LOCUS       NM_001384115            6287 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 3
            (Ptpn3), transcript variant 2, mRNA.
ACCESSION   NM_001384115 XM_006538098
VERSION     NM_001384115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6287)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6287)
  AUTHORS   Hou,S., Suresh,P.S., Qi,X., Lepp,A., Mirza,S.P. and Chen,G.
  TITLE     p38gamma Mitogen-activated protein kinase signals through
            phosphorylating its phosphatase PTPH1 in regulating ras protein
            oncogenesis and stress response
  JOURNAL   J Biol Chem 287 (33), 27895-27905 (2012)
   PUBMED   22730326
  REMARK    GeneRIF: p38gamma Mitogen-activated protein kinase signals through
            phosphorylating its phosphatase PTPH1 in regulating ras protein
            oncogenesis and stress response.
REFERENCE   3  (bases 1 to 6287)
  AUTHORS   Bauler,T.J., Hendriks,W.J. and King,P.D.
  TITLE     The FERM and PDZ domain-containing protein tyrosine phosphatases,
            PTPN4 and PTPN3, are both dispensable for T cell receptor signal
            transduction
  JOURNAL   PLoS One 3 (12), e4014 (2008)
   PUBMED   19107198
  REMARK    GeneRIF: PTPN3 and PTPN4 are dispensable for TCR signal
            transduction.
REFERENCE   4  (bases 1 to 6287)
  AUTHORS   Pilecka,I., Patrignani,C., Pescini,R., Curchod,M.L., Perrin,D.,
            Xue,Y., Yasenchak,J., Clark,A., Magnone,M.C., Zaratin,P.,
            Valenzuela,D., Rommel,C. and Hooft van Huijsduijnen,R.
  TITLE     Protein-tyrosine phosphatase H1 controls growth hormone receptor
            signaling and systemic growth
  JOURNAL   J Biol Chem 282 (48), 35405-35415 (2007)
   PUBMED   17921143
  REMARK    GeneRIF: PTP-H1 has a role in modulating GHR signaling and systemic
            growth through insulin-like growth factor 1 secretion
REFERENCE   5  (bases 1 to 6287)
  AUTHORS   Bauler,T.J., Hughes,E.D., Arimura,Y., Mustelin,T., Saunders,T.L.
            and King,P.D.
  TITLE     Normal TCR signal transduction in mice that lack catalytically
            active PTPN3 protein tyrosine phosphatase
  JOURNAL   J Immunol 178 (6), 3680-3687 (2007)
   PUBMED   17339465
REFERENCE   6  (bases 1 to 6287)
  AUTHORS   Cuajungco,M.P., Leyne,M., Mull,J., Gill,S.P., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, characterization, and genomic structure of the mouse
            Ikbkap gene
  JOURNAL   DNA Cell Biol 20 (9), 579-586 (2001)
   PUBMED   11747609
REFERENCE   7  (bases 1 to 6287)
  AUTHORS   Podsypanina,K., Ellenson,L.H., Nemes,A., Gu,J., Tamura,M.,
            Yamada,K.M., Cordon-Cardo,C., Catoretti,G., Fisher,P.E. and
            Parsons,R.
  TITLE     Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ
            systems
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1563-1568 (1999)
   PUBMED   9990064
REFERENCE   8  (bases 1 to 6287)
  AUTHORS   Jia,Z.
  TITLE     Protein phosphatases: structures and implications
  JOURNAL   Biochem Cell Biol 75 (1), 17-26 (1997)
   PUBMED   9192069
  REMARK    Review article
REFERENCE   9  (bases 1 to 6287)
  AUTHORS   Huang,K., Sommers,C.L., Grinberg,A., Kozak,C.A. and Love,P.E.
