LOCUS       NP_001371044             913 aa            linear   ROD 09-JUN-2024
DEFINITION  tyrosine-protein phosphatase non-receptor type 3 [Mus musculus].
ACCESSION   NP_001371044 XP_006538161
VERSION     NP_001371044.1
DBSOURCE    REFSEQ: accession NM_001384115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 913)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 913)
  AUTHORS   Hou,S., Suresh,P.S., Qi,X., Lepp,A., Mirza,S.P. and Chen,G.
  TITLE     p38gamma Mitogen-activated protein kinase signals through
            phosphorylating its phosphatase PTPH1 in regulating ras protein
            oncogenesis and stress response
  JOURNAL   J Biol Chem 287 (33), 27895-27905 (2012)
   PUBMED   22730326
  REMARK    GeneRIF: p38gamma Mitogen-activated protein kinase signals through
            phosphorylating its phosphatase PTPH1 in regulating ras protein
            oncogenesis and stress response.
REFERENCE   3  (residues 1 to 913)
  AUTHORS   Bauler,T.J., Hendriks,W.J. and King,P.D.
  TITLE     The FERM and PDZ domain-containing protein tyrosine phosphatases,
            PTPN4 and PTPN3, are both dispensable for T cell receptor signal
            transduction
  JOURNAL   PLoS One 3 (12), e4014 (2008)
   PUBMED   19107198
  REMARK    GeneRIF: PTPN3 and PTPN4 are dispensable for TCR signal
            transduction.
REFERENCE   4  (residues 1 to 913)
  AUTHORS   Pilecka,I., Patrignani,C., Pescini,R., Curchod,M.L., Perrin,D.,
            Xue,Y., Yasenchak,J., Clark,A., Magnone,M.C., Zaratin,P.,
            Valenzuela,D., Rommel,C. and Hooft van Huijsduijnen,R.
  TITLE     Protein-tyrosine phosphatase H1 controls growth hormone receptor
            signaling and systemic growth
  JOURNAL   J Biol Chem 282 (48), 35405-35415 (2007)
   PUBMED   17921143
  REMARK    GeneRIF: PTP-H1 has a role in modulating GHR signaling and systemic
            growth through insulin-like growth factor 1 secretion
REFERENCE   5  (residues 1 to 913)
  AUTHORS   Bauler,T.J., Hughes,E.D., Arimura,Y., Mustelin,T., Saunders,T.L.
            and King,P.D.
  TITLE     Normal TCR signal transduction in mice that lack catalytically
            active PTPN3 protein tyrosine phosphatase
  JOURNAL   J Immunol 178 (6), 3680-3687 (2007)
   PUBMED   17339465
REFERENCE   6  (residues 1 to 913)
  AUTHORS   Cuajungco,M.P., Leyne,M., Mull,J., Gill,S.P., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, characterization, and genomic structure of the mouse
            Ikbkap gene
  JOURNAL   DNA Cell Biol 20 (9), 579-586 (2001)
   PUBMED   11747609
REFERENCE   7  (residues 1 to 913)
  AUTHORS   Podsypanina,K., Ellenson,L.H., Nemes,A., Gu,J., Tamura,M.,
            Yamada,K.M., Cordon-Cardo,C., Catoretti,G., Fisher,P.E. and
            Parsons,R.
  TITLE     Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ
            systems
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1563-1568 (1999)
   PUBMED   9990064
REFERENCE   8  (residues 1 to 913)
  AUTHORS   Jia,Z.
  TITLE     Protein phosphatases: structures and implications
  JOURNAL   Biochem Cell Biol 75 (1), 17-26 (1997)
   PUBMED   9192069
  REMARK    Review article
REFERENCE   9  (residues 1 to 913)
  AUTHORS   Huang,K., Sommers,C.L., Grinberg,A., Kozak,C.A. and Love,P.E.
  TITLE     Cloning and characterization of PTP-K1, a novel nonreceptor protein
            tyrosine phosphatase highly expressed in bone marrow
  JOURNAL   Oncogene 13 (7), 1567-1573 (1996)
   PUBMED   8875997
REFERENCE   10 (residues 1 to 913)
  AUTHORS   Messerle,M., Follo,M., Nehls,M., Eggert,H. and Boehm,T.
