccacccaa acaatctaag aaaaatagtt ggaaccaaat
     1621 tcatttttca aactctcagc aagatctagt cacccatact aatgaatcct ttgatgtgcc
     1681 ctcttcccct gaaaagtcca ctcctaatgg tggcattcca catgataacc ttgttctaat
     1741 caaaatgaaa cctgatgaaa atggaaggtt tggattcaat gtaaagggag gatatgatca
     1801 gaagatgcct gtaattgttt cccgggtagc accaggaaca cctgctgacc tctgtgtccc
     1861 tcgcttgaat gaaggggacc aagtggtact aataaatggt cgggacattg cagaacatac
     1921 ccatgatcaa gtagtcttgt ttattaaagc tagctgtgag aaacattctg gggaactcgt
     1981 gctcctagtc cgacctaatg ctgtatatga tgtagtggaa gaaaaactag aaagtgaacc
     2041 agacttccag tatattcctg agaaagcccc actagatagt gtccatcaag atgaccattc
     2101 cttgcgggag tcaatgatcc agctagctga ggggcttatc actggaacag tactggcaca
     2161 gtttgatcaa ctctatcgga aaaaacctgg aatgacaatg tcttgtgcca aattacctca
     2221 gaacatttcc aaaaacagat acagagatat ttcaccttat gatgctacac gggtcctttt
     2281 aaaaggtaat gaagactaca tcaatgcaaa ctatataaat atggaaattc cttcttcaag
     2341 tattataaat caatacattg cttgtcaagg gccattacca cacacttgta aagatttttg
     2401 gcaaatgact tgggaacaag gctcctccat ggttgtgatg ttgaccacac aagttgaacg
     2461 tggcagagtt aaatgtcacc agtattggcc agaaccctca gaaagctcat cctatggatg
     2521 ctatcaagtc acctgccact ctgaagaagg aaaccctgcc tatatcttca ggaagatgac
     2581 actgtttaac caagagaaaa atgagagccg tcaacttact cagattcagt acacagcctg
     2641 gcctgaccat ggagtacctg atgattcgag tgactttctg gattttgttt gtcatgtacg
     2701 agaccagagg gctggaaaag aagagcccat tattgttcat tgcagtgctg gaattggaag
     2761 gactggggtt cttattacta tggaaactgc catgtgtctc attgaatgca atcagccagt
     2821 ttatccacta gacattgtaa gaacaatgag agatcaaaga gcaatgatga tccaaacacc
     2881 tagtcaatac agatttgtat gtgaagctat tctgaaagtt tatgaagaag gatttgttaa
     2941 accattaaca acatcatcaa ataaataaaa caaaaaggtt ggaacaagta ctgggaaact
     3001 gattttgtta tgttcactgt gccataatac tgcttgcaag aaatggcctc tcacacaaaa
     3061 agtgaagaac tcaaaaagac gtcaagaact tcagcactac tgcactttat gttttaaaaa
     3121 gtcactcaaa acctattact cacatggttg accattttgt gctttgctct gaacgacgag
     3181 tgaaaactga atatgttcag ggtagtttat ggaattttga ggtgttgcca tgcagtcccc
     3241 tcgggtagaa ttgccacaga taaggctcag aattctcatc tcttacacac ccgtaccttg
     3301 aaagcaaaaa ggagtaaaca tcaggagtct gctctggtct ttcccagtgg ttcatgtact
     3361 cgctctactg agtaccagat tttatttttc aaatgttagc aataccattc tcaacattag
     3421 ccagtacact gcctgtggat gcagcacatc ttccctgcca tcccaatagg gacctgctgt
     3481 tgagaagaac attggaacgt gctgttccca ggaaatgctg cacagtgtcc atttaccagc
     3541 atctcagaga actaactatg aatctatgga ttttcttgga tttaatgatg taacttatat
     3601 ttatcataag gttggcttat tccaaatcat gtgatttcac attcttgatg taaaggaatg
     3661 catgcatcgt gtcttaaccc cttaagtgcc ttgagatatc tttgtctaat gaaaaggcac
     3721 tcatttgacc ccataggagg tatgtatgta tactgtacat tcttatagtt ttatgaattt
     3781 ttaataagtt cacagtgttt ttaaaaacca gcttcttatg ttgagagtta tacaaagaag
     3841 ggtaaggaca ttctgtttct tactcagtgc ttgcttggac tttgccataa aagccaggat
     3901 ctctgtattc tgctgagagt gcatctgctg ctatggaatt gttcacagtc tgtacattcc
     3961 gttactgagt gacaggggtt aaagtttagc agcgtaactt aaaagagggt ttattcttca
     4021 aatttcatat ttactttatc ctaagttaaa aagtgttgtt taacatgtat attagaaata
     4081 aatatattgg tactcttaag ttatagtgac agagttaatt agttggaata ttaacatcta
     4141 taactaaagt gttgccctga agcatcattc taggtcatat caggctgtct tcacactgct
     4201 cttttcattg ggattcttta gacaaggaat tagacactat tgactttctc taaatgtgac
     4261 ccttcataat agtaaaatga cagttttcat gtcatcatag tttatatata cctattaaat
     4321 tataagcatg tcagtgagtc catcttgatg ggagatccag ctcccattgc agatgtgtat
     4381 gttttccttg ttttaagtct atggagacag atttttaaaa ttgcccattt aatgtgagaa
     4441 cttgctcact ttttcacatg ttattttata tggatatggt taaaatagac acatttgcta
     4501 gtggtttcag attacttatg cagtcttgat aaaacatagg ttccaatggt agatgttttg
     4561 gaatgctatt tagttgggag aatgatatac atttaaaaat ctttagtaaa atataaatca
     4621 ttgtttcata tattcagaat ccataatagt aaaattcagt atttaaatat taattgccag
     4681 ggtaccaaat aaattgtcac ttataaa
//