  TITLE     Cloning and characterization of PTP-K1, a novel nonreceptor protein
            tyrosine phosphatase highly expressed in bone marrow
  JOURNAL   Oncogene 13 (7), 1567-1573 (1996)
   PUBMED   8875997
REFERENCE   10 (bases 1 to 6287)
  AUTHORS   Messerle,M., Follo,M., Nehls,M., Eggert,H. and Boehm,T.
  TITLE     Dynamic changes in gene expression during in vitro differentiation
            of mouse embryonic stem cells
  JOURNAL   Cytokines Mol Ther 1 (2), 139-143 (1995)
   PUBMED   9384671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805921.7.
            
            On May 30, 2020 this sequence version replaced XM_006538098.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.6277.1,
                                           SRR9219379.12936.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL805921.7         160481-160569       c
            90-244              AL805921.7         130223-130377       c
            245-352             AL805921.7         125183-125290       c
            353-395             AL805921.7         125066-125108       c
            396-474             AL805921.7         122629-122707       c
            475-519             AL805921.7         118175-118219       c
            520-572             AL805921.7         115117-115169       c
            573-693             AL805921.7         110108-110228       c
            694-781             AL805921.7         108858-108945       c
            782-870             AL805921.7         105175-105263       c
            871-934             AL805921.7         100986-101049       c
            935-1107            AL805921.7         99728-99900         c
            1108-1242           AL805921.7         95422-95556         c
            1243-1419           AL805921.7         92522-92698         c
            1420-1606           AL805921.7         85914-86100         c
            1607-1684           AL805921.7         85706-85783         c
            1685-1741           AL805921.7         83819-83875         c
            1742-1898           AL805921.7         82098-82254         c
            1899-2059           AL805921.7         78709-78869         c
            2060-2150           AL805921.7         66414-66504         c
            2151-2212           AL805921.7         66085-66146         c
            2213-2359           AL805921.7         65107-65253         c
            2360-2488           AL805921.7         57706-57834         c
            2489-2634           AL805921.7         56551-56696         c
            2635-2770           AL805921.7         55902-56037         c
            2771-6287           AL805921.7         51046-54562         c
FEATURES             Location/Qualifiers
     source          1..6287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     gene            1..6287
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /note="protein tyrosine phosphatase, non-receptor type 3"
                     /db_xref="GeneID:545622"
                     /db_xref="MGI:MGI:105307"
     exon            1..89
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            90..244
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2848
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase H1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     3"
                     /protein_id="NP_001371044.1"
                     /db_xref="GeneID:545622"
                     /db_xref="MGI:MGI:105307"
                     /translation="MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFK
                     VNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCT
                     LHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGD
                     FNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYG
                     VELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQ
                     AESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKK
                     SVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPR
                     HSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNHSPHRESLSENNPAQSCL
                     TQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYCDKSDDGDGYL
                     VLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRD
                     ISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACP
                     EGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPY
                     DTTRVLLQGNEDYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQKLSLV
                     VMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQTEDCTIAYVSREMLVTNTETGEE
                     HTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVDGEPALVHCSAGIGRTGVLVTME
                     TAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQRLDPS"
     exon            245..352
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            353..395
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            396..474
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            475..519
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            520..572
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            573..693
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            694..781
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            782..870
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            871..934
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1107
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1242
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1419
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1606
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1684
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1741
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1898
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2059
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2150
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2212
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2359
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2488
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2634
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2770
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..6287
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4142..4147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /note="hexamer: AATAAA"
     regulatory      4147..4152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /note="hexamer: ATTACA"
     polyA_site      4161
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
     polyA_site      4164
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /note="major polyA site"
     regulatory      6264..6269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /note="hexamer: TATAAA"
     polyA_site      6287
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /note="major polyA site"
ORIGIN      
        1 agacggcggc caggtcgcgg cgcgagcgag cttcagtgcc gcccgcccgc gcgacctacc
       61 tgggcgcccc gcgcccccgg atgctgcagg ttactcggcg gccgttatga cctcccggtt
      121 acgtgcgttg ggtggaagaa ttaacaatac ccgaacctct gaattgccca aagagaaaac
      181 tcgatccgag gtcatctgca gcatacggtt tttagatggc ttggtacaga cctttaaagt
      241 taacaaacaa gatttgggcc agtcgcttct ggatatggcc tatggccacc tgggtgtgac
      301 ggagaaggaa tacttcggct tgcaacatgg cgacgaccca gtggactctc ctagatggct