  TITLE     Dynamic changes in gene expression during in vitro differentiation
            of mouse embryonic stem cells
  JOURNAL   Cytokines Mol Ther 1 (2), 139-143 (1995)
   PUBMED   9384671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805921.7.
            
            On May 30, 2020 this sequence version replaced XP_006538161.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.6277.1,
                                           SRR9219379.12936.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     Protein         1..913
                     /product="tyrosine-protein phosphatase non-receptor type
                     3"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase H1"
                     /calculated_mol_wt=103765
     Region          31..222
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          216..309
                     /region_name="FERM_C_PTPN4_PTPN3_like"
                     /note="FERM domain C-lobe of Protein tyrosine phosphatase
                     non-receptor proteins 3 and 4 (PTPN4 and PTPN3); cd13189"
                     /db_xref="CDD:270010"
     Site            order(226,243,245,251)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270010"
     Site            order(255,260..263,298,302,305..306)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270010"
     Site            298..309
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270010"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26045; propagated from
                     UniProtKB/Swiss-Prot (A2ALK8.1)"
     Site            359
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26045; propagated from
                     UniProtKB/Swiss-Prot (A2ALK8.1)"
     Region          364..400
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2ALK8.1)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26045; propagated from
                     UniProtKB/Swiss-Prot (A2ALK8.1)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P26045; propagated from
                     UniProtKB/Swiss-Prot (A2ALK8.1)"
     Site            381
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26045; propagated from
                     UniProtKB/Swiss-Prot (A2ALK8.1)"
     Region          417..473
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2ALK8.1)"
     Site            425
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26045; propagated from
                     UniProtKB/Swiss-Prot (A2ALK8.1)"
     Region          506..595
                     /region_name="PDZ_PTPN3-4-like"
                     /note="PDZ domain of tyrosine-protein phosphatase
                     non-receptor type 3 (PTPN3), tyrosine-protein phosphatase
                     non-receptor type 4 (PTNP4), and related domains; cd06706"
                     /db_xref="CDD:467190"
     Site            order(520..526,538,541,572,576,579..580)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467190"
     Region          631..904
                     /region_name="PTPc-N3"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 3; cd14600"
                     /db_xref="CDD:350448"
     CDS             1..913
                     /gene="Ptpn3"
                     /gene_synonym="9530011I20Rik; PTP-H1; PTPCL"
                     /coded_by="NM_001384115.1:107..2848"
                     /db_xref="GeneID:545622"
                     /db_xref="MGI:MGI:105307"
ORIGIN      
        1 mtsrlralgg rinntrtsel pkektrsevi csirfldglv qtfkvnkqdl gqslldmayg
       61 hlgvtekeyf glqhgddpvd sprwleaskp lrkqlkggfp ctlhfrvryf ipdpntlqqe
      121 qtrhlyflql kmdvcegrlt cplnsavvla syavqshfgd fnssihhpgy ladsqfipdq
      181 nddflskves lheqhsglkq seaescyini artldfygve lhggrdlhnl dlmigiasag
      241 iavyrkyict sfypwvnilk isfkrkkffi hqrqkqaesr ehivafnmln yrscknlwks
      301 cvehhsffqa kkllpqeknv lsqywtlgsr npkksvnnqy ckkviggmvw npvmrrslsv
      361 erletkslps rsppitpnwr sprlrheirk prhssadnla nemtyitete dvfytykgpl
      421 spkdsdsevs qnhsphresl sennpaqscl tqkssssvsp ssnapgscsp dgvdqrfled
      481 yhkvtkggfv edasqyycdk sddgdgylvl iritpdeegr fgfnlkggvd qkmplvvsri
      541 npespadtcm pklnegdqiv lingrdiseh thdqvvmfik asreshsrel alvirrkavr
      601 slaeirsede lsqlfpeamf pacpeggdsl egsmellkkg lesgtvliqf eqlyrkkpgl
      661 avsfaklpqn ldknrykdvl pydttrvllq gnedyinasy vnmempaanl vnkyiatqgp
      721 lpntcaqfwq vvwdqklslv vmlttlterg rtkchqywpd ppdimdhgif hiqcqtedct
      781 iayvsremlv tntetgeeht vthlqyvawp dhgvpddssd flefvkyvrs lrvdgepalv
      841 hcsagigrtg vlvtmetamc liernlpvyp ldivrkmrdq rammvqtssq ykfvceailr
      901 vyeeglvqrl dps
//