      361 tgaggcaagc aaacccctca ggaagcagct gaaaggaggt tttccctgta ccctgcattt
      421 tcgagtaaga tattttatac ctgatcccaa cacactgcag caggagcaaa ccaggcatct
      481 atatttctta caactgaaga tggatgtttg cgaaggaagg ttaacctgcc ctctcaactc
      541 agcggtggtt ctagcctcgt acgcagtaca atctcatttt ggagacttta attcttcaat
      601 acatcatcca ggctatcttg ccgacagcca gttcatacca gatcaaaatg atgacttttt
      661 aagcaaggtg gagtcactcc atgaacagca cagtgggcta aagcagtcgg aagccgaatc
      721 ttgctacatc aacatagctc gaacccttga cttctacgga gtggagcttc atggaggcag
      781 agatctgcac aacctagatc taatgatcgg gattgcgtct gcaggcattg cagtctaccg
      841 aaaatacatt tgcacaagtt tctacccttg ggtgaacata ctcaaaattt ctttcaaaag
      901 gaaaaagttc ttcatacacc agcggcaaaa acaggctgaa tccagggaac atatcgtggc
      961 cttcaacatg ctgaattacc gatcttgcaa aaacttgtgg aaatcctgcg tcgaacacca
     1021 ttcgttcttt caggcaaaaa agttactacc tcaggaaaag aatgttctct ctcagtactg
     1081 gactctaggc tccaggaacc ccaaaaagtc tgtaaataac caatattgca aaaaggtgat
     1141 tggagggatg gtgtggaacc cagtcatgag gaggtcctta tcagtggaac ggctggaaac
     1201 caagagcctg ccttcccggt cccctcccat cacccccaac tggcgaagtc ctcggctccg
     1261 gcatgaaatc cgcaagcccc gccattcctc cgcggacaac ctggccaatg agatgaccta
     1321 catcacagaa accgaggatg tgttctatac ctacaaggga cccctgtccc ccaaagacag
     1381 cgactctgaa gtctcccaga accacagccc acaccgggag agtttgtccg aaaacaaccc
     1441 agcccaaagc tgcctgaccc agaagtcatc cagttctgtg tctccatctt cgaatgctcc
     1501 aggctcctgc tctccagatg gagttgacca gcggttctta gaagactacc acaaggtgac
     1561 caaagggggg ttcgtcgagg acgccagcca gtactactgt gataagagtg acgatggaga
     1621 tggctaccta gtcctgatcc ggatcacacc agatgaagag ggaagatttg gctttaacct
     1681 taagggagga gtggatcaaa agatgccgct cgtggtctcg aggataaacc cagagtcacc
     1741 tgcagatacc tgcatgccta agctgaatga gggggatcag atcgtgttga tcaatggccg
     1801 ggacatctca gagcacactc atgaccaggt ggtgatgttc atcaaagcaa gccgggagtc
     1861 ccactcgaga gaactggccc tggtgatcag gagaaaagct gtgcgctcgc tggcggagat
     1921 cagatcagaa gatgagctga gtcagctttt cccagaagcc atgtttcctg catgtcctga
     1981 gggtggggac agtctggagg gatccatgga gctgctgaag aaaggtctgg aaagcggtac
     2041 agtgttgatc cagtttgagc aactctacag aaagaagccc ggcttagccg tctcatttgc
     2101 aaagctgcct cagaatttgg ataaaaaccg atacaaagat gtgttgcctt atgataccac
     2161 gcgggtatta ttgcagggaa atgaagatta cattaatgcc agttatgtga acatggagat
     2221 gcccgctgct aaccttgtga acaagtacat tgccactcag ggaccgctgc caaacacctg
     2281 tgcacagttt tggcaagttg tctgggatca gaagttgtct cttgttgtca tgctgacgac
     2341 tctcaccgag cgagggcgga ccaaatgtca ccagtactgg ccggatcccc ctgacatcat
     2401 ggaccatggc atctttcaca tccagtgtca gacagaggac tgtaccattg cttacgtgtc
     2461 ccgagaaatg ctagttacaa acacggagac cggggaagaa cacacagtga cccatctcca
     2521 gtatgtggcg tggcctgacc acggcgtacc tgatgactca tcagacttcc tggagtttgt
     2581 gaagtatgtg aggtccctga gggtcgacgg tgagcctgcc ctcgttcact gcagtgctgg
     2641 aataggtcgg acaggtgttt tagtcactat ggaaacagcc atgtgcttaa ttgagaggaa
     2701 cctgcctgtt tacccactgg atattgtccg gaaaatgaga gaccagcgcg cgatgatggt
     2761 gcagacgtca agccaataca agtttgtgtg tgaagcgatc cttcgagtgt acgaagaagg
     2821 cttagtccag aggctggatc ccagttagga caactgtgaa gtggtcgttc ctccttccct
     2881 agggcgactt cctgaagaag ggggcacaca ttcccctgga ggccccccca gagatgctgg
     2941 tcactgtggg aaagggatga gcttatctga acccaggcac tttaaatttc tgtggaaaag
     3001 ataccctgta cataaggact gatggtgtag atatgcatgc agctatgact cctttggccc
     3061 agagagaagc aacaggggat ctccagttgg gaactgtgtt tctccctaca tatcaccgtc
     3121 ccctgtcatc catccttgag caatgagagg ggacaccagc agtgtcctcc cgccagaagc
     3181 cagacaatgt ggctacttgt ggttgctcag gtgttttgtg tgttgttctg tgtgggattc
     3241 caagggctga acttccttgg caattcctgt ccattacccc tgacaccaag ggaaactcgg
     3301 atgaatgtac cacaggcagg gcacaaggga cttcaggctg gaggatgaac aggatctatt
     3361 ctgcccgccc tccctccctc cctccctccc tccgcctcat ctctacccct tctgcaatcc
     3421 aaagcacccc atttccccca ccccaaattc cttttcttca ggatcacgcc cagtgcctga
     3481 accagcttca tgatgtatgt tcaggtgaat tctctgccga gactgggaac taggctctgc
     3541 ataaggctga gtctcagctt cggaagcagg cgagcctctg ctcactcctt gtatactcgg
     3601 acgccatgac tggattcgcc gactactgaa tctctggatt gctgctactt caagctctca
     3661 cacttgaaac aagacaattt tcttgggggg tgggggatga tagcatccaa atattcagaa
     3721 ttttggaccc ttcttagaaa tgaccttcta gtaagtgacc atgagaaaca ctgcttctca
     3781 atcaagggtg gtgtgtgtgt gtgtgtccgt ctgtcattgt gtctctgtgt gtatgtgtgt
     3841 gtctgtgggt ggctgacttt ctcaggattc ctaacttgat tcaaattact gttgagttta
     3901 tgtaaagaat tcatctctgt acagaagaac aagtgtgttg ttcattcacc ctaggttaca
     3961 atggtctcca tttcatttca gaggagagaa tcagactaac tgaatataaa cacaatttga
     4021 tgttaattta ttctaagtac tctgggattt tgattgtcct aaagaattct gctctgtgaa
     4081 taccatgtta tttttttttt ttaatttgtg gcaggattgt agcgaattac tatttaagga
     4141 aaataaatta catgaatgct ctaaggtggt atttttaaat agctgttttt atgtatcgaa
     4201 aagaaagtca gcaagtttct taatggtatt ataggaaaag gatactttga tgttataatg
     4261 tatgtagatg aagctacata gatacttagc agatactgga ccaattaaag catttcctag
     4321 ttgcaagatg ggtaaggacc tgtacaaagg acctcaggtt tttgaaggtt ctttatctgc
     4381 aggctcagtt tatctgtcta cttccctccc ccctgtcttt tacccacaaa catcttagta
     4441 gtgctcaatg atgtgagtga gaaaggcact gctcagtgcc ctgtatactg agaaagtgga
     4501 atttggttct gtactgctca acaccaggta gccctcatag gaacctggga tcgatctgtg
     4561 cctctctttc cgtctgtgtg aaataatgaa aaacaacact tggaatttga ggacagaatt
     4621 agatcacact atggaaacta atttccagct tctggaatac ataaaccaat gccactgaag
     4681 aactaggaag gctggcttct tttgttggcc ccaagcatat cagacaagtg gaacccacca
     4741 ggttttcata gagcagtgtt gtagagggaa aagcacagag caccgatacc tttattcaag
     4801 ctgggttctg agaacgctct cagtaaagcc ccaagaagag gaggaggaga gagtactggg
     4861 tgcatttcag tggcactagg ctgtttaaca gacgaccgtt gtttgatagc aatgtttatc
     4921 actgccctgt gtgcaaagca cttgcagaat ctaaatgtcc ttggagactg ttttattatt
     4981 tttctgaaaa cacgttgagt gtggtcacga aaatgctgct gttacactta tgtaatattc
     5041 tgtgaagctt gaaaaagctg cagctggcct ctctctgcca ttgtatgggg ccagcacttc
     5101 agacacagtg gtagttgcca gaaacagagt ccgtgggatc ttgagaagga catgaaaatg
     5161 accccaaaga gtagagtgcc caagtgaact gggtcaatat taccaattta aaaaaccaaa
     5221 gttctgagct cttgttttcc tgcatctccc atatccacag ttgcttttga gaagctatgt
     5281 ttcatcctaa gaattgcatc agactcaggg taaatatttt gcctgggaaa tttggctggt
     5341 tgtgaatggg gaagatattt atatcctaca ttccagcacc ttcccaaaga acagattaga
     5401 caccccagtg tacttccttc atccggtggg ttccctgctg gtaccactct ccagaatcca
     5461 tacatggtgt gttgattttc cagagagaac aattaagtga agtttgttga ggggtagggg
     5521 gcaggatgga tggctctcaa acgtgtagcg gtacttttag tttcctcccg gggtcccatg
     5581 ggacttaaat atgttctgat gcttgtgtag attctcttat tgctgtgttc atggttggcc
     5641 ctctccccct cccctctgca cgcctttatc cttaaaaatt accatttggg gggggtgcag
     5701 taaattgcct cttcatcctc ccaaggcaac aaagaggagg catcagggaa aaatgggtga
     5761 gacttagtcc agaccccggc tttgccctca gccagtttgt ttatgttgga aagcactggt
     5821 gactggtggg actagatgaa ctcacagtta gatttcaggg aaacaaaatt taaccttaac
     5881 caagtctgaa gggctgacac agagaaacac ccggtctgtg acttgtcccc aaggggttgg
     5941 ttgtctcagt ccttatcact gtggaattac aaagataaat attaccaccc tcctggttct
     6001 tacctgtcat cctagagtag acctagaaaa gacagccaag ttccttgtga cctcagcctg
     6061 agcaatcaaa cctcgaagac tgatgatagc taacgtcgat ttcttgatag ctctcgtacc
     6121 accggagcaa ccacaggatt gtgtgctaag ccatattttg taaagttatc tttagtcgat
     6181 cagcaatatg ttttcctgta aatttggaat gttttctcat cctgacttgt tgtcggaact
     6241 ctactgaaaa acaacctgat caatataaaa gcgttcaagc tatgcaa
//
